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The map label for this gene is mutL [H]

Identifier: 28199765

GI number: 28199765

Start: 2223787

End: 2225652

Strand: Reverse

Name: mutL [H]

Synonym: PD1897

Alternate gene names: 28199765

Gene position: 2225652-2223787 (Counterclockwise)

Preceding gene: 28199766

Following gene: 28199764

Centisome position: 88.33

GC content: 57.88

Gene sequence:

>1866_bases
GTGCTGATGCCAATCCGTCAGCTACCCGAGATTTTGATTAACCAGATTGCCGCCGGGGAGGTGGTTGAGCGTCCCGCCTC
GGTGGTTAAAGAGTTGGTTGAGAATGCAATTGATGCCGGTGCGACGCGTGTGGACATTGAGTTGGAAGCAGCAGGGGTGC
GCTTGATTCGCATCCGTGACAACGGCCACGGTATGGCTGCTCAGGAATTGCCGCTGGCAGTCTTGCGGCACGCTACCAGC
AAGATTGCCTCATTGGATGATTTGGAAGCGGTCGCCACCCTGGGTTTCCGTGGTGAGGCACTGCCTTCGATTGCTTCGGT
GAGTCGGTTTACCTTGATGTCGCGTCGTGCCACGGATGAACACGGTGCGGTATTGCAGATTGAGGGAGGTACGCTGGGCG
AGGTGATCCCCCATGCGCATGCACCGGGGACCACCGTTGAGGTGCGTGAGTTGTTCTATAACGTGCCAGCGCGGCGTAAG
TTCCTCCGTGCTGAGCGTACCGAGCTGGGGCATATTGAGGAATGGGCACGTTCTCTGGCGCTGGCGCATCCAGATTTAGA
ATTGCGTCTTTCACATAATGGCAAACTTTCGCGTCGCTATAAGCCGGGTGACTGGTATTCAGATGTGCGCTTGATCGAGA
TTTTGGGAGAAGATTTTGCGCATCAGGCATTGCGTGTAGATCACAGTGGCGCGGGGTTACGTCTGCATGGGTGCATTGTG
CAGCCGCATTACTCGCGTTTGAATGCGGATCAGCAATATTTGTACGTCAATGGACGTCCAGTCCGTGATCGTAGTGTTGC
TCACGCCGTCAAACAGGCTTACAGCGATGTGCTCTATCAGGGGCGACATCCGGCGTATGTGCTGTTTCTGGAGCTGGACC
CGGCACGTGTGGACGTGAACGTACACCCGGCCAAACATGAGGTGCGTTTCCGTGATGCACGGCTCATCCATGATTTTGTC
TACCGTACTGTTCAGGGCACGTTGGCACAGACGCGTGCGGGTACGCCGCCGTTGGCGGTGGGTGTGGGTGATGTGGAGGG
GGAGGGTGCAAGGCCTCCTGGCCGTCATGCGGTGTCGTTTTCAGGGCGGCGTGGTGGTGCCTCGCATGTGCTGGGGAGCT
ACTCTGCCAGCACGGCTCCTCTGATGCAGGGTGTGCCAAGCGTGTCTGTGGCTGACGCGCCCGCAGCGTATGCAGCCCTG
TATGCTGCGCCACCGACGCAGGTAATGGATGCAGTGCCACAGATGCAGACGGGGCTACCGCTGGCTGCTGGGGCGGGCGA
CGTACCGCTACTTGGCTATGCCATCGCACAGCTGCATGGCATTTATATCTTGGCTGAGTGTGCCGATGGGCTGATTGTGG
TGGATATGCATGCGGCTCACGAGCGTATTGGTTACGAGCGCCTGAAGCGCGCCCATGATGGTATTGGGTTACGTACCCAG
CCACTGTTGGTGCCGATGACGTTGATGGTTGCCGAGCGTGAGGCTGATGTTGCTGAGTGTGAAGCTGAGACGTTGGCCAA
TCTTGGCTTTGAAGTGACCCGCAGTGGTCCGGGTTCGTTACAGGTGCGTAGCATCCCGGCGTTGCTTTCCCAAGCGGAGC
CAGAAATGTTACTGCGCGATGTGCTCAGCGATCTGAGTGAACATGGCCACACCCGGCGTGTGGCTGAGGCGCGTGATACG
TTGCTTGCGACGATGGCTTGTCATGGTGCTGTGCGTGCTCACCGGCGCTTGAGCATTTCCGAGATGAACGCGTTGTTGCG
TGATATGGAGGCTACGGAGCGCTCAGGTCAATGTAATCACGGACGTCCTACCTGGGCGCGTTTTAGTTTGGCTGAGATCG
ATCGTTGGTTTCTTAGGGGGCGGTGA

Upstream 100 bases:

>100_bases
GAGTGAATGTCCGGGTGTCGTTGCTGCGTGTTTCCCGTGTGTCTGAGTGTTTGATCGTTTTAGATCTGATGGCTGTTGCC
TGTCCGTTATCCTTGGAGAA

Downstream 100 bases:

>100_bases
TGCGGCGTGAATACCAATACGGGGCAGTATTGATATTGTTGGCTGTGGTCGCAGTGCTTTTCACGTTTTTCGCGTGGTGG
CAGCGTGATCGCGATGTTGC

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 621; Mature: 621

Protein sequence:

>621_residues
MLMPIRQLPEILINQIAAGEVVERPASVVKELVENAIDAGATRVDIELEAAGVRLIRIRDNGHGMAAQELPLAVLRHATS
KIASLDDLEAVATLGFRGEALPSIASVSRFTLMSRRATDEHGAVLQIEGGTLGEVIPHAHAPGTTVEVRELFYNVPARRK
FLRAERTELGHIEEWARSLALAHPDLELRLSHNGKLSRRYKPGDWYSDVRLIEILGEDFAHQALRVDHSGAGLRLHGCIV
QPHYSRLNADQQYLYVNGRPVRDRSVAHAVKQAYSDVLYQGRHPAYVLFLELDPARVDVNVHPAKHEVRFRDARLIHDFV
YRTVQGTLAQTRAGTPPLAVGVGDVEGEGARPPGRHAVSFSGRRGGASHVLGSYSASTAPLMQGVPSVSVADAPAAYAAL
YAAPPTQVMDAVPQMQTGLPLAAGAGDVPLLGYAIAQLHGIYILAECADGLIVVDMHAAHERIGYERLKRAHDGIGLRTQ
PLLVPMTLMVAEREADVAECEAETLANLGFEVTRSGPGSLQVRSIPALLSQAEPEMLLRDVLSDLSEHGHTRRVAEARDT
LLATMACHGAVRAHRRLSISEMNALLRDMEATERSGQCNHGRPTWARFSLAEIDRWFLRGR

Sequences:

>Translated_621_residues
MLMPIRQLPEILINQIAAGEVVERPASVVKELVENAIDAGATRVDIELEAAGVRLIRIRDNGHGMAAQELPLAVLRHATS
KIASLDDLEAVATLGFRGEALPSIASVSRFTLMSRRATDEHGAVLQIEGGTLGEVIPHAHAPGTTVEVRELFYNVPARRK
FLRAERTELGHIEEWARSLALAHPDLELRLSHNGKLSRRYKPGDWYSDVRLIEILGEDFAHQALRVDHSGAGLRLHGCIV
QPHYSRLNADQQYLYVNGRPVRDRSVAHAVKQAYSDVLYQGRHPAYVLFLELDPARVDVNVHPAKHEVRFRDARLIHDFV
YRTVQGTLAQTRAGTPPLAVGVGDVEGEGARPPGRHAVSFSGRRGGASHVLGSYSASTAPLMQGVPSVSVADAPAAYAAL
YAAPPTQVMDAVPQMQTGLPLAAGAGDVPLLGYAIAQLHGIYILAECADGLIVVDMHAAHERIGYERLKRAHDGIGLRTQ
PLLVPMTLMVAEREADVAECEAETLANLGFEVTRSGPGSLQVRSIPALLSQAEPEMLLRDVLSDLSEHGHTRRVAEARDT
LLATMACHGAVRAHRRLSISEMNALLRDMEATERSGQCNHGRPTWARFSLAEIDRWFLRGR
>Mature_621_residues
MLMPIRQLPEILINQIAAGEVVERPASVVKELVENAIDAGATRVDIELEAAGVRLIRIRDNGHGMAAQELPLAVLRHATS
KIASLDDLEAVATLGFRGEALPSIASVSRFTLMSRRATDEHGAVLQIEGGTLGEVIPHAHAPGTTVEVRELFYNVPARRK
FLRAERTELGHIEEWARSLALAHPDLELRLSHNGKLSRRYKPGDWYSDVRLIEILGEDFAHQALRVDHSGAGLRLHGCIV
QPHYSRLNADQQYLYVNGRPVRDRSVAHAVKQAYSDVLYQGRHPAYVLFLELDPARVDVNVHPAKHEVRFRDARLIHDFV
YRTVQGTLAQTRAGTPPLAVGVGDVEGEGARPPGRHAVSFSGRRGGASHVLGSYSASTAPLMQGVPSVSVADAPAAYAAL
YAAPPTQVMDAVPQMQTGLPLAAGAGDVPLLGYAIAQLHGIYILAECADGLIVVDMHAAHERIGYERLKRAHDGIGLRTQ
PLLVPMTLMVAEREADVAECEAETLANLGFEVTRSGPGSLQVRSIPALLSQAEPEMLLRDVLSDLSEHGHTRRVAEARDT
LLATMACHGAVRAHRRLSISEMNALLRDMEATERSGQCNHGRPTWARFSLAEIDRWFLRGR

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family [H]

Homologues:

Organism=Homo sapiens, GI4557757, Length=338, Percent_Identity=33.1360946745562, Blast_Score=180, Evalue=3e-45,
Organism=Homo sapiens, GI189458898, Length=324, Percent_Identity=30.5555555555556, Blast_Score=156, Evalue=5e-38,
Organism=Homo sapiens, GI4505911, Length=324, Percent_Identity=30.5555555555556, Blast_Score=156, Evalue=7e-38,
Organism=Homo sapiens, GI189458896, Length=315, Percent_Identity=29.8412698412698, Blast_Score=150, Evalue=3e-36,
Organism=Homo sapiens, GI4505913, Length=330, Percent_Identity=28.4848484848485, Blast_Score=136, Evalue=6e-32,
Organism=Homo sapiens, GI310128478, Length=330, Percent_Identity=28.4848484848485, Blast_Score=135, Evalue=8e-32,
Organism=Homo sapiens, GI310128480, Length=295, Percent_Identity=25.7627118644068, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI91992162, Length=329, Percent_Identity=26.7477203647416, Blast_Score=87, Evalue=5e-17,
Organism=Homo sapiens, GI91992160, Length=329, Percent_Identity=26.7477203647416, Blast_Score=87, Evalue=6e-17,
Organism=Homo sapiens, GI263191589, Length=244, Percent_Identity=28.6885245901639, Blast_Score=84, Evalue=4e-16,
Organism=Escherichia coli, GI1790612, Length=606, Percent_Identity=40.9240924092409, Blast_Score=365, Evalue=1e-102,
Organism=Caenorhabditis elegans, GI71991825, Length=318, Percent_Identity=32.3899371069182, Blast_Score=166, Evalue=3e-41,
Organism=Caenorhabditis elegans, GI17562796, Length=356, Percent_Identity=27.247191011236, Blast_Score=137, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6323819, Length=317, Percent_Identity=33.4384858044164, Blast_Score=167, Evalue=6e-42,
Organism=Saccharomyces cerevisiae, GI6324247, Length=159, Percent_Identity=33.9622641509434, Blast_Score=105, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6325093, Length=735, Percent_Identity=20.952380952381, Blast_Score=100, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6323063, Length=361, Percent_Identity=23.8227146814404, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI17136968, Length=335, Percent_Identity=33.4328358208955, Blast_Score=187, Evalue=2e-47,
Organism=Drosophila melanogaster, GI17136970, Length=379, Percent_Identity=26.9129287598945, Blast_Score=117, Evalue=3e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C [H]

EC number: NA

Molecular weight: Translated: 67774; Mature: 67774

Theoretical pI: Translated: 6.97; Mature: 6.97

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLMPIRQLPEILINQIAAGEVVERPASVVKELVENAIDAGATRVDIELEAAGVRLIRIRD
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEECCEEEEEEEE
NGHGMAAQELPLAVLRHATSKIASLDDLEAVATLGFRGEALPSIASVSRFTLMSRRATDE
CCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCC
HGAVLQIEGGTLGEVIPHAHAPGTTVEVRELFYNVPARRKFLRAERTELGHIEEWARSLA
CCCEEEECCCCHHHHCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHH
LAHPDLELRLSHNGKLSRRYKPGDWYSDVRLIEILGEDFAHQALRVDHSGAGLRLHGCIV
HCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHEECCCCCCEEEEEEEE
QPHYSRLNADQQYLYVNGRPVRDRSVAHAVKQAYSDVLYQGRHPAYVLFLELDPARVDVN
CCCHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCEEEEE
VHPAKHEVRFRDARLIHDFVYRTVQGTLAQTRAGTPPLAVGVGDVEGEGARPPGRHAVSF
ECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCEEEE
SGRRGGASHVLGSYSASTAPLMQGVPSVSVADAPAAYAALYAAPPTQVMDAVPQMQTGLP
CCCCCCHHHHHCCCCCCCCHHHHCCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHCCCC
LAAGAGDVPLLGYAIAQLHGIYILAECADGLIVVDMHAAHERIGYERLKRAHDGIGLRTQ
EECCCCCCHHHHHHHHHHHHHEEEEECCCCEEEEEEHHHHHHHHHHHHHHHHCCCCCCCC
PLLVPMTLMVAEREADVAECEAETLANLGFEVTRSGPGSLQVRSIPALLSQAEPEMLLRD
CHHHHHHHHHHHCCCCHHHHHHHHHHHCCEEEECCCCCCEEEEHHHHHHHCCCHHHHHHH
VLSDLSEHGHTRRVAEARDTLLATMACHGAVRAHRRLSISEMNALLRDMEATERSGQCNH
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCC
GRPTWARFSLAEIDRWFLRGR
CCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLMPIRQLPEILINQIAAGEVVERPASVVKELVENAIDAGATRVDIELEAAGVRLIRIRD
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEECCEEEEEEEE
NGHGMAAQELPLAVLRHATSKIASLDDLEAVATLGFRGEALPSIASVSRFTLMSRRATDE
CCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCC
HGAVLQIEGGTLGEVIPHAHAPGTTVEVRELFYNVPARRKFLRAERTELGHIEEWARSLA
CCCEEEECCCCHHHHCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHH
LAHPDLELRLSHNGKLSRRYKPGDWYSDVRLIEILGEDFAHQALRVDHSGAGLRLHGCIV
HCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHEECCCCCCEEEEEEEE
QPHYSRLNADQQYLYVNGRPVRDRSVAHAVKQAYSDVLYQGRHPAYVLFLELDPARVDVN
CCCHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCEEEEE
VHPAKHEVRFRDARLIHDFVYRTVQGTLAQTRAGTPPLAVGVGDVEGEGARPPGRHAVSF
ECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCEEEE
SGRRGGASHVLGSYSASTAPLMQGVPSVSVADAPAAYAALYAAPPTQVMDAVPQMQTGLP
CCCCCCHHHHHCCCCCCCCHHHHCCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHCCCC
LAAGAGDVPLLGYAIAQLHGIYILAECADGLIVVDMHAAHERIGYERLKRAHDGIGLRTQ
EECCCCCCHHHHHHHHHHHHHEEEEECCCCEEEEEEHHHHHHHHHHHHHHHHCCCCCCCC
PLLVPMTLMVAEREADVAECEAETLANLGFEVTRSGPGSLQVRSIPALLSQAEPEMLLRD
CHHHHHHHHHHHCCCCHHHHHHHHHHHCCEEEECCCCCCEEEEHHHHHHHCCCHHHHHHH
VLSDLSEHGHTRRVAEARDTLLATMACHGAVRAHRRLSISEMNALLRDMEATERSGQCNH
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCC
GRPTWARFSLAEIDRWFLRGR
CCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA