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The map label for this gene is aspC [H]

Identifier: 28199355

GI number: 28199355

Start: 1717705

End: 1718853

Strand: Reverse

Name: aspC [H]

Synonym: PD1474

Alternate gene names: 28199355

Gene position: 1718853-1717705 (Counterclockwise)

Preceding gene: 77747698

Following gene: 28199354

Centisome position: 68.21

GC content: 53.96

Gene sequence:

>1149_bases
ATGCAGGTCACGAGTAAGTTACCCCAAGTGGGGACCACGATATTTAGTGTGATGTCGCAGTTGGCGGATGTGTATGGGGC
GGTCAATTTAGGGCAGGGGTTTCCGGATTTTCCGGTGCCGTTGCGTTTGCAGGAGGCGTTGGCGGGTGCGGTGCGTGAGG
GACACAATCAGTATCCGCCGATGATTGGGGTGGCTGGGTTGCGTCAGGGAATCGCTGCGAAGGTGTTGCGCTGTTACGGT
GCGCAGGTGGATGCGGATGTTGAGATCACGGTGACCAGTGGGGCGACGGAGGCGATTTTTAATGCAATCCATGCGGTGGT
GGGGGCGGGTGATGAGGTCATTGTGCTTGATCCAGCGTATGACTGTTATGAGCCGGGGATTGTGTTGGCCGGTGCGCGTG
CGGTGCATGTGCCATTGGATGCGGTGAGTTTTAAGGTGGATTGGGAGCGGGTGGGTGCGGCGATCACGTCAAGAACGCGG
TTGTTGATCGTGAATAGTCCGCATAATCCGTCCGGGGCGTTGTTTTCAGCCGATGATATGCGGGCTTTAGCGGCTTTGTT
GGATGGGACGGATATTTTGCTGATTTCCGATGAGGTGTATGAGCATATTGTGTTTGATGGGTGTGGCCATGAGTCGGTGT
TGCGTTGGCCGCAGTTGCGTGCGCGTGCGTTTGTGATTTCTAGTTTCGGTAAAACCTATCATTGCACCGGATGGAAAATC
GGTTATGCGATTGCACCGTCGGCGCTTAGTGCGGAGTTTCGTAAGGTCCATCAATACAACACGTTTACTAGTTTTGGACC
GGCGCAATATGCGTTTGCTGCGATGTTGCATGAGGAGCCTGGGTATGTGGAGCAGGTTGGTTTGTTCTATCAGGCAAGAC
GGGATTGTTTCCGTGAGCAGTTGTTGACAACCAAGTTAGTGCCGTTGCCTGTGTCGGGAGGTTATTTTCAGTTGGTGGAT
TATGGGGCGGTCAGTGATTTGTCTGATGTGGAGTTTTCAAGGTGGTTAGCGGTGGAAAAGGGGGTGGCGTCGATTCCGTT
ATCGCCGTTCTATGAGACTGCTCCAGCGGGGCAGCGTTTGGTGCGGTTGTGTTTCGCTAAAAATGATATGACGTTGGGGG
CGGCGATCGAGCGGTTACAACGGCTTTGA

Upstream 100 bases:

>100_bases
GGCAGGTGTATGGTGGATGTTGCGGTCCATGGGGCGGTACTCGGATACACATTCAGTAGACTTTGCGTTCTTTTATGTTC
TGACGAGAGATAAGTCCTTC

Downstream 100 bases:

>100_bases
TGTGGAGGATGTGATGCAGGATTTGCGTATTTCTCTTGTTCAAGGTGAGACGCGGTGGCATGACGCAGCGGGTAATCGGC
ATTACTACGGTGCGCTGTTG

Product: putative aminotransferase

Products: N-succinyl-2-L-amino-6-oxoheptanedioate; L-glutamate

Alternate protein names: NA

Number of amino acids: Translated: 382; Mature: 382

Protein sequence:

>382_residues
MQVTSKLPQVGTTIFSVMSQLADVYGAVNLGQGFPDFPVPLRLQEALAGAVREGHNQYPPMIGVAGLRQGIAAKVLRCYG
AQVDADVEITVTSGATEAIFNAIHAVVGAGDEVIVLDPAYDCYEPGIVLAGARAVHVPLDAVSFKVDWERVGAAITSRTR
LLIVNSPHNPSGALFSADDMRALAALLDGTDILLISDEVYEHIVFDGCGHESVLRWPQLRARAFVISSFGKTYHCTGWKI
GYAIAPSALSAEFRKVHQYNTFTSFGPAQYAFAAMLHEEPGYVEQVGLFYQARRDCFREQLLTTKLVPLPVSGGYFQLVD
YGAVSDLSDVEFSRWLAVEKGVASIPLSPFYETAPAGQRLVRLCFAKNDMTLGAAIERLQRL

Sequences:

>Translated_382_residues
MQVTSKLPQVGTTIFSVMSQLADVYGAVNLGQGFPDFPVPLRLQEALAGAVREGHNQYPPMIGVAGLRQGIAAKVLRCYG
AQVDADVEITVTSGATEAIFNAIHAVVGAGDEVIVLDPAYDCYEPGIVLAGARAVHVPLDAVSFKVDWERVGAAITSRTR
LLIVNSPHNPSGALFSADDMRALAALLDGTDILLISDEVYEHIVFDGCGHESVLRWPQLRARAFVISSFGKTYHCTGWKI
GYAIAPSALSAEFRKVHQYNTFTSFGPAQYAFAAMLHEEPGYVEQVGLFYQARRDCFREQLLTTKLVPLPVSGGYFQLVD
YGAVSDLSDVEFSRWLAVEKGVASIPLSPFYETAPAGQRLVRLCFAKNDMTLGAAIERLQRL
>Mature_382_residues
MQVTSKLPQVGTTIFSVMSQLADVYGAVNLGQGFPDFPVPLRLQEALAGAVREGHNQYPPMIGVAGLRQGIAAKVLRCYG
AQVDADVEITVTSGATEAIFNAIHAVVGAGDEVIVLDPAYDCYEPGIVLAGARAVHVPLDAVSFKVDWERVGAAITSRTR
LLIVNSPHNPSGALFSADDMRALAALLDGTDILLISDEVYEHIVFDGCGHESVLRWPQLRARAFVISSFGKTYHCTGWKI
GYAIAPSALSAEFRKVHQYNTFTSFGPAQYAFAAMLHEEPGYVEQVGLFYQARRDCFREQLLTTKLVPLPVSGGYFQLVD
YGAVSDLSDVEFSRWLAVEKGVASIPLSPFYETAPAGQRLVRLCFAKNDMTLGAAIERLQRL

Specific function: Shows aminotransferase activity with methionine and histidine as substrates, and to a lesser extent also with phenylalanine [H]

COG id: COG0436

COG function: function code E; Aspartate/tyrosine/aromatic aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI56713254, Length=400, Percent_Identity=33, Blast_Score=225, Evalue=5e-59,
Organism=Homo sapiens, GI56713256, Length=400, Percent_Identity=33, Blast_Score=225, Evalue=5e-59,
Organism=Homo sapiens, GI95147551, Length=396, Percent_Identity=33.5858585858586, Blast_Score=219, Evalue=3e-57,
Organism=Homo sapiens, GI169881279, Length=396, Percent_Identity=33.5858585858586, Blast_Score=219, Evalue=3e-57,
Organism=Homo sapiens, GI169881281, Length=394, Percent_Identity=28.6802030456853, Blast_Score=172, Evalue=4e-43,
Organism=Homo sapiens, GI4507369, Length=335, Percent_Identity=25.0746268656716, Blast_Score=88, Evalue=1e-17,
Organism=Escherichia coli, GI1786816, Length=378, Percent_Identity=54.4973544973545, Blast_Score=397, Evalue=1e-112,
Organism=Escherichia coli, GI1788722, Length=358, Percent_Identity=25.9776536312849, Blast_Score=123, Evalue=2e-29,
Organism=Escherichia coli, GI1788627, Length=178, Percent_Identity=28.6516853932584, Blast_Score=87, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI71994472, Length=407, Percent_Identity=33.6609336609337, Blast_Score=213, Evalue=1e-55,
Organism=Caenorhabditis elegans, GI71994476, Length=407, Percent_Identity=33.6609336609337, Blast_Score=213, Evalue=1e-55,
Organism=Caenorhabditis elegans, GI17567369, Length=403, Percent_Identity=32.0099255583127, Blast_Score=194, Evalue=1e-49,
Organism=Caenorhabditis elegans, GI17567663, Length=341, Percent_Identity=21.9941348973607, Blast_Score=70, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6322401, Length=385, Percent_Identity=31.4285714285714, Blast_Score=181, Evalue=1e-46,
Organism=Drosophila melanogaster, GI28573069, Length=392, Percent_Identity=32.1428571428571, Blast_Score=206, Evalue=3e-53,
Organism=Drosophila melanogaster, GI24646114, Length=392, Percent_Identity=32.1428571428571, Blast_Score=206, Evalue=3e-53,
Organism=Drosophila melanogaster, GI28573067, Length=392, Percent_Identity=32.1428571428571, Blast_Score=206, Evalue=3e-53,
Organism=Drosophila melanogaster, GI28573065, Length=392, Percent_Identity=32.1428571428571, Blast_Score=206, Evalue=3e-53,
Organism=Drosophila melanogaster, GI18859735, Length=186, Percent_Identity=29.5698924731183, Blast_Score=71, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: 2.6.1.17

Molecular weight: Translated: 41476; Mature: 41476

Theoretical pI: Translated: 5.59; Mature: 5.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQVTSKLPQVGTTIFSVMSQLADVYGAVNLGQGFPDFPVPLRLQEALAGAVREGHNQYPP
CCCHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCC
MIGVAGLRQGIAAKVLRCYGAQVDADVEITVTSGATEAIFNAIHAVVGAGDEVIVLDPAY
CEEHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHHCCCCCEEEECCCC
DCYEPGIVLAGARAVHVPLDAVSFKVDWERVGAAITSRTRLLIVNSPHNPSGALFSADDM
CCCCCCEEEECCEEEEECHHHEEEEECHHHHHHHHHCCEEEEEEECCCCCCCCEECHHHH
RALAALLDGTDILLISDEVYEHIVFDGCGHESVLRWPQLRARAFVISSFGKTYHCTGWKI
HHHHHHHCCCEEEEECHHHHHHHHHCCCCCHHHHHCHHHHHHHHHHHHCCCEEEECCEEE
GYAIAPSALSAEFRKVHQYNTFTSFGPAQYAFAAMLHEEPGYVEQVGLFYQARRDCFREQ
EEEECCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
LLTTKLVPLPVSGGYFQLVDYGAVSDLSDVEFSRWLAVEKGVASIPLSPFYETAPAGQRL
HHHHCCEEECCCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHH
VRLCFAKNDMTLGAAIERLQRL
HHHHHHCCCCHHHHHHHHHHCC
>Mature Secondary Structure
MQVTSKLPQVGTTIFSVMSQLADVYGAVNLGQGFPDFPVPLRLQEALAGAVREGHNQYPP
CCCHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCC
MIGVAGLRQGIAAKVLRCYGAQVDADVEITVTSGATEAIFNAIHAVVGAGDEVIVLDPAY
CEEHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHHCCCCCEEEECCCC
DCYEPGIVLAGARAVHVPLDAVSFKVDWERVGAAITSRTRLLIVNSPHNPSGALFSADDM
CCCCCCEEEECCEEEEECHHHEEEEECHHHHHHHHHCCEEEEEEECCCCCCCCEECHHHH
RALAALLDGTDILLISDEVYEHIVFDGCGHESVLRWPQLRARAFVISSFGKTYHCTGWKI
HHHHHHHCCCEEEEECHHHHHHHHHCCCCCHHHHHCHHHHHHHHHHHHCCCEEEECCEEE
GYAIAPSALSAEFRKVHQYNTFTSFGPAQYAFAAMLHEEPGYVEQVGLFYQARRDCFREQ
EEEECCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
LLTTKLVPLPVSGGYFQLVDYGAVSDLSDVEFSRWLAVEKGVASIPLSPFYETAPAGQRL
HHHHCCEEECCCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHH
VRLCFAKNDMTLGAAIERLQRL
HHHHHHCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: N-succinyl-L-2,6-diaminoheptanedioate; 2-oxoglutarate

Specific reaction: N-succinyl-L-2,6-diaminoheptanedioate + 2-oxoglutarate = N-succinyl-2-L-amino-6-oxoheptanedioate + L-glutamate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905232; 9278503 [H]