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The map label for this gene is pgcA [H]

Identifier: 62184966

GI number: 62184966

Start: 388519

End: 390324

Strand: Direct

Name: pgcA [H]

Synonym: CAB336

Alternate gene names: 62184966

Gene position: 388519-390324 (Clockwise)

Preceding gene: 62184965

Following gene: 62184967

Centisome position: 33.95

GC content: 42.14

Gene sequence:

>1806_bases
ATGCAGCATCTTCAGAAGAAAATAGAAGCTCTTTGTAGCCCCATTACAACAAAGAATATCCTTACCTGGTTATCTAACGA
TTGTAATGAACAAGATAAGGATACCATAGCTGAGCTTCTAAACAATGATCCAAAACGTCTTGAAGAGCTATTCGGAATGA
CTCTTTCCTTTGGTACAGGTGGGCTGCGGAGCCCTATGGGATTAGGCACCAATAGAATCAATGTTTTTACTATAAGACGT
GCGACCCAGGGATTGGCTCAAGTATTAAAAAAACATCATCCCCATTCTGGAGATCTCATTCGCGTCGTTGTAGGCTATGA
TACGCGCCATAATTCTTTCGATTTTGCCCAAGAGACTGCTAAGGTTCTAGCAGGAAATAACATTCACGTTCTCCTATTTA
AACACCCTGAACCTTTGGCTCTTGTCTCTTTCACTTTAAGAGCAGAACGCGCTTTGGCAGGAGTCATGATTACCGCTTCT
CATAATCCTCCAGAGTATAACGGGTATAAAGTGTACATGGCATCGGGAGGCCAGGTGCTCCCCCCTTGGGATCAGGAAAT
CATGCACGCCTCAGCACATATAGAAGAGATCGCCATGGCTAGCTCATTACAAGATCCCTATATTCATTTTATAGGGGAGG
AATATGAGCAGCTCTATGTCGAAACTGTACATACACTGCAGCTCTATCCCGAAGATAATCGGATTTCTGGACCAGCAATC
CGTGTCAGCTATTCTCCACTACACGGAACAGGAGTCGCCATGATTCCTCGAGTGTTACGAGATTGGAATTTTCCTATGGT
CAACCTTGTCGAAAAACAGGCGATTCCTGATGGCGATTTCCCTACAGTACACTTGCCCAACCCTGAAGATCCTGAAGCAC
TCACTTTAGGTATTGAGCAAATGCTAAGAAATCAAGACGATATTTTTATCGCTACCGACCCGGATGCAGACCGGTTAGGA
GTGGTGTGTCTGCATGAGAATCAACCCTATAGATTTAACGGAAATCAAATAGCCTGTTTGCTTGCAGATCATATTTTACG
TGCTTTGTCTGCGCGCGCTCCTCTAGGAAAGGAGGATAAAGTAGTGAAAAGTTTAGTCACTACAGAGATGCTCTCCGCCA
TCGTAAAATTTTATGGCGGCGATATCGTGAATGTAGGGACAGGATTTAAATATATCGGTGAGAAAATAGAAGCTTGGCGA
GAGAGTGTAGTAAGATACATATTTGGTGCCGAAGAATCTTACGGCTACCTATACGGCACACATGTAGAAGATAAAGATGC
AATGAGTACATCAGCATTAATTACAGAGGCGGCTTTGCATCAGAAGCTCCAAGGAAAAACTCTTCGCGATGCGATTTTAG
ACTTATATGAAACCCATGGATATTTCATGAATAAAACACTTTCGTTGTCCTTTGAACAAGGACAAGAAAGTCTCATGAAG
TCTCATATAGAAAAGTTGGCAAAGCTCGATCCTTCCACCATGTCCTTAAGAGGCTATTCCATTCACACGTGTGAAAATTA
TGATCAAGGGACAGGAATCAATATTCCCTGCGGGATCACGTACAAATTGCCTCTCCCTAAGATGGCCATGTTGTGTTATT
ACTATCAAAATGGAGGAAAAATTATCGTGCGTCCTTCAGGAACAGAACCGAAAATCAAACTCTATTTTGAGCTTGTCAAT
CATTACGAAGTCATCACAGGAAACAAAAAAGAACAAAGACAACGAGAAGAGGAAAGCAGGGAACAATTAGAGAAATTCAT
TGCTGAATTTAAAGAGAAATTTTTCTCCATAGAGTCGGAAGAATAA

Upstream 100 bases:

>100_bases
TCTTAAAGCAATTTCCTTCTTTCCATACACGAAATTGTTTGCCTAGAGCTAGTTTTATGTTATGACGACATAAGATCGCG
ATGTGTTTTTAGGAACTTTT

Downstream 100 bases:

>100_bases
AATGAAAATCATCTTGTAGTAATATCTTCAGCGCATCTACACTGGCCTACATCGATGAAAAAGAATATCACTAAACAATG
TTCTTGATATAACTCAAGAC

Product: putative phosphomannomutase

Products: NA

Alternate protein names: PGM; Alpha-phosphoglucomutase; Glucose phosphomutase [H]

Number of amino acids: Translated: 601; Mature: 601

Protein sequence:

>601_residues
MQHLQKKIEALCSPITTKNILTWLSNDCNEQDKDTIAELLNNDPKRLEELFGMTLSFGTGGLRSPMGLGTNRINVFTIRR
ATQGLAQVLKKHHPHSGDLIRVVVGYDTRHNSFDFAQETAKVLAGNNIHVLLFKHPEPLALVSFTLRAERALAGVMITAS
HNPPEYNGYKVYMASGGQVLPPWDQEIMHASAHIEEIAMASSLQDPYIHFIGEEYEQLYVETVHTLQLYPEDNRISGPAI
RVSYSPLHGTGVAMIPRVLRDWNFPMVNLVEKQAIPDGDFPTVHLPNPEDPEALTLGIEQMLRNQDDIFIATDPDADRLG
VVCLHENQPYRFNGNQIACLLADHILRALSARAPLGKEDKVVKSLVTTEMLSAIVKFYGGDIVNVGTGFKYIGEKIEAWR
ESVVRYIFGAEESYGYLYGTHVEDKDAMSTSALITEAALHQKLQGKTLRDAILDLYETHGYFMNKTLSLSFEQGQESLMK
SHIEKLAKLDPSTMSLRGYSIHTCENYDQGTGINIPCGITYKLPLPKMAMLCYYYQNGGKIIVRPSGTEPKIKLYFELVN
HYEVITGNKKEQRQREEESREQLEKFIAEFKEKFFSIESEE

Sequences:

>Translated_601_residues
MQHLQKKIEALCSPITTKNILTWLSNDCNEQDKDTIAELLNNDPKRLEELFGMTLSFGTGGLRSPMGLGTNRINVFTIRR
ATQGLAQVLKKHHPHSGDLIRVVVGYDTRHNSFDFAQETAKVLAGNNIHVLLFKHPEPLALVSFTLRAERALAGVMITAS
HNPPEYNGYKVYMASGGQVLPPWDQEIMHASAHIEEIAMASSLQDPYIHFIGEEYEQLYVETVHTLQLYPEDNRISGPAI
RVSYSPLHGTGVAMIPRVLRDWNFPMVNLVEKQAIPDGDFPTVHLPNPEDPEALTLGIEQMLRNQDDIFIATDPDADRLG
VVCLHENQPYRFNGNQIACLLADHILRALSARAPLGKEDKVVKSLVTTEMLSAIVKFYGGDIVNVGTGFKYIGEKIEAWR
ESVVRYIFGAEESYGYLYGTHVEDKDAMSTSALITEAALHQKLQGKTLRDAILDLYETHGYFMNKTLSLSFEQGQESLMK
SHIEKLAKLDPSTMSLRGYSIHTCENYDQGTGINIPCGITYKLPLPKMAMLCYYYQNGGKIIVRPSGTEPKIKLYFELVN
HYEVITGNKKEQRQREEESREQLEKFIAEFKEKFFSIESEE
>Mature_601_residues
MQHLQKKIEALCSPITTKNILTWLSNDCNEQDKDTIAELLNNDPKRLEELFGMTLSFGTGGLRSPMGLGTNRINVFTIRR
ATQGLAQVLKKHHPHSGDLIRVVVGYDTRHNSFDFAQETAKVLAGNNIHVLLFKHPEPLALVSFTLRAERALAGVMITAS
HNPPEYNGYKVYMASGGQVLPPWDQEIMHASAHIEEIAMASSLQDPYIHFIGEEYEQLYVETVHTLQLYPEDNRISGPAI
RVSYSPLHGTGVAMIPRVLRDWNFPMVNLVEKQAIPDGDFPTVHLPNPEDPEALTLGIEQMLRNQDDIFIATDPDADRLG
VVCLHENQPYRFNGNQIACLLADHILRALSARAPLGKEDKVVKSLVTTEMLSAIVKFYGGDIVNVGTGFKYIGEKIEAWR
ESVVRYIFGAEESYGYLYGTHVEDKDAMSTSALITEAALHQKLQGKTLRDAILDLYETHGYFMNKTLSLSFEQGQESLMK
SHIEKLAKLDPSTMSLRGYSIHTCENYDQGTGINIPCGITYKLPLPKMAMLCYYYQNGGKIIVRPSGTEPKIKLYFELVN
HYEVITGNKKEQRQREEESREQLEKFIAEFKEKFFSIESEE

Specific function: Catalyzes the interconversion between glucose-6- phosphate and alpha-glucose-1-phosphate. This is the first step in the biosynthesis of diglucosyl-diacylglycerol (Glc2-DAG), i.e. the predominant glycolipid found in B.subtilis membrane, which is also used

COG id: COG1109

COG function: function code G; Phosphomannomutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphohexose mutase family [H]

Homologues:

Organism=Homo sapiens, GI31377548, Length=594, Percent_Identity=31.986531986532, Blast_Score=236, Evalue=5e-62,
Organism=Homo sapiens, GI63055049, Length=600, Percent_Identity=29.8333333333333, Blast_Score=216, Evalue=5e-56,
Organism=Escherichia coli, GI1789566, Length=369, Percent_Identity=24.390243902439, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71993870, Length=592, Percent_Identity=31.25, Blast_Score=233, Evalue=2e-61,
Organism=Caenorhabditis elegans, GI71993878, Length=314, Percent_Identity=34.3949044585987, Blast_Score=161, Evalue=8e-40,
Organism=Saccharomyces cerevisiae, GI6323934, Length=589, Percent_Identity=29.0322580645161, Blast_Score=191, Evalue=3e-49,
Organism=Drosophila melanogaster, GI20129809, Length=567, Percent_Identity=31.2169312169312, Blast_Score=242, Evalue=6e-64,
Organism=Drosophila melanogaster, GI24651977, Length=461, Percent_Identity=32.1041214750542, Blast_Score=224, Evalue=1e-58,
Organism=Drosophila melanogaster, GI24653722, Length=622, Percent_Identity=27.0096463022508, Blast_Score=187, Evalue=2e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005844
- InterPro:   IPR016055
- InterPro:   IPR005845
- InterPro:   IPR005846
- InterPro:   IPR005843
- InterPro:   IPR016066
- InterPro:   IPR005841 [H]

Pfam domain/function: PF02878 PGM_PMM_I; PF02879 PGM_PMM_II; PF02880 PGM_PMM_III; PF00408 PGM_PMM_IV [H]

EC number: =5.4.2.2 [H]

Molecular weight: Translated: 67801; Mature: 67801

Theoretical pI: Translated: 5.96; Mature: 5.96

Prosite motif: PS00710 PGM_PMM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQHLQKKIEALCSPITTKNILTWLSNDCNEQDKDTIAELLNNDPKRLEELFGMTLSFGTG
CHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCHHHHHHHHHCCCHHHHHHHHCCEEECCCC
GLRSPMGLGTNRINVFTIRRATQGLAQVLKKHHPHSGDLIRVVVGYDTRHNSFDFAQETA
CCCCCCCCCCCEEEEEEEHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCHHHHHHH
KVLAGNNIHVLLFKHPEPLALVSFTLRAERALAGVMITASHNPPEYNGYKVYMASGGQVL
HHHCCCCEEEEEEECCCCCEEHHHHHHHHHHHEEEEEEECCCCCCCCCEEEEEECCCEEC
PPWDQEIMHASAHIEEIAMASSLQDPYIHFIGEEYEQLYVETVHTLQLYPEDNRISGPAI
CCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHEEEEEEECCCCCCCCCEE
RVSYSPLHGTGVAMIPRVLRDWNFPMVNLVEKQAIPDGDFPTVHLPNPEDPEALTLGIEQ
EEEECCCCCCCHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCEEECCCCCCCHHHHHHHHH
MLRNQDDIFIATDPDADRLGVVCLHENQPYRFNGNQIACLLADHILRALSARAPLGKEDK
HHCCCCCEEEEECCCCCCEEEEEEECCCCEEECCCEEEHHHHHHHHHHHHHCCCCCCHHH
VVKSLVTTEMLSAIVKFYGGDIVNVGTGFKYIGEKIEAWRESVVRYIFGAEESYGYLYGT
HHHHHHHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEC
HVEDKDAMSTSALITEAALHQKLQGKTLRDAILDLYETHGYFMNKTLSLSFEQGQESLMK
CCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCEEECCEEEEEHHHHHHHHHH
SHIEKLAKLDPSTMSLRGYSIHTCENYDQGTGINIPCGITYKLPLPKMAMLCYYYQNGGK
HHHHHHHHCCCCCEEECCEEEEECCCCCCCCCCCCCCCEEEECCCHHHEEEEEEEECCCE
IIVRPSGTEPKIKLYFELVNHYEVITGNKKEQRQREEESREQLEKFIAEFKEKFFSIESE
EEEECCCCCCCEEEEEEHHHCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
E
C
>Mature Secondary Structure
MQHLQKKIEALCSPITTKNILTWLSNDCNEQDKDTIAELLNNDPKRLEELFGMTLSFGTG
CHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCHHHHHHHHHCCCHHHHHHHHCCEEECCCC
GLRSPMGLGTNRINVFTIRRATQGLAQVLKKHHPHSGDLIRVVVGYDTRHNSFDFAQETA
CCCCCCCCCCCEEEEEEEHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCHHHHHHH
KVLAGNNIHVLLFKHPEPLALVSFTLRAERALAGVMITASHNPPEYNGYKVYMASGGQVL
HHHCCCCEEEEEEECCCCCEEHHHHHHHHHHHEEEEEEECCCCCCCCCEEEEEECCCEEC
PPWDQEIMHASAHIEEIAMASSLQDPYIHFIGEEYEQLYVETVHTLQLYPEDNRISGPAI
CCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHEEEEEEECCCCCCCCCEE
RVSYSPLHGTGVAMIPRVLRDWNFPMVNLVEKQAIPDGDFPTVHLPNPEDPEALTLGIEQ
EEEECCCCCCCHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCEEECCCCCCCHHHHHHHHH
MLRNQDDIFIATDPDADRLGVVCLHENQPYRFNGNQIACLLADHILRALSARAPLGKEDK
HHCCCCCEEEEECCCCCCEEEEEEECCCCEEECCCEEEHHHHHHHHHHHHHCCCCCCHHH
VVKSLVTTEMLSAIVKFYGGDIVNVGTGFKYIGEKIEAWRESVVRYIFGAEESYGYLYGT
HHHHHHHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEC
HVEDKDAMSTSALITEAALHQKLQGKTLRDAILDLYETHGYFMNKTLSLSFEQGQESLMK
CCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCEEECCEEEEEHHHHHHHHHH
SHIEKLAKLDPSTMSLRGYSIHTCENYDQGTGINIPCGITYKLPLPKMAMLCYYYQNGGK
HHHHHHHHCCCCCEEECCEEEEECCCCCCCCCCCCCCCEEEECCCHHHEEEEEEEECCCE
IIVRPSGTEPKIKLYFELVNHYEVITGNKKEQRQREEESREQLEKFIAEFKEKFFSIESE
EEEECCCCCCCEEEEEEHHHCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
E
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377; 2127799 [H]