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The map label for this gene is purL

Identifier: 28572944

GI number: 28572944

Start: 910537

End: 912819

Strand: Reverse

Name: purL

Synonym: TW803

Alternate gene names: 28572944

Gene position: 912819-910537 (Counterclockwise)

Preceding gene: 28572945

Following gene: 28572940

Centisome position: 98.58

GC content: 48.75

Gene sequence:

>2283_bases
GTGAATATGAGCCTGCCAGCAGATCGAGATACCGCAAAAAAGCCTAGCGCGCAAAAGCCTAGCGCGCACGCACAGAACGC
GACTGCCGCCGTGGACGTCACAGCACTTGGCTTGACGGAGTCTGAGTATACACAAATTTGCTCGCTGCTAAAACGCTCTC
CAACAAAAAGTGAACTCGCGATCTATTCTGTTCTATGGAGCGAACATTGTTCCTACAAGTCTTCCCGTAGACACTTACGA
CAGTTAGCTGACCTAACAGAGGTAACAAAAAAACATTTGCTTGTTGGAATTGGTCAGAACGCCGGAGTTGTTGATATCGG
TGGTGGCTGGGCTGCAGCCTTCAAGATAGAAAGCCACAATCACCCGTCTTTTATTGAACCCTTCCAGGGTGCCGCAACGG
GCATTGGCGGTATCGTGCGTGACATTATTGCCATGGGTGCAAAACCTGTTGCACTAATGGACTCGTTGCGTTTCGGCGCT
GCGTCCGATCCAGACACACAGAGGGTTGCTGATGGCGTTGTCTCTGGGATCTCATTCTATGGAAACTGTCTCGGTGTGCC
CAATATAGGAGGAGAAACGGCATTCGATCCCGTATATCAAGGCAATCCTTTGGTGAATGTTTTGTGCGTTGGGGTTATGC
GACGGGAAAATATTCGCTTGGCGAATGCCAGCGGACCGGGAAACCTTGTAGTTCTATTTGGTGCCCCCACGGGAAGAGAT
GGCATTGGCGGCGCTTCGGTCCTCGCCTCAGATTCTTTTACATCCGATGCCAAAGCTAATCGGCCGGCCGTACAAATTGG
AGATCCGTTTGTAGAAAAACTACTTACCGAATGTTGCCTTGAATTGTATGCCGCTGATCTTGTGGTTGCTATTCAAGACC
TTGGTGCTGCGGGTATATCTTGCGCGGCGAGTGAGCTGGCACACAACGGCCGCGTCGGTATCCGTCTGGACTTGTCTGCA
GTTCCTCTCAGGGATACAACACTAGCACCTGATGAAATACTTGTATCAGAGTCTCAAGAGCGCATGATGGCCATTGTGCA
TCCGGACAATTTAGAAGCATTTTTTGAAATAACAAACCGTTGGGGTATCTCAGGGGCTGTTATTGGAGAAGTGGATAATT
CACAATATCTGACCGTTGTGCATGAAGGCAAAACACTGGTTAGGCTGAATCCAAAAACACTTACCGGCCCATCGTATAAC
CGTCCTGTCAAAAAGCCAGCATACCTCATTCGCAGGAGCGCAGCCAATAGACTGCCTGTTACAAATGACCCACACCTACT
TCGAGAAGATATTTTGCAGGTTATTTCTTGCCCAAATCTATCTGATAAAAGTGTGATTACCAATCAGTATGATCGTTATG
TCCAGGGCAATACCGCACTTTGTCATCCTGATGATGCGGGGGTAATCAGGATGTATAAGAATACCGGGGTTGCACTTTCA
TGTGATGGTAATTCGCGATACTCTTATCTTGATCCACACGCGGGGGCCCAGCTTGCAGTTGCGGAAGCTTACCGCAATGT
ATCGGTTGTTGGGGCCACGCCCCTTGCGGTAACAAACTGTCTCAATTTTGGTAACCCAGAAAACCCAGAAGTTATGTGGC
AGTTTAGGGAAACCTGTAGAGGGCTTTCTGATGCCTGTAAGCGGCTTGAGATTCCAATTACGGGGGGTAATGTTTCCTTT
TACAACCAGACCGACGGTAAAGACATATTTCCCACTCCGGTGGTTGGCATTCTTGGCATTGTAGATAATCTGACCCAAAC
ACTTACTTCCGGATGGAATGCGCCAGATCTCTTTATTTATCTTCTGGGTGTTACGCGACCCGAGTTTGGCGGAAGCGTTT
GGGCTGATACCATGTACGGCCACATTGGCGGGGTGCCACCTAAGCTAGATTTAGCGAGAGAAAGTCGCCTGTCTAATTTG
TTGGTTGCGGGTGCAAAGAAACGGGTTTTTGAGTCTGCGCATGACCTATCGGAAGGCGGTCTTATCCAGGCAATAGTTGA
AAGTTGCCTTCGTCACGGTTTTGGTGCTGATATCGCTCTTGATACAATCCGTGCAACGAGCCTAACAGAGGCACTTTTTA
GTGAAAGCGCTTCGCGTGTTCTTGTGTCTTGTAGATCTCAGGAGGATTTGCGTGACCTTTGCAGGAGAAATAGTTATGAA
TACACCCTAATTGGCACAACACGTCACACCGGAGAGCTTACGATTTCCGAGATCGGCAAATTCACTCTGAATGAGCTCAG
TGATGCTCGCCAAAAGGTCACTCGTGTCCTGTTTAGGGGATAA

Upstream 100 bases:

>100_bases
CCGCCCTGACCCTGCAATCGCCCGGTAAGCCCTGCGGCATATGCTGTCTTTTACCCCAAGGATTGGCAGTCGCGATTACA
GTTGCGAGGCAGGCTATTCG

Downstream 100 bases:

>100_bases
GGGTAGGTTTTCCCGGAAGATACCTTTATGCACTGGCCACTAAACGGTGCGCTGTCGGCGTTTTGTTTCCGATATGATCG
TCTCGAACAGGGAGCGTACA

Product: phosphoribosylformylglycinamidine synthase II

Products: NA

Alternate protein names: Phosphoribosylformylglycinamidine synthase II; FGAM synthase II

Number of amino acids: Translated: 760; Mature: 760

Protein sequence:

>760_residues
MNMSLPADRDTAKKPSAQKPSAHAQNATAAVDVTALGLTESEYTQICSLLKRSPTKSELAIYSVLWSEHCSYKSSRRHLR
QLADLTEVTKKHLLVGIGQNAGVVDIGGGWAAAFKIESHNHPSFIEPFQGAATGIGGIVRDIIAMGAKPVALMDSLRFGA
ASDPDTQRVADGVVSGISFYGNCLGVPNIGGETAFDPVYQGNPLVNVLCVGVMRRENIRLANASGPGNLVVLFGAPTGRD
GIGGASVLASDSFTSDAKANRPAVQIGDPFVEKLLTECCLELYAADLVVAIQDLGAAGISCAASELAHNGRVGIRLDLSA
VPLRDTTLAPDEILVSESQERMMAIVHPDNLEAFFEITNRWGISGAVIGEVDNSQYLTVVHEGKTLVRLNPKTLTGPSYN
RPVKKPAYLIRRSAANRLPVTNDPHLLREDILQVISCPNLSDKSVITNQYDRYVQGNTALCHPDDAGVIRMYKNTGVALS
CDGNSRYSYLDPHAGAQLAVAEAYRNVSVVGATPLAVTNCLNFGNPENPEVMWQFRETCRGLSDACKRLEIPITGGNVSF
YNQTDGKDIFPTPVVGILGIVDNLTQTLTSGWNAPDLFIYLLGVTRPEFGGSVWADTMYGHIGGVPPKLDLARESRLSNL
LVAGAKKRVFESAHDLSEGGLIQAIVESCLRHGFGADIALDTIRATSLTEALFSESASRVLVSCRSQEDLRDLCRRNSYE
YTLIGTTRHTGELTISEIGKFTLNELSDARQKVTRVLFRG

Sequences:

>Translated_760_residues
MNMSLPADRDTAKKPSAQKPSAHAQNATAAVDVTALGLTESEYTQICSLLKRSPTKSELAIYSVLWSEHCSYKSSRRHLR
QLADLTEVTKKHLLVGIGQNAGVVDIGGGWAAAFKIESHNHPSFIEPFQGAATGIGGIVRDIIAMGAKPVALMDSLRFGA
ASDPDTQRVADGVVSGISFYGNCLGVPNIGGETAFDPVYQGNPLVNVLCVGVMRRENIRLANASGPGNLVVLFGAPTGRD
GIGGASVLASDSFTSDAKANRPAVQIGDPFVEKLLTECCLELYAADLVVAIQDLGAAGISCAASELAHNGRVGIRLDLSA
VPLRDTTLAPDEILVSESQERMMAIVHPDNLEAFFEITNRWGISGAVIGEVDNSQYLTVVHEGKTLVRLNPKTLTGPSYN
RPVKKPAYLIRRSAANRLPVTNDPHLLREDILQVISCPNLSDKSVITNQYDRYVQGNTALCHPDDAGVIRMYKNTGVALS
CDGNSRYSYLDPHAGAQLAVAEAYRNVSVVGATPLAVTNCLNFGNPENPEVMWQFRETCRGLSDACKRLEIPITGGNVSF
YNQTDGKDIFPTPVVGILGIVDNLTQTLTSGWNAPDLFIYLLGVTRPEFGGSVWADTMYGHIGGVPPKLDLARESRLSNL
LVAGAKKRVFESAHDLSEGGLIQAIVESCLRHGFGADIALDTIRATSLTEALFSESASRVLVSCRSQEDLRDLCRRNSYE
YTLIGTTRHTGELTISEIGKFTLNELSDARQKVTRVLFRG
>Mature_760_residues
MNMSLPADRDTAKKPSAQKPSAHAQNATAAVDVTALGLTESEYTQICSLLKRSPTKSELAIYSVLWSEHCSYKSSRRHLR
QLADLTEVTKKHLLVGIGQNAGVVDIGGGWAAAFKIESHNHPSFIEPFQGAATGIGGIVRDIIAMGAKPVALMDSLRFGA
ASDPDTQRVADGVVSGISFYGNCLGVPNIGGETAFDPVYQGNPLVNVLCVGVMRRENIRLANASGPGNLVVLFGAPTGRD
GIGGASVLASDSFTSDAKANRPAVQIGDPFVEKLLTECCLELYAADLVVAIQDLGAAGISCAASELAHNGRVGIRLDLSA
VPLRDTTLAPDEILVSESQERMMAIVHPDNLEAFFEITNRWGISGAVIGEVDNSQYLTVVHEGKTLVRLNPKTLTGPSYN
RPVKKPAYLIRRSAANRLPVTNDPHLLREDILQVISCPNLSDKSVITNQYDRYVQGNTALCHPDDAGVIRMYKNTGVALS
CDGNSRYSYLDPHAGAQLAVAEAYRNVSVVGATPLAVTNCLNFGNPENPEVMWQFRETCRGLSDACKRLEIPITGGNVSF
YNQTDGKDIFPTPVVGILGIVDNLTQTLTSGWNAPDLFIYLLGVTRPEFGGSVWADTMYGHIGGVPPKLDLARESRLSNL
LVAGAKKRVFESAHDLSEGGLIQAIVESCLRHGFGADIALDTIRATSLTEALFSESASRVLVSCRSQEDLRDLCRRNSYE
YTLIGTTRHTGELTISEIGKFTLNELSDARQKVTRVLFRG

Specific function: Unknown

COG id: COG0046

COG function: function code F; Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGAMS family

Homologues:

Organism=Homo sapiens, GI31657129, Length=709, Percent_Identity=26.0930888575458, Blast_Score=123, Evalue=8e-28,
Organism=Escherichia coli, GI48994899, Length=765, Percent_Identity=25.2287581699346, Blast_Score=139, Evalue=7e-34,
Organism=Caenorhabditis elegans, GI17553022, Length=653, Percent_Identity=26.0336906584992, Blast_Score=105, Evalue=7e-23,
Organism=Saccharomyces cerevisiae, GI6321498, Length=799, Percent_Identity=24.1551939924906, Blast_Score=128, Evalue=3e-30,
Organism=Drosophila melanogaster, GI24582111, Length=637, Percent_Identity=24.9607535321821, Blast_Score=102, Evalue=7e-22,
Organism=Drosophila melanogaster, GI24582109, Length=637, Percent_Identity=24.9607535321821, Blast_Score=102, Evalue=7e-22,
Organism=Drosophila melanogaster, GI17137292, Length=637, Percent_Identity=24.9607535321821, Blast_Score=102, Evalue=7e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PURL_TROW8 (Q83H66)

Other databases:

- EMBL:   BX251412
- RefSeq:   NP_789724.1
- ProteinModelPortal:   Q83H66
- SMR:   Q83H66
- STRING:   Q83H66
- GeneID:   1065003
- GenomeReviews:   BX072543_GR
- KEGG:   tws:TW803
- eggNOG:   COG0046
- HOGENOM:   HBG311214
- OMA:   YGNSFGV
- PhylomeDB:   Q83H66
- ProtClustDB:   PRK01213
- BioCyc:   TWHI218496:TW0769-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00420
- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR010074
- InterPro:   IPR016188
- TIGRFAMs:   TIGR01736

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C; SSF56042 AIR_synth_C; SSF55326 PurM_N-like

EC number: =6.3.5.3

Molecular weight: Translated: 81740; Mature: 81740

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: PS00107 PROTEIN_KINASE_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNMSLPADRDTAKKPSAQKPSAHAQNATAAVDVTALGLTESEYTQICSLLKRSPTKSELA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCHHHHHHHHHHHHCCCCHHHHH
IYSVLWSEHCSYKSSRRHLRQLADLTEVTKKHLLVGIGQNAGVVDIGGGWAAAFKIESHN
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCEEEECCCEEEEEEEECCC
HPSFIEPFQGAATGIGGIVRDIIAMGAKPVALMDSLRFGAASDPDTQRVADGVVSGISFY
CCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHH
GNCLGVPNIGGETAFDPVYQGNPLVNVLCVGVMRRENIRLANASGPGNLVVLFGAPTGRD
HCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCEEEEECCCCCCEEEEEECCCCCC
GIGGASVLASDSFTSDAKANRPAVQIGDPFVEKLLTECCLELYAADLVVAIQDLGAAGIS
CCCCHHEEECCCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
CAASELAHNGRVGIRLDLSAVPLRDTTLAPDEILVSESQERMMAIVHPDNLEAFFEITNR
HHHHHHHCCCCEEEEEECCCCCCCCCCCCCHHHHHCCCCCCEEEEECCCCHHHHHHHHHH
WGISGAVIGEVDNSQYLTVVHEGKTLVRLNPKTLTGPSYNRPVKKPAYLIRRSAANRLPV
CCCCEEEEEECCCCCEEEEEECCCEEEEECCCEECCCCCCCCCCHHHHHHHHHCCCCCCC
TNDPHLLREDILQVISCPNLSDKSVITNQYDRYVQGNTALCHPDDAGVIRMYKNTGVALS
CCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCEEEECCCCCCEEEEEECCCEEEE
CDGNSRYSYLDPHAGAQLAVAEAYRNVSVVGATPLAVTNCLNFGNPENPEVMWQFRETCR
ECCCCCCCEECCCCCCCHHHHHHHCCEEEECCCHHHHHHHHCCCCCCCHHHHHHHHHHHC
GLSDACKRLEIPITGGNVSFYNQTDGKDIFPTPVVGILGIVDNLTQTLTSGWNAPDLFIY
CHHHHHHHEEEEEECCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEE
LLGVTRPEFGGSVWADTMYGHIGGVPPKLDLARESRLSNLLVAGAKKRVFESAHDLSEGG
EEECCCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
LIQAIVESCLRHGFGADIALDTIRATSLTEALFSESASRVLVSCRSQEDLRDLCRRNSYE
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCE
YTLIGTTRHTGELTISEIGKFTLNELSDARQKVTRVLFRG
EEEEECCCCCCCEEHHHHCHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNMSLPADRDTAKKPSAQKPSAHAQNATAAVDVTALGLTESEYTQICSLLKRSPTKSELA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCHHHHHHHHHHHHCCCCHHHHH
IYSVLWSEHCSYKSSRRHLRQLADLTEVTKKHLLVGIGQNAGVVDIGGGWAAAFKIESHN
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCEEEECCCEEEEEEEECCC
HPSFIEPFQGAATGIGGIVRDIIAMGAKPVALMDSLRFGAASDPDTQRVADGVVSGISFY
CCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHH
GNCLGVPNIGGETAFDPVYQGNPLVNVLCVGVMRRENIRLANASGPGNLVVLFGAPTGRD
HCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCEEEEECCCCCCEEEEEECCCCCC
GIGGASVLASDSFTSDAKANRPAVQIGDPFVEKLLTECCLELYAADLVVAIQDLGAAGIS
CCCCHHEEECCCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
CAASELAHNGRVGIRLDLSAVPLRDTTLAPDEILVSESQERMMAIVHPDNLEAFFEITNR
HHHHHHHCCCCEEEEEECCCCCCCCCCCCCHHHHHCCCCCCEEEEECCCCHHHHHHHHHH
WGISGAVIGEVDNSQYLTVVHEGKTLVRLNPKTLTGPSYNRPVKKPAYLIRRSAANRLPV
CCCCEEEEEECCCCCEEEEEECCCEEEEECCCEECCCCCCCCCCHHHHHHHHHCCCCCCC
TNDPHLLREDILQVISCPNLSDKSVITNQYDRYVQGNTALCHPDDAGVIRMYKNTGVALS
CCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCEEEECCCCCCEEEEEECCCEEEE
CDGNSRYSYLDPHAGAQLAVAEAYRNVSVVGATPLAVTNCLNFGNPENPEVMWQFRETCR
ECCCCCCCEECCCCCCCHHHHHHHCCEEEECCCHHHHHHHHCCCCCCCHHHHHHHHHHHC
GLSDACKRLEIPITGGNVSFYNQTDGKDIFPTPVVGILGIVDNLTQTLTSGWNAPDLFIY
CHHHHHHHEEEEEECCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEE
LLGVTRPEFGGSVWADTMYGHIGGVPPKLDLARESRLSNLLVAGAKKRVFESAHDLSEGG
EEECCCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
LIQAIVESCLRHGFGADIALDTIRATSLTEALFSESASRVLVSCRSQEDLRDLCRRNSYE
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCE
YTLIGTTRHTGELTISEIGKFTLNELSDARQKVTRVLFRG
EEEEECCCCCCCEEHHHHCHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12606174