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The map label for this gene is hemA

Identifier: 28572891

GI number: 28572891

Start: 846577

End: 847920

Strand: Direct

Name: hemA

Synonym: TW750

Alternate gene names: 28572891

Gene position: 846577-847920 (Clockwise)

Preceding gene: 28572883

Following gene: 28572892

Centisome position: 91.43

GC content: 46.95

Gene sequence:

>1344_bases
GTGCTTTTATGTGTCAGCGCCAATCACAAGAAGACTAGCTTTACTGTGCTCGAGCAGCTTGCACGCGTTAGTCCCGACTT
TGCTTCAGAGCTTGTAGAAGCAGAGGATATCGATGGAGCCGCAATTTTGTCGACCTGTAACAGGTTCGAGGTTTATATTG
ATGCGATACAGAAAGGTGACCAGGATGATGTGTGCAAAACAGGCCTCCTTGTGCAAAACCGCATAGGTGAGCTCTGCAAT
ATATCGCCGTCAACTATAATCGAGCAAACATCTTTTCTGGCGGGTTGTGAGGTCTCCAGGCATTTGTTTTCTGTAGCGAC
CGGTCTTGAATCAATGATAATTGGTGAGACAGAGATAGCAGGTCAGGTAAAGAGGGCTTTGACCTACGCACAAAAATGCA
GGACAACTTCGCCCGAGCTCGAGCGGTTATTTCAGAGAGCGTCTGCTGTTAACAGACATATAAGACAATCGACAAAGATA
AATGAGGTTGGGCAGTCGCTTGTAAGTCTTTCTCTGGACCTCGCAAGCAGTAGGATAGGCGACTGGTCTGGGGTGAGGGC
AATAATTGTTGGAACTGGTAAATATGCATCAAAGGCGCTTGCCCTGCTAAAAGAGCGTGGCGTTGTTGATATAAGCGTTT
ATTCCCCGTCTGGGCATGTAAATAATATCTGCAATACGGAGGGTGTTAGAAATATATTCAACCTCCAAACTGCCCTTTCT
GGCTGTGACCTTGTTGTGGGCTGTTCCTCGGTTGATAAACCCGTCATAACAAAGCAAGATATCGAAACGGCACAGGCAAG
CGGTTCACGAACGTCACGCGTAAGGCCTGTCGGACGCCCCTCAACAGACCTTACGGCAATTGAAGCGTCAAACCGCTCAC
GACATGTCTTGATAGATCTTGGATTACCACGGAATTTCGATCCTGCCATTTCAGACCTTCCGACCGCTGATCTAATTGAT
CTTGATATGCTAAGAGTTCACGCTCCATTCGACAATTTGGCCGCGGAAAAAATGGCCCACGAGCTTGCAATCGAGAGCTC
AAGTCAGTTTGTAAACGACTGCAAGCAGCACGAGGCCACCCCGGTGATCGTATCTTTTCGTAATTACCTCGAGAGTCTTA
CCCAAACATCTTTACGCAGAACTGATAATTGTAAACACGCCCAACATGCCCTCAAGCATTTTGTAAATTCGCTGATTCAT
ATACCCCTGACGCGCTGTAAGCAGCTTGCTGCAAATGGGGAGTCACACAAATTTGCCGAGTCTATGGAAATACTGTTTGA
TGTAAAGACAGATTGTACGGAAGGCACACAATATCAATCATCCTGCGGGAAATCTTTCGATTGA

Upstream 100 bases:

>100_bases
TGCAGACCGACCGGCACTCGGCCTGCAAGACAAGCTGTGTAAGGGAATGCGTGTGCCCTCAACTCCTGAAGCACCAGTCA
CCAGACCTATAATAACTTAA

Downstream 100 bases:

>100_bases
TGGATTATCCGTCAATCGACACCCTCTTAGAATCTGCCCATATTGTTACTCTGCCCATGAAGTACCCTTTCATGGGGCTT
AGCGAACGTCAAGCTGTTCT

Product: glutamyl-tRNA reductase

Products: NA

Alternate protein names: GluTR

Number of amino acids: Translated: 447; Mature: 447

Protein sequence:

>447_residues
MLLCVSANHKKTSFTVLEQLARVSPDFASELVEAEDIDGAAILSTCNRFEVYIDAIQKGDQDDVCKTGLLVQNRIGELCN
ISPSTIIEQTSFLAGCEVSRHLFSVATGLESMIIGETEIAGQVKRALTYAQKCRTTSPELERLFQRASAVNRHIRQSTKI
NEVGQSLVSLSLDLASSRIGDWSGVRAIIVGTGKYASKALALLKERGVVDISVYSPSGHVNNICNTEGVRNIFNLQTALS
GCDLVVGCSSVDKPVITKQDIETAQASGSRTSRVRPVGRPSTDLTAIEASNRSRHVLIDLGLPRNFDPAISDLPTADLID
LDMLRVHAPFDNLAAEKMAHELAIESSSQFVNDCKQHEATPVIVSFRNYLESLTQTSLRRTDNCKHAQHALKHFVNSLIH
IPLTRCKQLAANGESHKFAESMEILFDVKTDCTEGTQYQSSCGKSFD

Sequences:

>Translated_447_residues
MLLCVSANHKKTSFTVLEQLARVSPDFASELVEAEDIDGAAILSTCNRFEVYIDAIQKGDQDDVCKTGLLVQNRIGELCN
ISPSTIIEQTSFLAGCEVSRHLFSVATGLESMIIGETEIAGQVKRALTYAQKCRTTSPELERLFQRASAVNRHIRQSTKI
NEVGQSLVSLSLDLASSRIGDWSGVRAIIVGTGKYASKALALLKERGVVDISVYSPSGHVNNICNTEGVRNIFNLQTALS
GCDLVVGCSSVDKPVITKQDIETAQASGSRTSRVRPVGRPSTDLTAIEASNRSRHVLIDLGLPRNFDPAISDLPTADLID
LDMLRVHAPFDNLAAEKMAHELAIESSSQFVNDCKQHEATPVIVSFRNYLESLTQTSLRRTDNCKHAQHALKHFVNSLIH
IPLTRCKQLAANGESHKFAESMEILFDVKTDCTEGTQYQSSCGKSFD
>Mature_447_residues
MLLCVSANHKKTSFTVLEQLARVSPDFASELVEAEDIDGAAILSTCNRFEVYIDAIQKGDQDDVCKTGLLVQNRIGELCN
ISPSTIIEQTSFLAGCEVSRHLFSVATGLESMIIGETEIAGQVKRALTYAQKCRTTSPELERLFQRASAVNRHIRQSTKI
NEVGQSLVSLSLDLASSRIGDWSGVRAIIVGTGKYASKALALLKERGVVDISVYSPSGHVNNICNTEGVRNIFNLQTALS
GCDLVVGCSSVDKPVITKQDIETAQASGSRTSRVRPVGRPSTDLTAIEASNRSRHVLIDLGLPRNFDPAISDLPTADLID
LDMLRVHAPFDNLAAEKMAHELAIESSSQFVNDCKQHEATPVIVSFRNYLESLTQTSLRRTDNCKHAQHALKHFVNSLIH
IPLTRCKQLAANGESHKFAESMEILFDVKTDCTEGTQYQSSCGKSFD

Specific function: Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)

COG id: COG0373

COG function: function code H; Glutamyl-tRNA reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutamyl-tRNA reductase family

Homologues:

Organism=Escherichia coli, GI1787461, Length=438, Percent_Identity=24.8858447488584, Blast_Score=114, Evalue=1e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEM1_TROW8 (Q83H91)

Other databases:

- EMBL:   BX251412
- RefSeq:   NP_789671.1
- ProteinModelPortal:   Q83H91
- SMR:   Q83H91
- STRING:   Q83H91
- GeneID:   1064950
- GenomeReviews:   BX072543_GR
- KEGG:   tws:TW750
- eggNOG:   COG0373
- HOGENOM:   HBG732626
- OMA:   IVANRTY
- PhylomeDB:   Q83H91
- ProtClustDB:   PRK00045
- BioCyc:   TWHI218496:TW0716-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00087
- InterPro:   IPR000343
- InterPro:   IPR015896
- InterPro:   IPR015895
- InterPro:   IPR016040
- InterPro:   IPR018214
- InterPro:   IPR006151
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF000445
- TIGRFAMs:   TIGR01035

Pfam domain/function: PF00745 GlutR_dimer; PF05201 GlutR_N; PF01488 Shikimate_DH; SSF69075 4pyrrol_synth_GluRdtase_C; SSF69742 GlutR

EC number: =1.2.1.70

Molecular weight: Translated: 48839; Mature: 48839

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: PS00747 GLUTR

Important sites: ACT_SITE 46-46 BINDING 111-111 BINDING 122-122

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.1 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
3.1 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLCVSANHKKTSFTVLEQLARVSPDFASELVEAEDIDGAAILSTCNRFEVYIDAIQKGD
CEEEEECCCCCHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCC
QDDVCKTGLLVQNRIGELCNISPSTIIEQTSFLAGCEVSRHLFSVATGLESMIIGETEIA
CCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
GQVKRALTYAQKCRTTSPELERLFQRASAVNRHIRQSTKINEVGQSLVSLSLDLASSRIG
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
DWSGVRAIIVGTGKYASKALALLKERGVVDISVYSPSGHVNNICNTEGVRNIFNLQTALS
CCCCCEEEEEECCHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHC
GCDLVVGCSSVDKPVITKQDIETAQASGSRTSRVRPVGRPSTDLTAIEASNRSRHVLIDL
CCCEEEECCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEECCCCCCEEEEEE
GLPRNFDPAISDLPTADLIDLDMLRVHAPFDNLAAEKMAHELAIESSSQFVNDCKQHEAT
CCCCCCCCHHHCCCCCCHHHHHHHHEECCHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCC
PVIVSFRNYLESLTQTSLRRTDNCKHAQHALKHFVNSLIHIPLTRCKQLAANGESHKFAE
CHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCHHHHH
SMEILFDVKTDCTEGTQYQSSCGKSFD
HHHHHHCCCCCCCCCCCHHHHCCCCCC
>Mature Secondary Structure
MLLCVSANHKKTSFTVLEQLARVSPDFASELVEAEDIDGAAILSTCNRFEVYIDAIQKGD
CEEEEECCCCCHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCC
QDDVCKTGLLVQNRIGELCNISPSTIIEQTSFLAGCEVSRHLFSVATGLESMIIGETEIA
CCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
GQVKRALTYAQKCRTTSPELERLFQRASAVNRHIRQSTKINEVGQSLVSLSLDLASSRIG
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
DWSGVRAIIVGTGKYASKALALLKERGVVDISVYSPSGHVNNICNTEGVRNIFNLQTALS
CCCCCEEEEEECCHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHC
GCDLVVGCSSVDKPVITKQDIETAQASGSRTSRVRPVGRPSTDLTAIEASNRSRHVLIDL
CCCEEEECCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEECCCCCCEEEEEE
GLPRNFDPAISDLPTADLIDLDMLRVHAPFDNLAAEKMAHELAIESSSQFVNDCKQHEAT
CCCCCCCCHHHCCCCCCHHHHHHHHEECCHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCC
PVIVSFRNYLESLTQTSLRRTDNCKHAQHALKHFVNSLIHIPLTRCKQLAANGESHKFAE
CHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCHHHHH
SMEILFDVKTDCTEGTQYQSSCGKSFD
HHHHHHCCCCCCCCCCCHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12606174