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The map label for this gene is hemH

Identifier: 28572888

GI number: 28572888

Start: 843450

End: 844625

Strand: Reverse

Name: hemH

Synonym: TW747

Alternate gene names: 28572888

Gene position: 844625-843450 (Counterclockwise)

Preceding gene: 28572889

Following gene: 28572887

Centisome position: 91.22

GC content: 49.74

Gene sequence:

>1176_bases
GTGATACGCCGTAGCGCAGTGTCACGTGTCGTTGCTGAGGGTTCGGCTATTGCCTCGGATTCTGGGTTCGCACTCGGTGC
TTCGCAATACGATGCGGTTGTTCTTCTAAGTTTTGGCGGCCCAGAAGGTCCAGAAGATGTTGTCCCTTTCCTGAAAAAGG
TGACAAGCGGTAGAGGTGTGCCAGATGAGCGCCTCTACGAGGTCGCAGAGCATTACAATCATTTTTCTGGCATAAGTCCA
ATAAATGATTGTAATAGGCGACTGAGGGGTGCATTAGAAAAAGAGCTCTTTAGCAGGGGGATTAGAATTCCTGTGCTGTG
GGCCAACCGTAATTGGCAACCGCAACTGGAAGAAGTGCTGCGAGAAGCTTATGACAGGGGCTTTCGGGCTTTTTTGACAC
TTTTCACAAGTGCCTATAGTTGTTACTCGAGCTGTCGACAGTACAGAGAAGATATTGCCCATGCGGTAGAACGTGCTGGG
CTTTCCGGAAGGATTATTGTGGACAAGCTACGGCAGTTCTTTGATCACCCGGGGTTTGTTTTACCATTTATCGAAGGGAT
TCAAGATTGCCTGGAACAGGTTAAAGAGAGAGGATTCAAGGTCTCGCGTACGGCAATTCTTTTTAGCACTCATTCGATCC
CCGAATTGGATGCTGCATTTTCGGGTCCTGAAGATGCGCATTTCGGAAAGTATGGTGCATATGTTTCGCAGCACAAGGCT
GTTGTTGAGGTTATTATGTCAAGACTGCGTGTAACTGACCCGGACTTGCAAAATTATCAGTTGGTCTATCAGTCGCGCAG
TGGGGATCCAAGCACTCCTTGGCTTGAGCCTGATATCAATGATGCAATCAGGGTTTTGAGGGGTTGCGAAGCTGTTCTTA
TTGTTCCTCTTGGTTTTATCAGTGATCATATGGAAGTATTGTGGGATCTTGATAATGAGTCCATGCAGACCGCCCGGGAA
TGTGGGTTATTTGCTATTAGAACCCCCACTCCGGGGACTCACCCCCTGTATATTTCGGGTATGGTTGATCTCATTGTAGA
AAGACTTGAAGGAGTGCCGAGGAGCGCTCGCCCGGCCATGACGGACCTTGGGCCTTGGTTCGATGTCTGCCAACCGGGGT
GCTGCAAAAACAGTCGCTCCGGGTTCAAGCCAGCGTACGGCGGTGTAGCGCCCTAG

Upstream 100 bases:

>100_bases
CCCTGCGCTATACCCGGGCGCGGCGGTATGTTTTACTGGAAACCCCTTTTTACACGGGGCGGCGTATAGGTATAGCTGAT
GTCCAGGAAGTTTTATCTAC

Downstream 100 bases:

>100_bases
ATCTGCTTTTATGTATCCGTTACGCATTGGCACGCGTTCGAGCCTTCTTGCGACCGCACAGACGGCACAGGTACAAAAAA
CTATGCGCGATGTATTTTTG

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase

Number of amino acids: Translated: 391; Mature: 391

Protein sequence:

>391_residues
MIRRSAVSRVVAEGSAIASDSGFALGASQYDAVVLLSFGGPEGPEDVVPFLKKVTSGRGVPDERLYEVAEHYNHFSGISP
INDCNRRLRGALEKELFSRGIRIPVLWANRNWQPQLEEVLREAYDRGFRAFLTLFTSAYSCYSSCRQYREDIAHAVERAG
LSGRIIVDKLRQFFDHPGFVLPFIEGIQDCLEQVKERGFKVSRTAILFSTHSIPELDAAFSGPEDAHFGKYGAYVSQHKA
VVEVIMSRLRVTDPDLQNYQLVYQSRSGDPSTPWLEPDINDAIRVLRGCEAVLIVPLGFISDHMEVLWDLDNESMQTARE
CGLFAIRTPTPGTHPLYISGMVDLIVERLEGVPRSARPAMTDLGPWFDVCQPGCCKNSRSGFKPAYGGVAP

Sequences:

>Translated_391_residues
MIRRSAVSRVVAEGSAIASDSGFALGASQYDAVVLLSFGGPEGPEDVVPFLKKVTSGRGVPDERLYEVAEHYNHFSGISP
INDCNRRLRGALEKELFSRGIRIPVLWANRNWQPQLEEVLREAYDRGFRAFLTLFTSAYSCYSSCRQYREDIAHAVERAG
LSGRIIVDKLRQFFDHPGFVLPFIEGIQDCLEQVKERGFKVSRTAILFSTHSIPELDAAFSGPEDAHFGKYGAYVSQHKA
VVEVIMSRLRVTDPDLQNYQLVYQSRSGDPSTPWLEPDINDAIRVLRGCEAVLIVPLGFISDHMEVLWDLDNESMQTARE
CGLFAIRTPTPGTHPLYISGMVDLIVERLEGVPRSARPAMTDLGPWFDVCQPGCCKNSRSGFKPAYGGVAP
>Mature_391_residues
MIRRSAVSRVVAEGSAIASDSGFALGASQYDAVVLLSFGGPEGPEDVVPFLKKVTSGRGVPDERLYEVAEHYNHFSGISP
INDCNRRLRGALEKELFSRGIRIPVLWANRNWQPQLEEVLREAYDRGFRAFLTLFTSAYSCYSSCRQYREDIAHAVERAG
LSGRIIVDKLRQFFDHPGFVLPFIEGIQDCLEQVKERGFKVSRTAILFSTHSIPELDAAFSGPEDAHFGKYGAYVSQHKA
VVEVIMSRLRVTDPDLQNYQLVYQSRSGDPSTPWLEPDINDAIRVLRGCEAVLIVPLGFISDHMEVLWDLDNESMQTARE
CGLFAIRTPTPGTHPLYISGMVDLIVERLEGVPRSARPAMTDLGPWFDVCQPGCCKNSRSGFKPAYGGVAP

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family

Homologues:

Organism=Homo sapiens, GI60499025, Length=374, Percent_Identity=25.9358288770053, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI60499021, Length=374, Percent_Identity=25.9358288770053, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI17864156, Length=382, Percent_Identity=27.2251308900524, Blast_Score=105, Evalue=7e-23,
Organism=Drosophila melanogaster, GI45552018, Length=212, Percent_Identity=31.6037735849057, Blast_Score=90, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEMH_TROW8 (Q83H94)

Other databases:

- EMBL:   BX251412
- RefSeq:   NP_789668.1
- ProteinModelPortal:   Q83H94
- STRING:   Q83H94
- GeneID:   1064947
- GenomeReviews:   BX072543_GR
- KEGG:   tws:TW747
- eggNOG:   COG0276
- HOGENOM:   HBG697135
- OMA:   GNRNWHP
- ProtClustDB:   PRK00035
- BioCyc:   TWHI218496:TW0713-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00323
- InterPro:   IPR001015
- InterPro:   IPR019772
- PANTHER:   PTHR11108

Pfam domain/function: PF00762 Ferrochelatase

EC number: =4.99.1.1

Molecular weight: Translated: 43522; Mature: 43522

Theoretical pI: Translated: 6.06; Mature: 6.06

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRRSAVSRVVAEGSAIASDSGFALGASQYDAVVLLSFGGPEGPEDVVPFLKKVTSGRGV
CCCHHHHHHHHHCCCCEECCCCCEECCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCC
PDERLYEVAEHYNHFSGISPINDCNRRLRGALEKELFSRGIRIPVLWANRNWQPQLEEVL
CHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHH
REAYDRGFRAFLTLFTSAYSCYSSCRQYREDIAHAVERAGLSGRIIVDKLRQFFDHPGFV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCH
LPFIEGIQDCLEQVKERGFKVSRTAILFSTHSIPELDAAFSGPEDAHFGKYGAYVSQHKA
HHHHHHHHHHHHHHHHCCCEEEHEEEEEECCCCCCHHHHCCCCCCCCCCHHHHHHHHHHH
VVEVIMSRLRVTDPDLQNYQLVYQSRSGDPSTPWLEPDINDAIRVLRGCEAVLIVPLGFI
HHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHCCCEEEEEHHHHH
SDHMEVLWDLDNESMQTARECGLFAIRTPTPGTHPLYISGMVDLIVERLEGVPRSARPAM
HHHHHHHHCCCCHHHHHHHHCCEEEEECCCCCCCCEEHHHHHHHHHHHHHCCCCCCCCCH
TDLGPWFDVCQPGCCKNSRSGFKPAYGGVAP
HHCCCCHHHCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MIRRSAVSRVVAEGSAIASDSGFALGASQYDAVVLLSFGGPEGPEDVVPFLKKVTSGRGV
CCCHHHHHHHHHCCCCEECCCCCEECCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCC
PDERLYEVAEHYNHFSGISPINDCNRRLRGALEKELFSRGIRIPVLWANRNWQPQLEEVL
CHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHH
REAYDRGFRAFLTLFTSAYSCYSSCRQYREDIAHAVERAGLSGRIIVDKLRQFFDHPGFV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCH
LPFIEGIQDCLEQVKERGFKVSRTAILFSTHSIPELDAAFSGPEDAHFGKYGAYVSQHKA
HHHHHHHHHHHHHHHHCCCEEEHEEEEEECCCCCCHHHHCCCCCCCCCCHHHHHHHHHHH
VVEVIMSRLRVTDPDLQNYQLVYQSRSGDPSTPWLEPDINDAIRVLRGCEAVLIVPLGFI
HHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHCCCEEEEEHHHHH
SDHMEVLWDLDNESMQTARECGLFAIRTPTPGTHPLYISGMVDLIVERLEGVPRSARPAM
HHHHHHHHCCCCHHHHHHHHCCEEEEECCCCCCCCEEHHHHHHHHHHHHHCCCCCCCCCH
TDLGPWFDVCQPGCCKNSRSGFKPAYGGVAP
HHCCCCHHHCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12606174