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The map label for this gene is hemC [H]

Identifier: 28572887

GI number: 28572887

Start: 842474

End: 843439

Strand: Reverse

Name: hemC [H]

Synonym: TW746

Alternate gene names: 28572887

Gene position: 843439-842474 (Counterclockwise)

Preceding gene: 28572888

Following gene: 28572886

Centisome position: 91.09

GC content: 47.2

Gene sequence:

>966_bases
ATGTATCCGTTACGCATTGGCACGCGTTCGAGCCTTCTTGCGACCGCACAGACGGCACAGGTACAAAAAACTATGCGCGA
TGTATTTTTGCTTGATACGCAACAGGTTCTGATACAGACTGGGTCGGTGCGCCGTCGTGATGGGTCTTTTGTTGCCGCCC
TGCGGACTGCTCTTTTAGAAGGTGAGTGTGACCTGGCGGTTCATTCTCTAAAAGATATTCCGATTGCACCGCATGAAGGG
ACGCTTATAACAGCTGTTTTGCCGCGTGAAGACCCCTGTGATGTGCTGTGCGCCAGGAAAGACCTAACGCTAACAACTCT
TCCGTCTGGGGCAAAAGTAGGCACAGCATCAGCACGTCGTCGTGCTCAGATTCTGAATTTTCGTCCCGATTTGGATGTTG
TAAGTCTTCGAGGAAATATAGATAAGCGCCTTATACATCTTGATACTTTGGATGCCATTGTTTTATCTGCTGCGGGTCTC
AAACGGATTGACCGGGAGGATGCAATTACAGAATCATTCGACATACACGATTGGCCGACAGCTGCTGGTCAGGGCAGCCT
CGCTATCGAAGTATGCAGAGCGCAGTTGGACGACCCGCAAAACCGCGTCGCGGTGACCTACCGGCTTGATAACCCAATGG
CACGTGTCACAACTACGGCCGAGCGAGGTGTTCTGTCTCTTTTACAGGCTGACTGCTTTTCACCTATTGCCGTTCACGCA
GTTTATACGGCAAATGATAAATCCTTAAGATTACATGCAAAGGTTTTTTCTCGCGACGGGAAAATTTTCTGTGAAAGTAT
CCGTTTTGCAAGGCTTGTAAAGCAATTGACCGATACAAATCAAAATCACACAAAAAATTCTGGCAGTGATGATATTGGTA
ATGCTTTAGAAGTTGCAATGACTCTTGCAAAGACCGTTGTTGACGAACTTTTGTCAAAAAATGCACGAGAAATCTTGAAA
CAATGA

Upstream 100 bases:

>100_bases
CTTGGGCCTTGGTTCGATGTCTGCCAACCGGGGTGCTGCAAAAACAGTCGCTCCGGGTTCAAGCCAGCGTACGGCGGTGT
AGCGCCCTAGATCTGCTTTT

Downstream 100 bases:

>100_bases
GACACTCTTGCCACCATGTATGGATTACCCGAGGCGGGCAATGGGCGCGCGAAATTGCCGGTATGCTCAAAGTCCGGGGG
GTAACGAGTGTTGTACATCC

Product: porphobilinogen deaminase

Products: NA

Alternate protein names: PBG; Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase [H]

Number of amino acids: Translated: 321; Mature: 321

Protein sequence:

>321_residues
MYPLRIGTRSSLLATAQTAQVQKTMRDVFLLDTQQVLIQTGSVRRRDGSFVAALRTALLEGECDLAVHSLKDIPIAPHEG
TLITAVLPREDPCDVLCARKDLTLTTLPSGAKVGTASARRRAQILNFRPDLDVVSLRGNIDKRLIHLDTLDAIVLSAAGL
KRIDREDAITESFDIHDWPTAAGQGSLAIEVCRAQLDDPQNRVAVTYRLDNPMARVTTTAERGVLSLLQADCFSPIAVHA
VYTANDKSLRLHAKVFSRDGKIFCESIRFARLVKQLTDTNQNHTKNSGSDDIGNALEVAMTLAKTVVDELLSKNAREILK
Q

Sequences:

>Translated_321_residues
MYPLRIGTRSSLLATAQTAQVQKTMRDVFLLDTQQVLIQTGSVRRRDGSFVAALRTALLEGECDLAVHSLKDIPIAPHEG
TLITAVLPREDPCDVLCARKDLTLTTLPSGAKVGTASARRRAQILNFRPDLDVVSLRGNIDKRLIHLDTLDAIVLSAAGL
KRIDREDAITESFDIHDWPTAAGQGSLAIEVCRAQLDDPQNRVAVTYRLDNPMARVTTTAERGVLSLLQADCFSPIAVHA
VYTANDKSLRLHAKVFSRDGKIFCESIRFARLVKQLTDTNQNHTKNSGSDDIGNALEVAMTLAKTVVDELLSKNAREILK
Q
>Mature_321_residues
MYPLRIGTRSSLLATAQTAQVQKTMRDVFLLDTQQVLIQTGSVRRRDGSFVAALRTALLEGECDLAVHSLKDIPIAPHEG
TLITAVLPREDPCDVLCARKDLTLTTLPSGAKVGTASARRRAQILNFRPDLDVVSLRGNIDKRLIHLDTLDAIVLSAAGL
KRIDREDAITESFDIHDWPTAAGQGSLAIEVCRAQLDDPQNRVAVTYRLDNPMARVTTTAERGVLSLLQADCFSPIAVHA
VYTANDKSLRLHAKVFSRDGKIFCESIRFARLVKQLTDTNQNHTKNSGSDDIGNALEVAMTLAKTVVDELLSKNAREILK
Q

Specific function: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps [H]

COG id: COG0181

COG function: function code H; Porphobilinogen deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMBS family [H]

Homologues:

Organism=Homo sapiens, GI20149500, Length=282, Percent_Identity=35.1063829787234, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI66933009, Length=282, Percent_Identity=35.1063829787234, Blast_Score=124, Evalue=2e-28,
Organism=Escherichia coli, GI48994974, Length=336, Percent_Identity=33.9285714285714, Blast_Score=131, Evalue=6e-32,
Organism=Saccharomyces cerevisiae, GI6319996, Length=283, Percent_Identity=33.5689045936396, Blast_Score=108, Evalue=8e-25,
Organism=Drosophila melanogaster, GI20130425, Length=288, Percent_Identity=35.0694444444444, Blast_Score=119, Evalue=3e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000860
- InterPro:   IPR022419
- InterPro:   IPR022417
- InterPro:   IPR022418 [H]

Pfam domain/function: PF01379 Porphobil_deam; PF03900 Porphobil_deamC [H]

EC number: =2.5.1.61 [H]

Molecular weight: Translated: 35216; Mature: 35216

Theoretical pI: Translated: 8.14; Mature: 8.14

Prosite motif: PS00533 PORPHOBILINOGEN_DEAM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYPLRIGTRSSLLATAQTAQVQKTMRDVFLLDTQQVLIQTGSVRRRDGSFVAALRTALLE
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHCCCCCCCCCHHHHHHHHHHHC
GECDLAVHSLKDIPIAPHEGTLITAVLPREDPCDVLCARKDLTLTTLPSGAKVGTASARR
CCCCHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCEECCCCCEEEECCCCCCCCCHHHHH
RAQILNFRPDLDVVSLRGNIDKRLIHLDTLDAIVLSAAGLKRIDREDAITESFDIHDWPT
HHHHHCCCCCCCEEEECCCCCCEEEEHHHHHHHHHHHHHHHHHCHHHHHHCCCCCCCCCC
AAGQGSLAIEVCRAQLDDPQNRVAVTYRLDNPMARVTTTAERGVLSLLQADCFSPIAVHA
CCCCCCHHHHHHHHHCCCCCCEEEEEEEECCCCEEEEEHHHHHHHHHHHHHCCCCEEEEE
VYTANDKSLRLHAKVFSRDGKIFCESIRFARLVKQLTDTNQNHTKNSGSDDIGNALEVAM
EEECCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHH
TLAKTVVDELLSKNAREILKQ
HHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MYPLRIGTRSSLLATAQTAQVQKTMRDVFLLDTQQVLIQTGSVRRRDGSFVAALRTALLE
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHCCCCCCCCCHHHHHHHHHHHC
GECDLAVHSLKDIPIAPHEGTLITAVLPREDPCDVLCARKDLTLTTLPSGAKVGTASARR
CCCCHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCEECCCCCEEEECCCCCCCCCHHHHH
RAQILNFRPDLDVVSLRGNIDKRLIHLDTLDAIVLSAAGLKRIDREDAITESFDIHDWPT
HHHHHCCCCCCCEEEECCCCCCEEEEHHHHHHHHHHHHHHHHHCHHHHHHCCCCCCCCCC
AAGQGSLAIEVCRAQLDDPQNRVAVTYRLDNPMARVTTTAERGVLSLLQADCFSPIAVHA
CCCCCCHHHHHHHHHCCCCCCEEEEEEEECCCCEEEEEHHHHHHHHHHHHHCCCCEEEEE
VYTANDKSLRLHAKVFSRDGKIFCESIRFARLVKQLTDTNQNHTKNSGSDDIGNALEVAM
EEECCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHH
TLAKTVVDELLSKNAREILKQ
HHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA