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The map label for this gene is 28572886

Identifier: 28572886

GI number: 28572886

Start: 841752

End: 842477

Strand: Reverse

Name: 28572886

Synonym: TW745

Alternate gene names: NA

Gene position: 842477-841752 (Counterclockwise)

Preceding gene: 28572887

Following gene: 28572885

Centisome position: 90.99

GC content: 47.25

Gene sequence:

>726_bases
ATGAGACACTCTTGCCACCATGTATGGATTACCCGAGGCGGGCAATGGGCGCGCGAAATTGCCGGTATGCTCAAAGTCCG
GGGGGTAACGAGTGTTGTACATCCCGTGATTGATTGTGTGCCAGTAATGGGCTATGAAAATGAACTCCAGAAAATTCCAT
TTTTTGACTGGCTTATTGTGACAAGTTCGACTACTGCAGGATTGCTCAATACCCCTATTCCTCAGTCCGTCAAGGTGGCT
GCAGTTGGGAGGGAAACTGCCGAGTCTCTGATCCGTGCTGGGCACAGAGTTTCTTTGTGCCCCGAAAATGATTTTAGTTC
AGATGGGCTTGCAAGCGCCATACAGGCCCATCTGAATTTTCCGCGCAGAACGTGTGACAGTGTCATTTCGCAGCGTATTC
TGATTCTGACATCGGATCTTTCTGAAGGTTTCCTAAAAAGTGCACTCGAGCGTATGGGACATAAAGTAACAGTTCTGGTT
ATATATAAAACAGTTATCTTGGATATTCCGCCAATGCCGCAGTTAGACAACATCACTGCAGCGTTTGTGACAAGTGGAAG
TATCGCGCAGGGCATAGCCAAAACAGGCCTGTTTTTTGATTTGCCACTTGTGTGTATAGGTCACAAGACAGCCGAAATTT
GTCAACGCAGCGGGCTGCGAGTTGCTTCAATTGCAAGGACTAAGAATAAAGAGGGTCTTGTACAGGCGCTTTTTGAACTG
AGTTAG

Upstream 100 bases:

>100_bases
GCAGTGATGATATTGGTAATGCTTTAGAAGTTGCAATGACTCTTGCAAAGACCGTTGTTGACGAACTTTTGTCAAAAAAT
GCACGAGAAATCTTGAAACA

Downstream 100 bases:

>100_bases
ATTGGGTTTAATGTTTCAAAAAATACGCACTCGGCGTCTTCGTCTTTCGGAAGCAATGCGTAGATTGGCTTCTGAACATG
TTTTGGTCCCCCATAAACTG

Product: porphyrin biosynthesis protein

Products: uroporphyrinogen III; H2O

Alternate protein names: Porphyrin Biosynthesis Protein

Number of amino acids: Translated: 241; Mature: 241

Protein sequence:

>241_residues
MRHSCHHVWITRGGQWAREIAGMLKVRGVTSVVHPVIDCVPVMGYENELQKIPFFDWLIVTSSTTAGLLNTPIPQSVKVA
AVGRETAESLIRAGHRVSLCPENDFSSDGLASAIQAHLNFPRRTCDSVISQRILILTSDLSEGFLKSALERMGHKVTVLV
IYKTVILDIPPMPQLDNITAAFVTSGSIAQGIAKTGLFFDLPLVCIGHKTAEICQRSGLRVASIARTKNKEGLVQALFEL
S

Sequences:

>Translated_241_residues
MRHSCHHVWITRGGQWAREIAGMLKVRGVTSVVHPVIDCVPVMGYENELQKIPFFDWLIVTSSTTAGLLNTPIPQSVKVA
AVGRETAESLIRAGHRVSLCPENDFSSDGLASAIQAHLNFPRRTCDSVISQRILILTSDLSEGFLKSALERMGHKVTVLV
IYKTVILDIPPMPQLDNITAAFVTSGSIAQGIAKTGLFFDLPLVCIGHKTAEICQRSGLRVASIARTKNKEGLVQALFEL
S
>Mature_241_residues
MRHSCHHVWITRGGQWAREIAGMLKVRGVTSVVHPVIDCVPVMGYENELQKIPFFDWLIVTSSTTAGLLNTPIPQSVKVA
AVGRETAESLIRAGHRVSLCPENDFSSDGLASAIQAHLNFPRRTCDSVISQRILILTSDLSEGFLKSALERMGHKVTVLV
IYKTVILDIPPMPQLDNITAAFVTSGSIAQGIAKTGLFFDLPLVCIGHKTAEICQRSGLRVASIARTKNKEGLVQALFEL
S

Specific function: Unknown

COG id: COG1587

COG function: function code H; Uroporphyrinogen-III synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 4.2.1.75

Molecular weight: Translated: 26270; Mature: 26270

Theoretical pI: Translated: 8.62; Mature: 8.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRHSCHHVWITRGGQWAREIAGMLKVRGVTSVVHPVIDCVPVMGYENELQKIPFFDWLIV
CCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCEEEEEE
TSSTTAGLLNTPIPQSVKVAAVGRETAESLIRAGHRVSLCPENDFSSDGLASAIQAHLNF
ECCCCCCCCCCCCCCCEEEEECCHHHHHHHHHCCCEEEECCCCCCCCCHHHHHHHHHHCC
PRRTCDSVISQRILILTSDLSEGFLKSALERMGHKVTVLVIYKTVILDIPPMPQLDNITA
CHHHHHHHHHCEEEEEECCHHHHHHHHHHHHCCCEEEEEEEEHHHHHCCCCCCCCCCCEE
AFVTSGSIAQGIAKTGLFFDLPLVCIGHKTAEICQRSGLRVASIARTKNKEGLVQALFEL
EEEECCHHHHHHHHHCCHHCCCHHEECCCHHHHHHHCCCEEEHHHHHCCHHHHHHHHHHC
S
C
>Mature Secondary Structure
MRHSCHHVWITRGGQWAREIAGMLKVRGVTSVVHPVIDCVPVMGYENELQKIPFFDWLIV
CCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCEEEEEE
TSSTTAGLLNTPIPQSVKVAAVGRETAESLIRAGHRVSLCPENDFSSDGLASAIQAHLNF
ECCCCCCCCCCCCCCCEEEEECCHHHHHHHHHCCCEEEECCCCCCCCCHHHHHHHHHHCC
PRRTCDSVISQRILILTSDLSEGFLKSALERMGHKVTVLVIYKTVILDIPPMPQLDNITA
CHHHHHHHHHCEEEEEECCHHHHHHHHHHHHCCCEEEEEEEEHHHHHCCCCCCCCCCCEE
AFVTSGSIAQGIAKTGLFFDLPLVCIGHKTAEICQRSGLRVASIARTKNKEGLVQALFEL
EEEECCHHHHHHHHHCCHHCCCHHEECCCHHHHHHHCCCEEEHHHHHCCHHHHHHHHHHC
S
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: hydroxymethylbilane

Specific reaction: hydroxymethylbilane = uroporphyrinogen III + H2O

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA