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The map label for this gene is tdcB [H]

Identifier: 28572841

GI number: 28572841

Start: 791981

End: 793264

Strand: Reverse

Name: tdcB [H]

Synonym: TW700

Alternate gene names: 28572841

Gene position: 793264-791981 (Counterclockwise)

Preceding gene: 28572842

Following gene: 28572837

Centisome position: 85.67

GC content: 47.43

Gene sequence:

>1284_bases
GTGCGCCACGGTATCGTTCTTGAGGATTTTCGCGCGGCCGCGAAAGTAATGCACAGCAAGTTCGTTGTGCATACTCCGGT
CATACAGTCTGTTATGCTGTCAGACCTTGTCGGGTCTCCCGTTTATTTTAAGTGTGAAAACCTGCAAATAACAGGATCCT
ACAAGATAAGAGGGGTGTTCAATTATCTTCACAACCTCAAAAAAAGATCGACTGCTGTCGTTGCCGCAAGCGCTGGGAAT
CATGCACAGAGCGTGGCCTATGCTGCAAAACAAATAGGTATCAAGGCAGTTATTTTTATGCCAAGCAGTGTTAGTCTGCC
AAAGTACAACGCAACCAAAAAATACGGTGCGGAAATTATTCTAGATCAGGGTGATATTCAAACCCTCATATTCAAGGCAA
GACGGTATGCAAAAAAACATAAGTTCGTTTTTATCCCGCCATTTGATCACCGCGATATTGTTGTCGGCCAGGGCACAATT
GCCCTCGAACTGTTAGAGCAGGTTCCTGATCTAAGAACGGTAGTTGTGCCAACTGGCGGCGGAGGACTCGTGGCTGGTAT
TGCCTCTGCCGTTACCCTGGCGCAGAATCCCAGCGGAACGATCTTCACAAAAAGTGGCTTAGAACAGCCGGCCAAGTCTG
GCATACGGGTGGTTGGCGTTCAAGCAAAAACATCGGCGTCTTTTATAGAATCGATGGTTGCAGGAAAGCCAGTGAAGGTA
AATATAACCTCACATTTCGCAGATGGGATAGCGGTTCCAAAACCCGGAAAGATAACATTCGAACTCGCGAGATGTTTCGT
TGACAGGTTTGTCGAAGTTGGTGATCACGAAATTGCAGGCGCCATACTCACCCTGCTTGAAGACTCAAAAATAATAGTTG
AACCTGCCGCTGCCAGTGCTGCCGCAGCTGTTCTAAGTAAAAAAATCACAAATCTGAAAGGGTCAACAGTGATTGTTTTG
AGTGGCGGTAATATCGACCCAATGACTTTGAGCCAGATAATTCTCCGGGGGCTATCACTCAGGTCTCGGAGGCTAACCTT
ACGGGCACAACTCAAAGATGTGCCCGGGCAGCTGGCTGAATTTTCAAGAGTTGTTGCAAAAGCCGAGGCTAATGTTGTTG
CTGTCAATCATTCACGTGGTAACTACACGGATGACAATGGTCGCATCTCCTTCGGTGATGTCTTTATGGACATCGACCTT
GAAACCCGTGGCCACGAGCATTCTCAGAGTATTGTCCGTGCCCTTCGAGATTCCGGGTTTGTAGTTGAAGTTCTGGGATT
GTAA

Upstream 100 bases:

>100_bases
ATGGCAACTGCAAATGACACGTTTGAGCTTGTAAATTTCTTTGAAGCGATCAATACTTCTTATGAATCCAACGCTCGCTC
ATTAAGCTAGAGATTAATTC

Downstream 100 bases:

>100_bases
CCCCTGAGTAATGTTTTAACAAACACCAGTACCGTATAACTTGACAATAGTTACAACTTGACAACAGTAGTGTGCAGCAA
AATTACCGATTTTTACGGGA

Product: threonine dehydratase

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 427; Mature: 427

Protein sequence:

>427_residues
MRHGIVLEDFRAAAKVMHSKFVVHTPVIQSVMLSDLVGSPVYFKCENLQITGSYKIRGVFNYLHNLKKRSTAVVAASAGN
HAQSVAYAAKQIGIKAVIFMPSSVSLPKYNATKKYGAEIILDQGDIQTLIFKARRYAKKHKFVFIPPFDHRDIVVGQGTI
ALELLEQVPDLRTVVVPTGGGGLVAGIASAVTLAQNPSGTIFTKSGLEQPAKSGIRVVGVQAKTSASFIESMVAGKPVKV
NITSHFADGIAVPKPGKITFELARCFVDRFVEVGDHEIAGAILTLLEDSKIIVEPAAASAAAAVLSKKITNLKGSTVIVL
SGGNIDPMTLSQIILRGLSLRSRRLTLRAQLKDVPGQLAEFSRVVAKAEANVVAVNHSRGNYTDDNGRISFGDVFMDIDL
ETRGHEHSQSIVRALRDSGFVVEVLGL

Sequences:

>Translated_427_residues
MRHGIVLEDFRAAAKVMHSKFVVHTPVIQSVMLSDLVGSPVYFKCENLQITGSYKIRGVFNYLHNLKKRSTAVVAASAGN
HAQSVAYAAKQIGIKAVIFMPSSVSLPKYNATKKYGAEIILDQGDIQTLIFKARRYAKKHKFVFIPPFDHRDIVVGQGTI
ALELLEQVPDLRTVVVPTGGGGLVAGIASAVTLAQNPSGTIFTKSGLEQPAKSGIRVVGVQAKTSASFIESMVAGKPVKV
NITSHFADGIAVPKPGKITFELARCFVDRFVEVGDHEIAGAILTLLEDSKIIVEPAAASAAAAVLSKKITNLKGSTVIVL
SGGNIDPMTLSQIILRGLSLRSRRLTLRAQLKDVPGQLAEFSRVVAKAEANVVAVNHSRGNYTDDNGRISFGDVFMDIDL
ETRGHEHSQSIVRALRDSGFVVEVLGL
>Mature_427_residues
MRHGIVLEDFRAAAKVMHSKFVVHTPVIQSVMLSDLVGSPVYFKCENLQITGSYKIRGVFNYLHNLKKRSTAVVAASAGN
HAQSVAYAAKQIGIKAVIFMPSSVSLPKYNATKKYGAEIILDQGDIQTLIFKARRYAKKHKFVFIPPFDHRDIVVGQGTI
ALELLEQVPDLRTVVVPTGGGGLVAGIASAVTLAQNPSGTIFTKSGLEQPAKSGIRVVGVQAKTSASFIESMVAGKPVKV
NITSHFADGIAVPKPGKITFELARCFVDRFVEVGDHEIAGAILTLLEDSKIIVEPAAASAAAAVLSKKITNLKGSTVIVL
SGGNIDPMTLSQIILRGLSLRSRRLTLRAQLKDVPGQLAEFSRVVAKAEANVVAVNHSRGNYTDDNGRISFGDVFMDIDL
ETRGHEHSQSIVRALRDSGFVVEVLGL

Specific function: Acts on both serine and threonine, and properly considered as a hydroxy amino acid deaminase [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=311, Percent_Identity=34.0836012861736, Blast_Score=155, Evalue=5e-38,
Organism=Homo sapiens, GI19923959, Length=327, Percent_Identity=28.1345565749235, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI33469958, Length=327, Percent_Identity=30.8868501529052, Blast_Score=89, Evalue=6e-18,
Organism=Escherichia coli, GI1789505, Length=318, Percent_Identity=37.1069182389937, Blast_Score=161, Evalue=7e-41,
Organism=Escherichia coli, GI1790207, Length=403, Percent_Identity=30.7692307692308, Blast_Score=158, Evalue=5e-40,
Organism=Caenorhabditis elegans, GI71991565, Length=395, Percent_Identity=37.2151898734177, Blast_Score=211, Evalue=4e-55,
Organism=Caenorhabditis elegans, GI17537387, Length=399, Percent_Identity=36.3408521303258, Blast_Score=175, Evalue=4e-44,
Organism=Caenorhabditis elegans, GI17508781, Length=331, Percent_Identity=28.3987915407855, Blast_Score=125, Evalue=4e-29,
Organism=Saccharomyces cerevisiae, GI6322631, Length=309, Percent_Identity=34.9514563106796, Blast_Score=169, Evalue=1e-42,
Organism=Saccharomyces cerevisiae, GI6320930, Length=349, Percent_Identity=30.3724928366762, Blast_Score=150, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6319788, Length=284, Percent_Identity=23.943661971831, Blast_Score=75, Evalue=1e-14,
Organism=Drosophila melanogaster, GI21355833, Length=366, Percent_Identity=35.2459016393443, Blast_Score=172, Evalue=3e-43,
Organism=Drosophila melanogaster, GI24645328, Length=286, Percent_Identity=34.2657342657343, Blast_Score=125, Evalue=5e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR005789 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 45831; Mature: 45831

Theoretical pI: Translated: 10.26; Mature: 10.26

Prosite motif: PS00061 ADH_SHORT ; PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRHGIVLEDFRAAAKVMHSKFVVHTPVIQSVMLSDLVGSPVYFKCENLQITGSYKIRGVF
CCCCCCHHHHHHHHHHHHHCEEEEHHHHHHHHHHHHHCCCEEEEECCEEEECCEEEHHHH
NYLHNLKKRSTAVVAASAGNHAQSVAYAAKQIGIKAVIFMPSSVSLPKYNATKKYGAEII
HHHHHHHHCCEEEEEECCCCCHHHHHHHHHHCCEEEEEEECCCCCCCCCCCCHHCCCEEE
LDQGDIQTLIFKARRYAKKHKFVFIPPFDHRDIVVGQGTIALELLEQVPDLRTVVVPTGG
EECCCHHHHHHHHHHHHHHCCEEEECCCCCCCEEEECCHHHHHHHHHCCCCEEEEEECCC
GGLVAGIASAVTLAQNPSGTIFTKSGLEQPAKSGIRVVGVQAKTSASFIESMVAGKPVKV
CHHHHHHHHHHHEECCCCCCEEECCCCCCHHHCCCEEEEEECHHHHHHHHHHHCCCCEEE
NITSHFADGIAVPKPGKITFELARCFVDRFVEVGDHEIAGAILTLLEDSKIIVEPAAASA
EEEHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCEEEEECCCHHH
AAAVLSKKITNLKGSTVIVLSGGNIDPMTLSQIILRGLSLRSRRLTLRAQLKDVPGQLAE
HHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHCCCCCCCEEEEEHHHHCCCHHHHH
FSRVVAKAEANVVAVNHSRGNYTDDNGRISFGDVFMDIDLETRGHEHSQSIVRALRDSGF
HHHHHHHCCCCEEEEECCCCCCCCCCCEEEECEEEEEEEECCCCCHHHHHHHHHHHCCCC
VVEVLGL
EEEEECC
>Mature Secondary Structure
MRHGIVLEDFRAAAKVMHSKFVVHTPVIQSVMLSDLVGSPVYFKCENLQITGSYKIRGVF
CCCCCCHHHHHHHHHHHHHCEEEEHHHHHHHHHHHHHCCCEEEEECCEEEECCEEEHHHH
NYLHNLKKRSTAVVAASAGNHAQSVAYAAKQIGIKAVIFMPSSVSLPKYNATKKYGAEII
HHHHHHHHCCEEEEEECCCCCHHHHHHHHHHCCEEEEEEECCCCCCCCCCCCHHCCCEEE
LDQGDIQTLIFKARRYAKKHKFVFIPPFDHRDIVVGQGTIALELLEQVPDLRTVVVPTGG
EECCCHHHHHHHHHHHHHHCCEEEECCCCCCCEEEECCHHHHHHHHHCCCCEEEEEECCC
GGLVAGIASAVTLAQNPSGTIFTKSGLEQPAKSGIRVVGVQAKTSASFIESMVAGKPVKV
CHHHHHHHHHHHEECCCCCCEEECCCCCCHHHCCCEEEEEECHHHHHHHHHHHCCCCEEE
NITSHFADGIAVPKPGKITFELARCFVDRFVEVGDHEIAGAILTLLEDSKIIVEPAAASA
EEEHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCEEEEECCCHHH
AAAVLSKKITNLKGSTVIVLSGGNIDPMTLSQIILRGLSLRSRRLTLRAQLKDVPGQLAE
HHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHCCCCCCCEEEEEHHHHCCCHHHHH
FSRVVAKAEANVVAVNHSRGNYTDDNGRISFGDVFMDIDLETRGHEHSQSIVRALRDSGF
HHHHHHHCCCCEEEEECCCCCCCCCCCEEEECEEEEEEEECCCCCHHHHHHHHHHHCCCC
VVEVLGL
EEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA