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The map label for this gene is gabT [H]

Identifier: 28572796

GI number: 28572796

Start: 746050

End: 747348

Strand: Reverse

Name: gabT [H]

Synonym: TW652

Alternate gene names: 28572796

Gene position: 747348-746050 (Counterclockwise)

Preceding gene: 28572797

Following gene: 28572795

Centisome position: 80.71

GC content: 48.81

Gene sequence:

>1299_bases
GTGAGTAAGATAAAGCTTGTAACCGCGATACCCGGCCCTGAATCAGAGAGGCTACACAGGATAAGGCAGGCCACTGTTGC
AAGGGGTGTGTCGTCCACTTTCCCGATATATATCAAGGAGTCACACGGCTCAATCCTCATTGATGAAGACGGAAATCACC
TGATAGATATGGGATGTGGGATTGGTGTAACCACGCTGGGTCACAGCCATCCCGCCGTTGTGGATGCCGCGCGTGCTCAA
ATAAATAGTGTCTGGCACACTCTGTTTTCTATCACGCCTTACGAGTCGTATGTAGAGGTTTGTAAATTACTTGCTAAAAA
CACCCCGGGTGATTTCCCAAAAAAGAGTTTGCTGTTGAATTCGGGAGCTGAGGCGGTGGAAAATGCTGTCAAAATTTCCA
GGGCATACACAGGTCGTCCAACCGTTGCTGTCTTGGATAGATCATTTCATGGTCGGACTAATCTAACTTCGTCAATGACT
TATAGAGGCTCTCTGTATTCATCTGACTTTGGCCCTACAGCGAGCAATATAGTAAGCGCCCCGAATTCGTACCCGTTGCA
TGACAGGCTTTCAGGAAAAGAGGCCGCCGCAAGGACCATTTCATATCTGGAAACACGGGTTGCCGCAAGGAATATTGCTT
GCTTATTCTACGAGCCGATACAGGGTGAAGGTGGGGTTATCGTCCCGGCTGATGGATTCTTACCAGCGCTACAGGATTGG
TGCCGCGAAAACGATATTGTATTTGTCGCTGACGAGATCCAGTCGGGTTTTGGCAGAACGGGTTGTTTTTTTGCATCAGA
GACGGACGGACTTGAACCAGATATTGTGTGTTCGGCTAAGGGTATTGCAAACGGCCTGCCTCTTTCGGCTGTGACGGGAC
GCAGTGATATCGTTGATGCCGCGCGCCCCGGTACTCTTGGGGGTACTTTCACAGGAAATCATGTGTCATGCGCTGCTGCA
CTAGAGGTTTTTGAGCAATATAAGGACAATGCACCTCTGGATTCTGCTTCGCGTCTTGGTGACATCCTAAAGGAGCTTTT
ATTGAATCTTCAGTCAAAGCACCCTCAAATTGCCGAGGTAAGAGGTCGTGGCGCCATGTTTGGTGCCGAGTTTTCGGGAA
ACCACGCTGGGGAAATGGTCTCACGTGTTATAACTCGTGCTGCGGAGCTTGGCGTAATTTTTTTATCCTCCGGCGTCGAG
GGGAATGTTGTGAGGTTTCTTCCTAATGTTTTTATGGATAAAGAAACGATTGAAGAGGCGATCGGTGTCCTTGATTCAGC
AATCTCAAGTGTTGTTTAG

Upstream 100 bases:

>100_bases
CGTAGTAGGTGGGGTTGGGCCAATGACCCGTGCAATGCTTATGTCAAATGTTATAAACCTCTCAGAGAGAGATTTCAGAA
AAAGGTTGTATGCTTCATAG

Downstream 100 bases:

>100_bases
TGCTCCGAAGTATAAGTACCCCAATTAGATATATCCCTGGCAAGACTTTCGTGTTTGCTATGAAAAAGAACGCTTCCGGT
AACACGCGCCGAAGAATGCG

Product: 4-aminobutyrate aminotransferase

Products: NA

Alternate protein names: (S)-3-amino-2-methylpropionate transaminase; GABA aminotransferase; GABA-AT; Gamma-amino-N-butyrate transaminase; GABA transaminase; Glutamate:succinic semialdehyde transaminase; L-AIBAT [H]

Number of amino acids: Translated: 432; Mature: 431

Protein sequence:

>432_residues
MSKIKLVTAIPGPESERLHRIRQATVARGVSSTFPIYIKESHGSILIDEDGNHLIDMGCGIGVTTLGHSHPAVVDAARAQ
INSVWHTLFSITPYESYVEVCKLLAKNTPGDFPKKSLLLNSGAEAVENAVKISRAYTGRPTVAVLDRSFHGRTNLTSSMT
YRGSLYSSDFGPTASNIVSAPNSYPLHDRLSGKEAAARTISYLETRVAARNIACLFYEPIQGEGGVIVPADGFLPALQDW
CRENDIVFVADEIQSGFGRTGCFFASETDGLEPDIVCSAKGIANGLPLSAVTGRSDIVDAARPGTLGGTFTGNHVSCAAA
LEVFEQYKDNAPLDSASRLGDILKELLLNLQSKHPQIAEVRGRGAMFGAEFSGNHAGEMVSRVITRAAELGVIFLSSGVE
GNVVRFLPNVFMDKETIEEAIGVLDSAISSVV

Sequences:

>Translated_432_residues
MSKIKLVTAIPGPESERLHRIRQATVARGVSSTFPIYIKESHGSILIDEDGNHLIDMGCGIGVTTLGHSHPAVVDAARAQ
INSVWHTLFSITPYESYVEVCKLLAKNTPGDFPKKSLLLNSGAEAVENAVKISRAYTGRPTVAVLDRSFHGRTNLTSSMT
YRGSLYSSDFGPTASNIVSAPNSYPLHDRLSGKEAAARTISYLETRVAARNIACLFYEPIQGEGGVIVPADGFLPALQDW
CRENDIVFVADEIQSGFGRTGCFFASETDGLEPDIVCSAKGIANGLPLSAVTGRSDIVDAARPGTLGGTFTGNHVSCAAA
LEVFEQYKDNAPLDSASRLGDILKELLLNLQSKHPQIAEVRGRGAMFGAEFSGNHAGEMVSRVITRAAELGVIFLSSGVE
GNVVRFLPNVFMDKETIEEAIGVLDSAISSVV
>Mature_431_residues
SKIKLVTAIPGPESERLHRIRQATVARGVSSTFPIYIKESHGSILIDEDGNHLIDMGCGIGVTTLGHSHPAVVDAARAQI
NSVWHTLFSITPYESYVEVCKLLAKNTPGDFPKKSLLLNSGAEAVENAVKISRAYTGRPTVAVLDRSFHGRTNLTSSMTY
RGSLYSSDFGPTASNIVSAPNSYPLHDRLSGKEAAARTISYLETRVAARNIACLFYEPIQGEGGVIVPADGFLPALQDWC
RENDIVFVADEIQSGFGRTGCFFASETDGLEPDIVCSAKGIANGLPLSAVTGRSDIVDAARPGTLGGTFTGNHVSCAAAL
EVFEQYKDNAPLDSASRLGDILKELLLNLQSKHPQIAEVRGRGAMFGAEFSGNHAGEMVSRVITRAAELGVIFLSSGVEG
NVVRFLPNVFMDKETIEEAIGVLDSAISSVV

Specific function: 4-aminobutyrate (GABA) degradation. [C]

COG id: COG0160

COG function: function code E; 4-aminobutyrate aminotransferase and related aminotransferases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI24119277, Length=432, Percent_Identity=29.3981481481481, Blast_Score=155, Evalue=5e-38,
Organism=Homo sapiens, GI4557809, Length=413, Percent_Identity=28.3292978208232, Blast_Score=155, Evalue=7e-38,
Organism=Homo sapiens, GI13994255, Length=447, Percent_Identity=27.0693512304251, Blast_Score=153, Evalue=4e-37,
Organism=Homo sapiens, GI37574042, Length=410, Percent_Identity=27.3170731707317, Blast_Score=147, Evalue=3e-35,
Organism=Homo sapiens, GI226442709, Length=379, Percent_Identity=27.1767810026385, Blast_Score=136, Evalue=5e-32,
Organism=Homo sapiens, GI284507298, Length=321, Percent_Identity=29.2834890965732, Blast_Score=133, Evalue=3e-31,
Organism=Homo sapiens, GI226442705, Length=410, Percent_Identity=26.0975609756098, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI188536080, Length=449, Percent_Identity=26.2806236080178, Blast_Score=117, Evalue=3e-26,
Organism=Homo sapiens, GI38679950, Length=449, Percent_Identity=26.2806236080178, Blast_Score=117, Evalue=3e-26,
Organism=Homo sapiens, GI38679946, Length=449, Percent_Identity=26.2806236080178, Blast_Score=117, Evalue=3e-26,
Organism=Escherichia coli, GI1789016, Length=415, Percent_Identity=38.3132530120482, Blast_Score=300, Evalue=2e-82,
Organism=Escherichia coli, GI1787560, Length=419, Percent_Identity=36.0381861575179, Blast_Score=267, Evalue=9e-73,
Organism=Escherichia coli, GI1789759, Length=428, Percent_Identity=29.9065420560748, Blast_Score=186, Evalue=4e-48,
Organism=Escherichia coli, GI1788044, Length=404, Percent_Identity=29.9504950495049, Blast_Score=175, Evalue=4e-45,
Organism=Escherichia coli, GI145693181, Length=340, Percent_Identity=32.6470588235294, Blast_Score=160, Evalue=1e-40,
Organism=Escherichia coli, GI1786349, Length=375, Percent_Identity=27.2, Blast_Score=124, Evalue=8e-30,
Organism=Escherichia coli, GI1786991, Length=307, Percent_Identity=28.9902280130293, Blast_Score=107, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI25144271, Length=412, Percent_Identity=25.7281553398058, Blast_Score=155, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI71992977, Length=430, Percent_Identity=27.4418604651163, Blast_Score=150, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI32564660, Length=431, Percent_Identity=26.2180974477958, Blast_Score=145, Evalue=4e-35,
Organism=Caenorhabditis elegans, GI25144274, Length=238, Percent_Identity=28.9915966386555, Blast_Score=128, Evalue=6e-30,
Organism=Caenorhabditis elegans, GI17541228, Length=465, Percent_Identity=23.8709677419355, Blast_Score=100, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6324432, Length=398, Percent_Identity=33.9195979899498, Blast_Score=192, Evalue=6e-50,
Organism=Saccharomyces cerevisiae, GI6323470, Length=410, Percent_Identity=26.5853658536585, Blast_Score=141, Evalue=3e-34,
Organism=Saccharomyces cerevisiae, GI6321456, Length=402, Percent_Identity=26.1194029850746, Blast_Score=92, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6324386, Length=338, Percent_Identity=25.7396449704142, Blast_Score=78, Evalue=3e-15,
Organism=Drosophila melanogaster, GI161085790, Length=453, Percent_Identity=28.476821192053, Blast_Score=169, Evalue=4e-42,
Organism=Drosophila melanogaster, GI28574759, Length=456, Percent_Identity=28.5087719298246, Blast_Score=168, Evalue=7e-42,
Organism=Drosophila melanogaster, GI21357415, Length=439, Percent_Identity=26.4236902050114, Blast_Score=146, Evalue=3e-35,
Organism=Drosophila melanogaster, GI21356575, Length=418, Percent_Identity=28.2296650717703, Blast_Score=145, Evalue=5e-35,
Organism=Drosophila melanogaster, GI281366494, Length=399, Percent_Identity=26.3157894736842, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24667139, Length=399, Percent_Identity=26.3157894736842, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24667143, Length=399, Percent_Identity=26.3157894736842, Blast_Score=98, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004632
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.19; =2.6.1.22 [H]

Molecular weight: Translated: 46116; Mature: 45984

Theoretical pI: Translated: 5.79; Mature: 5.79

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKIKLVTAIPGPESERLHRIRQATVARGVSSTFPIYIKESHGSILIDEDGNHLIDMGCG
CCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCEEEEECCCCEEEECCCCEEEEECCC
IGVTTLGHSHPAVVDAARAQINSVWHTLFSITPYESYVEVCKLLAKNTPGDFPKKSLLLN
CCEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCHHHHHC
SGAEAVENAVKISRAYTGRPTVAVLDRSFHGRTNLTSSMTYRGSLYSSDFGPTASNIVSA
CCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCEEECCCCCCCCCCCCHHHHHCC
PNSYPLHDRLSGKEAAARTISYLETRVAARNIACLFYEPIQGEGGVIVPADGFLPALQDW
CCCCCCHHCCCCHHHHHHHHHHHHHHHHHHCEEEEEEECCCCCCCEEEECCCCHHHHHHH
CRENDIVFVADEIQSGFGRTGCFFASETDGLEPDIVCSAKGIANGLPLSAVTGRSDIVDA
HCCCCEEEEEHHHHCCCCCCCEEEECCCCCCCCCEEEECCCCCCCCCCEEECCCHHHHHC
ARPGTLGGTFTGNHVSCAAALEVFEQYKDNAPLDSASRLGDILKELLLNLQSKHPQIAEV
CCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHH
RGRGAMFGAEFSGNHAGEMVSRVITRAAELGVIFLSSGVEGNVVRFLPNVFMDKETIEEA
CCCCCEEECCCCCCHHHHHHHHHHHHHHHCCEEEEECCCCCCHHHHHHHHHCCHHHHHHH
IGVLDSAISSVV
HHHHHHHHHHCC
>Mature Secondary Structure 
SKIKLVTAIPGPESERLHRIRQATVARGVSSTFPIYIKESHGSILIDEDGNHLIDMGCG
CCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCEEEEECCCCEEEECCCCEEEEECCC
IGVTTLGHSHPAVVDAARAQINSVWHTLFSITPYESYVEVCKLLAKNTPGDFPKKSLLLN
CCEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCHHHHHC
SGAEAVENAVKISRAYTGRPTVAVLDRSFHGRTNLTSSMTYRGSLYSSDFGPTASNIVSA
CCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCEEECCCCCCCCCCCCHHHHHCC
PNSYPLHDRLSGKEAAARTISYLETRVAARNIACLFYEPIQGEGGVIVPADGFLPALQDW
CCCCCCHHCCCCHHHHHHHHHHHHHHHHHHCEEEEEEECCCCCCCEEEECCCCHHHHHHH
CRENDIVFVADEIQSGFGRTGCFFASETDGLEPDIVCSAKGIANGLPLSAVTGRSDIVDA
HCCCCEEEEEHHHHCCCCCCCEEEECCCCCCCCCEEEECCCCCCCCCCEEECCCHHHHHC
ARPGTLGGTFTGNHVSCAAALEVFEQYKDNAPLDSASRLGDILKELLLNLQSKHPQIAEV
CCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHH
RGRGAMFGAEFSGNHAGEMVSRVITRAAELGVIFLSSGVEGNVVRFLPNVFMDKETIEEA
CCCCCEEECCCCCCHHHHHHHHHHHHHHHCCEEEEECCCCCCHHHHHHHHHCCHHHHHHH
IGVLDSAISSVV
HHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11234002 [H]