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The map label for this gene is htrA [H]

Identifier: 28572788

GI number: 28572788

Start: 731763

End: 733025

Strand: Reverse

Name: htrA [H]

Synonym: TW643

Alternate gene names: 28572788

Gene position: 733025-731763 (Counterclockwise)

Preceding gene: 28572789

Following gene: 28572785

Centisome position: 79.17

GC content: 49.56

Gene sequence:

>1263_bases
ATGGGCGATGAACTTGAAAATGTGACGGGCAGCGATGCAACAGACGAGGTATTGGCGACCGCCAGGCGCATTGCAGTAAG
CTCAGGCAAGGGTAATTTTAAGGCACCTAAGCTGCGCCAGAAGCTCAAGCTTGCGGCCAAAAAGATGAAACCTAAGTGTA
TTCTGCACAAATATGTTTGGTTTGCACTTGTGATTGTTGCGGTGGCTTTCCTTTCGGGTTTCACCTCTTCTGTTGTAACC
TATCGGTTGCTGTCTTCCGACCAGCAAAAGGAATCACCGCTGTTGCCGCTTACACCCCCCATTTACTCCAGTGGCACAAA
AGAACTGGACTTGCCATCTGCCACCGCAAAAAGGGTCATCTCCAGCGTTGTCACCATCCAGGTATCTGCGGGTAATGGCA
TGTCCGGATCGGGATCCGGCGTTGTCTTCAATGACAATGGTGACATAGTTACAAATGCTCATGTTGTTACGCTGGACGGA
AGGGTTGACAAGCCAGATCTGCGTGTTCTTGCCCGCGACGGTAGGCGTTACAAAGCTGTTCTTGTCGGCGTCGATCGAAT
GCTTGATATTGCTGTTGTGAGAATAAAACCACGTGCTTTACCAGCGATTACATTTGGTGATTCCTCTGCTGTAACTGTGG
GATCATCGGTTATAGCTGTGGGTGCACCCTTGGGCTATGATTTTAGTGTTACTCGGGGGATTATTAGTTCAGTCCTGCGG
TCAATTAATTTAACTTCCTTTGGCCTTGCCGGTCAGGTTAACGCTGTTCCTGTTATACAGACTGATGCCGCCATAAACCC
CGGGAATTCGGGTGGTCCTCTTGTTGATCTTAACGGCAGGTTAATAGGTATCAATGTCGCAATTGCCTCTGCGGGGTTAT
TTTCTTCCGGAAATGTTGGCGTTGGGTTTGCTATTCCGTCCAATTTGGTCCACCGTGTTGCCACCGCCCTCGCAGCCAAT
CGCCCTGTCTCTCATGGATATCTTGGTGTATCTGTTTCTGATGGCAGTGATCGGGACGAATCCTATGAGGGTGCTATTGT
AAAGAGTGTAACCCCGCGCAGTCCAGCTGATACTGCCGGACTAAAACCGGGAGATCTGCTTCTCTCTATCGGGGGTAACA
AGATATCAAATATGATTGATCTAGTTGCCTTTGTTCGCAGTCGCCCAGGTGGTACCCCGGTGCCTATCCGGGTTGAGCGT
AACGGCAAAGAAATATCTCTTACGGTAACCCTCTCCAGTCTTGAGGAGATCAAGGGAACATAA

Upstream 100 bases:

>100_bases
CTGTGTTGTTTTTCATTTTTTCCGTATGGCTTTTACAGCCTTCTGTGAGCTTTTTACTGTAAAAGTGTCCTTGTAAGATA
CAAATACTGGCGAGGTTAAT

Downstream 100 bases:

>100_bases
ATACTAACCACAAATGTGTTACAATCGGCACAGGTGCGTGTATGCAGACGCATGTATAGTGAGGTACTATGAGTATTATG
AAGTGCAAACTGGTCCCTAA

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 420; Mature: 419

Protein sequence:

>420_residues
MGDELENVTGSDATDEVLATARRIAVSSGKGNFKAPKLRQKLKLAAKKMKPKCILHKYVWFALVIVAVAFLSGFTSSVVT
YRLLSSDQQKESPLLPLTPPIYSSGTKELDLPSATAKRVISSVVTIQVSAGNGMSGSGSGVVFNDNGDIVTNAHVVTLDG
RVDKPDLRVLARDGRRYKAVLVGVDRMLDIAVVRIKPRALPAITFGDSSAVTVGSSVIAVGAPLGYDFSVTRGIISSVLR
SINLTSFGLAGQVNAVPVIQTDAAINPGNSGGPLVDLNGRLIGINVAIASAGLFSSGNVGVGFAIPSNLVHRVATALAAN
RPVSHGYLGVSVSDGSDRDESYEGAIVKSVTPRSPADTAGLKPGDLLLSIGGNKISNMIDLVAFVRSRPGGTPVPIRVER
NGKEISLTVTLSSLEEIKGT

Sequences:

>Translated_420_residues
MGDELENVTGSDATDEVLATARRIAVSSGKGNFKAPKLRQKLKLAAKKMKPKCILHKYVWFALVIVAVAFLSGFTSSVVT
YRLLSSDQQKESPLLPLTPPIYSSGTKELDLPSATAKRVISSVVTIQVSAGNGMSGSGSGVVFNDNGDIVTNAHVVTLDG
RVDKPDLRVLARDGRRYKAVLVGVDRMLDIAVVRIKPRALPAITFGDSSAVTVGSSVIAVGAPLGYDFSVTRGIISSVLR
SINLTSFGLAGQVNAVPVIQTDAAINPGNSGGPLVDLNGRLIGINVAIASAGLFSSGNVGVGFAIPSNLVHRVATALAAN
RPVSHGYLGVSVSDGSDRDESYEGAIVKSVTPRSPADTAGLKPGDLLLSIGGNKISNMIDLVAFVRSRPGGTPVPIRVER
NGKEISLTVTLSSLEEIKGT
>Mature_419_residues
GDELENVTGSDATDEVLATARRIAVSSGKGNFKAPKLRQKLKLAAKKMKPKCILHKYVWFALVIVAVAFLSGFTSSVVTY
RLLSSDQQKESPLLPLTPPIYSSGTKELDLPSATAKRVISSVVTIQVSAGNGMSGSGSGVVFNDNGDIVTNAHVVTLDGR
VDKPDLRVLARDGRRYKAVLVGVDRMLDIAVVRIKPRALPAITFGDSSAVTVGSSVIAVGAPLGYDFSVTRGIISSVLRS
INLTSFGLAGQVNAVPVIQTDAAINPGNSGGPLVDLNGRLIGINVAIASAGLFSSGNVGVGFAIPSNLVHRVATALAANR
PVSHGYLGVSVSDGSDRDESYEGAIVKSVTPRSPADTAGLKPGDLLLSIGGNKISNMIDLVAFVRSRPGGTPVPIRVERN
GKEISLTVTLSSLEEIKGT

Specific function: A putative protease, its function overlaps that of the related putative proteases HhoA and HhoB [H]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein (Potential). Cell outer membrane (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PDZ (DHR) domain [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=291, Percent_Identity=33.3333333333333, Blast_Score=125, Evalue=6e-29,
Organism=Homo sapiens, GI22129776, Length=329, Percent_Identity=28.5714285714286, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI7019477, Length=296, Percent_Identity=35.1351351351351, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI24308541, Length=305, Percent_Identity=30.1639344262295, Blast_Score=110, Evalue=3e-24,
Organism=Escherichia coli, GI1786356, Length=284, Percent_Identity=39.4366197183099, Blast_Score=167, Evalue=9e-43,
Organism=Escherichia coli, GI1789629, Length=286, Percent_Identity=37.7622377622378, Blast_Score=154, Evalue=8e-39,
Organism=Escherichia coli, GI1789630, Length=286, Percent_Identity=34.2657342657343, Blast_Score=125, Evalue=5e-30,
Organism=Drosophila melanogaster, GI24646839, Length=272, Percent_Identity=33.8235294117647, Blast_Score=120, Evalue=1e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 43677; Mature: 43546

Theoretical pI: Translated: 10.26; Mature: 10.26

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGDELENVTGSDATDEVLATARRIAVSSGKGNFKAPKLRQKLKLAAKKMKPKCILHKYVW
CCCCCCCCCCCCCHHHHHHHHHHHEEECCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHH
FALVIVAVAFLSGFTSSVVTYRLLSSDQQKESPLLPLTPPIYSSGTKELDLPSATAKRVI
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHH
SSVVTIQVSAGNGMSGSGSGVVFNDNGDIVTNAHVVTLDGRVDKPDLRVLARDGRRYKAV
HEEEEEEEECCCCCCCCCCEEEECCCCCEEEEEEEEEECCCCCCCHHHEEECCCCEEEEE
LVGVDRMLDIAVVRIKPRALPAITFGDSSAVTVGSSVIAVGAPLGYDFSVTRGIISSVLR
EEEHHHHEEEEEEEECCCCCCEEEECCCCCEEECCEEEEECCCCCCCHHHHHHHHHHHHH
SINLTSFGLAGQVNAVPVIQTDAAINPGNSGGPLVDLNGRLIGINVAIASAGLFSSGNVG
HCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCEEEECCEEEEEEEEEEECCCCCCCCEE
VGFAIPSNLVHRVATALAANRPVSHGYLGVSVSDGSDRDESYEGAIVKSVTPRSPADTAG
EEEECHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCCCCEEEEECCCCCCCCCCC
LKPGDLLLSIGGNKISNMIDLVAFVRSRPGGTPVPIRVERNGKEISLTVTLSSLEEIKGT
CCCCCEEEEECCCHHHHHHHHHHHHHCCCCCCCEEEEECCCCCEEEEEEEECHHHHHCCC
>Mature Secondary Structure 
GDELENVTGSDATDEVLATARRIAVSSGKGNFKAPKLRQKLKLAAKKMKPKCILHKYVW
CCCCCCCCCCCCHHHHHHHHHHHEEECCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHH
FALVIVAVAFLSGFTSSVVTYRLLSSDQQKESPLLPLTPPIYSSGTKELDLPSATAKRVI
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHH
SSVVTIQVSAGNGMSGSGSGVVFNDNGDIVTNAHVVTLDGRVDKPDLRVLARDGRRYKAV
HEEEEEEEECCCCCCCCCCEEEECCCCCEEEEEEEEEECCCCCCCHHHEEECCCCEEEEE
LVGVDRMLDIAVVRIKPRALPAITFGDSSAVTVGSSVIAVGAPLGYDFSVTRGIISSVLR
EEEHHHHEEEEEEEECCCCCCEEEECCCCCEEECCEEEEECCCCCCCHHHHHHHHHHHHH
SINLTSFGLAGQVNAVPVIQTDAAINPGNSGGPLVDLNGRLIGINVAIASAGLFSSGNVG
HCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCEEEECCEEEEEEEEEEECCCCCCCCEE
VGFAIPSNLVHRVATALAANRPVSHGYLGVSVSDGSDRDESYEGAIVKSVTPRSPADTAG
EEEECHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCCCCEEEEECCCCCCCCCCC
LKPGDLLLSIGGNKISNMIDLVAFVRSRPGGTPVPIRVERNGKEISLTVTLSSLEEIKGT
CCCCCEEEEECCCHHHHHHHHHHHHHCCCCCCCEEEEECCCCCEEEEEEEECHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: Serine endopeptidases [C]

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]