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The map label for this gene is pncB1 [H]

Identifier: 28572786

GI number: 28572786

Start: 727985

End: 729313

Strand: Direct

Name: pncB1 [H]

Synonym: TW641

Alternate gene names: 28572786

Gene position: 727985-729313 (Clockwise)

Preceding gene: 28572783

Following gene: 28572787

Centisome position: 78.62

GC content: 45.15

Gene sequence:

>1329_bases
GTGGGCGGTGCAGGTCTCCTAACAGACCAATACGAGTTGTCGATGGTCAACGCAGCACGAATATCAGGGATAGCTGCTAA
AGAATGTGTTTTTGAGGTTTATTCTCGCGCATTGCCACCTGGCAGGCCATTTGGTGTGTTTGCAGGCCTTGAGAGGCTGC
TGGAAAAAATCGAAAATTTCTCCTTTGCAGATGACGAAATTACATGGCTTAGAGAAAAGAATATCGTTGATAATGAGACA
CTTGACTGGCTCCGGGGGTATAGCTTTTCTGGGTCAATTTCTGGCCACAAAGAGGGGGAAATCTTTTTCCCCAATACACC
CGTTCTAACTGTTAGAGCACCATTTGCAGAAGCAGTAGTTCTCGAAACCCTGATCCTAAGTTGCATAAATTTTGATAGCG
CTATTGCGTCAACGGCGGCACAACTTGTGTATCGCGCAAAAAACAAACCAGTTTATGAAATGGGCTCCAGAAGAACAAAT
GAACAGGCCGCTGTAGCAGCGGCACGCGCTGCGTACATTGCTGGGTTTGCTGCAACAAGCAATCTGGCAGCTGGGAAGAT
TTGGGATATACCAACCGTTGGAACTATGGGTCATGCATTTATACTTGCTCATAAAACGGAGAGTGAAGCTTTTTATGCAC
AGGTCAAACAGGGTGGGGGAAACAATATAACCCTCTTGATTGATACATACGATATCCAGGAAGCAATTGACAGTGCGGTA
ACTGTCGCAGGCAAAAATCTTGCAGCTGTAAGAATAGATTCGGGAAACCTACCAGAAGTGGTGCACGATGTACGCAGAAA
GCTCGACCTCGCGGGTGCAACTGAGACAAAGATCATTCTTACAGGCGACCTTGATGAGGCCTCAATTAGGCTCGTAAGCA
CCGCACCAGTTGATGCACTCGGGGTTGGAACATCTCTGGTAACTGCGGGAGGATTTCCATCTGCAGGCTTTGTTTATAAA
CCGGTGGCATGCAGAGAAAAAAACAGATGGAGAATGCTTTCGAAAAAATCAAAAAACAAAGTTAGCACCGGCGGGCAAAA
AAATGTCCAAAGAGTTCTTGACAAAAACAAGAAGATTATCAAAGAGCAAGTCCTTGTATTTGATCCCGATAATCCCCCAG
TGACAACCTATGACACGAATGTATTACAGATTACGAGTGAACATATAAGGTACGGAAAAAGAGTTGCAATAAACTCAACA
AATGAAATAAGGGCGTATCACAAATCGGTTATCAACCAAATCCCAGAAGAAGTATTCAACCTTGAGGGCAAAATAAATAC
CGAGCGGATCTCCTGGCATAGTGTGCAAGGCCATCGTCTAGAGGCCTAG

Upstream 100 bases:

>100_bases
GCCCTAGAATTCTTCCTCAACACAGAGCAAATAATACAACAAAACAGCATATACACCGCCAGCGAGGTGACAGACACGTA
ACTCCATATACACTTATCAT

Downstream 100 bases:

>100_bases
GACCCCGCCCTTTCACGGCGGTAGCACGGGTTCAAATCCCGTTGGGGTCACCCTTATTCTTTGGCCCTGTGGCGCAGTTG
GTTAGCGCGCCGCCCTGTCA

Product: nicotinate phosphoribosyltransferase

Products: NA

Alternate protein names: NAPRTase pncB1 [H]

Number of amino acids: Translated: 442; Mature: 441

Protein sequence:

>442_residues
MGGAGLLTDQYELSMVNAARISGIAAKECVFEVYSRALPPGRPFGVFAGLERLLEKIENFSFADDEITWLREKNIVDNET
LDWLRGYSFSGSISGHKEGEIFFPNTPVLTVRAPFAEAVVLETLILSCINFDSAIASTAAQLVYRAKNKPVYEMGSRRTN
EQAAVAAARAAYIAGFAATSNLAAGKIWDIPTVGTMGHAFILAHKTESEAFYAQVKQGGGNNITLLIDTYDIQEAIDSAV
TVAGKNLAAVRIDSGNLPEVVHDVRRKLDLAGATETKIILTGDLDEASIRLVSTAPVDALGVGTSLVTAGGFPSAGFVYK
PVACREKNRWRMLSKKSKNKVSTGGQKNVQRVLDKNKKIIKEQVLVFDPDNPPVTTYDTNVLQITSEHIRYGKRVAINST
NEIRAYHKSVINQIPEEVFNLEGKINTERISWHSVQGHRLEA

Sequences:

>Translated_442_residues
MGGAGLLTDQYELSMVNAARISGIAAKECVFEVYSRALPPGRPFGVFAGLERLLEKIENFSFADDEITWLREKNIVDNET
LDWLRGYSFSGSISGHKEGEIFFPNTPVLTVRAPFAEAVVLETLILSCINFDSAIASTAAQLVYRAKNKPVYEMGSRRTN
EQAAVAAARAAYIAGFAATSNLAAGKIWDIPTVGTMGHAFILAHKTESEAFYAQVKQGGGNNITLLIDTYDIQEAIDSAV
TVAGKNLAAVRIDSGNLPEVVHDVRRKLDLAGATETKIILTGDLDEASIRLVSTAPVDALGVGTSLVTAGGFPSAGFVYK
PVACREKNRWRMLSKKSKNKVSTGGQKNVQRVLDKNKKIIKEQVLVFDPDNPPVTTYDTNVLQITSEHIRYGKRVAINST
NEIRAYHKSVINQIPEEVFNLEGKINTERISWHSVQGHRLEA
>Mature_441_residues
GGAGLLTDQYELSMVNAARISGIAAKECVFEVYSRALPPGRPFGVFAGLERLLEKIENFSFADDEITWLREKNIVDNETL
DWLRGYSFSGSISGHKEGEIFFPNTPVLTVRAPFAEAVVLETLILSCINFDSAIASTAAQLVYRAKNKPVYEMGSRRTNE
QAAVAAARAAYIAGFAATSNLAAGKIWDIPTVGTMGHAFILAHKTESEAFYAQVKQGGGNNITLLIDTYDIQEAIDSAVT
VAGKNLAAVRIDSGNLPEVVHDVRRKLDLAGATETKIILTGDLDEASIRLVSTAPVDALGVGTSLVTAGGFPSAGFVYKP
VACREKNRWRMLSKKSKNKVSTGGQKNVQRVLDKNKKIIKEQVLVFDPDNPPVTTYDTNVLQITSEHIRYGKRVAINSTN
EIRAYHKSVINQIPEEVFNLEGKINTERISWHSVQGHRLEA

Specific function: Catalyzes the conversion of nicotinic acid (NA) to NA mononucleotide (NaMN) [H]

COG id: COG1488

COG function: function code H; Nicotinic acid phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAPRTase family [H]

Homologues:

Organism=Homo sapiens, GI194394158, Length=432, Percent_Identity=25, Blast_Score=112, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI71997952, Length=438, Percent_Identity=28.9954337899543, Blast_Score=150, Evalue=9e-37,
Organism=Caenorhabditis elegans, GI71997947, Length=438, Percent_Identity=28.9954337899543, Blast_Score=150, Evalue=9e-37,
Organism=Caenorhabditis elegans, GI71997955, Length=212, Percent_Identity=35.8490566037736, Blast_Score=120, Evalue=1e-27,
Organism=Drosophila melanogaster, GI24581587, Length=414, Percent_Identity=25.8454106280193, Blast_Score=120, Evalue=1e-27,
Organism=Drosophila melanogaster, GI161076680, Length=203, Percent_Identity=31.0344827586207, Blast_Score=96, Evalue=6e-20,
Organism=Drosophila melanogaster, GI24581595, Length=203, Percent_Identity=31.0344827586207, Blast_Score=96, Evalue=6e-20,
Organism=Drosophila melanogaster, GI28574709, Length=203, Percent_Identity=31.0344827586207, Blast_Score=96, Evalue=6e-20,
Organism=Drosophila melanogaster, GI24581593, Length=203, Percent_Identity=31.0344827586207, Blast_Score=96, Evalue=6e-20,
Organism=Drosophila melanogaster, GI24581591, Length=203, Percent_Identity=31.0344827586207, Blast_Score=96, Evalue=6e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015977
- InterPro:   IPR007229
- InterPro:   IPR006405
- InterPro:   IPR002638 [H]

Pfam domain/function: PF04095 NAPRTase [H]

EC number: =2.4.2.11 [H]

Molecular weight: Translated: 48258; Mature: 48127

Theoretical pI: Translated: 7.65; Mature: 7.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGGAGLLTDQYELSMVNAARISGIAAKECVFEVYSRALPPGRPFGVFAGLERLLEKIENF
CCCCCCCCCCHHHEEHHHHHHCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCC
SFADDEITWLREKNIVDNETLDWLRGYSFSGSISGHKEGEIFFPNTPVLTVRAPFAEAVV
CCCCCCEEEEECCCCCCCCHHHHHHCCCCCCCCCCCCCCCEECCCCCEEEEECCHHHHHH
LETLILSCINFDSAIASTAAQLVYRAKNKPVYEMGSRRTNEQAAVAAARAAYIAGFAATS
HHHHHHHHHCHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHC
NLAAGKIWDIPTVGTMGHAFILAHKTESEAFYAQVKQGGGNNITLLIDTYDIQEAIDSAV
CCCCCCEECCCCCCCCCCEEEEEECCCCHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHH
TVAGKNLAAVRIDSGNLPEVVHDVRRKLDLAGATETKIILTGDLDEASIRLVSTAPVDAL
EECCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCEEEEEEECCCCCEEEEEEECCCHHH
GVGTSLVTAGGFPSAGFVYKPVACREKNRWRMLSKKSKNKVSTGGQKNVQRVLDKNKKII
CCCCHHEECCCCCCCCCEECCHHHCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHH
KEQVLVFDPDNPPVTTYDTNVLQITSEHIRYGKRVAINSTNEIRAYHKSVINQIPEEVFN
HCEEEEECCCCCCEEEECCCEEEEEHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHHC
LEGKINTERISWHSVQGHRLEA
CCCCEECCEEEEECCCCCCCCC
>Mature Secondary Structure 
GGAGLLTDQYELSMVNAARISGIAAKECVFEVYSRALPPGRPFGVFAGLERLLEKIENF
CCCCCCCCCHHHEEHHHHHHCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCC
SFADDEITWLREKNIVDNETLDWLRGYSFSGSISGHKEGEIFFPNTPVLTVRAPFAEAVV
CCCCCCEEEEECCCCCCCCHHHHHHCCCCCCCCCCCCCCCEECCCCCEEEEECCHHHHHH
LETLILSCINFDSAIASTAAQLVYRAKNKPVYEMGSRRTNEQAAVAAARAAYIAGFAATS
HHHHHHHHHCHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHC
NLAAGKIWDIPTVGTMGHAFILAHKTESEAFYAQVKQGGGNNITLLIDTYDIQEAIDSAV
CCCCCCEECCCCCCCCCCEEEEEECCCCHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHH
TVAGKNLAAVRIDSGNLPEVVHDVRRKLDLAGATETKIILTGDLDEASIRLVSTAPVDAL
EECCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCEEEEEEECCCCCEEEEEEECCCHHH
GVGTSLVTAGGFPSAGFVYKPVACREKNRWRMLSKKSKNKVSTGGQKNVQRVLDKNKKII
CCCCHHEECCCCCCCCCEECCHHHCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHH
KEQVLVFDPDNPPVTTYDTNVLQITSEHIRYGKRVAINSTNEIRAYHKSVINQIPEEVFN
HCEEEEECCCCCCEEEECCCEEEEEHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHHC
LEGKINTERISWHSVQGHRLEA
CCCCEECCEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]