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The map label for this gene is ftsK

Identifier: 28572777

GI number: 28572777

Start: 717893

End: 720118

Strand: Reverse

Name: ftsK

Synonym: TW631

Alternate gene names: 28572777

Gene position: 720118-717893 (Counterclockwise)

Preceding gene: 28572778

Following gene: 28572776

Centisome position: 77.77

GC content: 44.74

Gene sequence:

>2226_bases
TTGAGTGCAAAGAAGTCGTATCTGAAAGTATGGCGCGGCCTTGCCGGGGCAGCAGGGTCTTGTGCCAGAGTGTTTTCAAA
GAAATCACTTGCCCGTAGGGATCGAAGGGATCAGTTGCCCTTTGCCCTGTTTTTATTCGGCTTAGTCGGTGCTGTCTTTC
AGTGGTTTTTGTATGGTAACTGGCTTTCTGGCATTGTTTCTGAATATACCGTTGCTGCATTTTTTGGCGGCTTTTCAATC
GTTCTTCCGATTTTGCTAATCGGGTTTTCAATTTGGCTTTTTCGTAATCCGCAAAAAACGCATGACAATATCCGTGTATC
TATTGGTCTATTTATGTTTTCAAGCTTTTCGGCAGCATTTTTACATTTTTCTGCTGGATTTCCTTATCCATCTTCTGGAA
TCCGGATTTTATCTACCGCGGGTGGGATTATTGGGTGGCTTGTAGGTTTACCACTTACTACATTGCCTAGCTACCTAGCT
AAGACTGTCTGCATTATATTTATTGTTCTCTCAGTGTCTGTTATTAGCAAAACACCAATATCAAAGATAGTGCGAGTTAT
TTTTAGATATGCAAAATGGCTTTTCAATTCCGACAGTGTAAAAACTTCCCCAAATAGCTCAGTCAGTTCATCGAGTGAGC
ACCAAGAATTAACTGGCAGGGATATGCCTGATACCGCAGGCGACAATAGGCATGATGAAACAGTAACCGTGTTGAGCGGA
ACCTCATTGACCGGCTCACCCGTATCTGAATATCGTGGTGAATCTTCAGATTATGCGCTTCCGAGTTTGGATATCCTCAA
TTCCTATCCTCCGGTCAAGCATGATGATGCAGAAAATGAGAAGGTGATTACGGCACTATCCGGCGTTCTTAGGCAATTTA
GCGTCAACGCGCGATTCTCGGGGTTTTCGAGGGGCCCGACAGTTACGCAGTACGAATTAGAACTCGGTGAAGGTGTAAAA
GTTGAACGGATTATTGCCCTTACAAAAAACATATCCTATGCTGTTGCATCAGACAAGGTAAGTATTCTTTCCCCTATTCC
AGGAAAAAGTGCAATTGGCATTGAAATACCTAATAAAAAGAGAGAACTTGTTGCCCTGGGTTCTGTTTTGCAGTCTATTC
ATCCAGATGCACATCCAATGACGGTTGGGCTTGGAAAAGATTCAAGCGGAGGTTTTGTTCTAACCAACCTCACCACTATG
CCACACCTACTTGTTGCCGGTGCGACCGGTTCTGGGAAATCTAGTTTTGTTAACTCCATGATCACGAGCATTCTGCTTCG
GGCCCATCCAAGTCAAGTGCGTTTGGTATTAATTGATCCAAAACGCGTCGAGCTTGCGATTTATTCTGGTGTTCCGCATC
TTATAACTCCGATTGTCACAGACCCGAAAAAGGCGTCTGAGGTTTTGCAATGGGTTGTAAAGGAAATGGAAAGGCGATAC
GATGACCTGGCAAGTTTCGGTTTTAGGCATATAGATGACTTTAATCTTGCAGTGCGTGCCAAAAAGATTGCATCCGACTC
GAGAGAGCTAACGCCTTATCCGTATCTTCTGGTAATAGTTGATGAGCTGGCCGACCTTATGCTGGTTGCCGCAAAGGATG
TCGAAGAATCGATAGTACGTATTACCCAGCTTGCGCGTGCCAGTGGAATTCATATTGTTTTGGCAACACAGAGACCAAGT
GTAAATGTTGTAACAGGCCTTATAAAGGCAAATGTCCCGAGTCGCTTAGCATTTGCCGTATCAAGTTTGGTGGATTCGCG
AGTTATACTCGACCGTCCGGGTGCTGAAAAACTGGTTGGTCAGGGTGATGGCTTATTTTTACCAATTAGCGCCGGTAAGC
CTATTAGGATCCAGTCATCCTGGGTAACGGAAAATGAGATTTTAAGGGTAGTTGAATACGTAAAATCGCAGGCTCACCCC
GACTATTATGTGCTTGAGGTGCAGAATCAGGGCAATATAGACTCGCATATAGGTGATGATATGCCTTTGTTATTGAAGGC
TACAGAGCTGGTTATAAACTCACAGCTCGGGTCAACATCAATGTTGCAAAGAAAGCTTCGAGTCGGATTTGCTAAGGCTG
GCAGGCTAATGGACCTTATGGAGAGTATGGGAATCGTTGGTCCGGGTCAGGGCTCGAAGGCCCGGGAAGTTTTGGTTACC
CCTCAGGATCTTGATTCGACATTGGCGAGAATATCAGCTTCTGTAAGTGACTCTAAACTCGATTAG

Upstream 100 bases:

>100_bases
ATGAACATGATCTCACACGGATTGTTAGGCGTGTTGTTGGTTCATGGGCTGGCCGTAAGATACGAAGGCATCCGGTTATC
GTTCCTCTGGTTGTTACTGT

Downstream 100 bases:

>100_bases
AGTGCAAGGCATTTCCTGTTTGCATTTCCTGTTTTACTGAATGCGCTGAGTTACAACTTGACCTGTGGACTTATTACGCT
CCTGCCAAGCCTGCGGCCCC

Product: FtsK/SpoIIIE homologue

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 741; Mature: 740

Protein sequence:

>741_residues
MSAKKSYLKVWRGLAGAAGSCARVFSKKSLARRDRRDQLPFALFLFGLVGAVFQWFLYGNWLSGIVSEYTVAAFFGGFSI
VLPILLIGFSIWLFRNPQKTHDNIRVSIGLFMFSSFSAAFLHFSAGFPYPSSGIRILSTAGGIIGWLVGLPLTTLPSYLA
KTVCIIFIVLSVSVISKTPISKIVRVIFRYAKWLFNSDSVKTSPNSSVSSSSEHQELTGRDMPDTAGDNRHDETVTVLSG
TSLTGSPVSEYRGESSDYALPSLDILNSYPPVKHDDAENEKVITALSGVLRQFSVNARFSGFSRGPTVTQYELELGEGVK
VERIIALTKNISYAVASDKVSILSPIPGKSAIGIEIPNKKRELVALGSVLQSIHPDAHPMTVGLGKDSSGGFVLTNLTTM
PHLLVAGATGSGKSSFVNSMITSILLRAHPSQVRLVLIDPKRVELAIYSGVPHLITPIVTDPKKASEVLQWVVKEMERRY
DDLASFGFRHIDDFNLAVRAKKIASDSRELTPYPYLLVIVDELADLMLVAAKDVEESIVRITQLARASGIHIVLATQRPS
VNVVTGLIKANVPSRLAFAVSSLVDSRVILDRPGAEKLVGQGDGLFLPISAGKPIRIQSSWVTENEILRVVEYVKSQAHP
DYYVLEVQNQGNIDSHIGDDMPLLLKATELVINSQLGSTSMLQRKLRVGFAKAGRLMDLMESMGIVGPGQGSKAREVLVT
PQDLDSTLARISASVSDSKLD

Sequences:

>Translated_741_residues
MSAKKSYLKVWRGLAGAAGSCARVFSKKSLARRDRRDQLPFALFLFGLVGAVFQWFLYGNWLSGIVSEYTVAAFFGGFSI
VLPILLIGFSIWLFRNPQKTHDNIRVSIGLFMFSSFSAAFLHFSAGFPYPSSGIRILSTAGGIIGWLVGLPLTTLPSYLA
KTVCIIFIVLSVSVISKTPISKIVRVIFRYAKWLFNSDSVKTSPNSSVSSSSEHQELTGRDMPDTAGDNRHDETVTVLSG
TSLTGSPVSEYRGESSDYALPSLDILNSYPPVKHDDAENEKVITALSGVLRQFSVNARFSGFSRGPTVTQYELELGEGVK
VERIIALTKNISYAVASDKVSILSPIPGKSAIGIEIPNKKRELVALGSVLQSIHPDAHPMTVGLGKDSSGGFVLTNLTTM
PHLLVAGATGSGKSSFVNSMITSILLRAHPSQVRLVLIDPKRVELAIYSGVPHLITPIVTDPKKASEVLQWVVKEMERRY
DDLASFGFRHIDDFNLAVRAKKIASDSRELTPYPYLLVIVDELADLMLVAAKDVEESIVRITQLARASGIHIVLATQRPS
VNVVTGLIKANVPSRLAFAVSSLVDSRVILDRPGAEKLVGQGDGLFLPISAGKPIRIQSSWVTENEILRVVEYVKSQAHP
DYYVLEVQNQGNIDSHIGDDMPLLLKATELVINSQLGSTSMLQRKLRVGFAKAGRLMDLMESMGIVGPGQGSKAREVLVT
PQDLDSTLARISASVSDSKLD
>Mature_740_residues
SAKKSYLKVWRGLAGAAGSCARVFSKKSLARRDRRDQLPFALFLFGLVGAVFQWFLYGNWLSGIVSEYTVAAFFGGFSIV
LPILLIGFSIWLFRNPQKTHDNIRVSIGLFMFSSFSAAFLHFSAGFPYPSSGIRILSTAGGIIGWLVGLPLTTLPSYLAK
TVCIIFIVLSVSVISKTPISKIVRVIFRYAKWLFNSDSVKTSPNSSVSSSSEHQELTGRDMPDTAGDNRHDETVTVLSGT
SLTGSPVSEYRGESSDYALPSLDILNSYPPVKHDDAENEKVITALSGVLRQFSVNARFSGFSRGPTVTQYELELGEGVKV
ERIIALTKNISYAVASDKVSILSPIPGKSAIGIEIPNKKRELVALGSVLQSIHPDAHPMTVGLGKDSSGGFVLTNLTTMP
HLLVAGATGSGKSSFVNSMITSILLRAHPSQVRLVLIDPKRVELAIYSGVPHLITPIVTDPKKASEVLQWVVKEMERRYD
DLASFGFRHIDDFNLAVRAKKIASDSRELTPYPYLLVIVDELADLMLVAAKDVEESIVRITQLARASGIHIVLATQRPSV
NVVTGLIKANVPSRLAFAVSSLVDSRVILDRPGAEKLVGQGDGLFLPISAGKPIRIQSSWVTENEILRVVEYVKSQAHPD
YYVLEVQNQGNIDSHIGDDMPLLLKATELVINSQLGSTSMLQRKLRVGFAKAGRLMDLMESMGIVGPGQGSKAREVLVTP
QDLDSTLARISASVSDSKLD

Specific function: DNA motor protein, which is both required to move DNA out of the region of the septum during cell division and for the septum formation. Tracks DNA in an ATP-dependent manner by generating positive supercoils in front of it and negative supercoils behind

COG id: COG1674

COG function: function code D; DNA segregation ATPase FtsK/SpoIIIE and related proteins

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein. Note=Located at the septum. The large C-terminal part of the protein is cytoplasmic (Potential)

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FtsK domain

Homologues:

Organism=Escherichia coli, GI1787117, Length=493, Percent_Identity=41.1764705882353, Blast_Score=365, Evalue=1e-102,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FTSK_TROW8 (Q83MI4)

Other databases:

- EMBL:   BX251412
- RefSeq:   NP_789557.1
- ProteinModelPortal:   Q83MI4
- SMR:   Q83MI4
- STRING:   Q83MI4
- GeneID:   1064836
- GenomeReviews:   BX072543_GR
- KEGG:   tws:TW631
- eggNOG:   COG1674
- HOGENOM:   HBG662140
- OMA:   SFGFRHI
- ProtClustDB:   CLSK375802
- BioCyc:   TWHI218496:TW0602-MONOMER
- InterPro:   IPR003593
- InterPro:   IPR018541
- InterPro:   IPR002543
- SMART:   SM00382
- SMART:   SM00843

Pfam domain/function: PF09397 Ftsk_gamma; PF01580 FtsK_SpoIIIE

EC number: NA

Molecular weight: Translated: 80532; Mature: 80401

Theoretical pI: Translated: 9.65; Mature: 9.65

Prosite motif: PS50901 FTSK; PS00053 RIBOSOMAL_S8

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xced054c)-; HASH(0xb93dde4)-; HASH(0xcced394)-; HASH(0xc106ecc)-; HASH(0xbe333e8)-;

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAKKSYLKVWRGLAGAAGSCARVFSKKSLARRDRRDQLPFALFLFGLVGAVFQWFLYGN
CCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
WLSGIVSEYTVAAFFGGFSIVLPILLIGFSIWLFRNPQKTHDNIRVSIGLFMFSSFSAAF
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHEECCCCCCCCCEEEEEHHHHHHHHHHHH
LHFSAGFPYPSSGIRILSTAGGIIGWLVGLPLTTLPSYLAKTVCIIFIVLSVSVISKTPI
HEEECCCCCCCCCCEEEECCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
SKIVRVIFRYAKWLFNSDSVKTSPNSSVSSSSEHQELTGRDMPDTAGDNRHDETVTVLSG
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCEEEEEEC
TSLTGSPVSEYRGESSDYALPSLDILNSYPPVKHDDAENEKVITALSGVLRQFSVNARFS
CCCCCCCHHHHCCCCCCCCCCCHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCC
GFSRGPTVTQYELELGEGVKVERIIALTKNISYAVASDKVSILSPIPGKSAIGIEIPNKK
CCCCCCCEEEEEEECCCCCCHHHHHHHHCCCEEEEECCCEEEECCCCCCCEEEEECCCCH
RELVALGSVLQSIHPDAHPMTVGLGKDSSGGFVLTNLTTMPHLLVAGATGSGKSSFVNSM
HHHHHHHHHHHHHCCCCCCEEEECCCCCCCCEEEEECCCCCEEEEECCCCCCHHHHHHHH
ITSILLRAHPSQVRLVLIDPKRVELAIYSGVPHLITPIVTDPKKASEVLQWVVKEMERRY
HHHHHHHCCCCCEEEEEECCCEEEEEEECCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHH
DDLASFGFRHIDDFNLAVRAKKIASDSRELTPYPYLLVIVDELADLMLVAAKDVEESIVR
HHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
ITQLARASGIHIVLATQRPSVNVVTGLIKANVPSRLAFAVSSLVDSRVILDRPGAEKLVG
HHHHHHHCCCEEEEEECCCCCHHHHHHHHCCCCHHHHHHHHHHHCCCEEECCCCHHHHHC
QGDGLFLPISAGKPIRIQSSWVTENEILRVVEYVKSQAHPDYYVLEVQNQGNIDSHIGDD
CCCCEEEEECCCCCEEEEECCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHCCCC
MPLLLKATELVINSQLGSTSMLQRKLRVGFAKAGRLMDLMESMGIVGPGQGSKAREVLVT
CHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEC
PQDLDSTLARISASVSDSKLD
CHHHHHHHHHHHHCCCCCCCH
>Mature Secondary Structure 
SAKKSYLKVWRGLAGAAGSCARVFSKKSLARRDRRDQLPFALFLFGLVGAVFQWFLYGN
CCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
WLSGIVSEYTVAAFFGGFSIVLPILLIGFSIWLFRNPQKTHDNIRVSIGLFMFSSFSAAF
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHEECCCCCCCCCEEEEEHHHHHHHHHHHH
LHFSAGFPYPSSGIRILSTAGGIIGWLVGLPLTTLPSYLAKTVCIIFIVLSVSVISKTPI
HEEECCCCCCCCCCEEEECCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
SKIVRVIFRYAKWLFNSDSVKTSPNSSVSSSSEHQELTGRDMPDTAGDNRHDETVTVLSG
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCEEEEEEC
TSLTGSPVSEYRGESSDYALPSLDILNSYPPVKHDDAENEKVITALSGVLRQFSVNARFS
CCCCCCCHHHHCCCCCCCCCCCHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCC
GFSRGPTVTQYELELGEGVKVERIIALTKNISYAVASDKVSILSPIPGKSAIGIEIPNKK
CCCCCCCEEEEEEECCCCCCHHHHHHHHCCCEEEEECCCEEEECCCCCCCEEEEECCCCH
RELVALGSVLQSIHPDAHPMTVGLGKDSSGGFVLTNLTTMPHLLVAGATGSGKSSFVNSM
HHHHHHHHHHHHHCCCCCCEEEECCCCCCCCEEEEECCCCCEEEEECCCCCCHHHHHHHH
ITSILLRAHPSQVRLVLIDPKRVELAIYSGVPHLITPIVTDPKKASEVLQWVVKEMERRY
HHHHHHHCCCCCEEEEEECCCEEEEEEECCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHH
DDLASFGFRHIDDFNLAVRAKKIASDSRELTPYPYLLVIVDELADLMLVAAKDVEESIVR
HHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
ITQLARASGIHIVLATQRPSVNVVTGLIKANVPSRLAFAVSSLVDSRVILDRPGAEKLVG
HHHHHHHCCCEEEEEECCCCCHHHHHHHHCCCCHHHHHHHHHHHCCCEEECCCCHHHHHC
QGDGLFLPISAGKPIRIQSSWVTENEILRVVEYVKSQAHPDYYVLEVQNQGNIDSHIGDD
CCCCEEEEECCCCCEEEEECCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHCCCC
MPLLLKATELVINSQLGSTSMLQRKLRVGFAKAGRLMDLMESMGIVGPGQGSKAREVLVT
CHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEC
PQDLDSTLARISASVSDSKLD
CHHHHHHHHHHHHCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12606174