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The map label for this gene is prsA [H]

Identifier: 28572733

GI number: 28572733

Start: 657383

End: 658429

Strand: Direct

Name: prsA [H]

Synonym: TW585

Alternate gene names: 28572733

Gene position: 657383-658429 (Clockwise)

Preceding gene: 28572732

Following gene: 28572734

Centisome position: 71.0

GC content: 46.42

Gene sequence:

>1047_bases
TTGACTGACTTGCTAAGTTGCGCACCGCATGCCCGGGGTGCAAATAATCGACCCGGTTTCTCGGACCGTGATGTGCAAAA
TGACGGGCCAATGCGCAACCTAGTGCTCATTGCAGGTCGCTCTCATCCGGACTTAGCCCGGGCAACCGCAGAAAGTCTCG
GTGTTGGACTTTTGCAAACGGATATCAGAACTTTTGCAAACGGTGAGATATACACACGATTCAATTCAAGTGTTCGTGGT
AAAGATGTGTTTGTTCTCCAGACCGGATGTGATCCCGTTAATGACGGACTTGTTGAGCTTCTGCTCTTGATTGACTCATG
TAAGCGTGCTTCTGCAAAGCACATTTCTGCTGTAACCCCATGCTATCCCTACTCACGTCAAGACAGAAAGGGATATGGTC
GTGAGCCGATTTCTGCCAGATTGGTTGCTGACTTGATTGCATGCGCAGGGGCCGACAGGATAATTACGGTTGACTTGCAT
GCTTCCCAGATACAGGGATTTTTCAATGGACCAGTTGATCACTTAACAGGCGTTCCTGCTCTTATAAAACATGTAAAATC
ACTTAGGATTGATAACCTGACAATTGTCTCACCTGATATTGGTCGGGTGAAGGTTGCGGATGTTTGGTCAGATAAACTAA
ATGCTCCGCTCGCAATTATTCATAAACGACGTGACCCGCGTGTTCACAATAATGTCACGATGCACGAAATTGTTGGTGAT
GTGCGCAGCAGAGTGTGTTTGGTGGTTGATGACCTGATTGATACCGGAGACACACTGGCAAAAGCAGCTATCGCATTAAA
AAAAGCCGGAGCCGTAAAAGTAATAGCAGCTGCAACCCATGGGATTTTTAGCACCCCAGAGCGTCTTGTTTCTTGTGGTG
AAATTGACCATGTTATTGTGACTGACTCTGTTCCCGCAAGTAAGGTATTTGATCGCGTTAAAACTGTTTCAATCGCCCCA
CTTTTAGCATGTGCAATCTGTGAGGTTGTAACGGAAGGTTCAATTAGTGAGATGCTTGACTGTGTCTCGAAGCGCATTGA
TAACTAA

Upstream 100 bases:

>100_bases
CGGGTAGTGTTATTAGAGATGATATCGAAGAAGGTGCGCTATCCCTTACAGAGCTAAAGCAAAAAACTATTCCAAAATGG
GCCGAGAATAGAGGAGACGG

Downstream 100 bases:

>100_bases
CCTGGCGCCGGTAAAAGCGGATGTGATAAGGGCACATGTGGGCAAGTGCCTGTTAGCTAGTATTAGTGATCTAACTAGTA
TTAGTGATCGCTTAAATATC

Product: ribose-phosphate pyrophosphokinase

Products: NA

Alternate protein names: RPPK; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase [H]

Number of amino acids: Translated: 348; Mature: 347

Protein sequence:

>348_residues
MTDLLSCAPHARGANNRPGFSDRDVQNDGPMRNLVLIAGRSHPDLARATAESLGVGLLQTDIRTFANGEIYTRFNSSVRG
KDVFVLQTGCDPVNDGLVELLLLIDSCKRASAKHISAVTPCYPYSRQDRKGYGREPISARLVADLIACAGADRIITVDLH
ASQIQGFFNGPVDHLTGVPALIKHVKSLRIDNLTIVSPDIGRVKVADVWSDKLNAPLAIIHKRRDPRVHNNVTMHEIVGD
VRSRVCLVVDDLIDTGDTLAKAAIALKKAGAVKVIAAATHGIFSTPERLVSCGEIDHVIVTDSVPASKVFDRVKTVSIAP
LLACAICEVVTEGSISEMLDCVSKRIDN

Sequences:

>Translated_348_residues
MTDLLSCAPHARGANNRPGFSDRDVQNDGPMRNLVLIAGRSHPDLARATAESLGVGLLQTDIRTFANGEIYTRFNSSVRG
KDVFVLQTGCDPVNDGLVELLLLIDSCKRASAKHISAVTPCYPYSRQDRKGYGREPISARLVADLIACAGADRIITVDLH
ASQIQGFFNGPVDHLTGVPALIKHVKSLRIDNLTIVSPDIGRVKVADVWSDKLNAPLAIIHKRRDPRVHNNVTMHEIVGD
VRSRVCLVVDDLIDTGDTLAKAAIALKKAGAVKVIAAATHGIFSTPERLVSCGEIDHVIVTDSVPASKVFDRVKTVSIAP
LLACAICEVVTEGSISEMLDCVSKRIDN
>Mature_347_residues
TDLLSCAPHARGANNRPGFSDRDVQNDGPMRNLVLIAGRSHPDLARATAESLGVGLLQTDIRTFANGEIYTRFNSSVRGK
DVFVLQTGCDPVNDGLVELLLLIDSCKRASAKHISAVTPCYPYSRQDRKGYGREPISARLVADLIACAGADRIITVDLHA
SQIQGFFNGPVDHLTGVPALIKHVKSLRIDNLTIVSPDIGRVKVADVWSDKLNAPLAIIHKRRDPRVHNNVTMHEIVGDV
RSRVCLVVDDLIDTGDTLAKAAIALKKAGAVKVIAAATHGIFSTPERLVSCGEIDHVIVTDSVPASKVFDRVKTVSIAPL
LACAICEVVTEGSISEMLDCVSKRIDN

Specific function: Utilized by both the de novo and the salvage pathways by which endogenously formed or exogenously added pyrimidine, purine, or pyridine bases are converted to the corresponding ribonucleoside monophosphates. [C]

COG id: COG0462

COG function: function code FE; Phosphoribosylpyrophosphate synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose-phosphate pyrophosphokinase family [H]

Homologues:

Organism=Homo sapiens, GI4506129, Length=318, Percent_Identity=43.0817610062893, Blast_Score=250, Evalue=1e-66,
Organism=Homo sapiens, GI84875539, Length=321, Percent_Identity=42.9906542056075, Blast_Score=248, Evalue=8e-66,
Organism=Homo sapiens, GI4506127, Length=315, Percent_Identity=43.1746031746032, Blast_Score=246, Evalue=2e-65,
Organism=Homo sapiens, GI28557709, Length=302, Percent_Identity=43.3774834437086, Blast_Score=241, Evalue=8e-64,
Organism=Homo sapiens, GI194018537, Length=317, Percent_Identity=35.0157728706625, Blast_Score=154, Evalue=2e-37,
Organism=Homo sapiens, GI4506133, Length=345, Percent_Identity=33.6231884057971, Blast_Score=150, Evalue=1e-36,
Organism=Homo sapiens, GI310128524, Length=152, Percent_Identity=32.8947368421053, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI310115209, Length=152, Percent_Identity=32.8947368421053, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI310118259, Length=152, Percent_Identity=32.8947368421053, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI310119946, Length=152, Percent_Identity=32.8947368421053, Blast_Score=86, Evalue=3e-17,
Organism=Escherichia coli, GI1787458, Length=316, Percent_Identity=44.9367088607595, Blast_Score=248, Evalue=3e-67,
Organism=Caenorhabditis elegans, GI17554702, Length=324, Percent_Identity=40.4320987654321, Blast_Score=230, Evalue=7e-61,
Organism=Caenorhabditis elegans, GI25149168, Length=303, Percent_Identity=41.9141914191419, Blast_Score=230, Evalue=8e-61,
Organism=Caenorhabditis elegans, GI71989924, Length=324, Percent_Identity=40.4320987654321, Blast_Score=230, Evalue=1e-60,
Organism=Caenorhabditis elegans, GI17554704, Length=298, Percent_Identity=41.9463087248322, Blast_Score=227, Evalue=8e-60,
Organism=Caenorhabditis elegans, GI17570245, Length=337, Percent_Identity=33.8278931750742, Blast_Score=182, Evalue=3e-46,
Organism=Saccharomyces cerevisiae, GI6319403, Length=327, Percent_Identity=39.7553516819572, Blast_Score=234, Evalue=1e-62,
Organism=Saccharomyces cerevisiae, GI6320946, Length=309, Percent_Identity=42.0711974110032, Blast_Score=232, Evalue=7e-62,
Organism=Saccharomyces cerevisiae, GI6321776, Length=316, Percent_Identity=38.6075949367089, Blast_Score=210, Evalue=3e-55,
Organism=Saccharomyces cerevisiae, GI6322667, Length=196, Percent_Identity=39.2857142857143, Blast_Score=154, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6324511, Length=97, Percent_Identity=43.298969072165, Blast_Score=90, Evalue=6e-19,
Organism=Drosophila melanogaster, GI21355239, Length=278, Percent_Identity=45.6834532374101, Blast_Score=240, Evalue=1e-63,
Organism=Drosophila melanogaster, GI45551540, Length=301, Percent_Identity=42.5249169435216, Blast_Score=228, Evalue=6e-60,
Organism=Drosophila melanogaster, GI281362873, Length=374, Percent_Identity=31.8181818181818, Blast_Score=174, Evalue=8e-44,
Organism=Drosophila melanogaster, GI24651454, Length=374, Percent_Identity=31.8181818181818, Blast_Score=174, Evalue=8e-44,
Organism=Drosophila melanogaster, GI24651458, Length=358, Percent_Identity=32.4022346368715, Blast_Score=173, Evalue=1e-43,
Organism=Drosophila melanogaster, GI24651456, Length=358, Percent_Identity=32.4022346368715, Blast_Score=173, Evalue=1e-43,
Organism=Drosophila melanogaster, GI45552010, Length=395, Percent_Identity=28.8607594936709, Blast_Score=145, Evalue=5e-35,
Organism=Drosophila melanogaster, GI24651462, Length=379, Percent_Identity=29.287598944591, Blast_Score=144, Evalue=8e-35,
Organism=Drosophila melanogaster, GI24651464, Length=379, Percent_Identity=29.287598944591, Blast_Score=144, Evalue=8e-35,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000842
- InterPro:   IPR005946
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.7.6.1 [H]

Molecular weight: Translated: 37475; Mature: 37343

Theoretical pI: Translated: 7.73; Mature: 7.73

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER ; PS00114 PRPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDLLSCAPHARGANNRPGFSDRDVQNDGPMRNLVLIAGRSHPDLARATAESLGVGLLQT
CCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHCCHHHHH
DIRTFANGEIYTRFNSSVRGKDVFVLQTGCDPVNDGLVELLLLIDSCKRASAKHISAVTP
HHHHHCCCEEEEEECCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
CYPYSRQDRKGYGREPISARLVADLIACAGADRIITVDLHASQIQGFFNGPVDHLTGVPA
CCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEEECHHHHHHHHCCCHHHHCCHHH
LIKHVKSLRIDNLTIVSPDIGRVKVADVWSDKLNAPLAIIHKRRDPRVHNNVTMHEIVGD
HHHHHHHHCCCCEEEECCCCCCEEEEEHHHHHCCCCEEEEECCCCCCCCCCCHHHHHHHH
VRSRVCLVVDDLIDTGDTLAKAAIALKKAGAVKVIAAATHGIFSTPERLVSCGEIDHVIV
HHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCEEEEEEHHCCCCCCHHHHHHCCCCCEEEE
TDSVPASKVFDRVKTVSIAPLLACAICEVVTEGSISEMLDCVSKRIDN
ECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
TDLLSCAPHARGANNRPGFSDRDVQNDGPMRNLVLIAGRSHPDLARATAESLGVGLLQT
CCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHCCHHHHH
DIRTFANGEIYTRFNSSVRGKDVFVLQTGCDPVNDGLVELLLLIDSCKRASAKHISAVTP
HHHHHCCCEEEEEECCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
CYPYSRQDRKGYGREPISARLVADLIACAGADRIITVDLHASQIQGFFNGPVDHLTGVPA
CCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEEECHHHHHHHHCCCHHHHCCHHH
LIKHVKSLRIDNLTIVSPDIGRVKVADVWSDKLNAPLAIIHKRRDPRVHNNVTMHEIVGD
HHHHHHHHCCCCEEEECCCCCCEEEEEHHHHHCCCCEEEEECCCCCCCCCCCHHHHHHHH
VRSRVCLVVDDLIDTGDTLAKAAIALKKAGAVKVIAAATHGIFSTPERLVSCGEIDHVIV
HHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCEEEEEEHHCCCCCCHHHHHHCCCCCEEEE
TDSVPASKVFDRVKTVSIAPLLACAICEVVTEGSISEMLDCVSKRIDN
ECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11572948; 12692562 [H]