| Definition | Tropheryma whipplei TW08/27, complete genome. |
|---|---|
| Accession | NC_004551 |
| Length | 925,938 |
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The map label for this gene is glmU [H]
Identifier: 28572732
GI number: 28572732
Start: 655551
End: 657386
Strand: Direct
Name: glmU [H]
Synonym: TW584
Alternate gene names: 28572732
Gene position: 655551-657386 (Clockwise)
Preceding gene: 28572723
Following gene: 28572733
Centisome position: 70.8
GC content: 44.12
Gene sequence:
>1836_bases ATGAGCAGTGAATCCACAGATACCGATGGCGTGAAAAGCGACCTTGCGATTGTCATTCTTGCGGCGGGCCGGGGGACGCG GATGCGCTCCTCTACCCCAAAGGTCTTGCACAATATCGCTGGGCTGCCCATGGTAGCCCATGTTTTGAGGGGTGCACAAT TATTAAAACCCTGTAAAACAATTGTGGTTTTCAGAGATGTACGGGTTGAACAATATATTCGCAATACATTCCCGGATGTA CTAACAGTGGCACAGTCTGATGCACTGTATGGAACGGGGTTCGGTGTCTTCTCTGCCATACCTTGGATTCGTTCAGAATC TTACGGTAACACTTATCCTAACACTCGGCACGAAAGTCATGCAGAGTATGAATTAGATGCCTGTGATTTAGATACCTGTA ATCCTGCCTCCGACCGGTTGAATGACCAAGAATCCCTTAAAGGAGGTCGACATATCCACACAAAATCGGGTGACGTGACG AATAATAAACCATTTCCCTCAAGGGTTTTAATCCTTTACGCAGATGTCCCGCTCGTACCATTTCAGTTGCTCGAAGAGCT TGTAAGAAAACCACTCAAACAAGCTGTTGGTGCAATAGTGACCACCCATTTGGACAATCCAAAGGGCTATGGAAGGGTAA TGCGAGATAACCTTGGTTCTATTGCCAAAATAATCGAAGATTCAAATATACTCCCTGAACAGTCAATAAACGAAGTGAAT ACCGGAGTGGGTATTTTTGATACAGAGTACCTGCAAGATGCGCTTAATAAGTTGTTAAAGTGCCATATAGCACACAGTCC TAATCAGGACTGTGTGACTAATCAGGACTGTGTGACTAATCAGGACTGTGTGACTAATCAGGACTGTGTGACTAATCAGG ACTGTGTGACTAATCAGGACTGTGTGCCCGCGGCACATACAGAAGCGCATGTATTATCACCCAAGGTTATAGTCACCGAG CAAATACACAAAAAAGCAGAATCAGAACACCAACACGCCGGACAATGGATGTGCCGTCAAGATACCGTTGGTGCACAGAA CACTAAAGAGGAAATGCGTCTAACAGATATAGTTGAATATTTTTACAACAATGGGTTGAGAGTGAATTCCATTACCACGA GCGATTCCGAGTTATTGCTTGGGGTAAATAACAGGGTGCAGCTTGCAAAAACTGAGAAGATTCTGAACGATCAAATTATT AAAAGGTGGCAGCTCTACGGTGTTACGATAAAAAGCCCGGAAACAACATGGATCGATTCAACAGTGCAACTATCAGAAGA TGTACTTATTCTTCCCGGGTGCATTCTATCAGGAAGAACACGAATTGAAGAAGGTGCTGTAATAGGGCCATTTGCTACGA TTTCTGATTCTTTTATTGGGAAAAATACAATCGTCAAAAGAGCCGAGATAATTGACGCACGAATTGAAGAAGGTGCTGTA ATAGGGCCATTTGCTTTTATCCGCCCAGGTACTGTTATAGGGAAAGATTCTAAAGTCGGAACATTCGTTGAGATAAAACA GAGCAATATAGGCCCCGAGAGCAAAGTGCCACACCTAAGCTATATCGGTGACGCGAATATCGGCTCACATGTCAATATAG GTGCCGGTAACATTTTTGCAAATTATGATGGAAAATTGAAGCATGAAACATGTATAGATGACGGTGTAAAAACCGGTGCT GGTAACGTGTTCGTTGCGCCAGTCAAGGTTGGTAGGGGTGCGTATACTGGCGCGGGTAGTGTTATTAGAGATGATATCGA AGAAGGTGCGCTATCCCTTACAGAGCTAAAGCAAAAAACTATTCCAAAATGGGCCGAGAATAGAGGAGACGGTTGA
Upstream 100 bases:
>100_bases TGGTGAAATTCTTATTGAATTCACTCACCAGCTTCTAAGATCTCTTGGGGTGTTTACTAAGACATGTTTCTTATGTGGTA TTTTGTCCGTTGGGTAAAGC
Downstream 100 bases:
>100_bases CTGACTTGCTAAGTTGCGCACCGCATGCCCGGGGTGCAAATAATCGACCCGGTTTCTCGGACCGTGATGTGCAAAATGAC GGGCCAATGCGCAACCTAGT
Product: peptidoglycan synthesis protein
Products: NA
Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase [H]
Number of amino acids: Translated: 611; Mature: 610
Protein sequence:
>611_residues MSSESTDTDGVKSDLAIVILAAGRGTRMRSSTPKVLHNIAGLPMVAHVLRGAQLLKPCKTIVVFRDVRVEQYIRNTFPDV LTVAQSDALYGTGFGVFSAIPWIRSESYGNTYPNTRHESHAEYELDACDLDTCNPASDRLNDQESLKGGRHIHTKSGDVT NNKPFPSRVLILYADVPLVPFQLLEELVRKPLKQAVGAIVTTHLDNPKGYGRVMRDNLGSIAKIIEDSNILPEQSINEVN TGVGIFDTEYLQDALNKLLKCHIAHSPNQDCVTNQDCVTNQDCVTNQDCVTNQDCVTNQDCVPAAHTEAHVLSPKVIVTE QIHKKAESEHQHAGQWMCRQDTVGAQNTKEEMRLTDIVEYFYNNGLRVNSITTSDSELLLGVNNRVQLAKTEKILNDQII KRWQLYGVTIKSPETTWIDSTVQLSEDVLILPGCILSGRTRIEEGAVIGPFATISDSFIGKNTIVKRAEIIDARIEEGAV IGPFAFIRPGTVIGKDSKVGTFVEIKQSNIGPESKVPHLSYIGDANIGSHVNIGAGNIFANYDGKLKHETCIDDGVKTGA GNVFVAPVKVGRGAYTGAGSVIRDDIEEGALSLTELKQKTIPKWAENRGDG
Sequences:
>Translated_611_residues MSSESTDTDGVKSDLAIVILAAGRGTRMRSSTPKVLHNIAGLPMVAHVLRGAQLLKPCKTIVVFRDVRVEQYIRNTFPDV LTVAQSDALYGTGFGVFSAIPWIRSESYGNTYPNTRHESHAEYELDACDLDTCNPASDRLNDQESLKGGRHIHTKSGDVT NNKPFPSRVLILYADVPLVPFQLLEELVRKPLKQAVGAIVTTHLDNPKGYGRVMRDNLGSIAKIIEDSNILPEQSINEVN TGVGIFDTEYLQDALNKLLKCHIAHSPNQDCVTNQDCVTNQDCVTNQDCVTNQDCVTNQDCVPAAHTEAHVLSPKVIVTE QIHKKAESEHQHAGQWMCRQDTVGAQNTKEEMRLTDIVEYFYNNGLRVNSITTSDSELLLGVNNRVQLAKTEKILNDQII KRWQLYGVTIKSPETTWIDSTVQLSEDVLILPGCILSGRTRIEEGAVIGPFATISDSFIGKNTIVKRAEIIDARIEEGAV IGPFAFIRPGTVIGKDSKVGTFVEIKQSNIGPESKVPHLSYIGDANIGSHVNIGAGNIFANYDGKLKHETCIDDGVKTGA GNVFVAPVKVGRGAYTGAGSVIRDDIEEGALSLTELKQKTIPKWAENRGDG >Mature_610_residues SSESTDTDGVKSDLAIVILAAGRGTRMRSSTPKVLHNIAGLPMVAHVLRGAQLLKPCKTIVVFRDVRVEQYIRNTFPDVL TVAQSDALYGTGFGVFSAIPWIRSESYGNTYPNTRHESHAEYELDACDLDTCNPASDRLNDQESLKGGRHIHTKSGDVTN NKPFPSRVLILYADVPLVPFQLLEELVRKPLKQAVGAIVTTHLDNPKGYGRVMRDNLGSIAKIIEDSNILPEQSINEVNT GVGIFDTEYLQDALNKLLKCHIAHSPNQDCVTNQDCVTNQDCVTNQDCVTNQDCVTNQDCVPAAHTEAHVLSPKVIVTEQ IHKKAESEHQHAGQWMCRQDTVGAQNTKEEMRLTDIVEYFYNNGLRVNSITTSDSELLLGVNNRVQLAKTEKILNDQIIK RWQLYGVTIKSPETTWIDSTVQLSEDVLILPGCILSGRTRIEEGAVIGPFATISDSFIGKNTIVKRAEIIDARIEEGAVI GPFAFIRPGTVIGKDSKVGTFVEIKQSNIGPESKVPHLSYIGDANIGSHVNIGAGNIFANYDGKLKHETCIDDGVKTGAG NVFVAPVKVGRGAYTGAGSVIRDDIEEGALSLTELKQKTIPKWAENRGDG
Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-GlcNAc. Responsible for the acetylation of Glc-N-1-P to give GlcNAc-1-P and for the uridyl transfer from UTP to GlcNAc-1-P which produces UDP-GlcNAc [H]
COG id: COG1207
COG function: function code M; N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains)
Gene ontology:
Cell location: Cytoplasm [H]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family [H]
Homologues:
Organism=Escherichia coli, GI1790168, Length=271, Percent_Identity=33.5793357933579, Blast_Score=157, Evalue=2e-39,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR005882 - InterPro: IPR001228 - InterPro: IPR011004 [H]
Pfam domain/function: PF01128 IspD [H]
EC number: =2.7.7.23; =2.3.1.157 [H]
Molecular weight: Translated: 66806; Mature: 66675
Theoretical pI: Translated: 5.96; Mature: 5.96
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
2.1 %Cys (Translated Protein) 1.0 %Met (Translated Protein) 3.1 %Cys+Met (Translated Protein) 2.1 %Cys (Mature Protein) 0.8 %Met (Mature Protein) 3.0 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MSSESTDTDGVKSDLAIVILAAGRGTRMRSSTPKVLHNIAGLPMVAHVLRGAQLLKPCKT CCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHH IVVFRDVRVEQYIRNTFPDVLTVAQSDALYGTGFGVFSAIPWIRSESYGNTYPNTRHESH EEHHHHHHHHHHHHHHCHHHHHHHCCCCEEECCCHHHHHCCHHHCCCCCCCCCCCCCCCC AEYELDACDLDTCNPASDRLNDQESLKGGRHIHTKSGDVTNNKPFPSRVLILYADVPLVP CCEEECCCCCCCCCCHHHHCCCHHHHCCCCEEECCCCCCCCCCCCCCEEEEEEECCCCCH FQLLEELVRKPLKQAVGAIVTTHLDNPKGYGRVMRDNLGSIAKIIEDSNILPEQSINEVN HHHHHHHHHHHHHHHHHHEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH TGVGIFDTEYLQDALNKLLKCHIAHSPNQDCVTNQDCVTNQDCVTNQDCVTNQDCVTNQD CCCCCEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC CVPAAHTEAHVLSPKVIVTEQIHKKAESEHQHAGQWMCRQDTVGAQNTKEEMRLTDIVEY CCCCCCCCHHCCCCCEEEHHHHHHHHHHHHHHHHCCEECCCCCCCCCCHHHHHHHHHHHH FYNNGLRVNSITTSDSELLLGVNNRVQLAKTEKILNDQIIKRWQLYGVTIKSPETTWIDS HHCCCEEEEEEECCCCEEEEECCCCEEHHHHHHHHHHHHHHHEEEEEEEECCCCCEECCC TVQLSEDVLILPGCILSGRTRIEEGAVIGPFATISDSFIGKNTIVKRAEIIDARIEEGAV EEECCCCEEEECCEEECCCCCCCCCCEECCHHHHCCCCCCCHHHHHHHHHHHHHHHCCCE IGPFAFIRPGTVIGKDSKVGTFVEIKQSNIGPESKVPHLSYIGDANIGSHVNIGAGNIFA ECCCHHCCCCEEECCCCCCCEEEEEECCCCCCCCCCCCEEECCCCCCCCEEEECCCCEEE NYDGKLKHETCIDDGVKTGAGNVFVAPVKVGRGAYTGAGSVIRDDIEEGALSLTELKQKT CCCCCCCHHHHHHCCCCCCCCCEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHH IPKWAENRGDG CCHHHHCCCCC >Mature Secondary Structure SSESTDTDGVKSDLAIVILAAGRGTRMRSSTPKVLHNIAGLPMVAHVLRGAQLLKPCKT CCCCCCCCCCCCCEEEEEEECCCCCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHH IVVFRDVRVEQYIRNTFPDVLTVAQSDALYGTGFGVFSAIPWIRSESYGNTYPNTRHESH EEHHHHHHHHHHHHHHCHHHHHHHCCCCEEECCCHHHHHCCHHHCCCCCCCCCCCCCCCC AEYELDACDLDTCNPASDRLNDQESLKGGRHIHTKSGDVTNNKPFPSRVLILYADVPLVP CCEEECCCCCCCCCCHHHHCCCHHHHCCCCEEECCCCCCCCCCCCCCEEEEEEECCCCCH FQLLEELVRKPLKQAVGAIVTTHLDNPKGYGRVMRDNLGSIAKIIEDSNILPEQSINEVN HHHHHHHHHHHHHHHHHHEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH TGVGIFDTEYLQDALNKLLKCHIAHSPNQDCVTNQDCVTNQDCVTNQDCVTNQDCVTNQD CCCCCEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC CVPAAHTEAHVLSPKVIVTEQIHKKAESEHQHAGQWMCRQDTVGAQNTKEEMRLTDIVEY CCCCCCCCHHCCCCCEEEHHHHHHHHHHHHHHHHCCEECCCCCCCCCCHHHHHHHHHHHH FYNNGLRVNSITTSDSELLLGVNNRVQLAKTEKILNDQIIKRWQLYGVTIKSPETTWIDS HHCCCEEEEEEECCCCEEEEECCCCEEHHHHHHHHHHHHHHHEEEEEEEECCCCCEECCC TVQLSEDVLILPGCILSGRTRIEEGAVIGPFATISDSFIGKNTIVKRAEIIDARIEEGAV EEECCCCEEEECCEEECCCCCCCCCCEECCHHHHCCCCCCCHHHHHHHHHHHHHHHCCCE IGPFAFIRPGTVIGKDSKVGTFVEIKQSNIGPESKVPHLSYIGDANIGSHVNIGAGNIFA ECCCHHCCCCEEECCCCCCCEEEEEECCCCCCCCCCCCEEECCCCCCCCEEEECCCCEEE NYDGKLKHETCIDDGVKTGAGNVFVAPVKVGRGAYTGAGSVIRDDIEEGALSLTELKQKT CCCCCCCHHHHHHCCCCCCCCCEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHH IPKWAENRGDG CCHHHHCCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 12606174 [H]