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The map label for this gene is pbp [H]

Identifier: 28572696

GI number: 28572696

Start: 584800

End: 586545

Strand: Reverse

Name: pbp [H]

Synonym: TW548

Alternate gene names: 28572696

Gene position: 586545-584800 (Counterclockwise)

Preceding gene: 28572697

Following gene: 28572695

Centisome position: 63.35

GC content: 45.13

Gene sequence:

>1746_bases
ATGAAAAGGAGTTCAAGTCGGGGTATTGCAACTCTTTTTGTTGTTGCCCTTCTGTCATCCGTTTTTATGGCAAGGTTGGT
GGATATACAAATAATCCGCGCCAAAGAGCTTGGGCGAGACTCGTATTTACAAAGATCAAAAACCCATGTAATACCCGGAG
TAAGAGGCAATATAGTTGATGCGTATAACAGAACACTTGCTGAAAGTCTTACGCAATACAGACTTGTGCTGTCTCCAAGC
AGAGTATCTGACTATTGGGCAAATGGTAAAAAAGTTATTCCTTCCGCTGCGTACCAGAAAATATCCGATGTCGTTCCAAT
TACACCCGCGGAGATATCCGATAAGGTTACCAATGCACTTAGAAAAAATAAGAATTCGCAGTATCTTGTTATATTCGATG
CGATTGGTGTTGATAAAAAGGGAATTCTTGAGAAAGAGAATATTCCGTGGCTTTATTTTGAGCGGGTCTATAAGCGCATT
TACCCATTTGGCGGTGTGGCCGGTAATTTATTGGGTTTCCTCAATATAGATCAAGTGCCACAGGCAGGACTTGAGTTATC
CTATGATAACTGTCTGTCTGGTCATGACGGAAAAGAAGATTATCTCGCCTCACCAGATGGTGTGCCGATTCCCGGGAGCA
ATCGCGTTGTTCAGCCCGCAAAACATGGCGGTCAACTTGCCCTGACAATTGATTCTGATCTGCAGTGGTACACACAGCAG
ATCCTTAAACAGTATTCCGAATTGGAATCAGCGCGCTGGGGTATGGTGGCGATTGTTTCTGTAAAAACCGGTAAAGTTTT
GGCGTTGGCTGATTACCCGACTGTTGATCCGAATAATGTTGGTGACACTGATGCCATCAATCGTGGGGCAAGAACTTTTT
CCGATCCGTATGAGCCGGGTTCTATTTTTAAGCCTGTGACTGCTTCAATTCTCTTGGACGCAGGTGGCCTTACACCGTCC
AGCAGATTCCGTGTTCCTTATAACTTTAGAGCACCTGGGGATGTGGATATTTCTGATGATGAGCGCCATGCCGATATGGA
TATGACACTTACAGGTATCCTTGTTGCATCCTCTAATTCCGGCATGTCGATTGCAAGCAGGTCTGTTGATCTTGCGGAGA
GGTACAGATATCTAAGAAATTTTGGTTTTGGAGCCTCTACGGGCTTGCGCTTTCCTGCTCAGTCAGAAGGATTACTTGGG
AATTACAAGCTTTGGGATCAACAAACGCGGTATGCAAGCTCGTTCGGCCAGGGCATTTCTGCGACAATCTTGCAATTAGC
TTCTGCATATCAGACAATTGCAAATGGAGGTGTGCGCAGACCGCTTTCGATGGTTACATCCTGCGGTGATAAGCCGACTG
AATCTAAAAAGGGCACGAGTGGCGTGTTCGGTCGGGTTGTAAGTCAGAAGTCTGCCTCTGCAACATCAAATATGCTAGAG
ATGGTTTACAGGCACAGCTGGCTTCATAACCTATGGAGGATTCCCGGTTATCGCATTTGCGCTAAAACCGGAACTGCCCA
GGTGGCTGCTGGTAATGGAAAATATGGCAAGAGCTATATTGTATCTGTTGCCGGATATGCACCGGCTGAGGATCCCGAAT
TTGTTGTTATAACCAGTATGTATAAGACAAAACAAAATACAGCAGCCGCTGTTGCGCCTGTTTTTCAAAAGGTTATGAGT
CATGTTTTAAAAAAGTATCGAGTTTTGCCATCTACAACATTGCCCACAGAATTAGCGCTGCGGTAA

Upstream 100 bases:

>100_bases
GCTGTTTCCCGCGCCATTGACGAATTGATGATTGACGAATTGATGTCAGAATTACTTCGAGTGTACATTGCTTATTGTTG
AGTGACTATTATTTAGACTG

Downstream 100 bases:

>100_bases
ACCTTTATAGAAAGGCAAGATATGCTAATCAGGCGTGCCGATATTCAACGCGTGACCGGCGGTATTTTGCACAACACCTC
TTTATCGGAAAGTTTGTTGC

Product: penicillin-binding protein

Products: NA

Alternate protein names: Penicillin-binding protein 3; PBP-3; Peptidoglycan glycosyltransferase 3 [H]

Number of amino acids: Translated: 581; Mature: 581

Protein sequence:

>581_residues
MKRSSSRGIATLFVVALLSSVFMARLVDIQIIRAKELGRDSYLQRSKTHVIPGVRGNIVDAYNRTLAESLTQYRLVLSPS
RVSDYWANGKKVIPSAAYQKISDVVPITPAEISDKVTNALRKNKNSQYLVIFDAIGVDKKGILEKENIPWLYFERVYKRI
YPFGGVAGNLLGFLNIDQVPQAGLELSYDNCLSGHDGKEDYLASPDGVPIPGSNRVVQPAKHGGQLALTIDSDLQWYTQQ
ILKQYSELESARWGMVAIVSVKTGKVLALADYPTVDPNNVGDTDAINRGARTFSDPYEPGSIFKPVTASILLDAGGLTPS
SRFRVPYNFRAPGDVDISDDERHADMDMTLTGILVASSNSGMSIASRSVDLAERYRYLRNFGFGASTGLRFPAQSEGLLG
NYKLWDQQTRYASSFGQGISATILQLASAYQTIANGGVRRPLSMVTSCGDKPTESKKGTSGVFGRVVSQKSASATSNMLE
MVYRHSWLHNLWRIPGYRICAKTGTAQVAAGNGKYGKSYIVSVAGYAPAEDPEFVVITSMYKTKQNTAAAVAPVFQKVMS
HVLKKYRVLPSTTLPTELALR

Sequences:

>Translated_581_residues
MKRSSSRGIATLFVVALLSSVFMARLVDIQIIRAKELGRDSYLQRSKTHVIPGVRGNIVDAYNRTLAESLTQYRLVLSPS
RVSDYWANGKKVIPSAAYQKISDVVPITPAEISDKVTNALRKNKNSQYLVIFDAIGVDKKGILEKENIPWLYFERVYKRI
YPFGGVAGNLLGFLNIDQVPQAGLELSYDNCLSGHDGKEDYLASPDGVPIPGSNRVVQPAKHGGQLALTIDSDLQWYTQQ
ILKQYSELESARWGMVAIVSVKTGKVLALADYPTVDPNNVGDTDAINRGARTFSDPYEPGSIFKPVTASILLDAGGLTPS
SRFRVPYNFRAPGDVDISDDERHADMDMTLTGILVASSNSGMSIASRSVDLAERYRYLRNFGFGASTGLRFPAQSEGLLG
NYKLWDQQTRYASSFGQGISATILQLASAYQTIANGGVRRPLSMVTSCGDKPTESKKGTSGVFGRVVSQKSASATSNMLE
MVYRHSWLHNLWRIPGYRICAKTGTAQVAAGNGKYGKSYIVSVAGYAPAEDPEFVVITSMYKTKQNTAAAVAPVFQKVMS
HVLKKYRVLPSTTLPTELALR
>Mature_581_residues
MKRSSSRGIATLFVVALLSSVFMARLVDIQIIRAKELGRDSYLQRSKTHVIPGVRGNIVDAYNRTLAESLTQYRLVLSPS
RVSDYWANGKKVIPSAAYQKISDVVPITPAEISDKVTNALRKNKNSQYLVIFDAIGVDKKGILEKENIPWLYFERVYKRI
YPFGGVAGNLLGFLNIDQVPQAGLELSYDNCLSGHDGKEDYLASPDGVPIPGSNRVVQPAKHGGQLALTIDSDLQWYTQQ
ILKQYSELESARWGMVAIVSVKTGKVLALADYPTVDPNNVGDTDAINRGARTFSDPYEPGSIFKPVTASILLDAGGLTPS
SRFRVPYNFRAPGDVDISDDERHADMDMTLTGILVASSNSGMSIASRSVDLAERYRYLRNFGFGASTGLRFPAQSEGLLG
NYKLWDQQTRYASSFGQGISATILQLASAYQTIANGGVRRPLSMVTSCGDKPTESKKGTSGVFGRVVSQKSASATSNMLE
MVYRHSWLHNLWRIPGYRICAKTGTAQVAAGNGKYGKSYIVSVAGYAPAEDPEFVVITSMYKTKQNTAAAVAPVFQKVMS
HVLKKYRVLPSTTLPTELALR

Specific function: Cell wall formation. Essential for the formation of a septum of the murein sacculus. Synthesis of cross-linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786272, Length=570, Percent_Identity=30, Blast_Score=200, Evalue=3e-52,
Organism=Escherichia coli, GI1786854, Length=626, Percent_Identity=22.6837060702875, Blast_Score=97, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: =2.4.1.129 [H]

Molecular weight: Translated: 63564; Mature: 63564

Theoretical pI: Translated: 9.84; Mature: 9.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRSSSRGIATLFVVALLSSVFMARLVDIQIIRAKELGRDSYLQRSKTHVIPGVRGNIVD
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHEEEEHHHCCCHHHHHHCCCEECCCCCCCHHH
AYNRTLAESLTQYRLVLSPSRVSDYWANGKKVIPSAAYQKISDVVPITPAEISDKVTNAL
HHHHHHHHHHHHEEEEECCCHHHHHHCCCCEECCHHHHHHHHCCCCCCCHHHHHHHHHHH
RKNKNSQYLVIFDAIGVDKKGILEKENIPWLYFERVYKRIYPFGGVAGNLLGFLNIDQVP
HHCCCCCEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHCCCCCCC
QAGLELSYDNCLSGHDGKEDYLASPDGVPIPGSNRVVQPAKHGGQLALTIDSDLQWYTQQ
CCCCEECHHHCCCCCCCCCCCCCCCCCCCCCCCCCEECCCCCCCEEEEEECCCHHHHHHH
ILKQYSELESARWGMVAIVSVKTGKVLALADYPTVDPNNVGDTDAINRGARTFSDPYEPG
HHHHHHHHHHCCCCEEEEEEECCCCEEEEECCCCCCCCCCCCHHHHHCCCCCCCCCCCCC
SIFKPVTASILLDAGGLTPSSRFRVPYNFRAPGDVDISDDERHADMDMTLTGILVASSNS
CCCCHHHHHHEEECCCCCCCCCEECCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEECCCC
GMSIASRSVDLAERYRYLRNFGFGASTGLRFPAQSEGLLGNYKLWDQQTRYASSFGQGIS
CCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCHH
ATILQLASAYQTIANGGVRRPLSMVTSCGDKPTESKKGTSGVFGRVVSQKSASATSNMLE
HHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
MVYRHSWLHNLWRIPGYRICAKTGTAQVAAGNGKYGKSYIVSVAGYAPAEDPEFVVITSM
HHHHHHHHHHHHCCCCEEEEECCCCEEEECCCCCCCCEEEEEEECCCCCCCCCEEEEEEH
YKTKQNTAAAVAPVFQKVMSHVLKKYRVLPSTTLPTELALR
HHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCC
>Mature Secondary Structure
MKRSSSRGIATLFVVALLSSVFMARLVDIQIIRAKELGRDSYLQRSKTHVIPGVRGNIVD
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHEEEEHHHCCCHHHHHHCCCEECCCCCCCHHH
AYNRTLAESLTQYRLVLSPSRVSDYWANGKKVIPSAAYQKISDVVPITPAEISDKVTNAL
HHHHHHHHHHHHEEEEECCCHHHHHHCCCCEECCHHHHHHHHCCCCCCCHHHHHHHHHHH
RKNKNSQYLVIFDAIGVDKKGILEKENIPWLYFERVYKRIYPFGGVAGNLLGFLNIDQVP
HHCCCCCEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHCCCCCCC
QAGLELSYDNCLSGHDGKEDYLASPDGVPIPGSNRVVQPAKHGGQLALTIDSDLQWYTQQ
CCCCEECHHHCCCCCCCCCCCCCCCCCCCCCCCCCEECCCCCCCEEEEEECCCHHHHHHH
ILKQYSELESARWGMVAIVSVKTGKVLALADYPTVDPNNVGDTDAINRGARTFSDPYEPG
HHHHHHHHHHCCCCEEEEEEECCCCEEEEECCCCCCCCCCCCHHHHHCCCCCCCCCCCCC
SIFKPVTASILLDAGGLTPSSRFRVPYNFRAPGDVDISDDERHADMDMTLTGILVASSNS
CCCCHHHHHHEEECCCCCCCCCEECCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEECCCC
GMSIASRSVDLAERYRYLRNFGFGASTGLRFPAQSEGLLGNYKLWDQQTRYASSFGQGIS
CCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCHH
ATILQLASAYQTIANGGVRRPLSMVTSCGDKPTESKKGTSGVFGRVVSQKSASATSNMLE
HHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
MVYRHSWLHNLWRIPGYRICAKTGTAQVAAGNGKYGKSYIVSVAGYAPAEDPEFVVITSM
HHHHHHHHHHHHCCCCEEEEECCCCEEEECCCCCCCCEEEEEEECCCCCCCCCEEEEEEH
YKTKQNTAAAVAPVFQKVMSHVLKKYRVLPSTTLPTELALR
HHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12522265 [H]