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The map label for this gene is uppS2

Identifier: 28572635

GI number: 28572635

Start: 525319

End: 526068

Strand: Reverse

Name: uppS2

Synonym: TW486

Alternate gene names: 28572635

Gene position: 526068-525319 (Counterclockwise)

Preceding gene: 161501890

Following gene: 28572634

Centisome position: 56.81

GC content: 44.53

Gene sequence:

>750_bases
GTGGAGATATTTTCAGTCGACTGGACGGGTCAAACTCCGCCGCATATCCCGAGGAAATCTTTGCCAAGACATGTTGCGGT
TGTTATGGATGGAAATGGGCGCTGGGCTAATCAGCGTAATTTGCCGCGTATTGAGGGGCATAAAGCCGGCGAAAGCGCTT
TGATTGATGTTGTGGCCGGGGCTGTTCAGGTTGGTGTACCGTATTTATCTCTGTATGTATTTTCAACAGAAAACTGGCTT
AGGGCACCTGATGAAGTTCGGTTTCTGTTAAGATTTACGCGCGATGTAATTGCTCGGCGTCGTGAACTTTTTGCTCATTG
GGGTGTTAGGGTGCGCTGGTCTGGCGTACCAAATAGGCTTGGTAAAGTTCTTGTCAAAGAATTGAGGGATACGGAGGAAA
TTACCAAGAAAAACACTGCTATGAATCTGAATGTGTGCCTCAATTACGGTTCGAGACAGGAAATTGTAAATGCTATAAAA
AGCATTGTAAGTGATGTAAATAGTGGTCTCATCTCTGCTAAGTCAGTTAACGAAAAAATCATCTCTAGGAGAATGTACAT
GCCTGATTTTCCAGATGTTGATTTATTCCTGCGATCTTCCGGTGAAAATAGGATGAGTAACTTTATGCTCTGGCAGTCTG
CATATGCAGAGCTTATCTTTATGTCAAAACTTTGGCCAGATTTTAGACGTGACGATTTCTGGGCTGCATTGCGTGCCTAC
TCGGGCAGAAGTCGTAGGTTTGGCAGATAG

Upstream 100 bases:

>100_bases
TGTCTTTGAGTATACGCAGTGGCATATTGATCATCCATTGAAAAGCCTAAAAATTGTTGCGAAGTCCTGGTGAGGATATG
CTGGCAGGAAATGTGTAATC

Downstream 100 bases:

>100_bases
AATGCGCTGTTGACACTGTTAACCTGTAAGACATTTCGCGCACGGTGTTCGTACACTTCTCATATGAAACAGTTTACTTA
CAATGATTTCGATCGAGAGC

Product: undecaprenyl pyrophosphate synthase

Products: NA

Alternate protein names: UPP synthase 1; Di-trans,poly-cis-decaprenylcistransferase 1; Undecaprenyl diphosphate synthase 1; UDS 1

Number of amino acids: Translated: 249; Mature: 249

Protein sequence:

>249_residues
MEIFSVDWTGQTPPHIPRKSLPRHVAVVMDGNGRWANQRNLPRIEGHKAGESALIDVVAGAVQVGVPYLSLYVFSTENWL
RAPDEVRFLLRFTRDVIARRRELFAHWGVRVRWSGVPNRLGKVLVKELRDTEEITKKNTAMNLNVCLNYGSRQEIVNAIK
SIVSDVNSGLISAKSVNEKIISRRMYMPDFPDVDLFLRSSGENRMSNFMLWQSAYAELIFMSKLWPDFRRDDFWAALRAY
SGRSRRFGR

Sequences:

>Translated_249_residues
MEIFSVDWTGQTPPHIPRKSLPRHVAVVMDGNGRWANQRNLPRIEGHKAGESALIDVVAGAVQVGVPYLSLYVFSTENWL
RAPDEVRFLLRFTRDVIARRRELFAHWGVRVRWSGVPNRLGKVLVKELRDTEEITKKNTAMNLNVCLNYGSRQEIVNAIK
SIVSDVNSGLISAKSVNEKIISRRMYMPDFPDVDLFLRSSGENRMSNFMLWQSAYAELIFMSKLWPDFRRDDFWAALRAY
SGRSRRFGR
>Mature_249_residues
MEIFSVDWTGQTPPHIPRKSLPRHVAVVMDGNGRWANQRNLPRIEGHKAGESALIDVVAGAVQVGVPYLSLYVFSTENWL
RAPDEVRFLLRFTRDVIARRRELFAHWGVRVRWSGVPNRLGKVLVKELRDTEEITKKNTAMNLNVCLNYGSRQEIVNAIK
SIVSDVNSGLISAKSVNEKIISRRMYMPDFPDVDLFLRSSGENRMSNFMLWQSAYAELIFMSKLWPDFRRDDFWAALRAY
SGRSRRFGR

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family

Homologues:

Organism=Homo sapiens, GI45580742, Length=222, Percent_Identity=32.4324324324324, Blast_Score=136, Evalue=1e-32,
Organism=Homo sapiens, GI45580738, Length=222, Percent_Identity=32.4324324324324, Blast_Score=136, Evalue=2e-32,
Organism=Escherichia coli, GI1786371, Length=227, Percent_Identity=40.9691629955947, Blast_Score=182, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI71993029, Length=230, Percent_Identity=31.7391304347826, Blast_Score=120, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6319474, Length=232, Percent_Identity=31.8965517241379, Blast_Score=129, Evalue=5e-31,
Organism=Saccharomyces cerevisiae, GI6323748, Length=215, Percent_Identity=33.0232558139535, Blast_Score=107, Evalue=2e-24,
Organism=Drosophila melanogaster, GI18857969, Length=247, Percent_Identity=33.1983805668016, Blast_Score=132, Evalue=3e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UPPS1_TROWT (Q83GJ0)

Other databases:

- EMBL:   AE014184
- RefSeq:   NP_787414.1
- ProteinModelPortal:   Q83GJ0
- SMR:   Q83GJ0
- STRING:   Q83GJ0
- GeneID:   1089536
- GenomeReviews:   AE014184_GR
- KEGG:   twh:TWT286
- eggNOG:   COG0020
- HOGENOM:   HBG627837
- OMA:   RVRWAGR
- ProtClustDB:   PRK14829
- BioCyc:   TWHI203267:TW286-MONOMER
- HAMAP:   MF_01139
- InterPro:   IPR001441
- InterPro:   IPR018520
- Gene3D:   G3DSA:3.40.1180.10
- PANTHER:   PTHR10291
- TIGRFAMs:   TIGR00055

Pfam domain/function: PF01255 Prenyltransf; SSF64005 UPP_synth

EC number: =2.5.1.31

Molecular weight: Translated: 28731; Mature: 28731

Theoretical pI: Translated: 10.74; Mature: 10.74

Prosite motif: PS01066 UPP_SYNTHASE

Important sites: ACT_SITE 30-30

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIFSVDWTGQTPPHIPRKSLPRHVAVVMDGNGRWANQRNLPRIEGHKAGESALIDVVAG
CEEEEECCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHH
AVQVGVPYLSLYVFSTENWLRAPDEVRFLLRFTRDVIARRRELFAHWGVRVRWSGVPNRL
HHHHCCCEEEEEEEECCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCHHH
GKVLVKELRDTEEITKKNTAMNLNVCLNYGSRQEIVNAIKSIVSDVNSGLISAKSVNEKI
HHHHHHHHHHHHHHHHHCCEEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
ISRRMYMPDFPDVDLFLRSSGENRMSNFMLWQSAYAELIFMSKLWPDFRRDDFWAALRAY
HHHHCCCCCCCCHHHEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
SGRSRRFGR
CCCCCCCCC
>Mature Secondary Structure
MEIFSVDWTGQTPPHIPRKSLPRHVAVVMDGNGRWANQRNLPRIEGHKAGESALIDVVAG
CEEEEECCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHH
AVQVGVPYLSLYVFSTENWLRAPDEVRFLLRFTRDVIARRRELFAHWGVRVRWSGVPNRL
HHHHCCCEEEEEEEECCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCHHH
GKVLVKELRDTEEITKKNTAMNLNVCLNYGSRQEIVNAIKSIVSDVNSGLISAKSVNEKI
HHHHHHHHHHHHHHHHHCCEEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
ISRRMYMPDFPDVDLFLRSSGENRMSNFMLWQSAYAELIFMSKLWPDFRRDDFWAALRAY
HHHHCCCCCCCCHHHEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
SGRSRRFGR
CCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12902375