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The map label for this gene is ctaB

Identifier: 28572583

GI number: 28572583

Start: 471644

End: 472546

Strand: Direct

Name: ctaB

Synonym: TW432

Alternate gene names: 28572583

Gene position: 471644-472546 (Clockwise)

Preceding gene: 28572578

Following gene: 28572585

Centisome position: 50.94

GC content: 47.18

Gene sequence:

>903_bases
ATGGGTATGCAGGGTCGTTCTTTCGCTAGACAAATAAGGGCTTACGTCTCCCTCACCAAACCTAGAGTTGTTGAACTTCT
ATTATTGACGACTGTACCGACCATGATTCTGGCTCAGCGTGGCGTGCCAAACCCTCTGAGCGTCTTGTCAGTCCTGCTCG
GCGGGGCAATGAGTGCCGGCGCAGCTGGAGCGTTTAATTGCTACATAGACAGAGACATAGATTCTAAGATGTCGAGGACG
AGAAATCGTCCCCTTGTAACAGGGGCACTGTCCCCAAAGGCATCCCTTATTTTTGCCTGGATGCTTTGTGTGATTTCAGT
CCTGTGGTTTTTATTGTTTGTAAACTGGCTCTCTGCCCTTTTATCCGCCATAGCCGTGTTTCTCTACGCTTTTTTTTATT
CAATCGTTCTAAAAAAGAGAACCCCCCAGAACATAGTCTGGGGTGGCCTCGCAGGGTGCATGCCTGTCTTGATAGCCTGG
GCCGCTGTAACAGGCTCTATAGATTGGCCAGCGATTGTCTTATTTGCTGTTGTTTTTTTGTGGACCCCACCGCATTACTG
GCCACTTTCCATCCATTATTCAGAGGATTATCGACTTACCTCGATACCGATGTTGGGTGCAATATTTCCCAGAAAATTGG
TTGTTTTGCAGGTACTTCTCTACGCGTTTGCTGTGGTTGCCTGCACATTACTGTTGATTCCAGTTGCACACATGACGCCC
CTGTACGGCCTGTTTTCCGCTGTACTGGGCGCATGGTTCGTTTATGAAATATATCGTTTATATGTGAGAGTTGTGCGCGG
ACATGAGATAAAGGCAATGCACATATTCAGCTTATCGAATACTTATCTTTCGCTTGTCTTCCTATCGGTTGGAATAGACG
GTGTTGTTTCTCAGCTTCTCTAG

Upstream 100 bases:

>100_bases
TTTATGTGTGGGTATTTTCAGTATTTATTTTCTAGCAGTGCCATATATGCTTCCCTATTCAGGTAGACTTGTCTGTGAGA
AACCGTCCGCTTTAATCTGA

Downstream 100 bases:

>100_bases
GCACTTTTCGGCTCGTACTTGACCGATATTGTTGAGCAAAGAAGGTCAGAGCCGCAGCCAGGAGTCCTGCCAGCATTAAA
TGGGATGCTACCAGATATTC

Product: protoheme IX farnesyltransferase

Products: NA

Alternate protein names: Heme B farnesyltransferase; Heme O synthase

Number of amino acids: Translated: 300; Mature: 299

Protein sequence:

>300_residues
MGMQGRSFARQIRAYVSLTKPRVVELLLLTTVPTMILAQRGVPNPLSVLSVLLGGAMSAGAAGAFNCYIDRDIDSKMSRT
RNRPLVTGALSPKASLIFAWMLCVISVLWFLLFVNWLSALLSAIAVFLYAFFYSIVLKKRTPQNIVWGGLAGCMPVLIAW
AAVTGSIDWPAIVLFAVVFLWTPPHYWPLSIHYSEDYRLTSIPMLGAIFPRKLVVLQVLLYAFAVVACTLLLIPVAHMTP
LYGLFSAVLGAWFVYEIYRLYVRVVRGHEIKAMHIFSLSNTYLSLVFLSVGIDGVVSQLL

Sequences:

>Translated_300_residues
MGMQGRSFARQIRAYVSLTKPRVVELLLLTTVPTMILAQRGVPNPLSVLSVLLGGAMSAGAAGAFNCYIDRDIDSKMSRT
RNRPLVTGALSPKASLIFAWMLCVISVLWFLLFVNWLSALLSAIAVFLYAFFYSIVLKKRTPQNIVWGGLAGCMPVLIAW
AAVTGSIDWPAIVLFAVVFLWTPPHYWPLSIHYSEDYRLTSIPMLGAIFPRKLVVLQVLLYAFAVVACTLLLIPVAHMTP
LYGLFSAVLGAWFVYEIYRLYVRVVRGHEIKAMHIFSLSNTYLSLVFLSVGIDGVVSQLL
>Mature_299_residues
GMQGRSFARQIRAYVSLTKPRVVELLLLTTVPTMILAQRGVPNPLSVLSVLLGGAMSAGAAGAFNCYIDRDIDSKMSRTR
NRPLVTGALSPKASLIFAWMLCVISVLWFLLFVNWLSALLSAIAVFLYAFFYSIVLKKRTPQNIVWGGLAGCMPVLIAWA
AVTGSIDWPAIVLFAVVFLWTPPHYWPLSIHYSEDYRLTSIPMLGAIFPRKLVVLQVLLYAFAVVACTLLLIPVAHMTPL
YGLFSAVLGAWFVYEIYRLYVRVVRGHEIKAMHIFSLSNTYLSLVFLSVGIDGVVSQLL

Specific function: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group

COG id: COG0109

COG function: function code O; Polyprenyltransferase (cytochrome oxidase assembly factor)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily

Homologues:

Organism=Homo sapiens, GI17921982, Length=253, Percent_Identity=30.0395256916996, Blast_Score=92, Evalue=5e-19,
Organism=Escherichia coli, GI1786631, Length=268, Percent_Identity=30.5970149253731, Blast_Score=122, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI71998235, Length=217, Percent_Identity=27.6497695852535, Blast_Score=76, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6325085, Length=271, Percent_Identity=26.5682656826568, Blast_Score=83, Evalue=4e-17,
Organism=Drosophila melanogaster, GI19921064, Length=264, Percent_Identity=29.5454545454545, Blast_Score=104, Evalue=6e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COXX_TROW8 (Q83NK0)

Other databases:

- EMBL:   BX251411
- RefSeq:   NP_789363.1
- STRING:   Q83NK0
- GeneID:   1064274
- GenomeReviews:   BX072543_GR
- KEGG:   tws:TW432
- eggNOG:   COG0109
- HOGENOM:   HBG656003
- OMA:   SYYQLTK
- PhylomeDB:   Q83NK0
- ProtClustDB:   PRK04375
- BioCyc:   TWHI218496:TW0408-MONOMER
- HAMAP:   MF_00154
- InterPro:   IPR006369
- InterPro:   IPR000537
- PANTHER:   PTHR11048:SF3
- TIGRFAMs:   TIGR01473

Pfam domain/function: PF01040 UbiA

EC number: 2.5.1.-

Molecular weight: Translated: 33279; Mature: 33148

Theoretical pI: Translated: 10.04; Mature: 10.04

Prosite motif: PS00943 UBIA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xb3f7f6c)-; HASH(0xc9ad9c8)-; HASH(0xc490ce8)-; HASH(0xc7023d8)-; HASH(0xc8aca58)-; HASH(0xbe00b64)-; HASH(0xba43b2c)-; HASH(0xc13604c)-; HASH(0xc265200)-;

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGMQGRSFARQIRAYVSLTKPRVVELLLLTTVPTMILAQRGVPNPLSVLSVLLGGAMSAG
CCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCC
AAGAFNCYIDRDIDSKMSRTRNRPLVTGALSPKASLIFAWMLCVISVLWFLLFVNWLSAL
CCCCEEEEEECCHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSAIAVFLYAFFYSIVLKKRTPQNIVWGGLAGCMPVLIAWAAVTGSIDWPAIVLFAVVFL
HHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
WTPPHYWPLSIHYSEDYRLTSIPMLGAIFPRKLVVLQVLLYAFAVVACTLLLIPVAHMTP
HCCCCCCEEEEEECCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LYGLFSAVLGAWFVYEIYRLYVRVVRGHEIKAMHIFSLSNTYLSLVFLSVGIDGVVSQLL
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHH
>Mature Secondary Structure 
GMQGRSFARQIRAYVSLTKPRVVELLLLTTVPTMILAQRGVPNPLSVLSVLLGGAMSAG
CCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCC
AAGAFNCYIDRDIDSKMSRTRNRPLVTGALSPKASLIFAWMLCVISVLWFLLFVNWLSAL
CCCCEEEEEECCHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSAIAVFLYAFFYSIVLKKRTPQNIVWGGLAGCMPVLIAWAAVTGSIDWPAIVLFAVVFL
HHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
WTPPHYWPLSIHYSEDYRLTSIPMLGAIFPRKLVVLQVLLYAFAVVACTLLLIPVAHMTP
HCCCCCCEEEEEECCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LYGLFSAVLGAWFVYEIYRLYVRVVRGHEIKAMHIFSLSNTYLSLVFLSVGIDGVVSQLL
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12606174