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The map label for this gene is tkt [H]

Identifier: 28572582

GI number: 28572582

Start: 469409

End: 471505

Strand: Reverse

Name: tkt [H]

Synonym: TW431

Alternate gene names: 28572582

Gene position: 471505-469409 (Counterclockwise)

Preceding gene: 28572584

Following gene: 28572581

Centisome position: 50.92

GC content: 48.35

Gene sequence:

>2097_bases
ATGGAATATAATGTTTCGCGGGAACGGAGGGCTTCTGCTTTGACTGTGTTTGTTTGGGATGATAAGGATGATCTGGCGGT
AAACACAGCCCGGGTACTTGCGGCAGACGCAGTTGAAAATGTCGGGAACGGTCACCCCGGAACGGCGATTAGTTTGGCAC
CCGCTGCTTATCTTTTGTTTCAGAAGGTTATGCGCCATAACCCCTCTGATCCTTCCTGGGCGGCGCGCGATAGATTCGTG
TTATCCTGCGGTCATAGTTCACTTACCCTATATATTCAGCTTTTTCTGGCCGGCTATAAACTTTCCCTGCAGGATCTTCG
AGGCCTTCGCCAGTGGGGCTCGCTGACTCCCGGACACCCGGAATATGGGCATACACCCGGGGTTGAAATTACAACAGGTC
CTCTTGGTCAAGGCCTTGCTAGCGCTGTTGGGTTTGCATATTCCGCGCGGTTCCAAAGGGGCCTCTTCAAGACGGATATA
TTCGATCATTATGTCTATGTGATCGCGAGTGAAGGTGATATAGAAGAAGGTGTTACTTCTGAGGCATGTTCTCTTGCTGG
ACTTCAGCAGCTCGGTAATCTTTTGGTGATTCTTGACAGAAACTATATAAGTATCGAAGATAATACTGATATAGCCCTTT
CTGAAGATATAAAGTCCAGATATCTGTCATACGGTTGGCAAGTAATCGAGGTTCCCTGGCGTCGAGCAGGGGCAGAGTAT
AGGGAGGATGTCCTCTCCCTCTATGAGGCCCTCTTGGAAGCGCAAAAGGATACTGATAGACCGTCGCTAATAATCCTGGA
AACGGTTATCGCTTGGCCATCACCGGGCAAACAAAATACGGGCGCTGCGCATGGTGCTGCACTTGGCGTAAATGAAGTGA
AAGACCTGAAGCGTATTCTGGGTTTTGATCCCGAAAAAACATTCGAGGTTCCAGACGGTGTTCTTCAGCACACTAAAGGG
GCACTTGATCGAGGCCAGTCACAGCAGGACAATTGGGAAAATGTCTTTTCATCTTGGCGTCAAGAGCATCCCATTGAGGC
TGCTTTATTTGACAGATTACAAAATGGGGTTACTCCGGATATAGATCATGTTTTGCCTGTTTTTTCCTCGGAGAAACCGA
TTTCTACCAGGGCGGCCAGTGGGCAAGTTATAAACCGTATCGCTGAAGTTATGCCAGAGTTATGGGGCGGGTCGGCGGAT
CTCGCAGAATCGAATAATACGACTATAAAGTCTGCGAACAGTTTCTTACCCGAAAGTGTGACAGTTGATCATTGGAAATC
TGATCGTTATGGTCGCATCCTGCACTTTGGAGTGAGGGAACATGCGATGGCTGCGATAATAAACGGAATTGTTCTCCACG
GGAATACAAGGGTATTTGGTGGGACTTTTTTGGTTTTCAGTGACTATATGCGTCCTGCGGTTAGACTTGCTGCACTCATG
AAGATACCATCTATTTTTGTTTGGACTCATGACTCAATAGGACTGGGAGAAGATGGGCCGACTCATCAACCGGTTGAACA
TCTTTGGGCCTTGCGTGCCATCCCTGGTTTATCTGTCATTCGGCCCGCTGATGCTAACGAGGTTGCCTGGGCTTGGAAAG
AAATTCTTGAGAGGCGTGATGGTCCGGTTGGGCTTGTTTTATCACGACAAAATCTTCCTGTGCTCGACAGGACTTGTCTT
GCACCTGCCAGCGAACTCAGAAAGGGAGCGTATATCCTAGCTGATGGATCGCGTTATCCGAGATTGATATTAATCGCGAC
GGGCTCAGAGGTCTCGCTGGCAATAGGTGCTAGGGAAGTTCTTGAAAATCGTGGTATTCCCACAAGAGTGGTTTCGGCGC
CGTGTCTTGAGTGGTTCGATCAACAAGAGAAAAGTTACCGCAACCATGTCCTTCCTCCAGACGTAGAAACCAGAATTTCT
GTTGAGGCAGGTTTGTCGCTGGGTTGGTCGAAGTATATTGGAGATAAGGGCGCATCCGTTTCTATAGAACACTATGGAGC
ATCAGCCGCTGGGGATGTTCTTTTTGAACGTTTCGGTTTTACCGTTGAGAATATTGTAAAAACAGCAGATGCTCTGTTGG
GAGGGTGTGGTGAATAG

Upstream 100 bases:

>100_bases
CTGAATAGGGAAGCATATATGGCACTGCTAGAAAATAAATACTGAAAATACCCACACATAAAATACTGGTCAGATCGACT
GTATTCGCATTGCAACCAGA

Downstream 100 bases:

>100_bases
CCTGCAGAAATTATCTACTGCCGGTGTAAGTGTGTGGCTTGATGACCTTTCCCGTTCGAGAATTACTGATGGTGACCTGA
AGAAGAGGATTGAGAAGCAG

Product: transketolase

Products: NA

Alternate protein names: TK [H]

Number of amino acids: Translated: 698; Mature: 698

Protein sequence:

>698_residues
MEYNVSRERRASALTVFVWDDKDDLAVNTARVLAADAVENVGNGHPGTAISLAPAAYLLFQKVMRHNPSDPSWAARDRFV
LSCGHSSLTLYIQLFLAGYKLSLQDLRGLRQWGSLTPGHPEYGHTPGVEITTGPLGQGLASAVGFAYSARFQRGLFKTDI
FDHYVYVIASEGDIEEGVTSEACSLAGLQQLGNLLVILDRNYISIEDNTDIALSEDIKSRYLSYGWQVIEVPWRRAGAEY
REDVLSLYEALLEAQKDTDRPSLIILETVIAWPSPGKQNTGAAHGAALGVNEVKDLKRILGFDPEKTFEVPDGVLQHTKG
ALDRGQSQQDNWENVFSSWRQEHPIEAALFDRLQNGVTPDIDHVLPVFSSEKPISTRAASGQVINRIAEVMPELWGGSAD
LAESNNTTIKSANSFLPESVTVDHWKSDRYGRILHFGVREHAMAAIINGIVLHGNTRVFGGTFLVFSDYMRPAVRLAALM
KIPSIFVWTHDSIGLGEDGPTHQPVEHLWALRAIPGLSVIRPADANEVAWAWKEILERRDGPVGLVLSRQNLPVLDRTCL
APASELRKGAYILADGSRYPRLILIATGSEVSLAIGAREVLENRGIPTRVVSAPCLEWFDQQEKSYRNHVLPPDVETRIS
VEAGLSLGWSKYIGDKGASVSIEHYGASAAGDVLFERFGFTVENIVKTADALLGGCGE

Sequences:

>Translated_698_residues
MEYNVSRERRASALTVFVWDDKDDLAVNTARVLAADAVENVGNGHPGTAISLAPAAYLLFQKVMRHNPSDPSWAARDRFV
LSCGHSSLTLYIQLFLAGYKLSLQDLRGLRQWGSLTPGHPEYGHTPGVEITTGPLGQGLASAVGFAYSARFQRGLFKTDI
FDHYVYVIASEGDIEEGVTSEACSLAGLQQLGNLLVILDRNYISIEDNTDIALSEDIKSRYLSYGWQVIEVPWRRAGAEY
REDVLSLYEALLEAQKDTDRPSLIILETVIAWPSPGKQNTGAAHGAALGVNEVKDLKRILGFDPEKTFEVPDGVLQHTKG
ALDRGQSQQDNWENVFSSWRQEHPIEAALFDRLQNGVTPDIDHVLPVFSSEKPISTRAASGQVINRIAEVMPELWGGSAD
LAESNNTTIKSANSFLPESVTVDHWKSDRYGRILHFGVREHAMAAIINGIVLHGNTRVFGGTFLVFSDYMRPAVRLAALM
KIPSIFVWTHDSIGLGEDGPTHQPVEHLWALRAIPGLSVIRPADANEVAWAWKEILERRDGPVGLVLSRQNLPVLDRTCL
APASELRKGAYILADGSRYPRLILIATGSEVSLAIGAREVLENRGIPTRVVSAPCLEWFDQQEKSYRNHVLPPDVETRIS
VEAGLSLGWSKYIGDKGASVSIEHYGASAAGDVLFERFGFTVENIVKTADALLGGCGE
>Mature_698_residues
MEYNVSRERRASALTVFVWDDKDDLAVNTARVLAADAVENVGNGHPGTAISLAPAAYLLFQKVMRHNPSDPSWAARDRFV
LSCGHSSLTLYIQLFLAGYKLSLQDLRGLRQWGSLTPGHPEYGHTPGVEITTGPLGQGLASAVGFAYSARFQRGLFKTDI
FDHYVYVIASEGDIEEGVTSEACSLAGLQQLGNLLVILDRNYISIEDNTDIALSEDIKSRYLSYGWQVIEVPWRRAGAEY
REDVLSLYEALLEAQKDTDRPSLIILETVIAWPSPGKQNTGAAHGAALGVNEVKDLKRILGFDPEKTFEVPDGVLQHTKG
ALDRGQSQQDNWENVFSSWRQEHPIEAALFDRLQNGVTPDIDHVLPVFSSEKPISTRAASGQVINRIAEVMPELWGGSAD
LAESNNTTIKSANSFLPESVTVDHWKSDRYGRILHFGVREHAMAAIINGIVLHGNTRVFGGTFLVFSDYMRPAVRLAALM
KIPSIFVWTHDSIGLGEDGPTHQPVEHLWALRAIPGLSVIRPADANEVAWAWKEILERRDGPVGLVLSRQNLPVLDRTCL
APASELRKGAYILADGSRYPRLILIATGSEVSLAIGAREVLENRGIPTRVVSAPCLEWFDQQEKSYRNHVLPPDVETRIS
VEAGLSLGWSKYIGDKGASVSIEHYGASAAGDVLFERFGFTVENIVKTADALLGGCGE

Specific function: Unknown

COG id: COG0021

COG function: function code G; Transketolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=596, Percent_Identity=24.6644295302013, Blast_Score=145, Evalue=1e-34,
Organism=Homo sapiens, GI4507521, Length=596, Percent_Identity=24.6644295302013, Blast_Score=145, Evalue=1e-34,
Organism=Homo sapiens, GI133778974, Length=594, Percent_Identity=22.0538720538721, Blast_Score=108, Evalue=2e-23,
Organism=Escherichia coli, GI1788808, Length=686, Percent_Identity=44.6064139941691, Blast_Score=531, Evalue=1e-152,
Organism=Escherichia coli, GI48994911, Length=675, Percent_Identity=43.5555555555556, Blast_Score=526, Evalue=1e-150,
Organism=Caenorhabditis elegans, GI17539652, Length=679, Percent_Identity=24.8895434462445, Blast_Score=149, Evalue=4e-36,
Organism=Saccharomyces cerevisiae, GI6325331, Length=680, Percent_Identity=43.0882352941177, Blast_Score=499, Evalue=1e-142,
Organism=Saccharomyces cerevisiae, GI6319593, Length=683, Percent_Identity=41.8740849194729, Blast_Score=484, Evalue=1e-137,
Organism=Drosophila melanogaster, GI45551847, Length=616, Percent_Identity=24.3506493506494, Blast_Score=140, Evalue=4e-33,
Organism=Drosophila melanogaster, GI45550715, Length=616, Percent_Identity=24.3506493506494, Blast_Score=140, Evalue=4e-33,
Organism=Drosophila melanogaster, GI24645119, Length=579, Percent_Identity=24.006908462867, Blast_Score=127, Evalue=3e-29,
Organism=Drosophila melanogaster, GI24666278, Length=500, Percent_Identity=24.4, Blast_Score=119, Evalue=7e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005478
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 76624; Mature: 76624

Theoretical pI: Translated: 5.32; Mature: 5.32

Prosite motif: PS00801 TRANSKETOLASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEYNVSRERRASALTVFVWDDKDDLAVNTARVLAADAVENVGNGHPGTAISLAPAAYLLF
CCCCCCHHHCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEHHHHHHHHH
QKVMRHNPSDPSWAARDRFVLSCGHSSLTLYIQLFLAGYKLSLQDLRGLRQWGSLTPGHP
HHHHHCCCCCCCCHHCCCEEEEECCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCC
EYGHTPGVEITTGPLGQGLASAVGFAYSARFQRGLFKTDIFDHYVYVIASEGDIEEGVTS
CCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHCCHHHHHHCEEEEEEECCCCCCCCCCH
EACSLAGLQQLGNLLVILDRNYISIEDNTDIALSEDIKSRYLSYGWQVIEVPWRRAGAEY
HHHHHHHHHHHCCEEEEEECCEEEECCCCCEEEHHHHHHHHHHCCCEEEECCHHHCCHHH
REDVLSLYEALLEAQKDTDRPSLIILETVIAWPSPGKQNTGAAHGAALGVNEVKDLKRIL
HHHHHHHHHHHHHHHCCCCCCCEEEEEHHHCCCCCCCCCCCCCCCHHCCHHHHHHHHHHH
GFDPEKTFEVPDGVLQHTKGALDRGQSQQDNWENVFSSWRQEHPIEAALFDRLQNGVTPD
CCCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHCCCCCC
IDHVLPVFSSEKPISTRAASGQVINRIAEVMPELWGGSADLAESNNTTIKSANSFLPESV
HHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCEEECHHCCCCCCC
TVDHWKSDRYGRILHFGVREHAMAAIINGIVLHGNTRVFGGTFLVFSDYMRPAVRLAALM
CCCCCCCCCCCCEEEECHHHHHHHHHHCCEEEECCCEEECCCHHHHHHHHHHHHHHHHHH
KIPSIFVWTHDSIGLGEDGPTHQPVEHLWALRAIPGLSVIRPADANEVAWAWKEILERRD
HCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHCCCCCEECCCCCCHHHHHHHHHHHHCC
GPVGLVLSRQNLPVLDRTCLAPASELRKGAYILADGSRYPRLILIATGSEVSLAIGAREV
CCEEEEEECCCCCCHHHHHCCCHHHHCCCEEEEECCCCCCEEEEEECCCCEEEEHHHHHH
LENRGIPTRVVSAPCLEWFDQQEKSYRNHVLPPDVETRISVEAGLSLGWSKYIGDKGASV
HHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEHHHCCCCCHHHHHCCCCCEE
SIEHYGASAAGDVLFERFGFTVENIVKTADALLGGCGE
EECCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MEYNVSRERRASALTVFVWDDKDDLAVNTARVLAADAVENVGNGHPGTAISLAPAAYLLF
CCCCCCHHHCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEHHHHHHHHH
QKVMRHNPSDPSWAARDRFVLSCGHSSLTLYIQLFLAGYKLSLQDLRGLRQWGSLTPGHP
HHHHHCCCCCCCCHHCCCEEEEECCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCC
EYGHTPGVEITTGPLGQGLASAVGFAYSARFQRGLFKTDIFDHYVYVIASEGDIEEGVTS
CCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHCCHHHHHHCEEEEEEECCCCCCCCCCH
EACSLAGLQQLGNLLVILDRNYISIEDNTDIALSEDIKSRYLSYGWQVIEVPWRRAGAEY
HHHHHHHHHHHCCEEEEEECCEEEECCCCCEEEHHHHHHHHHHCCCEEEECCHHHCCHHH
REDVLSLYEALLEAQKDTDRPSLIILETVIAWPSPGKQNTGAAHGAALGVNEVKDLKRIL
HHHHHHHHHHHHHHHCCCCCCCEEEEEHHHCCCCCCCCCCCCCCCHHCCHHHHHHHHHHH
GFDPEKTFEVPDGVLQHTKGALDRGQSQQDNWENVFSSWRQEHPIEAALFDRLQNGVTPD
CCCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHCCCCCC
IDHVLPVFSSEKPISTRAASGQVINRIAEVMPELWGGSADLAESNNTTIKSANSFLPESV
HHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCEEECHHCCCCCCC
TVDHWKSDRYGRILHFGVREHAMAAIINGIVLHGNTRVFGGTFLVFSDYMRPAVRLAALM
CCCCCCCCCCCCEEEECHHHHHHHHHHCCEEEECCCEEECCCHHHHHHHHHHHHHHHHHH
KIPSIFVWTHDSIGLGEDGPTHQPVEHLWALRAIPGLSVIRPADANEVAWAWKEILERRD
HCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHCCCCCEECCCCCCHHHHHHHHHHHHCC
GPVGLVLSRQNLPVLDRTCLAPASELRKGAYILADGSRYPRLILIATGSEVSLAIGAREV
CCEEEEEECCCCCCHHHHHCCCHHHHCCCEEEEECCCCCCEEEEEECCCCEEEEHHHHHH
LENRGIPTRVVSAPCLEWFDQQEKSYRNHVLPPDVETRISVEAGLSLGWSKYIGDKGASV
HHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEHHHCCCCCHHHHHCCCCCEE
SIEHYGASAAGDVLFERFGFTVENIVKTADALLGGCGE
EECCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]