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The map label for this gene is pyrC [H]

Identifier: 28572555

GI number: 28572555

Start: 437412

End: 438698

Strand: Direct

Name: pyrC [H]

Synonym: TW402

Alternate gene names: 28572555

Gene position: 437412-438698 (Clockwise)

Preceding gene: 28572554

Following gene: 28572556

Centisome position: 47.24

GC content: 44.29

Gene sequence:

>1287_bases
GTGACCCGCCAATCTTTTTTTATAAAAAATGTAACACTGCCAGGGCTTGGCGCGAGAACATTGTTTTTGTCTGGTGGTCT
TATCCAGGAGATTATTTGCAAAGACATTGAGGAGCATCAGTTTTTATCTACAAAAAATACTGATAAGGCTTCATGTCGGG
TTATAGACGCTGAAGGGTTTATTGCCCTTCCTGGTCTTGTTGACCTGCATACTCACTTGCGAAATTCCCGTGATGGTTCC
ATAAGGGATGTTACCAGTGCAGCTATTGCAGGTGGATATACAACAGTCTCGTCGATGCCAAATATGCATCCCGTGCAAGA
CTCGCCAGAGGCCGTAAATATCCTGAAGGCCATTGCAAAAGAGGATGCGGTATGTGATATTCGGCCGGTGGGTGCTGTAA
CAAAGGGACTAAGGGGTAATGAAATTACTGATATGCACTCTCTGCTGGATGCCGGTGTAAATATATTCAGCGATGATGGA
AATTGTGTGTATGATCCCGGGATCATACATCAAGCACTATCTTTTGCGGGGAGAAATAATTGTGTAATTGCCCAACATGC
CCAGGATCCCACATTGACAAAAAGTGCTCAAGGGGACACACAAGGCCCAATAGTTGCACCCAAGAGTCTATGGCCTTCAA
TTGCTGAAAGTACAATAGTTGCACGTGATATCCTGCTTGCCCGTGCAGCAAATGCACGGCTTCATGTGTGCCATGTTTCA
TCACAGGAAAGCGTTTATGCAATAGCCTGGGGTAAGAGTCTTGGTGTTCAAGTAACAGCTGAGGTTACTCCGCATCATCT
CTTGTTTTATGACTCCCTCGTAATGACAGGAGATACTCGATTCAAGGTGAACCCACCACTTCGATCAAAAGAGAGTGTGG
AATGTTTACGAGACGCTCTTATTCGGGGCGTGATTGATGTTGTTGCAACTGACCATGCTCCGCACAGGAATAAAAGTCCC
TTTTGGCATTCTGCGCCAAACGGCATGACCGGTTTAGAGTTTTCAGTTTCAGTGATCCAAAAAATTTTTGTTAACTCCGG
GCATCTAACTTGGCCAGAAGTTGTGCGGATAATGTCAAACAAACCTGCTGAAATTCTTGGTATGACACCTAATACAGTTA
AAGAAGGTTCCGCGGCTAATTTTTTTCTTTACAACCCTGACGTGACACGATTCGTAACATTTGATGATTCTTTAGGTCCG
AGTGTAAATTCTCCATATGCCGGGATGAACTTACCGGGGAAGGTTATGTACACCTTTTATGAGGGTAGACTTGTTTTTGA
AAACTAG

Upstream 100 bases:

>100_bases
TTATCAGATTCAGGTTCCACTCTTTATTACTGTCGGGACTCGTATAAGAGTCGATACCCGCACGGGGGCATATATCGGCA
AAGCATGAGGATATTAAATT

Downstream 100 bases:

>100_bases
GGCAAGATTGTCTTCTGCTTTTGTGAGGTTTAAAAATAGGCGTGCTTAGCTTTCGGTCTGCGGTATTCGTAATGGAAGAT
GGTTCTTGTTTTGAAGGTGT

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 428; Mature: 427

Protein sequence:

>428_residues
MTRQSFFIKNVTLPGLGARTLFLSGGLIQEIICKDIEEHQFLSTKNTDKASCRVIDAEGFIALPGLVDLHTHLRNSRDGS
IRDVTSAAIAGGYTTVSSMPNMHPVQDSPEAVNILKAIAKEDAVCDIRPVGAVTKGLRGNEITDMHSLLDAGVNIFSDDG
NCVYDPGIIHQALSFAGRNNCVIAQHAQDPTLTKSAQGDTQGPIVAPKSLWPSIAESTIVARDILLARAANARLHVCHVS
SQESVYAIAWGKSLGVQVTAEVTPHHLLFYDSLVMTGDTRFKVNPPLRSKESVECLRDALIRGVIDVVATDHAPHRNKSP
FWHSAPNGMTGLEFSVSVIQKIFVNSGHLTWPEVVRIMSNKPAEILGMTPNTVKEGSAANFFLYNPDVTRFVTFDDSLGP
SVNSPYAGMNLPGKVMYTFYEGRLVFEN

Sequences:

>Translated_428_residues
MTRQSFFIKNVTLPGLGARTLFLSGGLIQEIICKDIEEHQFLSTKNTDKASCRVIDAEGFIALPGLVDLHTHLRNSRDGS
IRDVTSAAIAGGYTTVSSMPNMHPVQDSPEAVNILKAIAKEDAVCDIRPVGAVTKGLRGNEITDMHSLLDAGVNIFSDDG
NCVYDPGIIHQALSFAGRNNCVIAQHAQDPTLTKSAQGDTQGPIVAPKSLWPSIAESTIVARDILLARAANARLHVCHVS
SQESVYAIAWGKSLGVQVTAEVTPHHLLFYDSLVMTGDTRFKVNPPLRSKESVECLRDALIRGVIDVVATDHAPHRNKSP
FWHSAPNGMTGLEFSVSVIQKIFVNSGHLTWPEVVRIMSNKPAEILGMTPNTVKEGSAANFFLYNPDVTRFVTFDDSLGP
SVNSPYAGMNLPGKVMYTFYEGRLVFEN
>Mature_427_residues
TRQSFFIKNVTLPGLGARTLFLSGGLIQEIICKDIEEHQFLSTKNTDKASCRVIDAEGFIALPGLVDLHTHLRNSRDGSI
RDVTSAAIAGGYTTVSSMPNMHPVQDSPEAVNILKAIAKEDAVCDIRPVGAVTKGLRGNEITDMHSLLDAGVNIFSDDGN
CVYDPGIIHQALSFAGRNNCVIAQHAQDPTLTKSAQGDTQGPIVAPKSLWPSIAESTIVARDILLARAANARLHVCHVSS
QESVYAIAWGKSLGVQVTAEVTPHHLLFYDSLVMTGDTRFKVNPPLRSKESVECLRDALIRGVIDVVATDHAPHRNKSPF
WHSAPNGMTGLEFSVSVIQKIFVNSGHLTWPEVVRIMSNKPAEILGMTPNTVKEGSAANFFLYNPDVTRFVTFDDSLGPS
VNSPYAGMNLPGKVMYTFYEGRLVFEN

Specific function: Involved In The Anaerobic Utilization Of Allantoin. [C]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI18105007, Length=390, Percent_Identity=26.6666666666667, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI19923821, Length=407, Percent_Identity=23.8329238329238, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI4503379, Length=410, Percent_Identity=22.4390243902439, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI1786722, Length=401, Percent_Identity=26.9326683291771, Blast_Score=118, Evalue=6e-28,
Organism=Escherichia coli, GI87082175, Length=395, Percent_Identity=24.5569620253165, Blast_Score=83, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI193204318, Length=368, Percent_Identity=26.0869565217391, Blast_Score=92, Evalue=7e-19,
Organism=Caenorhabditis elegans, GI71989490, Length=407, Percent_Identity=25.0614250614251, Blast_Score=78, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17539558, Length=404, Percent_Identity=24.5049504950495, Blast_Score=66, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI86575075, Length=396, Percent_Identity=22.979797979798, Blast_Score=65, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6322218, Length=395, Percent_Identity=27.0886075949367, Blast_Score=96, Evalue=8e-21,
Organism=Drosophila melanogaster, GI24642586, Length=453, Percent_Identity=25.8278145695364, Blast_Score=106, Evalue=4e-23,
Organism=Drosophila melanogaster, GI18859883, Length=464, Percent_Identity=25.4310344827586, Blast_Score=91, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR002195
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 46492; Mature: 46361

Theoretical pI: Translated: 6.67; Mature: 6.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRQSFFIKNVTLPGLGARTLFLSGGLIQEIICKDIEEHQFLSTKNTDKASCRVIDAEGF
CCCCCEEEEECCCCCCCCEEEEECCCHHHHHHHHCHHHHHHCCCCCCCCCEEEEECCCCC
IALPGLVDLHTHLRNSRDGSIRDVTSAAIAGGYTTVSSMPNMHPVQDSPEAVNILKAIAK
EECCCHHHHHHHHCCCCCCCHHHHHHHHHHCCCHHHHCCCCCCCCCCCHHHHHHHHHHHH
EDAVCDIRPVGAVTKGLRGNEITDMHSLLDAGVNIFSDDGNCVYDPGIIHQALSFAGRNN
CCCCEEEECCHHHHCCCCCCCHHHHHHHHHCCCEEEECCCCEEECCHHHHHHHHHCCCCC
CVIAQHAQDPTLTKSAQGDTQGPIVAPKSLWPSIAESTIVARDILLARAANARLHVCHVS
EEEEECCCCCCCCCCCCCCCCCCEECCHHHCHHHHHHHHHHHHHHHHHCCCCEEEEEEEC
SQESVYAIAWGKSLGVQVTAEVTPHHLLFYDSLVMTGDTRFKVNPPLRSKESVECLRDAL
CCCCEEEEEECCCCCEEEEEECCCCEEEEEECEEEECCCEEEECCCCCCHHHHHHHHHHH
IRGVIDVVATDHAPHRNKSPFWHSAPNGMTGLEFSVSVIQKIFVNSGHLTWPEVVRIMSN
HHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHCC
KPAEILGMTPNTVKEGSAANFFLYNPDVTRFVTFDDSLGPSVNSPYAGMNLPGKVMYTFY
CCCEEEECCCCCCCCCCCCEEEEECCCCEEEEEECCCCCCCCCCCCCCCCCCCEEEEEEE
EGRLVFEN
ECEEEECC
>Mature Secondary Structure 
TRQSFFIKNVTLPGLGARTLFLSGGLIQEIICKDIEEHQFLSTKNTDKASCRVIDAEGF
CCCCEEEEECCCCCCCCEEEEECCCHHHHHHHHCHHHHHHCCCCCCCCCEEEEECCCCC
IALPGLVDLHTHLRNSRDGSIRDVTSAAIAGGYTTVSSMPNMHPVQDSPEAVNILKAIAK
EECCCHHHHHHHHCCCCCCCHHHHHHHHHHCCCHHHHCCCCCCCCCCCHHHHHHHHHHHH
EDAVCDIRPVGAVTKGLRGNEITDMHSLLDAGVNIFSDDGNCVYDPGIIHQALSFAGRNN
CCCCEEEECCHHHHCCCCCCCHHHHHHHHHCCCEEEECCCCEEECCHHHHHHHHHCCCCC
CVIAQHAQDPTLTKSAQGDTQGPIVAPKSLWPSIAESTIVARDILLARAANARLHVCHVS
EEEEECCCCCCCCCCCCCCCCCCEECCHHHCHHHHHHHHHHHHHHHHHCCCCEEEEEEEC
SQESVYAIAWGKSLGVQVTAEVTPHHLLFYDSLVMTGDTRFKVNPPLRSKESVECLRDAL
CCCCEEEEEECCCCCEEEEEECCCCEEEEEECEEEECCCEEEECCCCCCHHHHHHHHHHH
IRGVIDVVATDHAPHRNKSPFWHSAPNGMTGLEFSVSVIQKIFVNSGHLTWPEVVRIMSN
HHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHCC
KPAEILGMTPNTVKEGSAANFFLYNPDVTRFVTFDDSLGPSVNSPYAGMNLPGKVMYTFY
CCCEEEECCCCCCCCCCCCEEEEECCCCEEEEEECCCCCCCCCCCCCCCCCCCEEEEEEE
EGRLVFEN
ECEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA