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The map label for this gene is clpP2

Identifier: 28572440

GI number: 28572440

Start: 319418

End: 320041

Strand: Direct

Name: clpP2

Synonym: TW284

Alternate gene names: 28572440

Gene position: 319418-320041 (Clockwise)

Preceding gene: 28572439

Following gene: 28572441

Centisome position: 34.5

GC content: 45.67

Gene sequence:

>624_bases
ATGTACCCAAATTCAAGATATATTTTGCCGAGTCTCGACGAGCGTACTGCCTATGGGTATAAACAGGTTGATCCGTACAC
AAAGCTGTTTGAAGATCGCATAGTTTTTCTTGGAGTTCAGATTGATGATGCATCTGCTGATGATGTTATGGCACAGCTCT
TGGTTCTTGAAGGTCAAGATGCTGAACGCGACATAATTATGTATATCAATTCACCTGGCGGGTCTTTTACAGCCATGACA
GCCATATACGACACGATGCAGTATATACGTCCGCAGATACAGACAGTGTGTCTTGGGCAGGCCGCCTCGGCTGCTGCCGT
GATCCTGTCGGCCGGAACTCCAGGAAAGAGACTTGCCTTGCCAAACGCAAGAATACTAATTCACCAGCCCGTTGTCGCCT
CTTCCGGTTACGGTCAGGCAAGTGATATAGAGATACAGGCTCGTGAAATAATGCGCATGCGCGAATGGCTAGAAAAAACA
CTTGCCCAACATTCCAATAAGTCTGTAAAACAAGTCAGTAAGGATATTGATCGTGATAAGATCCTTTCTTCCGAGCAGGC
TTTGGAATATGGCTTGATTGATCAGATATTGGTTAGTCGTAAAGCTGGCCTGGGTAAGAAATAG

Upstream 100 bases:

>100_bases
AGATTATGGAGGACGGCGACAGGGATCACTGGTTCACTGCCGAAGAGGCATTGGAATACGGTTTTGTTGATCATATACGT
ACCGAGTAGGAAAGGGCTTT

Downstream 100 bases:

>100_bases
GGGTTATGCTTGACGGATGATACCGAATATCGGTGTTCTTTTTGCGGAAAGGAACACCATCAGGTTGATGATCTGATAGC
CGGTCCGGATGTGCGTATAT

Product: ATP-dependent Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp 1

Number of amino acids: Translated: 207; Mature: 207

Protein sequence:

>207_residues
MYPNSRYILPSLDERTAYGYKQVDPYTKLFEDRIVFLGVQIDDASADDVMAQLLVLEGQDAERDIIMYINSPGGSFTAMT
AIYDTMQYIRPQIQTVCLGQAASAAAVILSAGTPGKRLALPNARILIHQPVVASSGYGQASDIEIQAREIMRMREWLEKT
LAQHSNKSVKQVSKDIDRDKILSSEQALEYGLIDQILVSRKAGLGKK

Sequences:

>Translated_207_residues
MYPNSRYILPSLDERTAYGYKQVDPYTKLFEDRIVFLGVQIDDASADDVMAQLLVLEGQDAERDIIMYINSPGGSFTAMT
AIYDTMQYIRPQIQTVCLGQAASAAAVILSAGTPGKRLALPNARILIHQPVVASSGYGQASDIEIQAREIMRMREWLEKT
LAQHSNKSVKQVSKDIDRDKILSSEQALEYGLIDQILVSRKAGLGKK
>Mature_207_residues
MYPNSRYILPSLDERTAYGYKQVDPYTKLFEDRIVFLGVQIDDASADDVMAQLLVLEGQDAERDIIMYINSPGGSFTAMT
AIYDTMQYIRPQIQTVCLGQAASAAAVILSAGTPGKRLALPNARILIHQPVVASSGYGQASDIEIQAREIMRMREWLEKT
LAQHSNKSVKQVSKDIDRDKILSSEQALEYGLIDQILVSRKAGLGKK

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family

Homologues:

Organism=Homo sapiens, GI5174419, Length=191, Percent_Identity=46.0732984293194, Blast_Score=175, Evalue=2e-44,
Organism=Escherichia coli, GI1786641, Length=195, Percent_Identity=46.6666666666667, Blast_Score=206, Evalue=7e-55,
Organism=Caenorhabditis elegans, GI17538017, Length=192, Percent_Identity=42.7083333333333, Blast_Score=162, Evalue=1e-40,
Organism=Drosophila melanogaster, GI20129427, Length=190, Percent_Identity=41.5789473684211, Blast_Score=166, Evalue=1e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CLPP1_TROWT (Q83G49)

Other databases:

- EMBL:   AE014184
- RefSeq:   NP_787608.1
- ProteinModelPortal:   Q83G49
- SMR:   Q83G49
- STRING:   Q83G49
- GeneID:   1089360
- GenomeReviews:   AE014184_GR
- KEGG:   twh:TWT480
- eggNOG:   COG0740
- HOGENOM:   HBG558421
- OMA:   QDPYTKL
- ProtClustDB:   PRK12553
- BioCyc:   TWHI203267:TW480-MONOMER
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00444
- InterPro:   IPR001907
- InterPro:   IPR018215
- PANTHER:   PTHR10381
- PRINTS:   PR00127

Pfam domain/function: PF00574 CLP_protease

EC number: =3.4.21.92

Molecular weight: Translated: 22957; Mature: 22957

Theoretical pI: Translated: 5.83; Mature: 5.83

Prosite motif: PS00382 CLP_PROTEASE_HIS; PS00381 CLP_PROTEASE_SER

Important sites: ACT_SITE 103-103 ACT_SITE 128-128

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYPNSRYILPSLDERTAYGYKQVDPYTKLFEDRIVFLGVQIDDASADDVMAQLLVLEGQD
CCCCCCEECCCCCCHHHCCCHHCCHHHHHHHCCEEEEEEEECCCCHHHHHHHHHHHCCCC
AERDIIMYINSPGGSFTAMTAIYDTMQYIRPQIQTVCLGQAASAAAVILSAGTPGKRLAL
CCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCEEEC
PNARILIHQPVVASSGYGQASDIEIQAREIMRMREWLEKTLAQHSNKSVKQVSKDIDRDK
CCCEEEEECCEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCHHH
ILSSEQALEYGLIDQILVSRKAGLGKK
HHCHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MYPNSRYILPSLDERTAYGYKQVDPYTKLFEDRIVFLGVQIDDASADDVMAQLLVLEGQD
CCCCCCEECCCCCCHHHCCCHHCCHHHHHHHCCEEEEEEEECCCCHHHHHHHHHHHCCCC
AERDIIMYINSPGGSFTAMTAIYDTMQYIRPQIQTVCLGQAASAAAVILSAGTPGKRLAL
CCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCEEEC
PNARILIHQPVVASSGYGQASDIEIQAREIMRMREWLEKTLAQHSNKSVKQVSKDIDRDK
CCCEEEEECCEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCHHH
ILSSEQALEYGLIDQILVSRKAGLGKK
HHCHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12902375