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The map label for this gene is clpP1

Identifier: 28572439

GI number: 28572439

Start: 318864

End: 319406

Strand: Direct

Name: clpP1

Synonym: TW283

Alternate gene names: 28572439

Gene position: 318864-319406 (Clockwise)

Preceding gene: 28572438

Following gene: 28572440

Centisome position: 34.44

GC content: 47.15

Gene sequence:

>543_bases
GTGAGCGAGACAAAGCAAACAGTTTTTGATCGCCTTCTTCAAGAGAGGATTGTTTGGCTTGGTGAGGCTATAGATGACAA
GCTTGCGAATGAGATATGCGCAAAAATATTGCTTCTGAATGCTGATGACCCGAAGGAAGACATTTTTCTGTATATCAATT
CACCGGGCGGGTCCATAACTGCAGGGATGGCGATTTATGACACCATGCAGTTTGTTAGCAATGATATTGTCACCGTTGGT
ATTGGGATGGCCGCCTCGATGGGTCAGGTGTTGCTTACTTCGGGCACCCAAAACAAGCGCTACATTATGCCGAATGCTCG
TGTTTTGCTTCATCAGCCATTGGCCGGTTTTGGGGGGACAGCGAGTGATATACAGACACAGGCGAAGTTGATTCTAGACA
TGAAGTATAGGCTCAGTCAGATAACCGCCTCTAGAACGGGTAAAACTGTTGAGCAGATTATGGAGGACGGCGACAGGGAT
CACTGGTTCACTGCCGAAGAGGCATTGGAATACGGTTTTGTTGATCATATACGTACCGAGTAG

Upstream 100 bases:

>100_bases
CCAGGAGAATCCCATTTTTGTACAGGATAATAAGACTTGGTGTTCGGAAGCGTGGTACCGTGTCAAGAAAACAGATAAAG
CGAGTTCTTAAGGGGTTGCC

Downstream 100 bases:

>100_bases
GAAAGGGCTTTATGTACCCAAATTCAAGATATATTTTGCCGAGTCTCGACGAGCGTACTGCCTATGGGTATAAACAGGTT
GATCCGTACACAAAGCTGTT

Product: ATP-dependent Clp protease proteolytic subunit 1

Products: NA

Alternate protein names: Endopeptidase Clp 1

Number of amino acids: Translated: 180; Mature: 179

Protein sequence:

>180_residues
MSETKQTVFDRLLQERIVWLGEAIDDKLANEICAKILLLNADDPKEDIFLYINSPGGSITAGMAIYDTMQFVSNDIVTVG
IGMAASMGQVLLTSGTQNKRYIMPNARVLLHQPLAGFGGTASDIQTQAKLILDMKYRLSQITASRTGKTVEQIMEDGDRD
HWFTAEEALEYGFVDHIRTE

Sequences:

>Translated_180_residues
MSETKQTVFDRLLQERIVWLGEAIDDKLANEICAKILLLNADDPKEDIFLYINSPGGSITAGMAIYDTMQFVSNDIVTVG
IGMAASMGQVLLTSGTQNKRYIMPNARVLLHQPLAGFGGTASDIQTQAKLILDMKYRLSQITASRTGKTVEQIMEDGDRD
HWFTAEEALEYGFVDHIRTE
>Mature_179_residues
SETKQTVFDRLLQERIVWLGEAIDDKLANEICAKILLLNADDPKEDIFLYINSPGGSITAGMAIYDTMQFVSNDIVTVGI
GMAASMGQVLLTSGTQNKRYIMPNARVLLHQPLAGFGGTASDIQTQAKLILDMKYRLSQITASRTGKTVEQIMEDGDRDH
WFTAEEALEYGFVDHIRTE

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family

Homologues:

Organism=Homo sapiens, GI5174419, Length=170, Percent_Identity=43.5294117647059, Blast_Score=157, Evalue=5e-39,
Organism=Escherichia coli, GI1786641, Length=173, Percent_Identity=50.8670520231214, Blast_Score=200, Evalue=5e-53,
Organism=Caenorhabditis elegans, GI17538017, Length=178, Percent_Identity=43.8202247191011, Blast_Score=160, Evalue=3e-40,
Organism=Drosophila melanogaster, GI20129427, Length=170, Percent_Identity=43.5294117647059, Blast_Score=156, Evalue=7e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CLPP1_TROW8 (Q83I19)

Other databases:

- EMBL:   BX251410
- RefSeq:   NP_789219.1
- ProteinModelPortal:   Q83I19
- SMR:   Q83I19
- STRING:   Q83I19
- GeneID:   1064572
- GenomeReviews:   BX072543_GR
- KEGG:   tws:TW283
- eggNOG:   COG0740
- HOGENOM:   HBG558421
- OMA:   QAGYLNP
- ProtClustDB:   CLSK537046
- BioCyc:   TWHI218496:TW0264-MONOMER
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00444
- InterPro:   IPR001907
- InterPro:   IPR018215
- PANTHER:   PTHR10381
- PRINTS:   PR00127

Pfam domain/function: PF00574 CLP_protease

EC number: =3.4.21.92

Molecular weight: Translated: 20005; Mature: 19874

Theoretical pI: Translated: 4.50; Mature: 4.50

Prosite motif: PS00382 CLP_PROTEASE_HIS; PS00381 CLP_PROTEASE_SER

Important sites: ACT_SITE 86-86 ACT_SITE 111-111

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSETKQTVFDRLLQERIVWLGEAIDDKLANEICAKILLLNADDPKEDIFLYINSPGGSIT
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCEEEEEEECCCCCEE
AGMAIYDTMQFVSNDIVTVGIGMAASMGQVLLTSGTQNKRYIMPNARVLLHQPLAGFGGT
HHHHHHHHHHHHHCCEEEEECCHHHHHCCEEEECCCCCCEEECCCCEEEEECCCCCCCCC
ASDIQTQAKLILDMKYRLSQITASRTGKTVEQIMEDGDRDHWFTAEEALEYGFVDHIRTE
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCEECHHHHHHHCCHHHHCCC
>Mature Secondary Structure 
SETKQTVFDRLLQERIVWLGEAIDDKLANEICAKILLLNADDPKEDIFLYINSPGGSIT
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCEEEEEEECCCCCEE
AGMAIYDTMQFVSNDIVTVGIGMAASMGQVLLTSGTQNKRYIMPNARVLLHQPLAGFGGT
HHHHHHHHHHHHHCCEEEEECCHHHHHCCEEEECCCCCCEEECCCCEEEEECCCCCCCCC
ASDIQTQAKLILDMKYRLSQITASRTGKTVEQIMEDGDRDHWFTAEEALEYGFVDHIRTE
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCEECHHHHHHHCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12606174