Click here to switch to the map view.

The map label for this gene is rnc [H]

Identifier: 28572359

GI number: 28572359

Start: 237204

End: 237851

Strand: Direct

Name: rnc [H]

Synonym: TW199

Alternate gene names: 28572359

Gene position: 237204-237851 (Clockwise)

Preceding gene: 28572358

Following gene: 28572360

Centisome position: 25.62

GC content: 45.83

Gene sequence:

>648_bases
TTGCGGAAGTTCAATCTAACACTTCCTCCTGGGTTGCTTCGTACGGCGTTTGTCCACAAGTCCTTTTCTTTTGAGAACGG
CGCGTGTCAGAATAACGAGCGTCTTGAGTTTCTTGGAGATGCTGTTCTTGGCCTTGTTGTATCGCATTACCTATTTGAGA
CCTGTCCTGAATACACTGAGGGCCAATTATCTGCCGCTCGCTCATATATTGTTTCCGGCACATCCATTGCACAAATCGCC
AAAGAGTTAAATCTTGGTCAGTTTATGTTGCTTGGGAAAGGGGAAAAACTTGCCGGTGGTATGGATAAAACATCTCTTTT
GGCTGATTTGCTTGAAAGTCTTATTGGGGCTGTTATGGTTGATCAGGGGTTCGAGAGTGCCAGAGATTTTGTATTAGCCC
TTGTTGGAGAAAAGCTAAGACAAGTAGGTGAGTTTTCTGTCGACGATCCAAAGACGAAACTGCAGAAGCTTACCCGAACA
CAGTTGGTGTACGAGGTTGTTACCGAGGGCCCGCCGCACAGTCGTACATTCAAGGCAAGCGTTATTGTGAATGAAAAGAG
ATTTTTCGGGCAAGGGTCAAGCAAAAAACAGGCTCAAGTTGCGGCTGCAATGTCTGCACTTGCATCTCTGGAGAACAAAA
GTTCATAG

Upstream 100 bases:

>100_bases
GCATCGCGCGCGCCGTATTCTTGACTCCAATGGAAATGAGCTCTTTATGGAATACAAGGGCCGCCGCGTCGGGTAGGTGG
ATGGCGTTGATGAACTTCTT

Downstream 100 bases:

>100_bases
CTTATTTCTTGATTAGAGCGTTTGTATGATACGATCCTAAGAAATCTAGGTAGGCTGAGGTGATGTGTTTTGAATAAGCT
TAGGGTTCGTGTTCTGTTTG

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III [H]

Number of amino acids: Translated: 215; Mature: 215

Protein sequence:

>215_residues
MRKFNLTLPPGLLRTAFVHKSFSFENGACQNNERLEFLGDAVLGLVVSHYLFETCPEYTEGQLSAARSYIVSGTSIAQIA
KELNLGQFMLLGKGEKLAGGMDKTSLLADLLESLIGAVMVDQGFESARDFVLALVGEKLRQVGEFSVDDPKTKLQKLTRT
QLVYEVVTEGPPHSRTFKASVIVNEKRFFGQGSSKKQAQVAAAMSALASLENKSS

Sequences:

>Translated_215_residues
MRKFNLTLPPGLLRTAFVHKSFSFENGACQNNERLEFLGDAVLGLVVSHYLFETCPEYTEGQLSAARSYIVSGTSIAQIA
KELNLGQFMLLGKGEKLAGGMDKTSLLADLLESLIGAVMVDQGFESARDFVLALVGEKLRQVGEFSVDDPKTKLQKLTRT
QLVYEVVTEGPPHSRTFKASVIVNEKRFFGQGSSKKQAQVAAAMSALASLENKSS
>Mature_215_residues
MRKFNLTLPPGLLRTAFVHKSFSFENGACQNNERLEFLGDAVLGLVVSHYLFETCPEYTEGQLSAARSYIVSGTSIAQIA
KELNLGQFMLLGKGEKLAGGMDKTSLLADLLESLIGAVMVDQGFESARDFVLALVGEKLRQVGEFSVDDPKTKLQKLTRT
QLVYEVVTEGPPHSRTFKASVIVNEKRFFGQGSSKKQAQVAAAMSALASLENKSS

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs [H]

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain [H]

Homologues:

Organism=Homo sapiens, GI155030236, Length=208, Percent_Identity=34.1346153846154, Blast_Score=109, Evalue=2e-24,
Organism=Homo sapiens, GI155030234, Length=208, Percent_Identity=34.1346153846154, Blast_Score=109, Evalue=2e-24,
Organism=Escherichia coli, GI1788920, Length=208, Percent_Identity=35.0961538461538, Blast_Score=109, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17506883, Length=218, Percent_Identity=31.651376146789, Blast_Score=87, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI193202651, Length=218, Percent_Identity=31.651376146789, Blast_Score=87, Evalue=8e-18,
Organism=Drosophila melanogaster, GI17137682, Length=209, Percent_Identity=33.4928229665072, Blast_Score=99, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907 [H]

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3 [H]

EC number: =3.1.26.3 [H]

Molecular weight: Translated: 23412; Mature: 23412

Theoretical pI: Translated: 8.21; Mature: 8.21

Prosite motif: PS50137 DS_RBD ; PS00517 RNASE_3_1 ; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKFNLTLPPGLLRTAFVHKSFSFENGACQNNERLEFLGDAVLGLVVSHYLFETCPEYTE
CCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCC
GQLSAARSYIVSGTSIAQIAKELNLGQFMLLGKGEKLAGGMDKTSLLADLLESLIGAVMV
HHHHHHHHHHHCCHHHHHHHHHCCCCCEEEEECCCHHCCCCCHHHHHHHHHHHHHHHHHH
DQGFESARDFVLALVGEKLRQVGEFSVDDPKTKLQKLTRTQLVYEVVTEGPPHSRTFKAS
HCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEE
VIVNEKRFFGQGSSKKQAQVAAAMSALASLENKSS
EEEECHHHCCCCCCHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MRKFNLTLPPGLLRTAFVHKSFSFENGACQNNERLEFLGDAVLGLVVSHYLFETCPEYTE
CCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCC
GQLSAARSYIVSGTSIAQIAKELNLGQFMLLGKGEKLAGGMDKTSLLADLLESLIGAVMV
HHHHHHHHHHHCCHHHHHHHHHCCCCCEEEEECCCHHCCCCCHHHHHHHHHHHHHHHHHH
DQGFESARDFVLALVGEKLRQVGEFSVDDPKTKLQKLTRTQLVYEVVTEGPPHSRTFKAS
HCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEE
VIVNEKRFFGQGSSKKQAQVAAAMSALASLENKSS
EEEECHHHCCCCCCHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12606174 [H]