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The map label for this gene is coaD

Identifier: 28572356

GI number: 28572356

Start: 234982

End: 235512

Strand: Direct

Name: coaD

Synonym: TW196

Alternate gene names: 28572356

Gene position: 234982-235512 (Clockwise)

Preceding gene: 28572355

Following gene: 28572358

Centisome position: 25.38

GC content: 47.46

Gene sequence:

>531_bases
ATGAGTAACAGGATAGCTGTTGTTCCGGGTACGTTTGACCCCGTTACAAGAGGACACATGGATATCCTTACCAGGACTTC
AAGAATTTTTAACACACTCTACGTCCTGGTTGCAAATAATCCGGATAAAACCCCACTTTTACCTATGCATGACCGAGTTG
ATCTGGTTGGACAGGCTTTGGAAGAATACGGATTTCCCCGCAGTGAGCCAAAATGTGACAGTGAATCAGACCGTAATGGG
CCAATAGTCAAGATTCATCGCTTTGAAAAAGGCCTGTTGGTTGATTGCTGTAAACAGCTTGGCGCGACCGTTATTGTAAG
GGGACTTATTTCGGCCGATGCACACCGAGAGGCGTCGATGGCATATGCCAATCGGAATATGAGTGGCATTGAGACTGTGT
TTATTTTACCTGACCCCCCACTGAGCGTTGTTTCAAGCAGCATGGTCAGGCAGCTTATCGCACTTGGTGGTGATATATCC
CCGTATGTACCGGCTTGTGTAACGCGTTTTTTTGGGACGCACAGCGGTTAG

Upstream 100 bases:

>100_bases
TTTATCCTGTACTATCATCTCCGCCGACCACCTGATTTTAGAGTCAGTTATCTAGCTGTGTGCGATTTTATATCTAGATG
TTCTATCCTGATACTCTGCG

Downstream 100 bases:

>100_bases
GGCAACCCTTAGATTCATTCTGCAGTTATGAGTTGTACCTGTCTAGGGGTTTTATTGCCGTTTAACCCCACTCTCGGATG
ATCTTGCAATATAAGTAATT

Product: phosphopantetheine adenylyltransferase

Products: NA

Alternate protein names: Dephospho-CoA pyrophosphorylase; Pantetheine-phosphate adenylyltransferase; PPAT

Number of amino acids: Translated: 176; Mature: 175

Protein sequence:

>176_residues
MSNRIAVVPGTFDPVTRGHMDILTRTSRIFNTLYVLVANNPDKTPLLPMHDRVDLVGQALEEYGFPRSEPKCDSESDRNG
PIVKIHRFEKGLLVDCCKQLGATVIVRGLISADAHREASMAYANRNMSGIETVFILPDPPLSVVSSSMVRQLIALGGDIS
PYVPACVTRFFGTHSG

Sequences:

>Translated_176_residues
MSNRIAVVPGTFDPVTRGHMDILTRTSRIFNTLYVLVANNPDKTPLLPMHDRVDLVGQALEEYGFPRSEPKCDSESDRNG
PIVKIHRFEKGLLVDCCKQLGATVIVRGLISADAHREASMAYANRNMSGIETVFILPDPPLSVVSSSMVRQLIALGGDIS
PYVPACVTRFFGTHSG
>Mature_175_residues
SNRIAVVPGTFDPVTRGHMDILTRTSRIFNTLYVLVANNPDKTPLLPMHDRVDLVGQALEEYGFPRSEPKCDSESDRNGP
IVKIHRFEKGLLVDCCKQLGATVIVRGLISADAHREASMAYANRNMSGIETVFILPDPPLSVVSSSMVRQLIALGGDISP
YVPACVTRFFGTHSG

Specific function: Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate

COG id: COG0669

COG function: function code H; Phosphopantetheine adenylyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the bacterial CoaD family

Homologues:

Organism=Escherichia coli, GI1790065, Length=164, Percent_Identity=32.9268292682927, Blast_Score=98, Evalue=3e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COAD_TROW8 (Q83I84)

Other databases:

- EMBL:   BX251410
- RefSeq:   NP_789136.1
- ProteinModelPortal:   Q83I84
- SMR:   Q83I84
- STRING:   Q83I84
- GeneID:   1064488
- GenomeReviews:   BX072543_GR
- KEGG:   tws:TW196
- eggNOG:   COG0669
- HOGENOM:   HBG288308
- OMA:   VHPVVAD
- ProtClustDB:   CLSK912544
- BioCyc:   TWHI218496:TW0181-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00151
- InterPro:   IPR004821
- InterPro:   IPR004820
- InterPro:   IPR001980
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PRINTS:   PR01020
- TIGRFAMs:   TIGR01510
- TIGRFAMs:   TIGR00125

Pfam domain/function: PF01467 CTP_transf_2

EC number: =2.7.7.3

Molecular weight: Translated: 19254; Mature: 19123

Theoretical pI: Translated: 7.50; Mature: 7.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNRIAVVPGTFDPVTRGHMDILTRTSRIFNTLYVLVANNPDKTPLLPMHDRVDLVGQAL
CCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHEEEEEECCCCCCCCCCCHHHHHHHHHHH
EEYGFPRSEPKCDSESDRNGPIVKIHRFEKGLLVDCCKQLGATVIVRGLISADAHREASM
HHCCCCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
AYANRNMSGIETVFILPDPPLSVVSSSMVRQLIALGGDISPYVPACVTRFFGTHSG
HHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SNRIAVVPGTFDPVTRGHMDILTRTSRIFNTLYVLVANNPDKTPLLPMHDRVDLVGQAL
CCCEEEECCCCCCCCCCHHHHHHHHHHHHHHEEEEEECCCCCCCCCCCHHHHHHHHHHH
EEYGFPRSEPKCDSESDRNGPIVKIHRFEKGLLVDCCKQLGATVIVRGLISADAHREASM
HHCCCCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
AYANRNMSGIETVFILPDPPLSVVSSSMVRQLIALGGDISPYVPACVTRFFGTHSG
HHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12606174