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The map label for this gene is hpt [H]

Identifier: 28572334

GI number: 28572334

Start: 213482

End: 213985

Strand: Direct

Name: hpt [H]

Synonym: TW172

Alternate gene names: 28572334

Gene position: 213482-213985 (Clockwise)

Preceding gene: 28572333

Following gene: 28572335

Centisome position: 23.06

GC content: 44.84

Gene sequence:

>504_bases
ATGAAGCCGCTTTTATCAGAAGCAGTAATCCATAGGAGACTTGCACAGCTCGCTTTGCAGATAGACGAGGATTATCGTGG
AACCTCGATTGTTCTGCTCGGGGTTTTAAAGGGTTCGATTATGCTTATGGCTGATCTAAGCAGGCTTTTGAGCAGTGATC
TCAGAATAGAGTGGGTTACATTATCATCCTACGGAAATGACACTGTTAGCAGCGGTAGTATACGGATTGTCCATGATTTA
GACGCCGACATAAGGGATAGGCATGTCCTTATTATTGAGGATATAGTTGATAGTGGTCTAACTCTCGGGTGGCTTTTGGC
CAAGATGCGCGAGAGACGTCCTGCAAGTATCGAGGCATGTGTTCTGTTACGCAAACCCCATGCGAGGGGCACTGACGTCA
GATACCTGGGTTTTGATATTCCAGATGAGTTTGTTATTGGTTATGGTATGGATTACGCCGAGAAATATCGTAATCTGAAG
TCAGTGTACGTTTTGGAGCAATAA

Upstream 100 bases:

>100_bases
TCTTGTGACATAAAGCATGTAAACCTGCCACGGTTAATTACGGCACAGAGGGTTGGTAATTACATTTACATGCACACCTT
ACGCGGTAAACTGTAAGCAT

Downstream 100 bases:

>100_bases
TCTTGTCGAAGATAACAAAATCCCCTGTGCTCTATATCGTGCTCCTTGTTGTGGGGGTTTGGGTCGCTGTCAATCTGTTT
CTCACAAATGCATATCAATC

Product: hypoxanthine phosphoribosyltransferase

Products: NA

Alternate protein names: HGPRT; HGPRTase [H]

Number of amino acids: Translated: 167; Mature: 167

Protein sequence:

>167_residues
MKPLLSEAVIHRRLAQLALQIDEDYRGTSIVLLGVLKGSIMLMADLSRLLSSDLRIEWVTLSSYGNDTVSSGSIRIVHDL
DADIRDRHVLIIEDIVDSGLTLGWLLAKMRERRPASIEACVLLRKPHARGTDVRYLGFDIPDEFVIGYGMDYAEKYRNLK
SVYVLEQ

Sequences:

>Translated_167_residues
MKPLLSEAVIHRRLAQLALQIDEDYRGTSIVLLGVLKGSIMLMADLSRLLSSDLRIEWVTLSSYGNDTVSSGSIRIVHDL
DADIRDRHVLIIEDIVDSGLTLGWLLAKMRERRPASIEACVLLRKPHARGTDVRYLGFDIPDEFVIGYGMDYAEKYRNLK
SVYVLEQ
>Mature_167_residues
MKPLLSEAVIHRRLAQLALQIDEDYRGTSIVLLGVLKGSIMLMADLSRLLSSDLRIEWVTLSSYGNDTVSSGSIRIVHDL
DADIRDRHVLIIEDIVDSGLTLGWLLAKMRERRPASIEACVLLRKPHARGTDVRYLGFDIPDEFVIGYGMDYAEKYRNLK
SVYVLEQ

Specific function: This Enzyme Acts Exclusively On Hypoxanthine; It Does Not Act On Guanine (By Similarity). [C]

COG id: COG0634

COG function: function code F; Hypoxanthine-guanine phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4504483, Length=176, Percent_Identity=33.5227272727273, Blast_Score=97, Evalue=6e-21,
Organism=Homo sapiens, GI9910262, Length=176, Percent_Identity=32.9545454545455, Blast_Score=90, Evalue=1e-18,
Organism=Escherichia coli, GI87081689, Length=160, Percent_Identity=45.625, Blast_Score=143, Evalue=6e-36,
Organism=Caenorhabditis elegans, GI17510817, Length=173, Percent_Identity=31.7919075144509, Blast_Score=85, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005904
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.8 [H]

Molecular weight: Translated: 18901; Mature: 18901

Theoretical pI: Translated: 6.12; Mature: 6.12

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPLLSEAVIHRRLAQLALQIDEDYRGTSIVLLGVLKGSIMLMADLSRLLSSDLRIEWVT
CCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEHHCHHHHHHHHHHHHCCCCEEEEEE
LSSYGNDTVSSGSIRIVHDLDADIRDRHVLIIEDIVDSGLTLGWLLAKMRERRPASIEAC
EECCCCCCCCCCCEEEEEECCCCCCCCEEEEEEHHHCCCCHHHHHHHHHHHCCCCCCEEE
VLLRKPHARGTDVRYLGFDIPDEFVIGYGMDYAEKYRNLKSVYVLEQ
EEEECCCCCCCCEEEEECCCCCHHEEECCCHHHHHHCCCHHEEEECC
>Mature Secondary Structure
MKPLLSEAVIHRRLAQLALQIDEDYRGTSIVLLGVLKGSIMLMADLSRLLSSDLRIEWVT
CCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEHHCHHHHHHHHHHHHCCCCEEEEEE
LSSYGNDTVSSGSIRIVHDLDADIRDRHVLIIEDIVDSGLTLGWLLAKMRERRPASIEAC
EECCCCCCCCCCCEEEEEECCCCCCCCEEEEEEHHHCCCCHHHHHHHHHHHCCCCCCEEE
VLLRKPHARGTDVRYLGFDIPDEFVIGYGMDYAEKYRNLKSVYVLEQ
EEEECCCCCCCCEEEEECCCCCHHEEECCCHHHHHHCCCHHEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12663927 [H]