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The map label for this gene is clpC [H]

Identifier: 28572245

GI number: 28572245

Start: 67380

End: 69902

Strand: Direct

Name: clpC [H]

Synonym: TW075

Alternate gene names: 28572245

Gene position: 67380-69902 (Clockwise)

Preceding gene: 28572244

Following gene: 28572246

Centisome position: 7.28

GC content: 49.46

Gene sequence:

>2523_bases
TTGGGTGAGGATATGTTTGAAAGGTTTACAGATAAAGCCCGCCGGGTTATAGTACTGGCGCAGGAGGAAGCGCGCACGCT
TAGCCACAATTACATTGGCACCGAGCATGTTCTTCTTGGCCTTATTAGCGAGGGTGATGGTATTGCCGCCCAGGCGCTTG
AGAGTCTTGATATTACCCTTGAGCGTGCGCGCGAGGGCGTGGCGGAACTAATAGGTCGGGGTCAGAACGCAACATCCGGG
CATATCCCGTTTACGCCTCGTGCGAAAAAGGTTCTAGAGCTTTCGCTCCGCGAGGCTCTTCAGCTTGGTCACAATTACAT
TGGCACTGAGCATATACTCCTTGGGATTCTTCATGAGGGTGAGGGTATCGCTGCACAGGTACTGGTGAATATGGGGGCTG
AACTGCCTGCAATTCAGCAGAGGGTTATGCACCTTTTAGAAGATGGAAGAGAACAAGAGCCCGTTTCGGTTGGCCCATCT
GAGTCAGGAAAAATTTCAGGCAGTCAGATACTTGATCAATTCGGGCGACACCTCACGCGTGCCGCGAAAGAGGGCAAGTT
GGACCCAGTTATTGGCCGTGAGAAGGAAATAGAGCGCGTGATGCAGGTGCTCTCGCGCAGAACGAAGAATAACCCAATCC
TAATCGGTGAGCCCGGTGTTGGAAAAACTGCTGTCGTCGAGGCTTTGGCTCAAGCGATAGTCAATGGTGATGTTCCGGTC
AATTTGCGCAACAAGCAAGTGTACTCGCTTGATTTGGGTTCTCTTATCGCTGGTAGCAGGTACAGGGGTGATTTTGAGGA
ACGCCTCAAGAAGGTTACGAAGGAAATACGTTCACGAGGGGACATTATCGTTTTTATAGATGAGATCCATTCCCTTGTTG
GGGCCGGGTCTGCTGAGGGTGCTATCGATGCAGCAACTATCCTGAAACCCCTTCTGGCCCGTGGTGAGCTTCAAACAATT
GGCGCAACAACCCTTGATGAGTATCGCAAGAATATTGAAAAGGATTCTGCTCTGGAAAGGCGCTTCCAGCCCGTCAACGT
GTCAGAGCCCAGCATACCAATGTGTATCCAGATACTGAAAGGGTTGCGTGATCGCTATGAGGCCCATCATAAGGTGAAAA
TCACCGATGAGGCAATTTATGCTGCAGTTACCCTTTCGAGTCGTTATATAAATGATAGGTTTTTACCAGACAAAGCCATA
GACTTGATTGATGAGGCCGGCGCCAGGCTGAGACTGTCTGTTTTGTCTAATCCGAGCCAACTGCGCGCTGTCGAGAAAAA
AATTCTCGCTGTTGTTGCCAGGAAAGACAAGGCGGTTGAAAAACAGGATTTCGATAAAGTTGGCGAGCTAAAACGGAAAG
AAAAGGCCCTAAGAGCTGAGTTACGGAAGATAAAGCGTGACTATGAGAATGGCAATATTGCAAGTGCCGGCACTGTAGAT
GAGGGCTTGATCGCTGAAGTGCTTGCGTCAGCGACTGGGGTTCCCGTTTTTCGACTAACCGAAGACGAGTCCGTGCGTCT
GATGATGATGGAAAGAAGTTTGCATCAGCGTGTGATTGGTCAGGACGAGGCGATTTCGTCTCTGTCAAGGGCGATGCGCC
GAACGCGCGCTGGATTGAAGGATCCAAACCGACCTTCCGGATCGTTTATTTTTGCCGGCCCGACCGGTGTCGGAAAAACC
GAGCTGGCCAAGGCTCTTGCCGAGTTTCTGTTTGATAATGAAGACGCCCTTGTAAGTCTTGACATGTCAGAGTACGGAGA
GCGGCACACTGTATCCAGGCTTTTTGGAGCCCCGCCCGGATTTGTTGGTTTCGAAGAAGGCGGACAACTGACAGAGAAAA
TACGCCGCAAGCCCTTTAGCGTTGTTTTATTTGATGAAATTGAAAAAGCCCATCCGGATGTTTTTAACTCGCTTTTGCAG
ATTTTGGAAGAAGGTCGTCTGAGTGACGCCCAGGGCCGTATGGTTGATTTTAGAAATACGATAATTGTTATGACAACTAA
CCTTGGCAGTCGCGATATAGCATCAGGCCCTGTCGGGTTTCAGTCGGGTGATGGTAGTTTTTTGGCCTATGAGGCTATGA
AGGCCAAGGTTAATGAGGAACTGAGGCGCAGTTTAAAGCCGGAGTTTCTCAATCGTATTGATGAAGTTATAGTTTTCCCG
CCCCTCAATAGAGACGAGCTTCTGCAAATACTGAAGATTTTTATCAAAAAGCTCGATGACCGTTTGCGCGATAGGACCAT
GCGTCTTTCTGTGACAGATGCTGCCCTAGAACAGTTGGTGCAAATTGGCTACGAACCCACCATGGGAGCAAGGCCCTTGC
GCCGAGCGGTTCAGCGCGAGGTTGAGGATAGGATTTCTGAAAAGATTCTGCTGGGCGAGATAAAGCCAAATCAAGAGATA
GAAATGGACTTTGTGAATGATAATTTCACGATTGTATCAAGGGATATGGATTACCCCCTATCTCCTCTTGTGCCGTCAGT
GACAACGGGTCTCGTTACTCCGGATCTTGCAAGTCACGTCTAG

Upstream 100 bases:

>100_bases
GGACCGCTTGAAAGATAATCTAGCTAGACTTACATCCGCCCTGCAATAGGCACTTATTGAAGAAAAATTTAGGATTCACT
CTCGCTGTTTTCTAGTATCC

Downstream 100 bases:

>100_bases
TTTCTGACATAATGCTCGCGATTTTTTGCGATGATCTGTTTTTCTTTAGAGCGCCTCGCGTGAAAAGCCTCACCGCGATG
CTTCTTGCCGCAATACTTTC

Product: Clp-family ATP-binding protease/regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 840; Mature: 839

Protein sequence:

>840_residues
MGEDMFERFTDKARRVIVLAQEEARTLSHNYIGTEHVLLGLISEGDGIAAQALESLDITLERAREGVAELIGRGQNATSG
HIPFTPRAKKVLELSLREALQLGHNYIGTEHILLGILHEGEGIAAQVLVNMGAELPAIQQRVMHLLEDGREQEPVSVGPS
ESGKISGSQILDQFGRHLTRAAKEGKLDPVIGREKEIERVMQVLSRRTKNNPILIGEPGVGKTAVVEALAQAIVNGDVPV
NLRNKQVYSLDLGSLIAGSRYRGDFEERLKKVTKEIRSRGDIIVFIDEIHSLVGAGSAEGAIDAATILKPLLARGELQTI
GATTLDEYRKNIEKDSALERRFQPVNVSEPSIPMCIQILKGLRDRYEAHHKVKITDEAIYAAVTLSSRYINDRFLPDKAI
DLIDEAGARLRLSVLSNPSQLRAVEKKILAVVARKDKAVEKQDFDKVGELKRKEKALRAELRKIKRDYENGNIASAGTVD
EGLIAEVLASATGVPVFRLTEDESVRLMMMERSLHQRVIGQDEAISSLSRAMRRTRAGLKDPNRPSGSFIFAGPTGVGKT
ELAKALAEFLFDNEDALVSLDMSEYGERHTVSRLFGAPPGFVGFEEGGQLTEKIRRKPFSVVLFDEIEKAHPDVFNSLLQ
ILEEGRLSDAQGRMVDFRNTIIVMTTNLGSRDIASGPVGFQSGDGSFLAYEAMKAKVNEELRRSLKPEFLNRIDEVIVFP
PLNRDELLQILKIFIKKLDDRLRDRTMRLSVTDAALEQLVQIGYEPTMGARPLRRAVQREVEDRISEKILLGEIKPNQEI
EMDFVNDNFTIVSRDMDYPLSPLVPSVTTGLVTPDLASHV

Sequences:

>Translated_840_residues
MGEDMFERFTDKARRVIVLAQEEARTLSHNYIGTEHVLLGLISEGDGIAAQALESLDITLERAREGVAELIGRGQNATSG
HIPFTPRAKKVLELSLREALQLGHNYIGTEHILLGILHEGEGIAAQVLVNMGAELPAIQQRVMHLLEDGREQEPVSVGPS
ESGKISGSQILDQFGRHLTRAAKEGKLDPVIGREKEIERVMQVLSRRTKNNPILIGEPGVGKTAVVEALAQAIVNGDVPV
NLRNKQVYSLDLGSLIAGSRYRGDFEERLKKVTKEIRSRGDIIVFIDEIHSLVGAGSAEGAIDAATILKPLLARGELQTI
GATTLDEYRKNIEKDSALERRFQPVNVSEPSIPMCIQILKGLRDRYEAHHKVKITDEAIYAAVTLSSRYINDRFLPDKAI
DLIDEAGARLRLSVLSNPSQLRAVEKKILAVVARKDKAVEKQDFDKVGELKRKEKALRAELRKIKRDYENGNIASAGTVD
EGLIAEVLASATGVPVFRLTEDESVRLMMMERSLHQRVIGQDEAISSLSRAMRRTRAGLKDPNRPSGSFIFAGPTGVGKT
ELAKALAEFLFDNEDALVSLDMSEYGERHTVSRLFGAPPGFVGFEEGGQLTEKIRRKPFSVVLFDEIEKAHPDVFNSLLQ
ILEEGRLSDAQGRMVDFRNTIIVMTTNLGSRDIASGPVGFQSGDGSFLAYEAMKAKVNEELRRSLKPEFLNRIDEVIVFP
PLNRDELLQILKIFIKKLDDRLRDRTMRLSVTDAALEQLVQIGYEPTMGARPLRRAVQREVEDRISEKILLGEIKPNQEI
EMDFVNDNFTIVSRDMDYPLSPLVPSVTTGLVTPDLASHV
>Mature_839_residues
GEDMFERFTDKARRVIVLAQEEARTLSHNYIGTEHVLLGLISEGDGIAAQALESLDITLERAREGVAELIGRGQNATSGH
IPFTPRAKKVLELSLREALQLGHNYIGTEHILLGILHEGEGIAAQVLVNMGAELPAIQQRVMHLLEDGREQEPVSVGPSE
SGKISGSQILDQFGRHLTRAAKEGKLDPVIGREKEIERVMQVLSRRTKNNPILIGEPGVGKTAVVEALAQAIVNGDVPVN
LRNKQVYSLDLGSLIAGSRYRGDFEERLKKVTKEIRSRGDIIVFIDEIHSLVGAGSAEGAIDAATILKPLLARGELQTIG
ATTLDEYRKNIEKDSALERRFQPVNVSEPSIPMCIQILKGLRDRYEAHHKVKITDEAIYAAVTLSSRYINDRFLPDKAID
LIDEAGARLRLSVLSNPSQLRAVEKKILAVVARKDKAVEKQDFDKVGELKRKEKALRAELRKIKRDYENGNIASAGTVDE
GLIAEVLASATGVPVFRLTEDESVRLMMMERSLHQRVIGQDEAISSLSRAMRRTRAGLKDPNRPSGSFIFAGPTGVGKTE
LAKALAEFLFDNEDALVSLDMSEYGERHTVSRLFGAPPGFVGFEEGGQLTEKIRRKPFSVVLFDEIEKAHPDVFNSLLQI
LEEGRLSDAQGRMVDFRNTIIVMTTNLGSRDIASGPVGFQSGDGSFLAYEAMKAKVNEELRRSLKPEFLNRIDEVIVFPP
LNRDELLQILKIFIKKLDDRLRDRTMRLSVTDAALEQLVQIGYEPTMGARPLRRAVQREVEDRISEKILLGEIKPNQEIE
MDFVNDNFTIVSRDMDYPLSPLVPSVTTGLVTPDLASHV

Specific function: Part Of A Stress-Induced Multi-Chaperone System, It Is Involved In The Recovery Of The Cell From Heat-Induced Damage, In Cooperation With Dnak, Dnaj And Grpe. Acts Before Dnak, In The Processing Of Protein Aggregates. Protein Binding Stimulates The Atpase

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Homo sapiens, GI13540606, Length=298, Percent_Identity=34.8993288590604, Blast_Score=193, Evalue=5e-49,
Organism=Escherichia coli, GI1788943, Length=871, Percent_Identity=45.0057405281286, Blast_Score=700, Evalue=0.0,
Organism=Escherichia coli, GI1787109, Length=792, Percent_Identity=39.2676767676768, Blast_Score=526, Evalue=1e-150,
Organism=Saccharomyces cerevisiae, GI6320464, Length=706, Percent_Identity=48.0169971671388, Blast_Score=602, Evalue=1e-173,
Organism=Saccharomyces cerevisiae, GI6323002, Length=877, Percent_Identity=36.4880273660205, Blast_Score=523, Evalue=1e-149,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR018368
- InterPro:   IPR001270
- InterPro:   IPR019489
- InterPro:   IPR004176
- InterPro:   IPR023150
- InterPro:   IPR001943 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF02861 Clp_N; PF10431 ClpB_D2-small; PF02151 UVR [H]

EC number: NA

Molecular weight: Translated: 93146; Mature: 93015

Theoretical pI: Translated: 6.08; Mature: 6.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGEDMFERFTDKARRVIVLAQEEARTLSHNYIGTEHVLLGLISEGDGIAAQALESLDITL
CCHHHHHHHHHHCCEEEEEECHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHH
ERAREGVAELIGRGQNATSGHIPFTPRAKKVLELSLREALQLGHNYIGTEHILLGILHEG
HHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHCCHHHHHEEEEECC
EGIAAQVLVNMGAELPAIQQRVMHLLEDGREQEPVSVGPSESGKISGSQILDQFGRHLTR
CCHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
AAKEGKLDPVIGREKEIERVMQVLSRRTKNNPILIGEPGVGKTAVVEALAQAIVNGDVPV
HHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCE
NLRNKQVYSLDLGSLIAGSRYRGDFEERLKKVTKEIRSRGDIIVFIDEIHSLVGAGSAEG
EECCCEEEEECHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCEEEEHHHHHHHHCCCCCCC
AIDAATILKPLLARGELQTIGATTLDEYRKNIEKDSALERRFQPVNVSEPSIPMCIQILK
CHHHHHHHHHHHHCCCCHHCCCHHHHHHHHHCCHHHHHHHHCCCCCCCCCCHHHHHHHHH
GLRDRYEAHHKVKITDEAIYAAVTLSSRYINDRFLPDKAIDLIDEAGARLRLSVLSNPSQ
HHHHHHHCCCEEEEEHHHEEHHHHHHHHHCCCCCCCHHHHHHHHHCCCEEEEEECCCHHH
LRAVEKKILAVVARKDKAVEKQDFDKVGELKRKEKALRAELRKIKRDYENGNIASAGTVD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
EGLIAEVLASATGVPVFRLTEDESVRLMMMERSLHQRVIGQDEAISSLSRAMRRTRAGLK
HHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCC
DPNRPSGSFIFAGPTGVGKTELAKALAEFLFDNEDALVSLDMSEYGERHTVSRLFGAPPG
CCCCCCCCEEEECCCCCCHHHHHHHHHHHHHCCCCCEEEECHHHCCCHHHHHHHHCCCCC
FVGFEEGGQLTEKIRRKPFSVVLFDEIEKAHPDVFNSLLQILEEGRLSDAQGRMVDFRNT
CCCCCCCCHHHHHHHCCCCEEEEHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCEEEECCE
IIVMTTNLGSRDIASGPVGFQSGDGSFLAYEAMKAKVNEELRRSLKPEFLNRIDEVIVFP
EEEEEECCCCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHCCCHHHHHHHHHEEECC
PLNRDELLQILKIFIKKLDDRLRDRTMRLSVTDAALEQLVQIGYEPTMGARPLRRAVQRE
CCCHHHHHHHHHHHHHHHHHHHHHHHEEEEEHHHHHHHHHHCCCCCCCCCHHHHHHHHHH
VEDRISEKILLGEIKPNQEIEMDFVNDNFTIVSRDMDYPLSPLVPSVTTGLVTPDLASHV
HHHHHHHCEEEECCCCCCCEEEEEECCCEEEEECCCCCCCCCCCCHHHHCCCCCHHHHCC
>Mature Secondary Structure 
GEDMFERFTDKARRVIVLAQEEARTLSHNYIGTEHVLLGLISEGDGIAAQALESLDITL
CHHHHHHHHHHCCEEEEEECHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHH
ERAREGVAELIGRGQNATSGHIPFTPRAKKVLELSLREALQLGHNYIGTEHILLGILHEG
HHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHCCHHHHHEEEEECC
EGIAAQVLVNMGAELPAIQQRVMHLLEDGREQEPVSVGPSESGKISGSQILDQFGRHLTR
CCHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
AAKEGKLDPVIGREKEIERVMQVLSRRTKNNPILIGEPGVGKTAVVEALAQAIVNGDVPV
HHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCE
NLRNKQVYSLDLGSLIAGSRYRGDFEERLKKVTKEIRSRGDIIVFIDEIHSLVGAGSAEG
EECCCEEEEECHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCEEEEHHHHHHHHCCCCCCC
AIDAATILKPLLARGELQTIGATTLDEYRKNIEKDSALERRFQPVNVSEPSIPMCIQILK
CHHHHHHHHHHHHCCCCHHCCCHHHHHHHHHCCHHHHHHHHCCCCCCCCCCHHHHHHHHH
GLRDRYEAHHKVKITDEAIYAAVTLSSRYINDRFLPDKAIDLIDEAGARLRLSVLSNPSQ
HHHHHHHCCCEEEEEHHHEEHHHHHHHHHCCCCCCCHHHHHHHHHCCCEEEEEECCCHHH
LRAVEKKILAVVARKDKAVEKQDFDKVGELKRKEKALRAELRKIKRDYENGNIASAGTVD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
EGLIAEVLASATGVPVFRLTEDESVRLMMMERSLHQRVIGQDEAISSLSRAMRRTRAGLK
HHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCC
DPNRPSGSFIFAGPTGVGKTELAKALAEFLFDNEDALVSLDMSEYGERHTVSRLFGAPPG
CCCCCCCCEEEECCCCCCHHHHHHHHHHHHHCCCCCEEEECHHHCCCHHHHHHHHCCCCC
FVGFEEGGQLTEKIRRKPFSVVLFDEIEKAHPDVFNSLLQILEEGRLSDAQGRMVDFRNT
CCCCCCCCHHHHHHHCCCCEEEEHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCEEEECCE
IIVMTTNLGSRDIASGPVGFQSGDGSFLAYEAMKAKVNEELRRSLKPEFLNRIDEVIVFP
EEEEEECCCCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHCCCHHHHHHHHHEEECC
PLNRDELLQILKIFIKKLDDRLRDRTMRLSVTDAALEQLVQIGYEPTMGARPLRRAVQRE
CCCHHHHHHHHHHHHHHHHHHHHHHHEEEEEHHHHHHHHHHCCCCCCCCCHHHHHHHHHH
VEDRISEKILLGEIKPNQEIEMDFVNDNFTIVSRDMDYPLSPLVPSVTTGLVTPDLASHV
HHHHHHHCEEEECCCCCCCEEEEEECCCEEEEECCCCCCCCCCCCHHHHCCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Serine endopeptidases [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]