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The map label for this gene is hepT [H]

Identifier: 28572234

GI number: 28572234

Start: 54106

End: 55122

Strand: Direct

Name: hepT [H]

Synonym: TW064

Alternate gene names: 28572234

Gene position: 54106-55122 (Clockwise)

Preceding gene: 28572233

Following gene: 28572235

Centisome position: 5.84

GC content: 48.77

Gene sequence:

>1017_bases
ATGCTTGTGTCAGGTATTTTTCTGTCCGATATTCTTGATCCATCTGGCAGTCTGAGTGATGATATTTCTCCCGCTCTCGA
TAGGGTTGAAGATCTTCTGCTAGAAACCGTTGGTGATTGTCATGAAATAGTAAGCCATTTGCTTGTCAGTGGCGGCAAGC
GCGCCCGTCCGCTTTTGGTTTTGCTCACATCTTGTATGGGTTCTGGCATTAATGATGCTGTTATACGTGCTGCCGCGGGG
ATTGAGTTAATACACCTGGGCTCTTTGTATCACGATGATGTTATGGATAATGCGTATATTCGTCATGGATCGATCACCGC
ACATCGTCTATGGGGTAAGTCTGCGGCTATTCTTGCGGGTGATTTTTTATTCGCCAAGGCAGGTGTGCTCGGTCTTAACC
TTGATAAGCGTGCAATTGCGGTGCAAACTGAGGCATTTCAGAGAATGATATCGGGTCAGCTCAGTGAAACTTTGGGTATT
TCTGACAGTCTTGACCCTCTTGAGGCTTATATAGAAGTTTCGAGAGGGAAGACAGGTTCTTTAATCGCCGCATCCGCTCA
GGTTGGGGCGATTTTAGGTGATGCCAGCCTATCAACTCTTGAGCCCCTGCGGGATTTTGGAGAGAGCATAGGGGTTGCTT
TCCAGCTTGTTGACGATGTGATCGATCTTTCGGGTAAATCCGGCAAGACCCCTGGGAGTGACATACGCGCTGGTGTCATG
AGTTTGCCGATTCTGCTTTTGAGTAACGCCGCGAAAGATGACAGAGACTCTGCGGTTTTGCTTGAGGAAATAGAGCGCGT
GCGGCGGCATAGCGGCGCATGTGGGAGTGATGATTATTCGTCAGAGATGAACGCGGTTTTGGCGCATTTGCGTAAGCATG
ATGTGACCGCACGCACTCTGGAAATCGCGAGAACGTGGGGAGATAAGGCCAAACATGCGTTGAAAAAACTTCCTGAATGT
GCCCCTCGTGATGCACTTTTGGCGTTTGTCGAAACGGTTGTTTCTCGTGAGTTTTAG

Upstream 100 bases:

>100_bases
TTGAACAGTGTGGTTTTCAGAATACATCCTGGAAAAGGTTAAGCTTTGGGGCAGTTGCCTTGCATAGGGCGCTGCGTGGT
CCGGAGTAGCAAACCCGTAC

Downstream 100 bases:

>100_bases
AGAATAGAGGTAAGGGTTTTGGCGAGGATTGCGGTAGTAGGTGCAGGTCCAGCGGGGATATATTCTGCCAATCTTCTTCT
TGCCGATGAATCCGTTGAGC

Product: polyprenyl diphosphate synthase

Products: NA

Alternate protein names: HEPPP synthase subunit 2 [H]

Number of amino acids: Translated: 338; Mature: 338

Protein sequence:

>338_residues
MLVSGIFLSDILDPSGSLSDDISPALDRVEDLLLETVGDCHEIVSHLLVSGGKRARPLLVLLTSCMGSGINDAVIRAAAG
IELIHLGSLYHDDVMDNAYIRHGSITAHRLWGKSAAILAGDFLFAKAGVLGLNLDKRAIAVQTEAFQRMISGQLSETLGI
SDSLDPLEAYIEVSRGKTGSLIAASAQVGAILGDASLSTLEPLRDFGESIGVAFQLVDDVIDLSGKSGKTPGSDIRAGVM
SLPILLLSNAAKDDRDSAVLLEEIERVRRHSGACGSDDYSSEMNAVLAHLRKHDVTARTLEIARTWGDKAKHALKKLPEC
APRDALLAFVETVVSREF

Sequences:

>Translated_338_residues
MLVSGIFLSDILDPSGSLSDDISPALDRVEDLLLETVGDCHEIVSHLLVSGGKRARPLLVLLTSCMGSGINDAVIRAAAG
IELIHLGSLYHDDVMDNAYIRHGSITAHRLWGKSAAILAGDFLFAKAGVLGLNLDKRAIAVQTEAFQRMISGQLSETLGI
SDSLDPLEAYIEVSRGKTGSLIAASAQVGAILGDASLSTLEPLRDFGESIGVAFQLVDDVIDLSGKSGKTPGSDIRAGVM
SLPILLLSNAAKDDRDSAVLLEEIERVRRHSGACGSDDYSSEMNAVLAHLRKHDVTARTLEIARTWGDKAKHALKKLPEC
APRDALLAFVETVVSREF
>Mature_338_residues
MLVSGIFLSDILDPSGSLSDDISPALDRVEDLLLETVGDCHEIVSHLLVSGGKRARPLLVLLTSCMGSGINDAVIRAAAG
IELIHLGSLYHDDVMDNAYIRHGSITAHRLWGKSAAILAGDFLFAKAGVLGLNLDKRAIAVQTEAFQRMISGQLSETLGI
SDSLDPLEAYIEVSRGKTGSLIAASAQVGAILGDASLSTLEPLRDFGESIGVAFQLVDDVIDLSGKSGKTPGSDIRAGVM
SLPILLLSNAAKDDRDSAVLLEEIERVRRHSGACGSDDYSSEMNAVLAHLRKHDVTARTLEIARTWGDKAKHALKKLPEC
APRDALLAFVETVVSREF

Specific function: Supplies heptaprenyl diphosphate, the precursor for the side chain of the isoprenoid quinone menaquinone-7 (MQ-7) [H]

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=339, Percent_Identity=26.8436578171091, Blast_Score=112, Evalue=6e-25,
Organism=Escherichia coli, GI1789578, Length=304, Percent_Identity=28.9473684210526, Blast_Score=125, Evalue=3e-30,
Organism=Escherichia coli, GI1786623, Length=235, Percent_Identity=35.3191489361702, Blast_Score=87, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17505681, Length=265, Percent_Identity=30.5660377358491, Blast_Score=109, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6319475, Length=319, Percent_Identity=27.2727272727273, Blast_Score=97, Evalue=4e-21,
Organism=Drosophila melanogaster, GI24651612, Length=252, Percent_Identity=26.1904761904762, Blast_Score=92, Evalue=4e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014119
- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.30 [H]

Molecular weight: Translated: 35989; Mature: 35989

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLVSGIFLSDILDPSGSLSDDISPALDRVEDLLLETVGDCHEIVSHLLVSGGKRARPLLV
CCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
LLTSCMGSGINDAVIRAAAGIELIHLGSLYHDDVMDNAYIRHGSITAHRLWGKSAAILAG
HHHHHHCCCCCHHHHHHHCCEEEEEECCHHHHHHHCCCEEECCCCCHHHHCCCCHHHHHH
DFLFAKAGVLGLNLDKRAIAVQTEAFQRMISGQLSETLGISDSLDPLEAYIEVSRGKTGS
HHHHHHCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCC
LIAASAQVGAILGDASLSTLEPLRDFGESIGVAFQLVDDVIDLSGKSGKTPGSDIRAGVM
EEEECHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHH
SLPILLLSNAAKDDRDSAVLLEEIERVRRHSGACGSDDYSSEMNAVLAHLRKHDVTARTL
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCHHHHH
EIARTWGDKAKHALKKLPECAPRDALLAFVETVVSREF
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLVSGIFLSDILDPSGSLSDDISPALDRVEDLLLETVGDCHEIVSHLLVSGGKRARPLLV
CCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
LLTSCMGSGINDAVIRAAAGIELIHLGSLYHDDVMDNAYIRHGSITAHRLWGKSAAILAG
HHHHHHCCCCCHHHHHHHCCEEEEEECCHHHHHHHCCCEEECCCCCHHHHCCCCHHHHHH
DFLFAKAGVLGLNLDKRAIAVQTEAFQRMISGQLSETLGISDSLDPLEAYIEVSRGKTGS
HHHHHHCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCC
LIAASAQVGAILGDASLSTLEPLRDFGESIGVAFQLVDDVIDLSGKSGKTPGSDIRAGVM
EEEECHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHH
SLPILLLSNAAKDDRDSAVLLEEIERVRRHSGACGSDDYSSEMNAVLAHLRKHDVTARTL
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCHHHHH
EIARTWGDKAKHALKKLPECAPRDALLAFVETVVSREF
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7629164 [H]