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The map label for this gene is rmlC [H]

Identifier: 28572208

GI number: 28572208

Start: 31892

End: 32515

Strand: Direct

Name: rmlC [H]

Synonym: TW035

Alternate gene names: 28572208

Gene position: 31892-32515 (Clockwise)

Preceding gene: 28572204

Following gene: 28572209

Centisome position: 3.44

GC content: 50.16

Gene sequence:

>624_bases
GTGGAATTACGTAATCTTAAAGTTAACGGCTGCCTCGAGGTTACCCCAGAGGTTCATGTGGACTCCAGGGGTTCATTCTC
TGAGGTGTACCGTTTTGATGTTTTGGAGAAAGAGATTGGGTATCCGCTCCGGGTTGCTCAGGTAAATCGTTCTTTTTCCA
AGAAGGCTGTTCTGCGAGGGCTGCATTACTCTCTTGCGCCGCACTCTCAGGCAAAGTACGTTATGTGTGCGAATGGCGCA
GTGTTAGATTTTGTGTTTGACCTTCGCTTGGGGTCACCGAGTTTCGGGGTGTGGGACGCGGTCCTGCTCGACTCTGTAGG
TTGTAGGGCTGTTTACATCCCAGAAGGGGTTGGTCACGCGTTTATTGCGTTATCCAAGACTGCCACTGTGAACTACTTGT
GCAGCGCAACCTACGATCCGGAGCGAGAGAAGAGTATTAATCCGCTCGATAAAAATCTCAATCTAGAATACCCTTTCACT
ACTCCTGAAATAGTGTTATCCGAGAGGGATGCTGCTGCCCCGACTTTACCTGAAGCGCAAAAGGGTGGTTTCCTGCCAAA
ATGGGATGAATGCCGGTGGGATGAATGCCGGGCAACACCCGAGACACACGGAAACATTCGATAA

Upstream 100 bases:

>100_bases
TAACTAAAGCACCGTCAAACACCGGGCAAAACAGTTCATCCGATTTTATTCCGCTCACTAGTTGATTTTATCGGCAGCGC
TTCTGTTATAGACTTGTCGA

Downstream 100 bases:

>100_bases
ATACCTTGGGCCATTCTAGCCAAGGCCGGGCCAAGTATGTTTTTAAGGAGATAGCTTGAAGGGTATTATCCTAGCTGGTG
GAACCGGATCAAGGCTCTGG

Product: epimerase

Products: NA

Alternate protein names: Thymidine diphospho-4-keto-rhamnose 3,5-epimerase; dTDP-4-keto-6-deoxyglucose 3,5-epimerase; dTDP-6-deoxy-D-xylo-4-hexulose 3,5-epimerase; dTDP-L-rhamnose synthase [H]

Number of amino acids: Translated: 207; Mature: 207

Protein sequence:

>207_residues
MELRNLKVNGCLEVTPEVHVDSRGSFSEVYRFDVLEKEIGYPLRVAQVNRSFSKKAVLRGLHYSLAPHSQAKYVMCANGA
VLDFVFDLRLGSPSFGVWDAVLLDSVGCRAVYIPEGVGHAFIALSKTATVNYLCSATYDPEREKSINPLDKNLNLEYPFT
TPEIVLSERDAAAPTLPEAQKGGFLPKWDECRWDECRATPETHGNIR

Sequences:

>Translated_207_residues
MELRNLKVNGCLEVTPEVHVDSRGSFSEVYRFDVLEKEIGYPLRVAQVNRSFSKKAVLRGLHYSLAPHSQAKYVMCANGA
VLDFVFDLRLGSPSFGVWDAVLLDSVGCRAVYIPEGVGHAFIALSKTATVNYLCSATYDPEREKSINPLDKNLNLEYPFT
TPEIVLSERDAAAPTLPEAQKGGFLPKWDECRWDECRATPETHGNIR
>Mature_207_residues
MELRNLKVNGCLEVTPEVHVDSRGSFSEVYRFDVLEKEIGYPLRVAQVNRSFSKKAVLRGLHYSLAPHSQAKYVMCANGA
VLDFVFDLRLGSPSFGVWDAVLLDSVGCRAVYIPEGVGHAFIALSKTATVNYLCSATYDPEREKSINPLDKNLNLEYPFT
TPEIVLSERDAAAPTLPEAQKGGFLPKWDECRWDECRATPETHGNIR

Specific function: Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose. Involved in the biosynthesis of the dTDP-L-rhamnose which is a component of the critical linker, D-N- acetylglucosamine-L-r

COG id: COG1898

COG function: function code M; dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family [H]

Homologues:

Organism=Escherichia coli, GI1788350, Length=178, Percent_Identity=35.9550561797753, Blast_Score=114, Evalue=5e-27,
Organism=Caenorhabditis elegans, GI17550412, Length=163, Percent_Identity=41.7177914110429, Blast_Score=119, Evalue=8e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR000888
- InterPro:   IPR014710
- ProDom:   PD001462 [H]

Pfam domain/function: PF00908 dTDP_sugar_isom [H]

EC number: =5.1.3.13 [H]

Molecular weight: Translated: 23109; Mature: 23109

Theoretical pI: Translated: 6.02; Mature: 6.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELRNLKVNGCLEVTPEVHVDSRGSFSEVYRFDVLEKEIGYPLRVAQVNRSFSKKAVLRG
CCCCCEEECCEEEECCCEEECCCCCHHHHHHHHHHHHHCCCCEEEEHHCCCHHHHHHHHH
LHYSLAPHSQAKYVMCANGAVLDFVFDLRLGSPSFGVWDAVLLDSVGCRAVYIPEGVGHA
HHHCCCCCCCCCEEEECCCCEEEEEEEEECCCCCCCHHHHHHHHCCCCEEEEECCCCCCE
FIALSKTATVNYLCSATYDPEREKSINPLDKNLNLEYPFTTPEIVLSERDAAAPTLPEAQ
EEEEECCCEEEEEEECCCCCHHHCCCCCCCCCCEEECCCCCHHEEEECCCCCCCCCCCHH
KGGFLPKWDECRWDECRATPETHGNIR
CCCCCCCCCCCCCHHHCCCCCCCCCCC
>Mature Secondary Structure
MELRNLKVNGCLEVTPEVHVDSRGSFSEVYRFDVLEKEIGYPLRVAQVNRSFSKKAVLRG
CCCCCEEECCEEEECCCEEECCCCCHHHHHHHHHHHHHCCCCEEEEHHCCCHHHHHHHHH
LHYSLAPHSQAKYVMCANGAVLDFVFDLRLGSPSFGVWDAVLLDSVGCRAVYIPEGVGHA
HHHCCCCCCCCCEEEECCCCEEEEEEEEECCCCCCCHHHHHHHHCCCCEEEEECCCCCCE
FIALSKTATVNYLCSATYDPEREKSINPLDKNLNLEYPFTTPEIVLSERDAAAPTLPEAQ
EEEEECCCEEEEEEECCCCCHHHCCCCCCCCCCEEECCCCCHHEEEECCCCCCCCCCCHH
KGGFLPKWDECRWDECRATPETHGNIR
CCCCCCCCCCCCCHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA