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The map label for this gene is purE [H]

Identifier: 28572204

GI number: 28572204

Start: 28311

End: 28853

Strand: Direct

Name: purE [H]

Synonym: TW029

Alternate gene names: 28572204

Gene position: 28311-28853 (Clockwise)

Preceding gene: 28572203

Following gene: 28572208

Centisome position: 3.06

GC content: 48.07

Gene sequence:

>543_bases
ATGACTGGTAAAAACATCAACGATGAAGGTAGCAAATGCCCCGCTCTTGTTTGGCTCCTAATGGGTTCTGATTCGGATTG
GCCCGTTATGTCAGGCGCCGCAGATATCCTGCAGCAGATGAATATATCTTTCAGAGTAAATGTTGTTTCTGCCCATCGCC
AGCCGGAAAAGATGATTAGCTGCGCCAAACGCGCTCGTGACATGGGATTCAAAGTTCTGATAGCTGCTGCCGGTGGAGCC
GCACACTTGCCCGGAATGCTTGCAAGTGTCACAACTCTCCCTGTTATCGGAGTTCCGGTTGGGCAGAAAAATCTGTCAGG
CCTCGATTCTCTTTTATCGATTGTTCAAATGCCCTCTGGTGTTCCGGTGGCCTGTGTCGGCATAGATTCTGCTAAAAACG
CTGCCCTTCTGGCCGCAAGGATTTTGGGGGTTCAATCAGCCGACATAGAAGCATCCAGAATAGCAGATAGTTTGTCTGCA
TATCAGCAAAGCCTGTTTGATCAATCAAATGAAAAGGACAGAATGATAAATGAGCCGAAATAG

Upstream 100 bases:

>100_bases
GAGAGAGTCACATGCGGTGTAAGCAATGCACGTCATGCGTCTCAATGCTGTATACCAATTGCAATATAAGTGACGGTGAT
ACAAATTTGGTGGTTCAAAT

Downstream 100 bases:

>100_bases
CAAGTTTTTCGCAAAAATTTTCGGGCACATCTTTGGCCTGTTATTTCCGGCATAAAGTTTTACCAGATCGCCTTACGATT
TATGTGTTAGAGTTGCGTAT

Product: phosphoribosylaminoimidazole carboxylase catalytic subunit PurE

Products: NA

Alternate protein names: N5-CAIR mutase; 5-(carboxyamino)imidazole ribonucleotide mutase [H]

Number of amino acids: Translated: 180; Mature: 179

Protein sequence:

>180_residues
MTGKNINDEGSKCPALVWLLMGSDSDWPVMSGAADILQQMNISFRVNVVSAHRQPEKMISCAKRARDMGFKVLIAAAGGA
AHLPGMLASVTTLPVIGVPVGQKNLSGLDSLLSIVQMPSGVPVACVGIDSAKNAALLAARILGVQSADIEASRIADSLSA
YQQSLFDQSNEKDRMINEPK

Sequences:

>Translated_180_residues
MTGKNINDEGSKCPALVWLLMGSDSDWPVMSGAADILQQMNISFRVNVVSAHRQPEKMISCAKRARDMGFKVLIAAAGGA
AHLPGMLASVTTLPVIGVPVGQKNLSGLDSLLSIVQMPSGVPVACVGIDSAKNAALLAARILGVQSADIEASRIADSLSA
YQQSLFDQSNEKDRMINEPK
>Mature_179_residues
TGKNINDEGSKCPALVWLLMGSDSDWPVMSGAADILQQMNISFRVNVVSAHRQPEKMISCAKRARDMGFKVLIAAAGGAA
HLPGMLASVTTLPVIGVPVGQKNLSGLDSLLSIVQMPSGVPVACVGIDSAKNAALLAARILGVQSADIEASRIADSLSAY
QQSLFDQSNEKDRMINEPK

Specific function: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) [H]

COG id: COG0041

COG function: function code F; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR carboxylase family [H]

Homologues:

Organism=Escherichia coli, GI1786734, Length=113, Percent_Identity=55.7522123893805, Blast_Score=132, Evalue=1e-32,
Organism=Saccharomyces cerevisiae, GI6324702, Length=128, Percent_Identity=59.375, Blast_Score=148, Evalue=4e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000031 [H]

Pfam domain/function: PF00731 AIRC [H]

EC number: =5.4.99.18 [H]

Molecular weight: Translated: 18947; Mature: 18816

Theoretical pI: Translated: 7.35; Mature: 7.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
6.7 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGKNINDEGSKCPALVWLLMGSDSDWPVMSGAADILQQMNISFRVNVVSAHRQPEKMIS
CCCCCCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHCCCEEEEEEEECCCCHHHHHH
CAKRARDMGFKVLIAAAGGAAHLPGMLASVTTLPVIGVPVGQKNLSGLDSLLSIVQMPSG
HHHHHHHCCEEEEEEECCCHHHHHHHHHHHHHCCEEECCCCCHHHHHHHHHHHHHHCCCC
VPVACVGIDSAKNAALLAARILGVQSADIEASRIADSLSAYQQSLFDQSNEKDRMINEPK
CCEEEEECCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure 
TGKNINDEGSKCPALVWLLMGSDSDWPVMSGAADILQQMNISFRVNVVSAHRQPEKMIS
CCCCCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHCCCEEEEEEEECCCCHHHHHH
CAKRARDMGFKVLIAAAGGAAHLPGMLASVTTLPVIGVPVGQKNLSGLDSLLSIVQMPSG
HHHHHHHCCEEEEEEECCCHHHHHHHHHHHHHCCEEECCCCCHHHHHHHHHHHHHHCCCC
VPVACVGIDSAKNAALLAARILGVQSADIEASRIADSLSAYQQSLFDQSNEKDRMINEPK
CCEEEEECCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9679194 [H]