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The map label for this gene is bccA [H]

Identifier: 28572195

GI number: 28572195

Start: 20441

End: 22216

Strand: Reverse

Name: bccA [H]

Synonym: TW020

Alternate gene names: 28572195

Gene position: 22216-20441 (Counterclockwise)

Preceding gene: 28572196

Following gene: 28572193

Centisome position: 2.4

GC content: 46.11

Gene sequence:

>1776_bases
ATGAAAAAAATAACCCGACTATTGATAGCGAACCGCGGCGAAATAGCGGTAAGGGTTATACGTGCCTGTCGCGATAAAGC
AATTGCCTCCATTGCAATATATTCGGATCAAGACAGGGATGCGGTACATACTCAACTTGCGGATGAAGCTTACTGCCTGG
AGGGTGAAACCGCTGCCGAAACCTACCTAAACATAGAGAAAATACTCGATATAGCAAAACTCAGTCGGGCAGATGGAATA
CATCCGGGATACGGCTTTCTTGCCGAAAGCCCCGAATTTGCTGAAGCGGTATCAAGTGCGGGTATTACATGGGTCGGTCC
ACGCGCAGGGGTCATAGCGCTCCTGGCAGACAAATTATCGGCACGAAAGATTGCAGAACAGGTTGGAGTGCCGGTCCCCC
CGGGTGGCGAACATGTGGTCTCTTGTGCATCTGAAGTGCATAATTTTGCAGACAAGTATGGACTTCCAATTGCAATAAAG
GCTGCGTATGGCGGTGGTGGTCTTGGCATGAAAGTTGTAAAACAAAAAAAGAATATAGATGAGCTTTTCGCATCAGCACA
ACGTGAAGCGCAGGCGGCATTCGGAAACAAGGAATGTTTCATAGAAAAATATATTGATAGACCACGACATGTAGAAACAC
AATGTCTGGCTGATCTGTTTGGCAATGTACAAGTCGTTTCCACGCGAGACTGTTCCGTGCAGCGCAGACACCAAAAACTA
ATTGAAGAAGCGCCCGCCTACACGCTGACAGATAAACAAGAAGAAACCCTTATCACCGCGAGCAAGGCTGTTATGAAAGC
AGCTGAATATTCAGGTGCAGGCACCTGCGAATTTCTCATTGACCAAGATGGGAAAATATTTTTTCTGGAAGTTAATGCAA
GGCTTCAAGTTGAACACCCAGTAACAGAAGAGATAACCGGAATTGATCTCGTTCTGGAGCAGATAAATATAGCTGAGGGA
AAGCTGCTCAAAAACCTTGAAACACCCGTATACAAAGGACATAGTCTGGAGTTTAGGATAAATGCTGAGGATGCAAACAG
TGGTTTTATGCCGAGACATGGGAAGGTTGTAAAATTCGAACCCCCTGGCGGTCTAGGAATTCGTATTGATAGTGGAATAA
AGGCGGGCGATACAATAGGGGCAGCCTTTGATTCTCTGCTGTGCAAACTCATTGTTACGGGAAACAATAGGGAATGCGCT
TTGGCACGTGCCAGGCGGGCTCTTGATGAGTTTGTAATTGACGGTGTGACAACGCTTATTCCGTTCCACAGGAATATTCT
CAATCAACCCGACTTCATAAATGGAGGGATGTATACGGGTTGGGTGGAAAACGAATATAGCAAGCTAGTTAACAAGCAAA
CTGATGCAAGTACGGTGCCGGATATACAAGACACTCTGTCTGTATCAAAAAATTTAAGAGAAATAATTGTTGAGGTAAAC
AGAAAACAAATTAGAGTGCGCCTGCCATCCCCCATAGGGGAATATCCCACAGAAAGGCAAAAACCTCCCGGCAGGCGGGT
AGGGCACAATTTCAGACAGAAAACACAGGAGAAGAACCCCGATTCTATTTTTTCGCCAATGCAAGCGGTTGTTGTGAAAG
TAAATGTTACGGAAGGCCAGTCCGTCAAAAAAGACGACCTGTTAATCGTGCTTGAGGCCATGAAAATGGAACAGCCGATA
GTGGCCCCACGAGATGGGGTAGTTGAAAAAATCAACGCGCACACAGGCGAGACAGTGCCAAGCGGTCACGAATTGTTACG
CTTGAAGAAGGTTTGA

Upstream 100 bases:

>100_bases
GTCGGGATACACCCCACCGGGTCTGTGCCTGGAATAGGCGGGATGCCAAGCAGCGCGGTAACACGCATTAGGTACACAAT
CAAGGCTGGCTACTAGATAT

Downstream 100 bases:

>100_bases
AAAAAAATACACACCCCATTGCAAGGCGCTGCCAGAGCGCTGCCCAGAATGTCAGATTTCGGAAGAGATCAGGGCGACGC
GCTGTCGGTTCTCACGTGCG

Product: acyl-CoA carboxylase complex A subunit

Products: NA

Alternate protein names: Biotin carboxylase; Biotin carboxyl carrier protein; BCCP [H]

Number of amino acids: Translated: 591; Mature: 591

Protein sequence:

>591_residues
MKKITRLLIANRGEIAVRVIRACRDKAIASIAIYSDQDRDAVHTQLADEAYCLEGETAAETYLNIEKILDIAKLSRADGI
HPGYGFLAESPEFAEAVSSAGITWVGPRAGVIALLADKLSARKIAEQVGVPVPPGGEHVVSCASEVHNFADKYGLPIAIK
AAYGGGGLGMKVVKQKKNIDELFASAQREAQAAFGNKECFIEKYIDRPRHVETQCLADLFGNVQVVSTRDCSVQRRHQKL
IEEAPAYTLTDKQEETLITASKAVMKAAEYSGAGTCEFLIDQDGKIFFLEVNARLQVEHPVTEEITGIDLVLEQINIAEG
KLLKNLETPVYKGHSLEFRINAEDANSGFMPRHGKVVKFEPPGGLGIRIDSGIKAGDTIGAAFDSLLCKLIVTGNNRECA
LARARRALDEFVIDGVTTLIPFHRNILNQPDFINGGMYTGWVENEYSKLVNKQTDASTVPDIQDTLSVSKNLREIIVEVN
RKQIRVRLPSPIGEYPTERQKPPGRRVGHNFRQKTQEKNPDSIFSPMQAVVVKVNVTEGQSVKKDDLLIVLEAMKMEQPI
VAPRDGVVEKINAHTGETVPSGHELLRLKKV

Sequences:

>Translated_591_residues
MKKITRLLIANRGEIAVRVIRACRDKAIASIAIYSDQDRDAVHTQLADEAYCLEGETAAETYLNIEKILDIAKLSRADGI
HPGYGFLAESPEFAEAVSSAGITWVGPRAGVIALLADKLSARKIAEQVGVPVPPGGEHVVSCASEVHNFADKYGLPIAIK
AAYGGGGLGMKVVKQKKNIDELFASAQREAQAAFGNKECFIEKYIDRPRHVETQCLADLFGNVQVVSTRDCSVQRRHQKL
IEEAPAYTLTDKQEETLITASKAVMKAAEYSGAGTCEFLIDQDGKIFFLEVNARLQVEHPVTEEITGIDLVLEQINIAEG
KLLKNLETPVYKGHSLEFRINAEDANSGFMPRHGKVVKFEPPGGLGIRIDSGIKAGDTIGAAFDSLLCKLIVTGNNRECA
LARARRALDEFVIDGVTTLIPFHRNILNQPDFINGGMYTGWVENEYSKLVNKQTDASTVPDIQDTLSVSKNLREIIVEVN
RKQIRVRLPSPIGEYPTERQKPPGRRVGHNFRQKTQEKNPDSIFSPMQAVVVKVNVTEGQSVKKDDLLIVLEAMKMEQPI
VAPRDGVVEKINAHTGETVPSGHELLRLKKV
>Mature_591_residues
MKKITRLLIANRGEIAVRVIRACRDKAIASIAIYSDQDRDAVHTQLADEAYCLEGETAAETYLNIEKILDIAKLSRADGI
HPGYGFLAESPEFAEAVSSAGITWVGPRAGVIALLADKLSARKIAEQVGVPVPPGGEHVVSCASEVHNFADKYGLPIAIK
AAYGGGGLGMKVVKQKKNIDELFASAQREAQAAFGNKECFIEKYIDRPRHVETQCLADLFGNVQVVSTRDCSVQRRHQKL
IEEAPAYTLTDKQEETLITASKAVMKAAEYSGAGTCEFLIDQDGKIFFLEVNARLQVEHPVTEEITGIDLVLEQINIAEG
KLLKNLETPVYKGHSLEFRINAEDANSGFMPRHGKVVKFEPPGGLGIRIDSGIKAGDTIGAAFDSLLCKLIVTGNNRECA
LARARRALDEFVIDGVTTLIPFHRNILNQPDFINGGMYTGWVENEYSKLVNKQTDASTVPDIQDTLSVSKNLREIIVEVN
RKQIRVRLPSPIGEYPTERQKPPGRRVGHNFRQKTQEKNPDSIFSPMQAVVVKVNVTEGQSVKKDDLLIVLEAMKMEQPI
VAPRDGVVEKINAHTGETVPSGHELLRLKKV

Specific function: This protein carries two functions:biotin carboxyl carrier protein and biotin carboxyltransferase [H]

COG id: COG4770

COG function: function code I; Acetyl/propionyl-CoA carboxylase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotinyl-binding domain [H]

Homologues:

Organism=Homo sapiens, GI106049528, Length=448, Percent_Identity=44.4196428571429, Blast_Score=372, Evalue=1e-103,
Organism=Homo sapiens, GI106049295, Length=448, Percent_Identity=44.4196428571429, Blast_Score=372, Evalue=1e-103,
Organism=Homo sapiens, GI106049292, Length=448, Percent_Identity=44.4196428571429, Blast_Score=372, Evalue=1e-103,
Organism=Homo sapiens, GI116805327, Length=451, Percent_Identity=40.7982261640798, Blast_Score=354, Evalue=2e-97,
Organism=Homo sapiens, GI295821183, Length=628, Percent_Identity=34.2356687898089, Blast_Score=347, Evalue=2e-95,
Organism=Homo sapiens, GI189095269, Length=449, Percent_Identity=40.0890868596882, Blast_Score=340, Evalue=2e-93,
Organism=Homo sapiens, GI65506442, Length=448, Percent_Identity=40.1785714285714, Blast_Score=340, Evalue=2e-93,
Organism=Homo sapiens, GI38679971, Length=503, Percent_Identity=29.6222664015905, Blast_Score=214, Evalue=2e-55,
Organism=Homo sapiens, GI38679977, Length=503, Percent_Identity=29.6222664015905, Blast_Score=214, Evalue=2e-55,
Organism=Homo sapiens, GI38679967, Length=503, Percent_Identity=29.6222664015905, Blast_Score=214, Evalue=2e-55,
Organism=Homo sapiens, GI38679960, Length=503, Percent_Identity=29.6222664015905, Blast_Score=213, Evalue=3e-55,
Organism=Homo sapiens, GI38679974, Length=503, Percent_Identity=29.6222664015905, Blast_Score=213, Evalue=3e-55,
Organism=Homo sapiens, GI134142062, Length=502, Percent_Identity=29.4820717131474, Blast_Score=209, Evalue=7e-54,
Organism=Escherichia coli, GI1789654, Length=444, Percent_Identity=43.018018018018, Blast_Score=350, Evalue=1e-97,
Organism=Caenorhabditis elegans, GI17562816, Length=448, Percent_Identity=44.8660714285714, Blast_Score=373, Evalue=1e-103,
Organism=Caenorhabditis elegans, GI71987519, Length=452, Percent_Identity=41.3716814159292, Blast_Score=336, Evalue=2e-92,
Organism=Caenorhabditis elegans, GI17567343, Length=447, Percent_Identity=39.8210290827741, Blast_Score=327, Evalue=1e-89,
Organism=Caenorhabditis elegans, GI133931226, Length=492, Percent_Identity=28.8617886178862, Blast_Score=180, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI71997168, Length=511, Percent_Identity=27.0058708414873, Blast_Score=179, Evalue=5e-45,
Organism=Caenorhabditis elegans, GI71997163, Length=511, Percent_Identity=27.2015655577299, Blast_Score=178, Evalue=7e-45,
Organism=Saccharomyces cerevisiae, GI6319695, Length=461, Percent_Identity=43.6008676789588, Blast_Score=365, Evalue=1e-101,
Organism=Saccharomyces cerevisiae, GI6321376, Length=462, Percent_Identity=43.0735930735931, Blast_Score=348, Evalue=1e-96,
Organism=Saccharomyces cerevisiae, GI6319685, Length=442, Percent_Identity=39.8190045248869, Blast_Score=315, Evalue=1e-86,
Organism=Saccharomyces cerevisiae, GI6324343, Length=513, Percent_Identity=30.0194931773879, Blast_Score=209, Evalue=9e-55,
Organism=Saccharomyces cerevisiae, GI6323863, Length=485, Percent_Identity=30.9278350515464, Blast_Score=208, Evalue=2e-54,
Organism=Saccharomyces cerevisiae, GI6322331, Length=299, Percent_Identity=23.0769230769231, Blast_Score=70, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24652212, Length=527, Percent_Identity=42.1252371916509, Blast_Score=370, Evalue=1e-102,
Organism=Drosophila melanogaster, GI24652210, Length=527, Percent_Identity=42.1252371916509, Blast_Score=370, Evalue=1e-102,
Organism=Drosophila melanogaster, GI24652214, Length=527, Percent_Identity=42.1252371916509, Blast_Score=370, Evalue=1e-102,
Organism=Drosophila melanogaster, GI19921944, Length=527, Percent_Identity=42.1252371916509, Blast_Score=370, Evalue=1e-102,
Organism=Drosophila melanogaster, GI24652216, Length=527, Percent_Identity=42.1252371916509, Blast_Score=370, Evalue=1e-102,
Organism=Drosophila melanogaster, GI281363050, Length=448, Percent_Identity=45.5357142857143, Blast_Score=369, Evalue=1e-102,
Organism=Drosophila melanogaster, GI24652224, Length=448, Percent_Identity=45.5357142857143, Blast_Score=369, Evalue=1e-102,
Organism=Drosophila melanogaster, GI24652222, Length=448, Percent_Identity=45.5357142857143, Blast_Score=369, Evalue=1e-102,
Organism=Drosophila melanogaster, GI24652220, Length=448, Percent_Identity=45.5357142857143, Blast_Score=369, Evalue=1e-102,
Organism=Drosophila melanogaster, GI24652218, Length=448, Percent_Identity=45.5357142857143, Blast_Score=369, Evalue=1e-102,
Organism=Drosophila melanogaster, GI24651757, Length=452, Percent_Identity=40.7079646017699, Blast_Score=345, Evalue=5e-95,
Organism=Drosophila melanogaster, GI24651759, Length=411, Percent_Identity=40.3892944038929, Blast_Score=305, Evalue=4e-83,
Organism=Drosophila melanogaster, GI161076407, Length=496, Percent_Identity=29.4354838709677, Blast_Score=202, Evalue=6e-52,
Organism=Drosophila melanogaster, GI24586460, Length=496, Percent_Identity=29.4354838709677, Blast_Score=202, Evalue=6e-52,
Organism=Drosophila melanogaster, GI161076409, Length=496, Percent_Identity=29.6370967741936, Blast_Score=202, Evalue=7e-52,
Organism=Drosophila melanogaster, GI24586458, Length=496, Percent_Identity=29.6370967741936, Blast_Score=202, Evalue=7e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR001882
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR000089
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054
- InterPro:   IPR011053 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00364 Biotin_lipoyl; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14 [H]

Molecular weight: Translated: 64933; Mature: 64933

Theoretical pI: Translated: 6.84; Mature: 6.84

Prosite motif: PS50975 ATP_GRASP ; PS00867 CPSASE_2 ; PS50979 BC ; PS50968 BIOTINYL_LIPOYL ; PS00188 BIOTIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKITRLLIANRGEIAVRVIRACRDKAIASIAIYSDQDRDAVHTQLADEAYCLEGETAAE
CCHHHHHHHCCCCHHHHHHHHHHHHHHHEEEEEECCCCCHHHHHHHCCCCEEECCCHHHH
TYLNIEKILDIAKLSRADGIHPGYGFLAESPEFAEAVSSAGITWVGPRAGVIALLADKLS
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHCCCEEECCCCCHHHHHHHHHH
ARKIAEQVGVPVPPGGEHVVSCASEVHNFADKYGLPIAIKAAYGGGGLGMKVVKQKKNID
HHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHCCHH
ELFASAQREAQAAFGNKECFIEKYIDRPRHVETQCLADLFGNVQVVSTRDCSVQRRHQKL
HHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHCCEEEEEECCCHHHHHHHHH
IEEAPAYTLTDKQEETLITASKAVMKAAEYSGAGTCEFLIDQDGKIFFLEVNARLQVEHP
HHHCCCEEECCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEEEEECCEEEECCC
VTEEITGIDLVLEQINIAEGKLLKNLETPVYKGHSLEFRINAEDANSGFMPRHGKVVKFE
CHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCEEEEEEECCCCCCCCCCCCCEEEEEC
PPGGLGIRIDSGIKAGDTIGAAFDSLLCKLIVTGNNRECALARARRALDEFVIDGVTTLI
CCCCEEEEECCCCCCCCHHHHHHHHHHHEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHH
PFHRNILNQPDFINGGMYTGWVENEYSKLVNKQTDASTVPDIQDTLSVSKNLREIIVEVN
HHHHHHCCCCCCCCCCEEECCCCHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCC
RKQIRVRLPSPIGEYPTERQKPPGRRVGHNFRQKTQEKNPDSIFSPMQAVVVKVNVTEGQ
CCEEEEECCCCCCCCCCCCCCCCCHHHCCHHHHHHCCCCCHHHHCCCEEEEEEEECCCCC
SVKKDDLLIVLEAMKMEQPIVAPRDGVVEKINAHTGETVPSGHELLRLKKV
CCCCCCEEEEEEHHHCCCCCCCCCCCHHHHHHCCCCCCCCCCHHHHEEECC
>Mature Secondary Structure
MKKITRLLIANRGEIAVRVIRACRDKAIASIAIYSDQDRDAVHTQLADEAYCLEGETAAE
CCHHHHHHHCCCCHHHHHHHHHHHHHHHEEEEEECCCCCHHHHHHHCCCCEEECCCHHHH
TYLNIEKILDIAKLSRADGIHPGYGFLAESPEFAEAVSSAGITWVGPRAGVIALLADKLS
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHCCCEEECCCCCHHHHHHHHHH
ARKIAEQVGVPVPPGGEHVVSCASEVHNFADKYGLPIAIKAAYGGGGLGMKVVKQKKNID
HHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHCCHH
ELFASAQREAQAAFGNKECFIEKYIDRPRHVETQCLADLFGNVQVVSTRDCSVQRRHQKL
HHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHCCEEEEEECCCHHHHHHHHH
IEEAPAYTLTDKQEETLITASKAVMKAAEYSGAGTCEFLIDQDGKIFFLEVNARLQVEHP
HHHCCCEEECCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEEEEECCEEEECCC
VTEEITGIDLVLEQINIAEGKLLKNLETPVYKGHSLEFRINAEDANSGFMPRHGKVVKFE
CHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCEEEEEEECCCCCCCCCCCCCEEEEEC
PPGGLGIRIDSGIKAGDTIGAAFDSLLCKLIVTGNNRECALARARRALDEFVIDGVTTLI
CCCCEEEEECCCCCCCCHHHHHHHHHHHEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHH
PFHRNILNQPDFINGGMYTGWVENEYSKLVNKQTDASTVPDIQDTLSVSKNLREIIVEVN
HHHHHHCCCCCCCCCCEEECCCCHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCC
RKQIRVRLPSPIGEYPTERQKPPGRRVGHNFRQKTQEKNPDSIFSPMQAVVVKVNVTEGQ
CCEEEEECCCCCCCCCCCCCCCCCHHHCCHHHHHHCCCCCHHHHCCCEEEEEEEECCCCC
SVKKDDLLIVLEAMKMEQPIVAPRDGVVEKINAHTGETVPSGHELLRLKKV
CCCCCCEEEEEEHHHCCCCCCCCCCCHHHHHHCCCCCCCCCCHHHHEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7909542; 11234002 [H]