Click here to switch to the map view.

The map label for this gene is lpdA [H]

Identifier: 28572194

GI number: 28572194

Start: 18975

End: 20372

Strand: Direct

Name: lpdA [H]

Synonym: TW019

Alternate gene names: 28572194

Gene position: 18975-20372 (Clockwise)

Preceding gene: 28572191

Following gene: 28572197

Centisome position: 2.05

GC content: 48.71

Gene sequence:

>1398_bases
GTGTCTGTCAAGAAAAATCATAAAATAGTTGTTATTGGCGGTGGCCCAGGTGGTTATTCAGCGGCTCTGAGCGGTGCCCT
GCTTGGCGCTGATGTTGTGCTGATTGAGAATCAGGCTGTCGGCGGGTCTGCGACTTTAACAGACGTTGTTCCCTCAAAAA
CACTTATTGCCTCGGCAGAGCGGGCTGTTTTTGTTGCCCAGGGTGCTGATTTTGGTATTCGTTTTCAGAACTGCGTTTCA
GCCGATATAGGGCACATAAACCGGCGAATTATGGATCTTACCAGAGCTCAAAGTGCTGATATGTTCTCGACCTTGACTGG
TGCTGGGGTTAGGGTAGTTTATGGCCATGCCGCTTTGGATGGACCGAATCGGGTTCTTGTATCGGTGTCAGGTCAAGAGA
AATATGAGTTCTTTGCAAATACGGTTGTTGTTGCAACAGGTTCTAGTCCAAGGGTTTTACCAAATGCCATTCCTGACGGG
AAGAGAATACTTACATGGAAACAGCTTTATACCCTTGAGCAGGTTCCTGAGCATATCATTGTAGTTGGCTCGGGCGTGAC
TGGCGCTGAATTTGCATCAGCTTTCAGGAATTTAGGAAGCGAAGTTACACTGGTTTCCAGCAGGGACAGGGTGTTACCTG
GGGGAGATGAAGATGCTGCAGATTTGATTCAGGAAGTTTTTATAAATTCGGGAATGAAACTGCTCAACCGGGCACGTGCT
CAAGCCGCCGCAGCCTGCAATGGGGGTGTTGTGGTAACCCTTACCGACGGTACAGAGGTGCGCGGGACCCATTGCCTAAT
GGCTGTTGGCAGTGTTCCTAATACTTCTGGGATTGGTTTAGAAACAGCGAATATTGCACTGAATCCAGCAGGGCGAATTA
CGGTAAATAGAGTGGCCTGTTCAAGCGTTCCCGGGGTATATGCGGCAGGGGACTGTTCGGATTTTTTACCCCTTGCATCT
GTTGCCGAGATGCAAGGCCAGGTTGCCGTTTATCACGCAATGGGGGAGAATGCTAATCCAATTGAACTTAAAAATTTAGC
CTCAACAGTTTTTACAACCCCGGAAATTGCCACTGTTGGTAGGTCCGAGAAGGCTATAGACAAAGCCAGGGCCACCGCCC
TGAAGGTTGACTTAGCAACAAATTCCCGTGCAAAAATTCTGGGTATAAAGACGGGCTTCGTTAAGATGATTGTATCTCGT
GAAACAGGCACCGTACTTGGCGGTGTTGTTGTTGCACCAAATGCAAGTGACTTAATTTTTCCAATATCGGTTGCTGTTCA
AAATCGCCTTAGCGCTGATCAATTATCACAAAGCTTTGCCGTCTATCCGTCCCTAACAATATCTTTGTGGCACGCAGCCC
GCGCTTCGCACGTGAGAACCGACAGCGCGTCGCCCTGA

Upstream 100 bases:

>100_bases
GTATTGCAGATATCTTCCATGGCGGCTGATTTCCAGGATAATCCAACAAGAACACCGCCGTCAAGCAGCACTATACTTGA
GTCTGGTAAGAAGGCTGAGA

Downstream 100 bases:

>100_bases
TCTCTTCCGAAATCTGACATTCTGGGCAGCGCTCTGGCAGCGCCTTGCAATGGGGTGTGTATTTTTTTTCAAACCTTCTT
CAAGCGTAACAATTCGTGAC

Product: flavoprotein disulfide reductase

Products: NA

Alternate protein names: NAD(P)H quinone reductase; NAD(P)H: menadione oxidoreductase; NADH-menadione reductase [H]

Number of amino acids: Translated: 465; Mature: 464

Protein sequence:

>465_residues
MSVKKNHKIVVIGGGPGGYSAALSGALLGADVVLIENQAVGGSATLTDVVPSKTLIASAERAVFVAQGADFGIRFQNCVS
ADIGHINRRIMDLTRAQSADMFSTLTGAGVRVVYGHAALDGPNRVLVSVSGQEKYEFFANTVVVATGSSPRVLPNAIPDG
KRILTWKQLYTLEQVPEHIIVVGSGVTGAEFASAFRNLGSEVTLVSSRDRVLPGGDEDAADLIQEVFINSGMKLLNRARA
QAAAACNGGVVVTLTDGTEVRGTHCLMAVGSVPNTSGIGLETANIALNPAGRITVNRVACSSVPGVYAAGDCSDFLPLAS
VAEMQGQVAVYHAMGENANPIELKNLASTVFTTPEIATVGRSEKAIDKARATALKVDLATNSRAKILGIKTGFVKMIVSR
ETGTVLGGVVVAPNASDLIFPISVAVQNRLSADQLSQSFAVYPSLTISLWHAARASHVRTDSASP

Sequences:

>Translated_465_residues
MSVKKNHKIVVIGGGPGGYSAALSGALLGADVVLIENQAVGGSATLTDVVPSKTLIASAERAVFVAQGADFGIRFQNCVS
ADIGHINRRIMDLTRAQSADMFSTLTGAGVRVVYGHAALDGPNRVLVSVSGQEKYEFFANTVVVATGSSPRVLPNAIPDG
KRILTWKQLYTLEQVPEHIIVVGSGVTGAEFASAFRNLGSEVTLVSSRDRVLPGGDEDAADLIQEVFINSGMKLLNRARA
QAAAACNGGVVVTLTDGTEVRGTHCLMAVGSVPNTSGIGLETANIALNPAGRITVNRVACSSVPGVYAAGDCSDFLPLAS
VAEMQGQVAVYHAMGENANPIELKNLASTVFTTPEIATVGRSEKAIDKARATALKVDLATNSRAKILGIKTGFVKMIVSR
ETGTVLGGVVVAPNASDLIFPISVAVQNRLSADQLSQSFAVYPSLTISLWHAARASHVRTDSASP
>Mature_464_residues
SVKKNHKIVVIGGGPGGYSAALSGALLGADVVLIENQAVGGSATLTDVVPSKTLIASAERAVFVAQGADFGIRFQNCVSA
DIGHINRRIMDLTRAQSADMFSTLTGAGVRVVYGHAALDGPNRVLVSVSGQEKYEFFANTVVVATGSSPRVLPNAIPDGK
RILTWKQLYTLEQVPEHIIVVGSGVTGAEFASAFRNLGSEVTLVSSRDRVLPGGDEDAADLIQEVFINSGMKLLNRARAQ
AAAACNGGVVVTLTDGTEVRGTHCLMAVGSVPNTSGIGLETANIALNPAGRITVNRVACSSVPGVYAAGDCSDFLPLASV
AEMQGQVAVYHAMGENANPIELKNLASTVFTTPEIATVGRSEKAIDKARATALKVDLATNSRAKILGIKTGFVKMIVSRE
TGTVLGGVVVAPNASDLIFPISVAVQNRLSADQLSQSFAVYPSLTISLWHAARASHVRTDSASP

Specific function: May contribute to virulence by increasing resistance to reactive oxygen intermediates. It can reduce 2,6-dimethyl-1,4- benzoquinone (DMBQ), 5-hydroxy-1,4-naphthaquinone (5-HNQ) and menadione. NAD(P)H is the physiological reductant rather than NADH [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=469, Percent_Identity=29.637526652452, Blast_Score=164, Evalue=2e-40,
Organism=Homo sapiens, GI50301238, Length=457, Percent_Identity=26.9146608315098, Blast_Score=122, Evalue=9e-28,
Organism=Homo sapiens, GI291045266, Length=456, Percent_Identity=25.219298245614, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI22035672, Length=457, Percent_Identity=22.9759299781182, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI33519430, Length=450, Percent_Identity=24, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI33519428, Length=450, Percent_Identity=24, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI33519426, Length=450, Percent_Identity=24, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI148277065, Length=450, Percent_Identity=24, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI148277071, Length=449, Percent_Identity=23.3853006681514, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI291045268, Length=451, Percent_Identity=23.5033259423503, Blast_Score=86, Evalue=6e-17,
Organism=Escherichia coli, GI87082354, Length=435, Percent_Identity=28.2758620689655, Blast_Score=169, Evalue=3e-43,
Organism=Escherichia coli, GI1786307, Length=468, Percent_Identity=28.4188034188034, Blast_Score=154, Evalue=1e-38,
Organism=Escherichia coli, GI87081717, Length=451, Percent_Identity=26.1640798226164, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1789915, Length=346, Percent_Identity=25.4335260115607, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1789065, Length=295, Percent_Identity=24.7457627118644, Blast_Score=63, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI32565766, Length=471, Percent_Identity=30.3609341825902, Blast_Score=172, Evalue=4e-43,
Organism=Caenorhabditis elegans, GI17557007, Length=462, Percent_Identity=26.6233766233766, Blast_Score=116, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI71983419, Length=434, Percent_Identity=24.8847926267281, Blast_Score=96, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI71983429, Length=434, Percent_Identity=24.8847926267281, Blast_Score=96, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6321091, Length=484, Percent_Identity=25.8264462809917, Blast_Score=140, Evalue=3e-34,
Organism=Saccharomyces cerevisiae, GI6325240, Length=479, Percent_Identity=25.678496868476, Blast_Score=115, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6325166, Length=386, Percent_Identity=26.6839378238342, Blast_Score=110, Evalue=5e-25,
Organism=Drosophila melanogaster, GI21358499, Length=458, Percent_Identity=30.1310043668122, Blast_Score=177, Evalue=2e-44,
Organism=Drosophila melanogaster, GI24640553, Length=464, Percent_Identity=23.0603448275862, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24640549, Length=464, Percent_Identity=23.0603448275862, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24640551, Length=464, Percent_Identity=23.0603448275862, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI17737741, Length=469, Percent_Identity=23.6673773987207, Blast_Score=89, Evalue=7e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006258
- InterPro:   IPR004099
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.6.5.2 [H]

Molecular weight: Translated: 48277; Mature: 48145

Theoretical pI: Translated: 7.92; Mature: 7.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVKKNHKIVVIGGGPGGYSAALSGALLGADVVLIENQAVGGSATLTDVVPSKTLIASAE
CCCCCCCEEEEEECCCCCHHHHHHHHHCCCEEEEEECCCCCCCCEEECCCCCCHHHHCCC
RAVFVAQGADFGIRFQNCVSADIGHINRRIMDLTRAQSADMFSTLTGAGVRVVYGHAALD
CEEEEECCCCCCEEEHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCEEEEEEEEEEC
GPNRVLVSVSGQEKYEFFANTVVVATGSSPRVLPNAIPDGKRILTWKQLYTLEQVPEHII
CCCEEEEEECCCCCEEEEEEEEEEEECCCCCCCCCCCCCCCEEEEHHHHHHHHHCCCEEE
VVGSGVTGAEFASAFRNLGSEVTLVSSRDRVLPGGDEDAADLIQEVFINSGMKLLNRARA
EEECCCCHHHHHHHHHHCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHH
QAAAACNGGVVVTLTDGTEVRGTHCLMAVGSVPNTSGIGLETANIALNPAGRITVNRVAC
HHHHCCCCCEEEEECCCCCCCCCEEEEEECCCCCCCCCCEEEEEEEECCCCCEEEEEEEC
SSVPGVYAAGDCSDFLPLASVAEMQGQVAVYHAMGENANPIELKNLASTVFTTPEIATVG
CCCCCEEECCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCEEHHHHHHHHCCCCCCEECC
RSEKAIDKARATALKVDLATNSRAKILGIKTGFVKMIVSRETGTVLGGVVVAPNASDLIF
CCHHHHHHHHHEEEEEEECCCCCEEEEEEECCEEEEEEECCCCCEEEEEEECCCCCCEEE
PISVAVQNRLSADQLSQSFAVYPSLTISLWHAARASHVRTDSASP
EEHHHHHHCCCHHHHHCCEEECCCEEEEEHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
SVKKNHKIVVIGGGPGGYSAALSGALLGADVVLIENQAVGGSATLTDVVPSKTLIASAE
CCCCCCEEEEEECCCCCHHHHHHHHHCCCEEEEEECCCCCCCCEEECCCCCCHHHHCCC
RAVFVAQGADFGIRFQNCVSADIGHINRRIMDLTRAQSADMFSTLTGAGVRVVYGHAALD
CEEEEECCCCCCEEEHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCEEEEEEEEEEC
GPNRVLVSVSGQEKYEFFANTVVVATGSSPRVLPNAIPDGKRILTWKQLYTLEQVPEHII
CCCEEEEEECCCCCEEEEEEEEEEEECCCCCCCCCCCCCCCEEEEHHHHHHHHHCCCEEE
VVGSGVTGAEFASAFRNLGSEVTLVSSRDRVLPGGDEDAADLIQEVFINSGMKLLNRARA
EEECCCCHHHHHHHHHHCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHH
QAAAACNGGVVVTLTDGTEVRGTHCLMAVGSVPNTSGIGLETANIALNPAGRITVNRVAC
HHHHCCCCCEEEEECCCCCCCCCEEEEEECCCCCCCCCCEEEEEEEECCCCCEEEEEEEC
SSVPGVYAAGDCSDFLPLASVAEMQGQVAVYHAMGENANPIELKNLASTVFTTPEIATVG
CCCCCEEECCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCEEHHHHHHHHCCCCCCEECC
RSEKAIDKARATALKVDLATNSRAKILGIKTGFVKMIVSRETGTVLGGVVVAPNASDLIF
CCHHHHHHHHHEEEEEEECCCCCEEEEEEECCEEEEEEECCCCCEEEEEEECCCCCCEEE
PISVAVQNRLSADQLSQSFAVYPSLTISLWHAARASHVRTDSASP
EEHHHHHHCCCHHHHHCCEEECCCEEEEEHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]