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The map label for this gene is htpX

Identifier: 28572188

GI number: 28572188

Start: 12752

End: 13627

Strand: Direct

Name: htpX

Synonym: TW013

Alternate gene names: 28572188

Gene position: 12752-13627 (Clockwise)

Preceding gene: 28572187

Following gene: 28572189

Centisome position: 1.38

GC content: 49.32

Gene sequence:

>876_bases
TTGATGTACAGCTTTATTGCGAGAAACAAAATCAATACCTTTTTGATATTGTTTGTTTTCATACTGGCCTGCGGGGGTTT
TGGCCTGCTTGCCGGCAGATTCCTCGGTATGTCATTTTTTCTTTTTATCTTGTTATTAGCAGCGGGCTATGCGTGTGTGC
AGTATTTTTTCTCTGGACGTTTAGCCGTTTTGATGTCGGGTGCCCGGAAAATTAGCCGGAACGACAACCCGCGCCTCTGG
AATACTGTTGAGAATTTATCAATAACAACCGGCTTGCCAATGCCGGAGGTGTACATTGTTGACGACCCCGCCCCTAATGC
ATTTGCAACAGGCCGCGACCCAAAACATGCCAAGGTTGCCGCAACATCCGGTCTGCTTGAGATACTTGATGATTCCGAGC
TTGAGGGTGTCATGGCCCACGAAATGGGCCATGTAAAGAACTACGATATAAGGGTTAGCACTATCGTTTTTGGCCTCGTT
TCAGCCGTTGGCCTTATTTCAGATATGGTCCTTCGGGCTCTAATTTGGGGGGATAATCGTCGCGAAGGAAATTCTGCCTT
TTCGTTTGCTATTGTCTTATTTTTCTCCCTCCTTGCCCCCATTGCGGCAATGCTGGTTCAGTTGGCGGTTTCCAGGGAAA
GGGAGTATTTGGCGGATGCAACCGGCGCCTTGACAACAAGATATCCTGCCGCCCTGGCCTCTGCCCTTGCCAAACTGGAG
GGCAATGCAAGACCGCTGCAAAGACAGAGCAGTAGCATGGCCCATTTGTGGATTTCAAACCCAATGCCCCGGGGGTTCTT
CAGAAAGCTTTTTTCTACCCACCCACCCACCGAGGAGAGGATTAGGCGATTGAAAGAAATGGGGAACCAGTTCTGA

Upstream 100 bases:

>100_bases
TCGTGAGTTTTTTGATGTTGAGCGATCAGAGGCCCTTCAGTCTCCCCCGAAGATTGTTTTCTAGGCAAATGAACAGAGCC
GAATGTTTTGATGTGAGTAT

Downstream 100 bases:

>100_bases
TTGGCTAAGGTGTTATTTGCCTCCTATGCGTTGCTTGCAGTGGCTTCGCTTGGCAGGAGCGCTTATCAGATCTCGACTCG
GTTTTATGAGGCCCCCCTTG

Product: integral membrane heat shock protease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 291; Mature: 291

Protein sequence:

>291_residues
MMYSFIARNKINTFLILFVFILACGGFGLLAGRFLGMSFFLFILLLAAGYACVQYFFSGRLAVLMSGARKISRNDNPRLW
NTVENLSITTGLPMPEVYIVDDPAPNAFATGRDPKHAKVAATSGLLEILDDSELEGVMAHEMGHVKNYDIRVSTIVFGLV
SAVGLISDMVLRALIWGDNRREGNSAFSFAIVLFFSLLAPIAAMLVQLAVSREREYLADATGALTTRYPAALASALAKLE
GNARPLQRQSSSMAHLWISNPMPRGFFRKLFSTHPPTEERIRRLKEMGNQF

Sequences:

>Translated_291_residues
MMYSFIARNKINTFLILFVFILACGGFGLLAGRFLGMSFFLFILLLAAGYACVQYFFSGRLAVLMSGARKISRNDNPRLW
NTVENLSITTGLPMPEVYIVDDPAPNAFATGRDPKHAKVAATSGLLEILDDSELEGVMAHEMGHVKNYDIRVSTIVFGLV
SAVGLISDMVLRALIWGDNRREGNSAFSFAIVLFFSLLAPIAAMLVQLAVSREREYLADATGALTTRYPAALASALAKLE
GNARPLQRQSSSMAHLWISNPMPRGFFRKLFSTHPPTEERIRRLKEMGNQF
>Mature_291_residues
MMYSFIARNKINTFLILFVFILACGGFGLLAGRFLGMSFFLFILLLAAGYACVQYFFSGRLAVLMSGARKISRNDNPRLW
NTVENLSITTGLPMPEVYIVDDPAPNAFATGRDPKHAKVAATSGLLEILDDSELEGVMAHEMGHVKNYDIRVSTIVFGLV
SAVGLISDMVLRALIWGDNRREGNSAFSFAIVLFFSLLAPIAAMLVQLAVSREREYLADATGALTTRYPAALASALAKLE
GNARPLQRQSSSMAHLWISNPMPRGFFRKLFSTHPPTEERIRRLKEMGNQF

Specific function: Unknown Function. Overexpression Of A Truncated Form Of The Htpx Protein Leads To An Increase In The Degradation Of Abnormal Proteins. [C]

COG id: COG0501

COG function: function code O; Zn-dependent protease with chaperone function

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M48B family

Homologues:

Organism=Escherichia coli, GI1788133, Length=281, Percent_Identity=30.9608540925267, Blast_Score=104, Evalue=5e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HTPX_TROW8 (Q83IG0)

Other databases:

- EMBL:   BX251410
- RefSeq:   NP_788968.1
- ProteinModelPortal:   Q83IG0
- SMR:   Q83IG0
- STRING:   Q83IG0
- GeneID:   1064364
- GenomeReviews:   BX072543_GR
- KEGG:   tws:TW013
- eggNOG:   COG0501
- HOGENOM:   HBG739460
- OMA:   RTHPETH
- PhylomeDB:   Q83IG0
- ProtClustDB:   CLSK229358
- BioCyc:   TWHI218496:TW0013-MONOMER
- GO:   GO:0006508
- HAMAP:   MF_00188
- InterPro:   IPR022919
- InterPro:   IPR001915

Pfam domain/function: PF01435 Peptidase_M48

EC number: 3.4.24.-

Molecular weight: Translated: 32179; Mature: 32179

Theoretical pI: Translated: 9.81; Mature: 9.81

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: ACT_SITE 141-141

Signals:

None

Transmembrane regions:

HASH(0xad878c8)-; HASH(0xbb03b14)-; HASH(0xbb03ad8)-; HASH(0xbb055a0)-;

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMYSFIARNKINTFLILFVFILACGGFGLLAGRFLGMSFFLFILLLAAGYACVQYFFSGR
CCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCH
LAVLMSGARKISRNDNPRLWNTVENLSITTGLPMPEVYIVDDPAPNAFATGRDPKHAKVA
HHHHHHHHHHHCCCCCCCHHHHHHCCEEECCCCCCEEEEEECCCCCCCCCCCCCCCHHHH
ATSGLLEILDDSELEGVMAHEMGHVKNYDIRVSTIVFGLVSAVGLISDMVLRALIWGDNR
HHHHHHHHHCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
REGNSAFSFAIVLFFSLLAPIAAMLVQLAVSREREYLADATGALTTRYPAALASALAKLE
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GNARPLQRQSSSMAHLWISNPMPRGFFRKLFSTHPPTEERIRRLKEMGNQF
CCCCCHHHHCCCCEEEEECCCCCHHHHHHHHCCCCCHHHHHHHHHHHCCCH
>Mature Secondary Structure
MMYSFIARNKINTFLILFVFILACGGFGLLAGRFLGMSFFLFILLLAAGYACVQYFFSGR
CCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCH
LAVLMSGARKISRNDNPRLWNTVENLSITTGLPMPEVYIVDDPAPNAFATGRDPKHAKVA
HHHHHHHHHHHCCCCCCCHHHHHHCCEEECCCCCCEEEEEECCCCCCCCCCCCCCCHHHH
ATSGLLEILDDSELEGVMAHEMGHVKNYDIRVSTIVFGLVSAVGLISDMVLRALIWGDNR
HHHHHHHHHCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
REGNSAFSFAIVLFFSLLAPIAAMLVQLAVSREREYLADATGALTTRYPAALASALAKLE
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GNARPLQRQSSSMAHLWISNPMPRGFFRKLFSTHPPTEERIRRLKEMGNQF
CCCCCHHHHCCCCEEEEECCCCCHHHHHHHHCCCCCHHHHHHHHHHHCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12606174