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The map label for this gene is gcvR [H]

Identifier: 27365257

GI number: 27365257

Start: 1905147

End: 1905689

Strand: Reverse

Name: gcvR [H]

Synonym: VV1_1911

Alternate gene names: 27365257

Gene position: 1905689-1905147 (Counterclockwise)

Preceding gene: 27365260

Following gene: 27365256

Centisome position: 58.07

GC content: 47.15

Gene sequence:

>543_bases
ATGACTCAACATCTGGTAATTACCGCAATGGGCACGGATCGGCCAGGCATCTGTAACCAGGTTGTCCAACTGGTGACGCG
TGCGGGTTGTAACATTATTGACAGTCGAATCGCCATTTTTGGCAATGAGTTTACCCTCATCATGCTGCTGTCTGGCAACA
CTAATGGCGTCACTCGAGTCGAGACCACTTTACCACTGCTCGGCCAAGAACATGATCTCATCACCATAATGAAGCGAACG
TCGGCTCATCATCCAACGACAAATTGCTACACCATTGAGGTGTTTGTTGAATCGGATGACCGCGTCGGCCTCACCGAAAA
ATTCACACAATTCTTTGCAGAAAAGCAAATCGGCCTGAGCGCACTCAGTGCCCAAACCATCGATAAAGCCGCGGTACAAA
TGGAGCAAGACCAGTTCCACATCGCGATTACGGCACACGTACAAAACGAATCCAATTTAATGCAGATTCAGGAAGATTTT
AATGATCTTTGCCGTTCGCTGAACGTACAAGGCACGCTGAACTTTATAAAAAACACCCTTTAA

Upstream 100 bases:

>100_bases
ACAGCGTTCCCTAACATAAAAAACGGAAGCGACTCGACATTTTCCATAAACTTCTGTGTTACCATCCGGAAAAAACAAAA
TGCACAATAAGAGCGAATCT

Downstream 100 bases:

>100_bases
AAGGAATAATGACATGAATATGCTGCAAGCAGGCTCCCCTGCTCCAGAATTTTCTTTGCCTGATCAAAATGGAAATCTTG
TCTCGCTCAAAGACCTCAAA

Product: glycine cleavage system transcriptional antiactivator GcvR

Products: NA

Alternate protein names: Gcv operon repressor [H]

Number of amino acids: Translated: 180; Mature: 179

Protein sequence:

>180_residues
MTQHLVITAMGTDRPGICNQVVQLVTRAGCNIIDSRIAIFGNEFTLIMLLSGNTNGVTRVETTLPLLGQEHDLITIMKRT
SAHHPTTNCYTIEVFVESDDRVGLTEKFTQFFAEKQIGLSALSAQTIDKAAVQMEQDQFHIAITAHVQNESNLMQIQEDF
NDLCRSLNVQGTLNFIKNTL

Sequences:

>Translated_180_residues
MTQHLVITAMGTDRPGICNQVVQLVTRAGCNIIDSRIAIFGNEFTLIMLLSGNTNGVTRVETTLPLLGQEHDLITIMKRT
SAHHPTTNCYTIEVFVESDDRVGLTEKFTQFFAEKQIGLSALSAQTIDKAAVQMEQDQFHIAITAHVQNESNLMQIQEDF
NDLCRSLNVQGTLNFIKNTL
>Mature_179_residues
TQHLVITAMGTDRPGICNQVVQLVTRAGCNIIDSRIAIFGNEFTLIMLLSGNTNGVTRVETTLPLLGQEHDLITIMKRTS
AHHPTTNCYTIEVFVESDDRVGLTEKFTQFFAEKQIGLSALSAQTIDKAAVQMEQDQFHIAITAHVQNESNLMQIQEDFN
DLCRSLNVQGTLNFIKNTL

Specific function: Negative transcriptional regulator of the glycine cleavage system operon (GCV). Does not autoregulate its own expression. It is not yet known how gcvR acts as a repressor. It does not seem to bind DNA. It could interact with gcvA and suppress its activato

COG id: COG2716

COG function: function code E; Glycine cleavage system regulatory protein

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI87082113, Length=176, Percent_Identity=43.1818181818182, Blast_Score=144, Evalue=3e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR016867 [H]

Pfam domain/function: PF01842 ACT [H]

EC number: NA

Molecular weight: Translated: 20039; Mature: 19908

Theoretical pI: Translated: 5.17; Mature: 5.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQHLVITAMGTDRPGICNQVVQLVTRAGCNIIDSRIAIFGNEFTLIMLLSGNTNGVTRV
CCCEEEEEEECCCCCCHHHHHHHHHHHCCCCEECCEEEEECCCEEEEEEEECCCCCEEEE
ETTLPLLGQEHDLITIMKRTSAHHPTTNCYTIEVFVESDDRVGLTEKFTQFFAEKQIGLS
EEECCCCCCCCCEEEEEECCCCCCCCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHCCHH
ALSAQTIDKAAVQMEQDQFHIAITAHVQNESNLMQIQEDFNDLCRSLNVQGTLNFIKNTL
HHHHHHHHHHHHEECCCEEEEEEEEEECCCCHHHHHHHHHHHHHHHCCCCEEHHHHHCCC
>Mature Secondary Structure 
TQHLVITAMGTDRPGICNQVVQLVTRAGCNIIDSRIAIFGNEFTLIMLLSGNTNGVTRV
CCEEEEEEECCCCCCHHHHHHHHHHHCCCCEECCEEEEECCCEEEEEEEECCCCCEEEE
ETTLPLLGQEHDLITIMKRTSAHHPTTNCYTIEVFVESDDRVGLTEKFTQFFAEKQIGLS
EEECCCCCCCCCEEEEEECCCCCCCCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHCCHH
ALSAQTIDKAAVQMEQDQFHIAITAHVQNESNLMQIQEDFNDLCRSLNVQGTLNFIKNTL
HHHHHHHHHHHHEECCCEEEEEEEEEECCCCHHHHHHHHHHHHHHHCCCCEEHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9537378; 9205837; 9278503; 2016588 [H]