Click here to switch to the map view.

The map label for this gene is yjcE [H]

Identifier: 27364807

GI number: 27364807

Start: 1397890

End: 1399224

Strand: Reverse

Name: yjcE [H]

Synonym: VV1_1422

Alternate gene names: 27364807

Gene position: 1399224-1397890 (Counterclockwise)

Preceding gene: 326423836

Following gene: 326423832

Centisome position: 42.64

GC content: 44.27

Gene sequence:

>1335_bases
ATGTCGGTCTACTATACTCTCTGCTTTCTATCCGCTGCAGCAATGTTGATTGCTTTTGTAAACAGCAAGATAGGCAAAAT
GCAGACTACCATCGCGATTACCGCAGGTTCAATGGTGCTCTCATTACTTATTTTAATTGCTGGTCAGAACAACTGGTTCC
ACTTAACTGAAATCGCCACACAAACCATGTCGAGCATCGACTTTGAAGATTTCCTCCTCAAAGGTATTTTGGGCTTCTTA
TTGTTTGCCGGTGGTTTAGGTATCAAACTACCCAACCTTAAAGACCAAAAATGGGAAATTACCGTGTTGGCGCTAGGTGC
GACACTTTTCTCTACTTTCTTTATTGGTTTTGCTCTGTATGGCATTTGCCAGCTCATTGGTATTCAGTTTGATCTGATTT
ACTGCCTGCTTTTCGGTGCACTCATTTCACCGACCGACCCGATCGCCGTTTTGGCTATCGTGAAAAAACTCAAGGCACCT
CGTAGAATCTCAACGCAAATTGAAGGGGAATCACTCTTCAATGATGGTTTTGGCCTTGTGATTTTTGTGACCTTGTTTAC
CATCGCATTTGGCCACGAAACACCCACGGTAGGTAGCGTTACCATGTTGTTTATCCAGGAAGCCATCGGCGGTATTTTGT
ATGGTTTCGCATTGGGGTTACTCTTCCATTATCTTATCTGTGCCACTGATGACCACTCAATGGAGCTACTACTCACCATT
GGCATCCCAACGGCAGGTTATGCTTTTGCAGAAGTGCTCCATGTTTCTGGTCCATTAGCAATGGTGGTCTCTGGCATTAT
GATTGGTAACTGGACACGATTCATCGGCTTCTCTAAAGAGAGTGAAGATCATCTCGATCATTTCTGGGAACTGGTGGATG
AGTTTCTTAACGGTGTGCTTTTCCTTCTGATTGGTATGTCGATGTTGCTGTTTAAATTCCATCAAGAGGACTGGATTTTG
ATGGCCATCGCTATTCCACTGGTCTTAATCGCTCGTTACCTCAGCGTATTTTTGTCCTATATCGGCTTTAAACGCTTCCG
CCAATACAATCCATGGTCAATTAAAATCCTCACTTGGGGCGGGTTGCGCGGTGGCTTGGCCTTAGCGATGGCACTCTCAA
TTCCATCGGGTATCTGGGTTATTTCAGATAAACTCATCGACGTGAAAGAGATTATTCTGGTGATGACCTACGCGGTGGTG
GTTTTTTCAATATTGGTTCAGGGTTCAACCATCACTCCAATGATCGAGAAAGCCAAAAAATCAGAAGCTGAATTCGAAGC
GAAGCAAAGTTCGGTGACTGTTCCTGAGGGCAAGACAGAATCCATTACATCATAA

Upstream 100 bases:

>100_bases
CTGCAATCCTCTTGGACTATTTTACTAGGAAAAAGAGATTGCTATTTGCTCATCAAACGAGGAGAATTTCGTTCACAAAT
TGTTACAAATAGAGAACTGT

Downstream 100 bases:

>100_bases
TGATTAAGGGCCTTAGGGCCCTTTTTACTTCAGCCATTCATTAACAGTGGTGAGATAACACAGTTTCGACCATGCGCTTT
TGCGTAATAGAGGCCTTCAT

Product: Na+/H+ antiporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 444; Mature: 443

Protein sequence:

>444_residues
MSVYYTLCFLSAAAMLIAFVNSKIGKMQTTIAITAGSMVLSLLILIAGQNNWFHLTEIATQTMSSIDFEDFLLKGILGFL
LFAGGLGIKLPNLKDQKWEITVLALGATLFSTFFIGFALYGICQLIGIQFDLIYCLLFGALISPTDPIAVLAIVKKLKAP
RRISTQIEGESLFNDGFGLVIFVTLFTIAFGHETPTVGSVTMLFIQEAIGGILYGFALGLLFHYLICATDDHSMELLLTI
GIPTAGYAFAEVLHVSGPLAMVVSGIMIGNWTRFIGFSKESEDHLDHFWELVDEFLNGVLFLLIGMSMLLFKFHQEDWIL
MAIAIPLVLIARYLSVFLSYIGFKRFRQYNPWSIKILTWGGLRGGLALAMALSIPSGIWVISDKLIDVKEIILVMTYAVV
VFSILVQGSTITPMIEKAKKSEAEFEAKQSSVTVPEGKTESITS

Sequences:

>Translated_444_residues
MSVYYTLCFLSAAAMLIAFVNSKIGKMQTTIAITAGSMVLSLLILIAGQNNWFHLTEIATQTMSSIDFEDFLLKGILGFL
LFAGGLGIKLPNLKDQKWEITVLALGATLFSTFFIGFALYGICQLIGIQFDLIYCLLFGALISPTDPIAVLAIVKKLKAP
RRISTQIEGESLFNDGFGLVIFVTLFTIAFGHETPTVGSVTMLFIQEAIGGILYGFALGLLFHYLICATDDHSMELLLTI
GIPTAGYAFAEVLHVSGPLAMVVSGIMIGNWTRFIGFSKESEDHLDHFWELVDEFLNGVLFLLIGMSMLLFKFHQEDWIL
MAIAIPLVLIARYLSVFLSYIGFKRFRQYNPWSIKILTWGGLRGGLALAMALSIPSGIWVISDKLIDVKEIILVMTYAVV
VFSILVQGSTITPMIEKAKKSEAEFEAKQSSVTVPEGKTESITS
>Mature_443_residues
SVYYTLCFLSAAAMLIAFVNSKIGKMQTTIAITAGSMVLSLLILIAGQNNWFHLTEIATQTMSSIDFEDFLLKGILGFLL
FAGGLGIKLPNLKDQKWEITVLALGATLFSTFFIGFALYGICQLIGIQFDLIYCLLFGALISPTDPIAVLAIVKKLKAPR
RISTQIEGESLFNDGFGLVIFVTLFTIAFGHETPTVGSVTMLFIQEAIGGILYGFALGLLFHYLICATDDHSMELLLTIG
IPTAGYAFAEVLHVSGPLAMVVSGIMIGNWTRFIGFSKESEDHLDHFWELVDEFLNGVLFLLIGMSMLLFKFHQEDWILM
AIAIPLVLIARYLSVFLSYIGFKRFRQYNPWSIKILTWGGLRGGLALAMALSIPSGIWVISDKLIDVKEIILVMTYAVVV
FSILVQGSTITPMIEKAKKSEAEFEAKQSSVTVPEGKTESITS

Specific function: Unknown

COG id: COG0025

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family [H]

Homologues:

Organism=Homo sapiens, GI148727259, Length=336, Percent_Identity=27.6785714285714, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI15529998, Length=339, Percent_Identity=27.4336283185841, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI27777632, Length=349, Percent_Identity=25.214899713467, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI27734935, Length=356, Percent_Identity=24.438202247191, Blast_Score=86, Evalue=6e-17,
Organism=Homo sapiens, GI294997330, Length=442, Percent_Identity=22.3981900452489, Blast_Score=83, Evalue=6e-16,
Organism=Homo sapiens, GI110227626, Length=445, Percent_Identity=22.247191011236, Blast_Score=82, Evalue=7e-16,
Organism=Homo sapiens, GI41872703, Length=375, Percent_Identity=25.0666666666667, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI5454070, Length=379, Percent_Identity=23.2189973614776, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI14211919, Length=409, Percent_Identity=24.2053789731051, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI194239733, Length=355, Percent_Identity=25.6338028169014, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI4759144, Length=341, Percent_Identity=27.8592375366569, Blast_Score=75, Evalue=1e-13,
Organism=Escherichia coli, GI1790501, Length=357, Percent_Identity=27.1708683473389, Blast_Score=91, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI71999819, Length=402, Percent_Identity=25.1243781094527, Blast_Score=109, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI71999817, Length=402, Percent_Identity=25.1243781094527, Blast_Score=109, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI71999821, Length=402, Percent_Identity=25.1243781094527, Blast_Score=109, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI71987535, Length=340, Percent_Identity=25.8823529411765, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI71987537, Length=340, Percent_Identity=25.8823529411765, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI71990924, Length=368, Percent_Identity=23.6413043478261, Blast_Score=92, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI71990932, Length=368, Percent_Identity=23.6413043478261, Blast_Score=91, Evalue=8e-19,
Organism=Caenorhabditis elegans, GI25150332, Length=324, Percent_Identity=24.3827160493827, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI71980847, Length=367, Percent_Identity=24.2506811989101, Blast_Score=89, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI71993582, Length=336, Percent_Identity=27.0833333333333, Blast_Score=81, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI71993590, Length=336, Percent_Identity=27.0833333333333, Blast_Score=81, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI71992107, Length=300, Percent_Identity=24, Blast_Score=76, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI71992101, Length=300, Percent_Identity=24, Blast_Score=75, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI25147678, Length=315, Percent_Identity=24.4444444444444, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71987559, Length=336, Percent_Identity=22.6190476190476, Blast_Score=69, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI71987545, Length=336, Percent_Identity=22.6190476190476, Blast_Score=68, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6320663, Length=349, Percent_Identity=25.7879656160458, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI221473212, Length=350, Percent_Identity=26, Blast_Score=92, Evalue=9e-19,
Organism=Drosophila melanogaster, GI281364513, Length=350, Percent_Identity=26, Blast_Score=92, Evalue=1e-18,
Organism=Drosophila melanogaster, GI221473222, Length=350, Percent_Identity=26, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI221473215, Length=350, Percent_Identity=26, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI221510734, Length=356, Percent_Identity=24.7191011235955, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI221510738, Length=339, Percent_Identity=25.3687315634218, Blast_Score=89, Evalue=6e-18,
Organism=Drosophila melanogaster, GI281360447, Length=408, Percent_Identity=24.5098039215686, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI221510736, Length=339, Percent_Identity=25.3687315634218, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI221510732, Length=339, Percent_Identity=25.3687315634218, Blast_Score=83, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24585580, Length=339, Percent_Identity=25.3687315634218, Blast_Score=82, Evalue=7e-16,
Organism=Drosophila melanogaster, GI24585578, Length=339, Percent_Identity=25.3687315634218, Blast_Score=82, Evalue=7e-16,
Organism=Drosophila melanogaster, GI221510740, Length=339, Percent_Identity=25.3687315634218, Blast_Score=82, Evalue=7e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR018422
- InterPro:   IPR004705 [H]

Pfam domain/function: PF00999 Na_H_Exchanger [H]

EC number: NA

Molecular weight: Translated: 48846; Mature: 48714

Theoretical pI: Translated: 5.61; Mature: 5.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVYYTLCFLSAAAMLIAFVNSKIGKMQTTIAITAGSMVLSLLILIAGQNNWFHLTEIAT
CCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEHHHHHHHHHHHHCCCCCCEEHHHHHH
QTMSSIDFEDFLLKGILGFLLFAGGLGIKLPNLKDQKWEITVLALGATLFSTFFIGFALY
HHHHHCCHHHHHHHHHHHHHHHHCCCCEECCCCCCCCEEEEEEEHHHHHHHHHHHHHHHH
GICQLIGIQFDLIYCLLFGALISPTDPIAVLAIVKKLKAPRRISTQIEGESLFNDGFGLV
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCHHHCCCCCCHHHCCCCHHH
IFVTLFTIAFGHETPTVGSVTMLFIQEAIGGILYGFALGLLFHYLICATDDHSMELLLTI
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEE
GIPTAGYAFAEVLHVSGPLAMVVSGIMIGNWTRFIGFSKESEDHLDHFWELVDEFLNGVL
CCCCCHHHHHHHHHCCCCHHHHHHHHHHCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHH
FLLIGMSMLLFKFHQEDWILMAIAIPLVLIARYLSVFLSYIGFKRFRQYNPWSIKILTWG
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEC
GLRGGLALAMALSIPSGIWVISDKLIDVKEIILVMTYAVVVFSILVQGSTITPMIEKAKK
CCCHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
SEAEFEAKQSSVTVPEGKTESITS
HHHHHHHHHCCEECCCCCCCCCCC
>Mature Secondary Structure 
SVYYTLCFLSAAAMLIAFVNSKIGKMQTTIAITAGSMVLSLLILIAGQNNWFHLTEIAT
CHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEHHHHHHHHHHHHCCCCCCEEHHHHHH
QTMSSIDFEDFLLKGILGFLLFAGGLGIKLPNLKDQKWEITVLALGATLFSTFFIGFALY
HHHHHCCHHHHHHHHHHHHHHHHCCCCEECCCCCCCCEEEEEEEHHHHHHHHHHHHHHHH
GICQLIGIQFDLIYCLLFGALISPTDPIAVLAIVKKLKAPRRISTQIEGESLFNDGFGLV
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCHHHCCCCCCHHHCCCCHHH
IFVTLFTIAFGHETPTVGSVTMLFIQEAIGGILYGFALGLLFHYLICATDDHSMELLLTI
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEE
GIPTAGYAFAEVLHVSGPLAMVVSGIMIGNWTRFIGFSKESEDHLDHFWELVDEFLNGVL
CCCCCHHHHHHHHHCCCCHHHHHHHHHHCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHH
FLLIGMSMLLFKFHQEDWILMAIAIPLVLIARYLSVFLSYIGFKRFRQYNPWSIKILTWG
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEC
GLRGGLALAMALSIPSGIWVISDKLIDVKEIILVMTYAVVVFSILVQGSTITPMIEKAKK
CCCHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
SEAEFEAKQSSVTVPEGKTESITS
HHHHHHHHHCCEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8265357; 9278503 [H]