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The map label for this gene is lysC [H]

Identifier: 326423836

GI number: 326423836

Start: 1403180

End: 1404652

Strand: Reverse

Name: lysC [H]

Synonym: NA

Alternate gene names: 326423836

Gene position: 1404652-1403180 (Counterclockwise)

Preceding gene: 27364811

Following gene: 27364807

Centisome position: 42.8

GC content: 48.54

Gene sequence:

>1473_bases
ATGGATTTTCTGATTATTCAAACTGACCTCTCTAAACTGCTCTGCCCCTTTCCTCACCAAAACAAACATCGGATGTTGGA
TTACCAACGGTTAATATTTTTCGGAAGTCGTGGGAGAAATGCCGTGAGCGCATTGAATGTAGCGAAATTTGGTGGAACAA
GTGTTGCAAACTTTGAGGCAATGAGTCGTTGCTCGGCCATTATTGAAAACAATCCAGAGACACGCTTAGTGGTAAGCAGT
GCATGCTCTGGCGTCACTAACCTATTGGTAGAGTTGGCCAATGGTGTTCAATCACAGGAAAGACGCGCTGAACTTCTAGC
CCAATTGGCTGAAATTCATGACGCGATTCTCAATCAATTGGAAGATGCAACAGAAGCGGCGGCGGAAGTGTATGCCATTC
TAGATACCATCACTAGCCTTGCTGAAGCCGCATCGATTCAAGCCAGCAATAAACTCACCGACCACTTGGTCGCGTGTGGT
GAGTTGATGTCGACTCATATTCTGGCCCAGTTGATGCGTGAGCGTGGAGTCAACGCGGTGCGATTTGATATTCGAGAAGT
CCTACGCACAGATGACAACTTTGGCCGCGCAGAACCTGACGTGGCAAAGATTGCAGAGCTGGCGCAAGAGAAGCTTTTAC
CACTTTGCCGCGATTACGTGGTAGTGACTCAAGGCTTCATCGGCTCGGATGAGGAAGGTAATACCACCACCTTAGGCCGT
GGTGGCAGTGATTACAGTGCGGCTTTGATTGCCGAAGGCGTTAAAGCAAGTGGCCTAGAGATTTGGACCGATGTTCCAGG
GATCTACACCACTGATCCTCGCATTGCGGCGAAAGCAGCGCCAATTCCAGAAATCAGCTTTGCAGAAGCGTCTGAAATGG
CTAACTTTGGTGCCAAAATTCTGCACCCATCAACGCTCGTTCCAGCCCTTCGTCACGACATTCCAGTTTTTGTCGGATCG
TCAAAAGAGCCAGAAAAAGGCGGTACTTGGATTCGCCACGAAGCACAAAGCTCGCCGCTTTTCCGTGCACTGGCACTGCG
TTGCAATCAGACTATGGTCACCTTACGCAGTGCGAAAATGTTCCATGCGTACGGCTTCTTAGCCAAAGTATTTGAAATTC
TCGCAAAACATAAAATCTCCGTGGATTTGATCACAACCTCAGAGATCAGCGTTTCCCTCACTCTAGACAAAACGGACACT
TCTGGTGGTGCACCTGAACTGCCACAGGCCGCGCGAGAGGAGCTTGAAGAGCTATGCACTGTTGAAGTCGAGCACAACCT
TTGTCTGGTGGCCTTGATCGGCAATCATATGGAGACAAAGGGTTACGCTAAAGAAGTCTTCAGCACCTTAGGGGATTTCA
ATTTGCGTATGATCTGTTACGGGGCAAGTGATCACAACCTTTGCTTCTTAGTCGATGCACACGACTCTAAGAGCGTGATC
CAAAAACTGCATCAAGATCTTTTTGAACGCTAA

Upstream 100 bases:
NA

Downstream 100 bases:
NA

Product: asparate kinase, monofunctional class

Products: NA

Alternate protein names: Aspartate kinase III; AKIII; Lysine-sensitive aspartokinase III [H]

Number of amino acids: Translated: 490; Mature: 490

Protein sequence:
NA

Sequences:

>Translated_490_residues
MDFLIIQTDLSKLLCPFPHQNKHRMLDYQRLIFFGSRGRNAVSALNVAKFGGTSVANFEAMSRCSAIIENNPETRLVVSS
ACSGVTNLLVELANGVQSQERRAELLAQLAEIHDAILNQLEDATEAAAEVYAILDTITSLAEAASIQASNKLTDHLVACG
ELMSTHILAQLMRERGVNAVRFDIREVLRTDDNFGRAEPDVAKIAELAQEKLLPLCRDYVVVTQGFIGSDEEGNTTTLGR
GGSDYSAALIAEGVKASGLEIWTDVPGIYTTDPRIAAKAAPIPEISFAEASEMANFGAKILHPSTLVPALRHDIPVFVGS
SKEPEKGGTWIRHEAQSSPLFRALALRCNQTMVTLRSAKMFHAYGFLAKVFEILAKHKISVDLITTSEISVSLTLDKTDT
SGGAPELPQAAREELEELCTVEVEHNLCLVALIGNHMETKGYAKEVFSTLGDFNLRMICYGASDHNLCFLVDAHDSKSVI
QKLHQDLFER
>Mature_490_residues
MDFLIIQTDLSKLLCPFPHQNKHRMLDYQRLIFFGSRGRNAVSALNVAKFGGTSVANFEAMSRCSAIIENNPETRLVVSS
ACSGVTNLLVELANGVQSQERRAELLAQLAEIHDAILNQLEDATEAAAEVYAILDTITSLAEAASIQASNKLTDHLVACG
ELMSTHILAQLMRERGVNAVRFDIREVLRTDDNFGRAEPDVAKIAELAQEKLLPLCRDYVVVTQGFIGSDEEGNTTTLGR
GGSDYSAALIAEGVKASGLEIWTDVPGIYTTDPRIAAKAAPIPEISFAEASEMANFGAKILHPSTLVPALRHDIPVFVGS
SKEPEKGGTWIRHEAQSSPLFRALALRCNQTMVTLRSAKMFHAYGFLAKVFEILAKHKISVDLITTSEISVSLTLDKTDT
SGGAPELPQAAREELEELCTVEVEHNLCLVALIGNHMETKGYAKEVFSTLGDFNLRMICYGASDHNLCFLVDAHDSKSVI
QKLHQDLFER

Specific function: Lysine biosynthesis; first step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1790455, Length=450, Percent_Identity=57.5555555555556, Blast_Score=467, Evalue=1e-133,
Organism=Escherichia coli, GI1786183, Length=467, Percent_Identity=31.2633832976445, Blast_Score=190, Evalue=2e-49,
Organism=Escherichia coli, GI1790376, Length=302, Percent_Identity=31.4569536423841, Blast_Score=122, Evalue=6e-29,
Organism=Saccharomyces cerevisiae, GI6320893, Length=496, Percent_Identity=29.2338709677419, Blast_Score=166, Evalue=7e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR001048
- InterPro:   IPR005260
- InterPro:   IPR001341
- InterPro:   IPR018042 [H]

Pfam domain/function: PF00696 AA_kinase; PF01842 ACT [H]

EC number: =2.7.2.4 [H]

Molecular weight: Translated: 53528; Mature: 53528

Theoretical pI: Translated: 5.14; Mature: 5.14

Prosite motif: PS00324 ASPARTOKINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFLIIQTDLSKLLCPFPHQNKHRMLDYQRLIFFGSRGRNAVSALNVAKFGGTSVANFEA
CCEEEEECCHHHHCCCCCCCCCHHHHHHHHHHEECCCCCCHHHHHHHHHCCCCCHHHHHH
MSRCSAIIENNPETRLVVSSACSGVTNLLVELANGVQSQERRAELLAQLAEIHDAILNQL
HHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
EDATEAAAEVYAILDTITSLAEAASIQASNKLTDHLVACGELMSTHILAQLMRERGVNAV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
RFDIREVLRTDDNFGRAEPDVAKIAELAQEKLLPLCRDYVVVTQGFIGSDEEGNTTTLGR
HHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEECCC
GGSDYSAALIAEGVKASGLEIWTDVPGIYTTDPRIAAKAAPIPEISFAEASEMANFGAKI
CCCCHHHHHHHCCCCCCCCEEEECCCCCEECCCCHHHCCCCCCCCCHHHHHHHHHCCHHH
LHPSTLVPALRHDIPVFVGSSKEPEKGGTWIRHEAQSSPLFRALALRCNQTMVTLRSAKM
CCCHHHHHHHHCCCCEEECCCCCCCCCCCEEEECCCCCHHHHHHHHHCCCHHHHHHHHHH
FHAYGFLAKVFEILAKHKISVDLITTSEISVSLTLDKTDTSGGAPELPQAAREELEELCT
HHHHHHHHHHHHHHHHCCCEEEEEEECCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHE
VEVEHNLCLVALIGNHMETKGYAKEVFSTLGDFNLRMICYGASDHNLCFLVDAHDSKSVI
EEECCCEEEEEEECCCCCCHHHHHHHHHHHCCCCEEEEEEECCCCCEEEEEECCCCHHHH
QKLHQDLFER
HHHHHHHHCC
>Mature Secondary Structure
MDFLIIQTDLSKLLCPFPHQNKHRMLDYQRLIFFGSRGRNAVSALNVAKFGGTSVANFEA
CCEEEEECCHHHHCCCCCCCCCHHHHHHHHHHEECCCCCCHHHHHHHHHCCCCCHHHHHH
MSRCSAIIENNPETRLVVSSACSGVTNLLVELANGVQSQERRAELLAQLAEIHDAILNQL
HHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
EDATEAAAEVYAILDTITSLAEAASIQASNKLTDHLVACGELMSTHILAQLMRERGVNAV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
RFDIREVLRTDDNFGRAEPDVAKIAELAQEKLLPLCRDYVVVTQGFIGSDEEGNTTTLGR
HHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEECCC
GGSDYSAALIAEGVKASGLEIWTDVPGIYTTDPRIAAKAAPIPEISFAEASEMANFGAKI
CCCCHHHHHHHCCCCCCCCEEEECCCCCEECCCCHHHCCCCCCCCCHHHHHHHHHCCHHH
LHPSTLVPALRHDIPVFVGSSKEPEKGGTWIRHEAQSSPLFRALALRCNQTMVTLRSAKM
CCCHHHHHHHHCCCCEEECCCCCCCCCCCEEEECCCCCHHHHHHHHHCCCHHHHHHHHHH
FHAYGFLAKVFEILAKHKISVDLITTSEISVSLTLDKTDTSGGAPELPQAAREELEELCT
HHHHHHHHHHHHHHHHCCCEEEEEEECCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHE
VEVEHNLCLVALIGNHMETKGYAKEVFSTLGDFNLRMICYGASDHNLCFLVDAHDSKSVI
EEECCCEEEEEEECCCCCCHHHHHHHHHHHCCCCEEEEEEECCCCCEEEEEECCCCHHHH
QKLHQDLFER
HHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3003049; 8265357; 9278503; 6312411 [H]