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The map label for this gene is frdB [H]

Identifier: 27364669

GI number: 27364669

Start: 1252336

End: 1253094

Strand: Reverse

Name: frdB [H]

Synonym: VV1_1268

Alternate gene names: 27364669

Gene position: 1253094-1252336 (Counterclockwise)

Preceding gene: 27364670

Following gene: 27364668

Centisome position: 38.18

GC content: 49.14

Gene sequence:

>759_bases
ATGTCGGCAAACCGCATTCAAAAAGTAGACATTCTGCGTTACGACCCAGCAACAGACGCAGAACCTCGTTTTCAGGCTTT
CGAAGTCCCGTTTGATGAAACCATGTCGGTACTTGATGCTCTGGGCTACGTCAAAGATCATCTCGACAAAAACCTCTCTT
ACCGTTGGTCTTGTCGTATGGCGATTTGTGGCTCGTGCGGCATCATGGTCAACGGCGTGCCAAAACTGGCGTGTAAGAGC
TTCCTGCGCGACTACCCAGACGGCGTGAAAATCGAGCCATTAGCAAACTTCCCAATCGAGAAAGATTTGATTGTCGATAT
GACGCCGTTCATCGAGCGCCTAGAAGCGATCAAACCTTACATCATTGGCAACGACCGCAAGCCAGAAGATGGTACTAACC
TACAAACCCCTGAACAGCTGGCAAAATACAAGCAGTTCGCGGGTTGTATTAACTGTGGTCTTTGCTACGCAGCGTGTCCG
CAGTTCGGTTTGAACCCAGAGTTCATTGGTCCAGCAGCACTGACTTTGGCACACCGCTACAACCTAGATAGCCGTGACAA
TGGTAAAGCAGAGCGTATGAAGCTAATCAATGGCGAAAACGGTGCGTGGGGCTGTACGTTTGTTGGCTATTGTTCTGAAG
TTTGTCCGAAGAATGTTGATCCTGCTGCCGCGGTTAACCAAGGCAAAGTCGAGTCATCAATGGACTTCGTCATTGCAATG
CTGAAACCTGATGGTTCACCAAAGAAAGTGGAGGCATAA

Upstream 100 bases:

>100_bases
AGTCTCAGCCTAAAGCACGTTTGTATGGTGAAGCAGCAGAGAAAGCTGCCGCTGAAGAAGCCGCTAAGGCCGCAGAGAAA
AACGCAGAGGAGCAAGCATA

Downstream 100 bases:

>100_bases
GAATGAGCAATCGTAAACCTTACGTTCGTGAAGTAAAACGCACTTGGTGGAAAGATCACCCATTCTACCGCTTCTACATG
CTACGTGAAGCCACTGTGCT

Product: fumarate reductase iron-sulfur subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 252; Mature: 251

Protein sequence:

>252_residues
MSANRIQKVDILRYDPATDAEPRFQAFEVPFDETMSVLDALGYVKDHLDKNLSYRWSCRMAICGSCGIMVNGVPKLACKS
FLRDYPDGVKIEPLANFPIEKDLIVDMTPFIERLEAIKPYIIGNDRKPEDGTNLQTPEQLAKYKQFAGCINCGLCYAACP
QFGLNPEFIGPAALTLAHRYNLDSRDNGKAERMKLINGENGAWGCTFVGYCSEVCPKNVDPAAAVNQGKVESSMDFVIAM
LKPDGSPKKVEA

Sequences:

>Translated_252_residues
MSANRIQKVDILRYDPATDAEPRFQAFEVPFDETMSVLDALGYVKDHLDKNLSYRWSCRMAICGSCGIMVNGVPKLACKS
FLRDYPDGVKIEPLANFPIEKDLIVDMTPFIERLEAIKPYIIGNDRKPEDGTNLQTPEQLAKYKQFAGCINCGLCYAACP
QFGLNPEFIGPAALTLAHRYNLDSRDNGKAERMKLINGENGAWGCTFVGYCSEVCPKNVDPAAAVNQGKVESSMDFVIAM
LKPDGSPKKVEA
>Mature_251_residues
SANRIQKVDILRYDPATDAEPRFQAFEVPFDETMSVLDALGYVKDHLDKNLSYRWSCRMAICGSCGIMVNGVPKLACKSF
LRDYPDGVKIEPLANFPIEKDLIVDMTPFIERLEAIKPYIIGNDRKPEDGTNLQTPEQLAKYKQFAGCINCGLCYAACPQ
FGLNPEFIGPAALTLAHRYNLDSRDNGKAERMKLINGENGAWGCTFVGYCSEVCPKNVDPAAAVNQGKVESSMDFVIAML
KPDGSPKKVEA

Specific function: Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth [H]

COG id: COG0479

COG function: function code C; Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 4Fe-4S ferredoxin-type domain [H]

Homologues:

Organism=Homo sapiens, GI115387094, Length=233, Percent_Identity=34.3347639484979, Blast_Score=137, Evalue=1e-32,
Organism=Escherichia coli, GI1790596, Length=243, Percent_Identity=72.4279835390947, Blast_Score=389, Evalue=1e-110,
Organism=Escherichia coli, GI1786943, Length=228, Percent_Identity=38.5964912280702, Blast_Score=151, Evalue=4e-38,
Organism=Caenorhabditis elegans, GI17533915, Length=236, Percent_Identity=34.7457627118644, Blast_Score=140, Evalue=5e-34,
Organism=Saccharomyces cerevisiae, GI6322987, Length=237, Percent_Identity=33.7552742616034, Blast_Score=140, Evalue=2e-34,
Organism=Drosophila melanogaster, GI24643156, Length=249, Percent_Identity=32.1285140562249, Blast_Score=139, Evalue=2e-33,
Organism=Drosophila melanogaster, GI17137106, Length=235, Percent_Identity=34.468085106383, Blast_Score=137, Evalue=7e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006058
- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR012675
- InterPro:   IPR001041
- InterPro:   IPR012285
- InterPro:   IPR009051
- InterPro:   IPR004489 [H]

Pfam domain/function: NA

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 27874; Mature: 27743

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: PS00197 2FE2S_FER_1 ; PS51085 2FE2S_FER_2 ; PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
7.5 %Cys+Met (Translated Protein)
4.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
7.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSANRIQKVDILRYDPATDAEPRFQAFEVPFDETMSVLDALGYVKDHLDKNLSYRWSCRM
CCCCCCEEEEEEEECCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEE
AICGSCGIMVNGVPKLACKSFLRDYPDGVKIEPLANFPIEKDLIVDMTPFIERLEAIKPY
EEECCCCEEECCCHHHHHHHHHHHCCCCCEECCCCCCCCCCCCEECHHHHHHHHHHHCCE
IIGNDRKPEDGTNLQTPEQLAKYKQFAGCINCGLCYAACPQFGLNPEFIGPAALTLAHRY
EECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHC
NLDSRDNGKAERMKLINGENGAWGCTFVGYCSEVCPKNVDPAAAVNQGKVESSMDFVIAM
CCCCCCCCHHHHEEEECCCCCCCHHHHHHHHHHHCCCCCCCHHHCCCCCCCCCCEEEEEE
LKPDGSPKKVEA
ECCCCCCCCCCC
>Mature Secondary Structure 
SANRIQKVDILRYDPATDAEPRFQAFEVPFDETMSVLDALGYVKDHLDKNLSYRWSCRM
CCCCCEEEEEEEECCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEE
AICGSCGIMVNGVPKLACKSFLRDYPDGVKIEPLANFPIEKDLIVDMTPFIERLEAIKPY
EEECCCCEEECCCHHHHHHHHHHHCCCCCEECCCCCCCCCCCCEECHHHHHHHHHHHCCE
IIGNDRKPEDGTNLQTPEQLAKYKQFAGCINCGLCYAACPQFGLNPEFIGPAALTLAHRY
EECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHC
NLDSRDNGKAERMKLINGENGAWGCTFVGYCSEVCPKNVDPAAAVNQGKVESSMDFVIAM
CCCCCCCCHHHHEEEECCCCCCCHHHHHHHHHHHCCCCCCCHHHCCCCCCCCCCEEEEEE
LKPDGSPKKVEA
ECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]