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The map label for this gene is accC [H]

Identifier: 27364636

GI number: 27364636

Start: 1213002

End: 1214348

Strand: Reverse

Name: accC [H]

Synonym: VV1_1234

Alternate gene names: 27364636

Gene position: 1214348-1213002 (Counterclockwise)

Preceding gene: 27364637

Following gene: 27364635

Centisome position: 37.0

GC content: 50.33

Gene sequence:

>1347_bases
ATGCTAGATAAAGTAGTCATCGCGAACCGAGGTGAAATCGCACTTCGTATCCTTCGCGCGTGTAAAGAACTCGGCATCAA
AACCGTTGCCGTGCACTCCACCGCCGATCGCGATCTAAAACACGTACTGCTGGCAGATGAAACTGTGTGTATCGGTCCTG
CTCGTGGTATCGACAGCTATCTGAACATTCCTCGCATTATTTCAGCAGCAGAAGTGACTGGCGCGGTGGCGATCCACCCA
GGTTACGGTTTCTTGTCTGAAAACGCAGACTTTGCTGAACAAGTAGAACGTAGCGGGTTCATCTTTGTGGGTCCAAAAGC
GGACACCATCCGCATGATGGGTGACAAAGTATCGGCTATCACTGCAATGAAAAAAGCGGGCGTTCCATGTGTACCTGGTT
CTGATGGTCCACTTGATAACGACGAAGTGAAAAACCGAGCACACGCGAAACGTATTGGTTACCCAGTGATCATCAAAGCC
TCTGGTGGCGGTGGTGGTCGTGGTATGCGTGTGGTTCGTAAAGAAGCAGACCTCGTTCAAGCAATTGCCATGACGCGTGC
AGAAGCAAAAGCAGCATTCAACAACGACATGGTTTACATGGAGAAATTCCTAGAAAACCCACGTCACGTTGAAGTTCAAG
TGATTGCAGATGGCCAAGGCGGCGCTATCCACCTAGGTGAGCGTGATTGTTCAATGCAGCGTCGTCACCAAAAGGTTGTT
GAAGAAGCACCAGCTCCAGGTATTACTGAAGAGATGCGTAAGTACATCGGCGAACGTTGTACTCGTGCATGTCTAGAGAT
CGGTTACCGCGGTGCAGGTACATTCGAATTCCTCTACGAAAACGGTGAGTTCTACTTCATTGAAATGAACACCCGTATTC
AGGTTGAGCACCCAGTGACTGAAATGGTGACTGGTGTTGACCTGATCAAAGAACAGCTGCGCGTTGCGGCGGGTCAGCCT
CTGTCATTCACGCAGAACGACATTAAGATCCGTGGCCATGCGATTGAATGTCGTATCAACGCGGAAGACCCAGAACGCTT
CCTACCGTCTCCAGGTAAGATTGAACGCTTCCACGCACCAGGCGGTATGGGTGTTCGTTGGGAATCGCACATCTACAGCG
GCTACACCGTGCCACCGCACTACGACTCAATGATCGGTAAGCTGATCACTTACGGTGAAAACCGTGACGTTGCGATTGCA
CGTATGAAGAACGCCCTGGGTGAGATGTTCATTGAAGGCATCAAGACCAACATTCCGCTGCAAGTGAGCATCATGAACGA
TGAAAACTTCCAGCACGGTGGTGCCAACATCCACTACCTAGAGAAAAAACTCGGCCTTCAGCACTAA

Upstream 100 bases:

>100_bases
AGCCGACAAATCTGGCGTGGTAACAGCAATCCTTGTTGAAGACGGCCAGCCTGTTGAGTTTGACCAACCACTTGTAGTTA
TCGAATAAGCGGAGTTCGCT

Downstream 100 bases:

>100_bases
GCGCAGCGCACTGGTTACCATGCCCACTTCGGTGGGCATTTTTCATTGAGCGGATTTTTTCGTTTGCAGGGAAAGTCTGC
TAAACTCTGCGCCAAATTTA

Product: acetyl-CoA carboxylase biotin carboxylase subunit

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A; ACC [H]

Number of amino acids: Translated: 448; Mature: 448

Protein sequence:

>448_residues
MLDKVVIANRGEIALRILRACKELGIKTVAVHSTADRDLKHVLLADETVCIGPARGIDSYLNIPRIISAAEVTGAVAIHP
GYGFLSENADFAEQVERSGFIFVGPKADTIRMMGDKVSAITAMKKAGVPCVPGSDGPLDNDEVKNRAHAKRIGYPVIIKA
SGGGGGRGMRVVRKEADLVQAIAMTRAEAKAAFNNDMVYMEKFLENPRHVEVQVIADGQGGAIHLGERDCSMQRRHQKVV
EEAPAPGITEEMRKYIGERCTRACLEIGYRGAGTFEFLYENGEFYFIEMNTRIQVEHPVTEMVTGVDLIKEQLRVAAGQP
LSFTQNDIKIRGHAIECRINAEDPERFLPSPGKIERFHAPGGMGVRWESHIYSGYTVPPHYDSMIGKLITYGENRDVAIA
RMKNALGEMFIEGIKTNIPLQVSIMNDENFQHGGANIHYLEKKLGLQH

Sequences:

>Translated_448_residues
MLDKVVIANRGEIALRILRACKELGIKTVAVHSTADRDLKHVLLADETVCIGPARGIDSYLNIPRIISAAEVTGAVAIHP
GYGFLSENADFAEQVERSGFIFVGPKADTIRMMGDKVSAITAMKKAGVPCVPGSDGPLDNDEVKNRAHAKRIGYPVIIKA
SGGGGGRGMRVVRKEADLVQAIAMTRAEAKAAFNNDMVYMEKFLENPRHVEVQVIADGQGGAIHLGERDCSMQRRHQKVV
EEAPAPGITEEMRKYIGERCTRACLEIGYRGAGTFEFLYENGEFYFIEMNTRIQVEHPVTEMVTGVDLIKEQLRVAAGQP
LSFTQNDIKIRGHAIECRINAEDPERFLPSPGKIERFHAPGGMGVRWESHIYSGYTVPPHYDSMIGKLITYGENRDVAIA
RMKNALGEMFIEGIKTNIPLQVSIMNDENFQHGGANIHYLEKKLGLQH
>Mature_448_residues
MLDKVVIANRGEIALRILRACKELGIKTVAVHSTADRDLKHVLLADETVCIGPARGIDSYLNIPRIISAAEVTGAVAIHP
GYGFLSENADFAEQVERSGFIFVGPKADTIRMMGDKVSAITAMKKAGVPCVPGSDGPLDNDEVKNRAHAKRIGYPVIIKA
SGGGGGRGMRVVRKEADLVQAIAMTRAEAKAAFNNDMVYMEKFLENPRHVEVQVIADGQGGAIHLGERDCSMQRRHQKVV
EEAPAPGITEEMRKYIGERCTRACLEIGYRGAGTFEFLYENGEFYFIEMNTRIQVEHPVTEMVTGVDLIKEQLRVAAGQP
LSFTQNDIKIRGHAIECRINAEDPERFLPSPGKIERFHAPGGMGVRWESHIYSGYTVPPHYDSMIGKLITYGENRDVAIA
RMKNALGEMFIEGIKTNIPLQVSIMNDENFQHGGANIHYLEKKLGLQH

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI116805327, Length=440, Percent_Identity=48.4090909090909, Blast_Score=421, Evalue=1e-118,
Organism=Homo sapiens, GI189095269, Length=443, Percent_Identity=46.7268623024831, Blast_Score=397, Evalue=1e-111,
Organism=Homo sapiens, GI65506442, Length=443, Percent_Identity=46.7268623024831, Blast_Score=397, Evalue=1e-110,
Organism=Homo sapiens, GI295821183, Length=443, Percent_Identity=46.7268623024831, Blast_Score=397, Evalue=1e-110,
Organism=Homo sapiens, GI106049528, Length=452, Percent_Identity=44.6902654867257, Blast_Score=371, Evalue=1e-103,
Organism=Homo sapiens, GI106049295, Length=452, Percent_Identity=44.6902654867257, Blast_Score=371, Evalue=1e-103,
Organism=Homo sapiens, GI106049292, Length=452, Percent_Identity=44.6902654867257, Blast_Score=371, Evalue=1e-103,
Organism=Homo sapiens, GI38679977, Length=504, Percent_Identity=30.7539682539683, Blast_Score=237, Evalue=1e-62,
Organism=Homo sapiens, GI38679967, Length=504, Percent_Identity=30.7539682539683, Blast_Score=237, Evalue=1e-62,
Organism=Homo sapiens, GI38679960, Length=504, Percent_Identity=30.7539682539683, Blast_Score=237, Evalue=1e-62,
Organism=Homo sapiens, GI38679974, Length=504, Percent_Identity=30.7539682539683, Blast_Score=237, Evalue=1e-62,
Organism=Homo sapiens, GI38679971, Length=504, Percent_Identity=30.7539682539683, Blast_Score=237, Evalue=2e-62,
Organism=Homo sapiens, GI134142062, Length=504, Percent_Identity=29.5634920634921, Blast_Score=228, Evalue=8e-60,
Organism=Escherichia coli, GI1789654, Length=447, Percent_Identity=85.4586129753915, Blast_Score=781, Evalue=0.0,
Organism=Escherichia coli, GI1786216, Length=238, Percent_Identity=27.7310924369748, Blast_Score=84, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17567343, Length=443, Percent_Identity=45.5981941309255, Blast_Score=395, Evalue=1e-110,
Organism=Caenorhabditis elegans, GI71987519, Length=442, Percent_Identity=46.3800904977376, Blast_Score=387, Evalue=1e-108,
Organism=Caenorhabditis elegans, GI17562816, Length=449, Percent_Identity=44.097995545657, Blast_Score=358, Evalue=2e-99,
Organism=Caenorhabditis elegans, GI71997168, Length=446, Percent_Identity=30.4932735426009, Blast_Score=203, Evalue=2e-52,
Organism=Caenorhabditis elegans, GI71997163, Length=446, Percent_Identity=30.4932735426009, Blast_Score=203, Evalue=2e-52,
Organism=Caenorhabditis elegans, GI133931226, Length=490, Percent_Identity=28.1632653061224, Blast_Score=199, Evalue=2e-51,
Organism=Saccharomyces cerevisiae, GI6319685, Length=443, Percent_Identity=42.4379232505643, Blast_Score=351, Evalue=1e-97,
Organism=Saccharomyces cerevisiae, GI6319695, Length=440, Percent_Identity=44.5454545454545, Blast_Score=345, Evalue=9e-96,
Organism=Saccharomyces cerevisiae, GI6321376, Length=440, Percent_Identity=45.9090909090909, Blast_Score=338, Evalue=9e-94,
Organism=Saccharomyces cerevisiae, GI6324343, Length=510, Percent_Identity=30.3921568627451, Blast_Score=235, Evalue=8e-63,
Organism=Saccharomyces cerevisiae, GI6323863, Length=452, Percent_Identity=32.7433628318584, Blast_Score=228, Evalue=1e-60,
Organism=Drosophila melanogaster, GI24651757, Length=441, Percent_Identity=47.3922902494331, Blast_Score=409, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24652212, Length=445, Percent_Identity=47.1910112359551, Blast_Score=389, Evalue=1e-108,
Organism=Drosophila melanogaster, GI24652210, Length=445, Percent_Identity=47.1910112359551, Blast_Score=389, Evalue=1e-108,
Organism=Drosophila melanogaster, GI24652214, Length=445, Percent_Identity=47.1910112359551, Blast_Score=389, Evalue=1e-108,
Organism=Drosophila melanogaster, GI19921944, Length=445, Percent_Identity=47.1910112359551, Blast_Score=389, Evalue=1e-108,
Organism=Drosophila melanogaster, GI24652216, Length=445, Percent_Identity=47.1910112359551, Blast_Score=389, Evalue=1e-108,
Organism=Drosophila melanogaster, GI281363050, Length=445, Percent_Identity=47.1910112359551, Blast_Score=388, Evalue=1e-108,
Organism=Drosophila melanogaster, GI24652224, Length=445, Percent_Identity=47.1910112359551, Blast_Score=388, Evalue=1e-108,
Organism=Drosophila melanogaster, GI24652222, Length=445, Percent_Identity=47.1910112359551, Blast_Score=388, Evalue=1e-108,
Organism=Drosophila melanogaster, GI24652220, Length=445, Percent_Identity=47.1910112359551, Blast_Score=388, Evalue=1e-108,
Organism=Drosophila melanogaster, GI24652218, Length=445, Percent_Identity=47.1910112359551, Blast_Score=388, Evalue=1e-108,
Organism=Drosophila melanogaster, GI24651759, Length=402, Percent_Identity=47.5124378109453, Blast_Score=371, Evalue=1e-103,
Organism=Drosophila melanogaster, GI161076409, Length=503, Percent_Identity=30.6163021868787, Blast_Score=218, Evalue=6e-57,
Organism=Drosophila melanogaster, GI24586458, Length=503, Percent_Identity=30.6163021868787, Blast_Score=218, Evalue=7e-57,
Organism=Drosophila melanogaster, GI161076407, Length=503, Percent_Identity=30.6163021868787, Blast_Score=218, Evalue=7e-57,
Organism=Drosophila melanogaster, GI24586460, Length=503, Percent_Identity=30.6163021868787, Blast_Score=218, Evalue=7e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 49409; Mature: 49409

Theoretical pI: Translated: 7.06; Mature: 7.06

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDKVVIANRGEIALRILRACKELGIKTVAVHSTADRDLKHVLLADETVCIGPARGIDSY
CCCCEEEECCCHHHHHHHHHHHHCCCEEEEEECCCCCCHHEEEEECCEEEECCCCCCHHH
LNIPRIISAAEVTGAVAIHPGYGFLSENADFAEQVERSGFIFVGPKADTIRMMGDKVSAI
CCCHHHHHHHHHCCEEEEECCCCCCCCCCHHHHHHHHCCEEEECCCCCEEHHCCCHHHHH
TAMKKAGVPCVPGSDGPLDNDEVKNRAHAKRIGYPVIIKASGGGGGRGMRVVRKEADLVQ
HHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHH
AIAMTRAEAKAAFNNDMVYMEKFLENPRHVEVQVIADGQGGAIHLGERDCSMQRRHQKVV
HHHHHHHHHHHHHCCCHHHHHHHHCCCCEEEEEEEECCCCCEEEECCCCHHHHHHHHHHH
EEAPAPGITEEMRKYIGERCTRACLEIGYRGAGTFEFLYENGEFYFIEMNTRIQVEHPVT
HHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCEEEEEECCEEEECCCHH
EMVTGVDLIKEQLRVAAGQPLSFTQNDIKIRGHAIECRINAEDPERFLPSPGKIERFHAP
HHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEEEEEECCCCCHHHCCCCCCEEEEECC
GGMGVRWESHIYSGYTVPPHYDSMIGKLITYGENRDVAIARMKNALGEMFIEGIKTNIPL
CCCCCEECCCEECCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCE
QVSIMNDENFQHGGANIHYLEKKLGLQH
EEEEECCCCCCCCCCEEEEEHHHCCCCC
>Mature Secondary Structure
MLDKVVIANRGEIALRILRACKELGIKTVAVHSTADRDLKHVLLADETVCIGPARGIDSY
CCCCEEEECCCHHHHHHHHHHHHCCCEEEEEECCCCCCHHEEEEECCEEEECCCCCCHHH
LNIPRIISAAEVTGAVAIHPGYGFLSENADFAEQVERSGFIFVGPKADTIRMMGDKVSAI
CCCHHHHHHHHHCCEEEEECCCCCCCCCCHHHHHHHHCCEEEECCCCCEEHHCCCHHHHH
TAMKKAGVPCVPGSDGPLDNDEVKNRAHAKRIGYPVIIKASGGGGGRGMRVVRKEADLVQ
HHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHH
AIAMTRAEAKAAFNNDMVYMEKFLENPRHVEVQVIADGQGGAIHLGERDCSMQRRHQKVV
HHHHHHHHHHHHHCCCHHHHHHHHCCCCEEEEEEEECCCCCEEEECCCCHHHHHHHHHHH
EEAPAPGITEEMRKYIGERCTRACLEIGYRGAGTFEFLYENGEFYFIEMNTRIQVEHPVT
HHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCEEEEEECCEEEECCCHH
EMVTGVDLIKEQLRVAAGQPLSFTQNDIKIRGHAIECRINAEDPERFLPSPGKIERFHAP
HHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEEEEEECCCCCHHHCCCCCCEEEEECC
GGMGVRWESHIYSGYTVPPHYDSMIGKLITYGENRDVAIARMKNALGEMFIEGIKTNIPL
CCCCCEECCCEECCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCE
QVSIMNDENFQHGGANIHYLEKKLGLQH
EEEEECCCCCCCCCCEEEEEHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]