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The map label for this gene is ilvY [H]

Identifier: 27364499

GI number: 27364499

Start: 1067467

End: 1068357

Strand: Reverse

Name: ilvY [H]

Synonym: VV1_1076

Alternate gene names: 27364499

Gene position: 1068357-1067467 (Counterclockwise)

Preceding gene: 27364501

Following gene: 27364498

Centisome position: 32.55

GC content: 41.64

Gene sequence:

>891_bases
ATGAACATCAAAAGCTTACAGCTATTTATTCACCTCTGTGATAGTAAAAACTTTGCCAAGACGGCAGCAGCAATGCACAT
CAGTCCATCCGCGCTCAGTCGTCAAATTCAAAAGCTAGAAGAAGAAACTAGCCAGCAACTCTTCACTAGAGACAATCGTA
GTGTTGAAATAACACCTGCAGGTAAAAAACTGATGCCAGTTGCACTTAAAATGCTTAACGAATGGCAACAGTATCAATTA
CAAAACCGTTATTCAGAAACCGAACTCAAAGGGGAAATACGCTTATTTTGTTCCGTCACCGCCAGCTATAGCCACTTGCC
AGAACTTCTTTCTGAATTTCGACTACAACATCCTTTTATTGAATTCAAAATATCTACCGGTGATCCTGCACAAGCCATGG
ATAAAATTCTGAACGGAGAGGCTGATATTGCTATTTCCGCCAAACCAGACACAGTACCAGCAAAAGTGGCTTTTGAGCCC
ATCAGCGAAATTCCACTCTCTGTAATTGCACCTCAAGGAGTGAGCAGTTTCACGGATGAAATGAACCGTGATAAGCCTGA
TTGGTCTTCGATCCCCTATATAGTTCCTGAAGCAGGTACCGCTAGAGAAAGGGCGAATACTTGGTTTAAAAAGATGAAAA
TTAAACCCAATATTTATGCTCAGGTTTCAGGTCATGAAGCGATTGTGAGTATGGTAGCTTTGGGGTGTGGTATCGGTATT
GCTCCGGATGTTGTGATCAACAACAGCCCAGTCAAAGAGAAAATACAGAGACTAAAAGTCGCTCCCATTAAACCTTTTGA
GTTGGGGGTATGCTGCATCAAATCTCAACTCGAAAATCCCCTAATTCAAGCCTTATGGAAAGTTGCTGAAAGTAAGTACA
TCGTGATTTAA

Upstream 100 bases:

>100_bases
CTCACCGAATGAATTCATACTAAAACAGACTTTAAGTTGCTCAAAGTGATATATTCACAATTAGTAATTGCAAATAGTGC
AACACGGAAAGACATATACA

Downstream 100 bases:

>100_bases
GCAGCAATGCAAAGCCTGTCATACCAACCTAACTAAAAATATGATCTAATTGAGACTGTTACTTCTTCGTGATAAATGAC
GCTATGGACAGTCTTAATAA

Product: DNA-binding transcriptional regulator IlvY

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 296; Mature: 296

Protein sequence:

>296_residues
MNIKSLQLFIHLCDSKNFAKTAAAMHISPSALSRQIQKLEEETSQQLFTRDNRSVEITPAGKKLMPVALKMLNEWQQYQL
QNRYSETELKGEIRLFCSVTASYSHLPELLSEFRLQHPFIEFKISTGDPAQAMDKILNGEADIAISAKPDTVPAKVAFEP
ISEIPLSVIAPQGVSSFTDEMNRDKPDWSSIPYIVPEAGTARERANTWFKKMKIKPNIYAQVSGHEAIVSMVALGCGIGI
APDVVINNSPVKEKIQRLKVAPIKPFELGVCCIKSQLENPLIQALWKVAESKYIVI

Sequences:

>Translated_296_residues
MNIKSLQLFIHLCDSKNFAKTAAAMHISPSALSRQIQKLEEETSQQLFTRDNRSVEITPAGKKLMPVALKMLNEWQQYQL
QNRYSETELKGEIRLFCSVTASYSHLPELLSEFRLQHPFIEFKISTGDPAQAMDKILNGEADIAISAKPDTVPAKVAFEP
ISEIPLSVIAPQGVSSFTDEMNRDKPDWSSIPYIVPEAGTARERANTWFKKMKIKPNIYAQVSGHEAIVSMVALGCGIGI
APDVVINNSPVKEKIQRLKVAPIKPFELGVCCIKSQLENPLIQALWKVAESKYIVI
>Mature_296_residues
MNIKSLQLFIHLCDSKNFAKTAAAMHISPSALSRQIQKLEEETSQQLFTRDNRSVEITPAGKKLMPVALKMLNEWQQYQL
QNRYSETELKGEIRLFCSVTASYSHLPELLSEFRLQHPFIEFKISTGDPAQAMDKILNGEADIAISAKPDTVPAKVAFEP
ISEIPLSVIAPQGVSSFTDEMNRDKPDWSSIPYIVPEAGTARERANTWFKKMKIKPNIYAQVSGHEAIVSMVALGCGIGI
APDVVINNSPVKEKIQRLKVAPIKPFELGVCCIKSQLENPLIQALWKVAESKYIVI

Specific function: This protein activates the transcription of the ilvC gene in the presence of acetolactate or acetohydroxybutyrate. IlvY is also a negative regulator of its own expression [H]

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790208, Length=292, Percent_Identity=47.6027397260274, Blast_Score=285, Evalue=2e-78,
Organism=Escherichia coli, GI1787806, Length=264, Percent_Identity=22.7272727272727, Blast_Score=85, Evalue=5e-18,
Organism=Escherichia coli, GI145693105, Length=291, Percent_Identity=24.0549828178694, Blast_Score=85, Evalue=7e-18,
Organism=Escherichia coli, GI1788887, Length=250, Percent_Identity=24.8, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1788296, Length=235, Percent_Identity=27.2340425531915, Blast_Score=78, Evalue=7e-16,
Organism=Escherichia coli, GI1788297, Length=251, Percent_Identity=26.6932270916335, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1788748, Length=298, Percent_Identity=23.489932885906, Blast_Score=74, Evalue=8e-15,
Organism=Escherichia coli, GI1787530, Length=260, Percent_Identity=22.3076923076923, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1787879, Length=248, Percent_Identity=23.7903225806452, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1787601, Length=146, Percent_Identity=28.0821917808219, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI157672245, Length=232, Percent_Identity=21.1206896551724, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1790399, Length=253, Percent_Identity=25.296442687747, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI145693193, Length=126, Percent_Identity=30.952380952381, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI2367136, Length=256, Percent_Identity=23.4375, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 33037; Mature: 33037

Theoretical pI: Translated: 8.20; Mature: 8.20

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIKSLQLFIHLCDSKNFAKTAAAMHISPSALSRQIQKLEEETSQQLFTRDNRSVEITPA
CCCHHEEEEEEECCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECC
GKKLMPVALKMLNEWQQYQLQNRYSETELKGEIRLFCSVTASYSHLPELLSEFRLQHPFI
CCHHHHHHHHHHHHHHHHHHHHHCCHHHHCCEEEEEEEECCCHHHHHHHHHHHHHCCCEE
EFKISTGDPAQAMDKILNGEADIAISAKPDTVPAKVAFEPISEIPLSVIAPQGVSSFTDE
EEEECCCCHHHHHHHHHCCCCCEEEECCCCCCCHHEECCCHHHCCCEEECCCCHHHHHHH
MNRDKPDWSSIPYIVPEAGTARERANTWFKKMKIKPNIYAQVSGHEAIVSMVALGCGIGI
HCCCCCCCCCCCEEECCCCCHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHCCCCC
APDVVINNSPVKEKIQRLKVAPIKPFELGVCCIKSQLENPLIQALWKVAESKYIVI
CCCEEECCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHCCCEEEC
>Mature Secondary Structure
MNIKSLQLFIHLCDSKNFAKTAAAMHISPSALSRQIQKLEEETSQQLFTRDNRSVEITPA
CCCHHEEEEEEECCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECC
GKKLMPVALKMLNEWQQYQLQNRYSETELKGEIRLFCSVTASYSHLPELLSEFRLQHPFI
CCHHHHHHHHHHHHHHHHHHHHHCCHHHHCCEEEEEEEECCCHHHHHHHHHHHHHCCCEE
EFKISTGDPAQAMDKILNGEADIAISAKPDTVPAKVAFEPISEIPLSVIAPQGVSSFTDE
EEEECCCCHHHHHHHHHCCCCCEEEECCCCCCCHHEECCCHHHCCCEEECCCCHHHHHHH
MNRDKPDWSSIPYIVPEAGTARERANTWFKKMKIKPNIYAQVSGHEAIVSMVALGCGIGI
HCCCCCCCCCCCEEECCCCCHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHCCCCC
APDVVINNSPVKEKIQRLKVAPIKPFELGVCCIKSQLENPLIQALWKVAESKYIVI
CCCEEECCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHCCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]