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The map label for this gene is neuA [H]

Identifier: 27364252

GI number: 27364252

Start: 811877

End: 812578

Strand: Reverse

Name: neuA [H]

Synonym: VV1_0803

Alternate gene names: 27364252

Gene position: 812578-811877 (Counterclockwise)

Preceding gene: 27364253

Following gene: 27364251

Centisome position: 24.76

GC content: 47.01

Gene sequence:

>702_bases
ATGAAAATACTGGCGATTACTCCTGCCCGCGGGGGCAGCAAGCGGCTACCAGGCAAGAACATCAAAAATTTAAATGGTAA
GCCTCTAATCCAATGGACAATAGATGCCGCCTTAGCGGTGCAAGAGATCGCTCGCGTCATGGTGACGACGGACTGTGACG
AGATTGCGGAGATTGCGAAAAAAGCGGGGGCAGAGGTGCCGTTTATCCGCCCACCAGAGTTAGCCACCGACACCAGTTCC
AGTTCCGATGTGATCCGTCATGCGCTGGATTTTTATCGCGCACAAGGTGAAGAGTTTGATTTTGTCTTACTGTTACAACC
CACGTCACCAATTCGCAGTGCGGATGACATCCGCCACGCGATCGAGCAACTTATAGCGCATACGGCGGATGCCGTCGTGT
CAGTGTGCCCTTGTGATCACTCGCCACTTTGGGCTAATACCTTACCAGACGATCGCTCGATGGCCGATTTTATCCGTCAT
GAAGTTAGCCAGTTGAGAAGTCAGGATCTTCCTGATTACTATCGAATTAATGGTGCAATCTACTTAACAAGAGTGAGCAG
ATTCTACCAAGAAAACTCGCTATTCTTATCTTCAAACATATTTGCCTATGTAATGGATAATGAAAGCTCGGTTGATATTG
ACCATGAGTTGGATTTTCTGATTGCAGAAACGGTATTAAAATATAGGGAACAAAATGCATAA

Upstream 100 bases:

>100_bases
CATCCATGTATTTCCATTTCATGAATATTGGCTAGATATTGGTCGCATGGACGACTATAAGCGTGCACAAGTGGATATTC
TCACGTTAGGTTTATAAATA

Downstream 100 bases:

>100_bases
GTTATTGATCATCGGTGCGGGACAATTGGGTAGCCGCCATTTGCAAGGTGCACTGGCTGCGACTGAAAGCTTAGATATTA
CTGTTGTCGATCCGTCACAA

Product: N-acetylneuraminate cytidylyltransferase

Products: NA

Alternate protein names: CMP-N-acetylneuraminic acid synthase; CMP-NeuNAc synthase; CMP-sialic acid synthase [H]

Number of amino acids: Translated: 233; Mature: 233

Protein sequence:

>233_residues
MKILAITPARGGSKRLPGKNIKNLNGKPLIQWTIDAALAVQEIARVMVTTDCDEIAEIAKKAGAEVPFIRPPELATDTSS
SSDVIRHALDFYRAQGEEFDFVLLLQPTSPIRSADDIRHAIEQLIAHTADAVVSVCPCDHSPLWANTLPDDRSMADFIRH
EVSQLRSQDLPDYYRINGAIYLTRVSRFYQENSLFLSSNIFAYVMDNESSVDIDHELDFLIAETVLKYREQNA

Sequences:

>Translated_233_residues
MKILAITPARGGSKRLPGKNIKNLNGKPLIQWTIDAALAVQEIARVMVTTDCDEIAEIAKKAGAEVPFIRPPELATDTSS
SSDVIRHALDFYRAQGEEFDFVLLLQPTSPIRSADDIRHAIEQLIAHTADAVVSVCPCDHSPLWANTLPDDRSMADFIRH
EVSQLRSQDLPDYYRINGAIYLTRVSRFYQENSLFLSSNIFAYVMDNESSVDIDHELDFLIAETVLKYREQNA
>Mature_233_residues
MKILAITPARGGSKRLPGKNIKNLNGKPLIQWTIDAALAVQEIARVMVTTDCDEIAEIAKKAGAEVPFIRPPELATDTSS
SSDVIRHALDFYRAQGEEFDFVLLLQPTSPIRSADDIRHAIEQLIAHTADAVVSVCPCDHSPLWANTLPDDRSMADFIRH
EVSQLRSQDLPDYYRINGAIYLTRVSRFYQENSLFLSSNIFAYVMDNESSVDIDHELDFLIAETVLKYREQNA

Specific function: Activates Kdo (A Required 8-Carbon Sugar) For Incorporation Into Bacterial Lipopolysaccharide In Gram-Negative Bacteria (By Similarity). [C]

COG id: COG1083

COG function: function code M; CMP-N-acetylneuraminic acid synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CMP-NeuNAc synthase family [H]

Homologues:

Organism=Homo sapiens, GI8923900, Length=228, Percent_Identity=35.0877192982456, Blast_Score=104, Evalue=8e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003329 [H]

Pfam domain/function: PF02348 CTP_transf_3 [H]

EC number: =2.7.7.43 [H]

Molecular weight: Translated: 26150; Mature: 26150

Theoretical pI: Translated: 4.75; Mature: 4.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKILAITPARGGSKRLPGKNIKNLNGKPLIQWTIDAALAVQEIARVMVTTDCDEIAEIAK
CEEEEECCCCCCCCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHCCCHHHHHHHHH
KAGAEVPFIRPPELATDTSSSSDVIRHALDFYRAQGEEFDFVLLLQPTSPIRSADDIRHA
HCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCHHHHHHH
IEQLIAHTADAVVSVCPCDHSPLWANTLPDDRSMADFIRHEVSQLRSQDLPDYYRINGAI
HHHHHHHHHHHHHEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEECCEE
YLTRVSRFYQENSLFLSSNIFAYVMDNESSVDIDHELDFLIAETVLKYREQNA
EEHHHHHHHHHCCEEEECCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKILAITPARGGSKRLPGKNIKNLNGKPLIQWTIDAALAVQEIARVMVTTDCDEIAEIAK
CEEEEECCCCCCCCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHCCCHHHHHHHHH
KAGAEVPFIRPPELATDTSSSSDVIRHALDFYRAQGEEFDFVLLLQPTSPIRSADDIRHA
HCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCHHHHHHH
IEQLIAHTADAVVSVCPCDHSPLWANTLPDDRSMADFIRHEVSQLRSQDLPDYYRINGAI
HHHHHHHHHHHHHEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEECCEE
YLTRVSRFYQENSLFLSSNIFAYVMDNESSVDIDHELDFLIAETVLKYREQNA
EEHHHHHHHHHCCEEEECCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1398032; 7830552; 8113198; 8045888; 10710307 [H]