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The map label for this gene is ung

Identifier: 27364002

GI number: 27364002

Start: 540527

End: 541207

Strand: Reverse

Name: ung

Synonym: VV1_0540

Alternate gene names: 27364002

Gene position: 541207-540527 (Counterclockwise)

Preceding gene: 27364003

Following gene: 326423729

Centisome position: 16.49

GC content: 46.84

Gene sequence:

>681_bases
ATGACACAGCAACTCACTTGGCACGATGTAATTGGTGCGGAAAAAGAGCAAAGCTATTTTCAACAGACACTCAACTTTGT
TGAAGCAGAGCGACAAGCTGGCAAAGTGATTTACCCTCCAGCAAAGGATGTCTTCAATGCCTTTCGTTATACCGAGTTTC
AAGATGTCAAAGTGGTGATCTTAGGACAGGATCCTTACCATGGCCCCAACCAAGCTCATGGTTTGTGTTTTTCAGTATTA
CCGGGTATCAAGACACCTCCTTCTTTGGTGAATATGTACAAAGAGTTGGCGCAGGATATCCAGGGCTTTCAGATCCCGGC
GCATGGTTACCTTGAAGCTTGGGCTAAACAAGGCGTATTGCTGCTCAATACGGTGCTTACGGTGGAGCAGGGCAAAGCGC
ATTCTCACGCTTCATTAGGATGGGAAACATTCACTGACAAAGTGATTGAGGCGATCAATCAGCACCAACAAGGTGTGGTA
TTCCTATTGTGGGGATCGCACGCACAGAAAAAAGGCCGCTTTATTGATCGCCATAAGCATGTGGTTCTCACCGCGCCACA
CCCATCCCCTCTTTCTGCTCACCGCGGCTTTTTGGGCTGTAAGCATTTTTCACAAGCGAATCAACATTTACTTGATCAAG
GAAAGCAAGCAATAGACTGGCAACTACCTTTGTCGCTCTAA

Upstream 100 bases:

>100_bases
CACAAAGTCACGAAAAAAACCAATAGCCTGTGATGAATTTGGTTAGGGGAGTGACCTGACATAGAATAACCGCCTGATGG
TTTTCAATAGGATTCTCCCC

Downstream 100 bases:

>100_bases
GCACATTTGAATGTAATTTCGTAGAAAGCGATGGTTTTTTGAGCGACATCTAAGCCGAATGGCGTTCTATCTTATACACT
TACAACAAATGAGGTGTTAA

Product: uracil-DNA glycosylase

Products: NA

Alternate protein names: UDG

Number of amino acids: Translated: 226; Mature: 225

Protein sequence:

>226_residues
MTQQLTWHDVIGAEKEQSYFQQTLNFVEAERQAGKVIYPPAKDVFNAFRYTEFQDVKVVILGQDPYHGPNQAHGLCFSVL
PGIKTPPSLVNMYKELAQDIQGFQIPAHGYLEAWAKQGVLLLNTVLTVEQGKAHSHASLGWETFTDKVIEAINQHQQGVV
FLLWGSHAQKKGRFIDRHKHVVLTAPHPSPLSAHRGFLGCKHFSQANQHLLDQGKQAIDWQLPLSL

Sequences:

>Translated_226_residues
MTQQLTWHDVIGAEKEQSYFQQTLNFVEAERQAGKVIYPPAKDVFNAFRYTEFQDVKVVILGQDPYHGPNQAHGLCFSVL
PGIKTPPSLVNMYKELAQDIQGFQIPAHGYLEAWAKQGVLLLNTVLTVEQGKAHSHASLGWETFTDKVIEAINQHQQGVV
FLLWGSHAQKKGRFIDRHKHVVLTAPHPSPLSAHRGFLGCKHFSQANQHLLDQGKQAIDWQLPLSL
>Mature_225_residues
TQQLTWHDVIGAEKEQSYFQQTLNFVEAERQAGKVIYPPAKDVFNAFRYTEFQDVKVVILGQDPYHGPNQAHGLCFSVLP
GIKTPPSLVNMYKELAQDIQGFQIPAHGYLEAWAKQGVLLLNTVLTVEQGKAHSHASLGWETFTDKVIEAINQHQQGVVF
LLWGSHAQKKGRFIDRHKHVVLTAPHPSPLSAHRGFLGCKHFSQANQHLLDQGKQAIDWQLPLSL

Specific function: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine

COG id: COG0692

COG function: function code L; Uracil DNA glycosylase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uracil-DNA glycosylase family

Homologues:

Organism=Homo sapiens, GI19718751, Length=216, Percent_Identity=55.5555555555556, Blast_Score=246, Evalue=1e-65,
Organism=Homo sapiens, GI6224979, Length=216, Percent_Identity=55.5555555555556, Blast_Score=246, Evalue=1e-65,
Organism=Escherichia coli, GI1788934, Length=220, Percent_Identity=72.2727272727273, Blast_Score=335, Evalue=2e-93,
Organism=Caenorhabditis elegans, GI17556304, Length=216, Percent_Identity=48.6111111111111, Blast_Score=222, Evalue=2e-58,
Organism=Saccharomyces cerevisiae, GI6323620, Length=233, Percent_Identity=44.6351931330472, Blast_Score=180, Evalue=2e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UNG_VIBVU (Q8DEP7)

Other databases:

- EMBL:   AE016795
- RefSeq:   NP_759530.1
- ProteinModelPortal:   Q8DEP7
- SMR:   Q8DEP7
- GeneID:   1177492
- GenomeReviews:   AE016795_GR
- KEGG:   vvu:VV1_0540
- HOGENOM:   HBG605450
- OMA:   GAHAQKK
- ProtClustDB:   PRK05254
- BioCyc:   VVUL216895:VV1_0540-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00148
- InterPro:   IPR002043
- InterPro:   IPR018085
- InterPro:   IPR005122
- Gene3D:   G3DSA:3.40.470.10
- PANTHER:   PTHR11264
- TIGRFAMs:   TIGR00628

Pfam domain/function: PF03167 UDG; SSF52141 UDNA_glycsylseSF

EC number: =3.2.2.27

Molecular weight: Translated: 25447; Mature: 25316

Theoretical pI: Translated: 7.86; Mature: 7.86

Prosite motif: PS00130 U_DNA_GLYCOSYLASE

Important sites: ACT_SITE 64-64

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQQLTWHDVIGAEKEQSYFQQTLNFVEAERQAGKVIYPPAKDVFNAFRYTEFQDVKVVI
CCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHCCCEECCCHHHHHHHHHCCCCCCEEEEE
LGQDPYHGPNQAHGLCFSVLPGIKTPPSLVNMYKELAQDIQGFQIPAHGYLEAWAKQGVL
ECCCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCEE
LLNTVLTVEQGKAHSHASLGWETFTDKVIEAINQHQQGVVFLLWGSHAQKKGRFIDRHKH
EEHHHHHHCCCCCCCCHHCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCEECCCCE
VVLTAPHPSPLSAHRGFLGCKHFSQANQHLLDQGKQAIDWQLPLSL
EEEECCCCCCCHHHCCHHHHHHHHHHHHHHHHCCCHHEEEECCCCC
>Mature Secondary Structure 
TQQLTWHDVIGAEKEQSYFQQTLNFVEAERQAGKVIYPPAKDVFNAFRYTEFQDVKVVI
CCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHCCCEECCCHHHHHHHHHCCCCCCEEEEE
LGQDPYHGPNQAHGLCFSVLPGIKTPPSLVNMYKELAQDIQGFQIPAHGYLEAWAKQGVL
ECCCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCEE
LLNTVLTVEQGKAHSHASLGWETFTDKVIEAINQHQQGVVFLLWGSHAQKKGRFIDRHKH
EEHHHHHHCCCCCCCCHHCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCEECCCCE
VVLTAPHPSPLSAHRGFLGCKHFSQANQHLLDQGKQAIDWQLPLSL
EEEECCCCCCCHHHCCHHHHHHHHHHHHHHHHCCCHHEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA