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The map label for this gene is adk [H]

Identifier: 27363670

GI number: 27363670

Start: 179952

End: 180596

Strand: Reverse

Name: adk [H]

Synonym: VV1_0188

Alternate gene names: 27363670

Gene position: 180596-179952 (Counterclockwise)

Preceding gene: 27363671

Following gene: 27363669

Centisome position: 5.5

GC content: 46.05

Gene sequence:

>645_bases
ATGCGCATCATTCTTCTAGGTGCTCCAGGTGCAGGTAAAGGCACACAGGCTCAATTCATCATGGAGAAGTATGGTATTCC
ACAAATCTCTACTGGTGACATGCTACGTGCTGCTATCAAAGCAGGTACTGAGCTTGGTAAACAAGCAAAAGCTGTTATCG
ACGCTGGTCAGCTAGTTTCTGATGAAATCATTCTTGGTCTAATCAAAGAGCGTATTGCTCAAGAAGATTGTGCGAAAGGT
TTCCTATTGGATGGTTTCCCACGTACGATCCCACAAGCTGACGGTCTTAAAGAGATGGGTGTGGCAGTTGATTACGTTAT
CGAGTTTGACGTTGCTGACGATGTGATCGTTGAGCGTATGGCTGGCCGTCGTGCGCACCTGCCTTCAGGTCGTACTTACC
ACGTTGTTTACAACCCACCTAAAGTGGAAGGTAAAGACGACGTAACAGGTGAAGATCTTGTTGTTCGTGACGACGACAAA
GAAGAAACCGTACGCGCTCGTTTAGGTGTTTACCACTCACAAACTGCACCACTTATCGAGTACTACGGTAAAGAAGCCGC
AGAAGGCAACACGAAGTACCTAAAATTTGATGGTACTAAGCAAGTTGCTCAAGTGAGTGCTGATATCGAGAAGGCATTAG
CATAA

Upstream 100 bases:

>100_bases
TGTCAATTTGAAGAACACTTATACCGAAACTTACCGTGGGGCATAGCCCAGTAGGCAGTGAGCTTCGGTATAAATCATCA
TAATCGAAAGAGGATTCAAC

Downstream 100 bases:

>100_bases
TAGGTAATACCTATTATCAACCGTTTTCAGAATTTTGTTATAGTGAAGCGACCTTAAGGTCGCTTTTTTATTATGGCCAT
CAGCAGTTTAGTTTTGTCAT

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase [H]

Number of amino acids: Translated: 214; Mature: 214

Protein sequence:

>214_residues
MRIILLGAPGAGKGTQAQFIMEKYGIPQISTGDMLRAAIKAGTELGKQAKAVIDAGQLVSDEIILGLIKERIAQEDCAKG
FLLDGFPRTIPQADGLKEMGVAVDYVIEFDVADDVIVERMAGRRAHLPSGRTYHVVYNPPKVEGKDDVTGEDLVVRDDDK
EETVRARLGVYHSQTAPLIEYYGKEAAEGNTKYLKFDGTKQVAQVSADIEKALA

Sequences:

>Translated_214_residues
MRIILLGAPGAGKGTQAQFIMEKYGIPQISTGDMLRAAIKAGTELGKQAKAVIDAGQLVSDEIILGLIKERIAQEDCAKG
FLLDGFPRTIPQADGLKEMGVAVDYVIEFDVADDVIVERMAGRRAHLPSGRTYHVVYNPPKVEGKDDVTGEDLVVRDDDK
EETVRARLGVYHSQTAPLIEYYGKEAAEGNTKYLKFDGTKQVAQVSADIEKALA
>Mature_214_residues
MRIILLGAPGAGKGTQAQFIMEKYGIPQISTGDMLRAAIKAGTELGKQAKAVIDAGQLVSDEIILGLIKERIAQEDCAKG
FLLDGFPRTIPQADGLKEMGVAVDYVIEFDVADDVIVERMAGRRAHLPSGRTYHVVYNPPKVEGKDDVTGEDLVVRDDDK
EETVRARLGVYHSQTAPLIEYYGKEAAEGNTKYLKFDGTKQVAQVSADIEKALA

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth [H]

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family [H]

Homologues:

Organism=Homo sapiens, GI7524346, Length=188, Percent_Identity=50.531914893617, Blast_Score=202, Evalue=3e-52,
Organism=Homo sapiens, GI4502013, Length=188, Percent_Identity=50.531914893617, Blast_Score=201, Evalue=3e-52,
Organism=Homo sapiens, GI19923437, Length=185, Percent_Identity=43.7837837837838, Blast_Score=162, Evalue=3e-40,
Organism=Homo sapiens, GI310110345, Length=182, Percent_Identity=43.4065934065934, Blast_Score=152, Evalue=2e-37,
Organism=Homo sapiens, GI53832003, Length=182, Percent_Identity=43.4065934065934, Blast_Score=152, Evalue=2e-37,
Organism=Homo sapiens, GI8051579, Length=182, Percent_Identity=43.4065934065934, Blast_Score=152, Evalue=2e-37,
Organism=Homo sapiens, GI53832001, Length=182, Percent_Identity=43.4065934065934, Blast_Score=152, Evalue=2e-37,
Organism=Homo sapiens, GI4502011, Length=183, Percent_Identity=31.1475409836066, Blast_Score=102, Evalue=2e-22,
Organism=Homo sapiens, GI22749187, Length=186, Percent_Identity=29.5698924731183, Blast_Score=102, Evalue=4e-22,
Organism=Homo sapiens, GI28144899, Length=182, Percent_Identity=30.7692307692308, Blast_Score=90, Evalue=1e-18,
Organism=Homo sapiens, GI28144897, Length=182, Percent_Identity=30.7692307692308, Blast_Score=90, Evalue=1e-18,
Organism=Homo sapiens, GI7706497, Length=211, Percent_Identity=31.2796208530806, Blast_Score=84, Evalue=8e-17,
Organism=Homo sapiens, GI21450759, Length=139, Percent_Identity=25.8992805755396, Blast_Score=67, Evalue=8e-12,
Organism=Escherichia coli, GI1786680, Length=213, Percent_Identity=75.1173708920188, Blast_Score=337, Evalue=5e-94,
Organism=Caenorhabditis elegans, GI17552384, Length=218, Percent_Identity=45.8715596330275, Blast_Score=207, Evalue=3e-54,
Organism=Caenorhabditis elegans, GI17537943, Length=187, Percent_Identity=35.2941176470588, Blast_Score=120, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI17567503, Length=216, Percent_Identity=32.4074074074074, Blast_Score=110, Evalue=6e-25,
Organism=Caenorhabditis elegans, GI17550688, Length=186, Percent_Identity=31.7204301075269, Blast_Score=84, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI17533833, Length=215, Percent_Identity=30.2325581395349, Blast_Score=83, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6320432, Length=218, Percent_Identity=45.4128440366972, Blast_Score=199, Evalue=3e-52,
Organism=Saccharomyces cerevisiae, GI6321018, Length=194, Percent_Identity=43.298969072165, Blast_Score=152, Evalue=4e-38,
Organism=Saccharomyces cerevisiae, GI6322828, Length=214, Percent_Identity=30.8411214953271, Blast_Score=102, Evalue=7e-23,
Organism=Drosophila melanogaster, GI22026816, Length=211, Percent_Identity=45.4976303317536, Blast_Score=193, Evalue=7e-50,
Organism=Drosophila melanogaster, GI17737899, Length=185, Percent_Identity=45.4054054054054, Blast_Score=157, Evalue=4e-39,
Organism=Drosophila melanogaster, GI24645822, Length=185, Percent_Identity=45.4054054054054, Blast_Score=157, Evalue=4e-39,
Organism=Drosophila melanogaster, GI17647141, Length=181, Percent_Identity=34.2541436464088, Blast_Score=111, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24663208, Length=181, Percent_Identity=34.2541436464088, Blast_Score=111, Evalue=3e-25,
Organism=Drosophila melanogaster, GI221459597, Length=213, Percent_Identity=28.6384976525822, Blast_Score=92, Evalue=3e-19,
Organism=Drosophila melanogaster, GI21356893, Length=213, Percent_Identity=28.6384976525822, Blast_Score=92, Evalue=3e-19,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006259
- InterPro:   IPR000850
- InterPro:   IPR007862 [H]

Pfam domain/function: PF00406 ADK; PF05191 ADK_lid [H]

EC number: =2.7.4.3 [H]

Molecular weight: Translated: 23236; Mature: 23236

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIILLGAPGAGKGTQAQFIMEKYGIPQISTGDMLRAAIKAGTELGKQAKAVIDAGQLVS
CEEEEEECCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DEIILGLIKERIAQEDCAKGFLLDGFPRTIPQADGLKEMGVAVDYVIEFDVADDVIVERM
HHHHHHHHHHHHHHHHHHCCCEECCCCCCCCCCCCHHHHCCEEEEEEEECCHHHHHHHHH
AGRRAHLPSGRTYHVVYNPPKVEGKDDVTGEDLVVRDDDKEETVRARLGVYHSQTAPLIE
CCCCCCCCCCCEEEEEECCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHCCCCCHHHH
YYGKEAAEGNTKYLKFDGTKQVAQVSADIEKALA
HHCCCCCCCCCEEEEECCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRIILLGAPGAGKGTQAQFIMEKYGIPQISTGDMLRAAIKAGTELGKQAKAVIDAGQLVS
CEEEEEECCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DEIILGLIKERIAQEDCAKGFLLDGFPRTIPQADGLKEMGVAVDYVIEFDVADDVIVERM
HHHHHHHHHHHHHHHHHHCCCEECCCCCCCCCCCCHHHHCCEEEEEEEECCHHHHHHHHH
AGRRAHLPSGRTYHVVYNPPKVEGKDDVTGEDLVVRDDDKEETVRARLGVYHSQTAPLIE
CCCCCCCCCCCEEEEEECCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHCCCCCHHHH
YYGKEAAEGNTKYLKFDGTKQVAQVSADIEKALA
HHCCCCCCCCCEEEEECCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA