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The map label for this gene is hemH [H]

Identifier: 27363669

GI number: 27363669

Start: 178803

End: 179813

Strand: Reverse

Name: hemH [H]

Synonym: VV1_0187

Alternate gene names: 27363669

Gene position: 179813-178803 (Counterclockwise)

Preceding gene: 27363670

Following gene: 27363668

Centisome position: 5.48

GC content: 46.98

Gene sequence:

>1011_bases
ATGTCGCCACCTTTTCGTAAAACCACCTTCAGCCACTATCGTAGAGAAAGTATGAACAACACAAAAAAACGCGGAGTGCT
TTTAGTCAATCTCGGAACTCCCGAAGAAGCAACGGCCCCAGCCGTAAAACGATTTTTAAGCCAGTTTTTGCATGATCAGC
GTGTAGTGGATATGACGCGTTGGCTATGGTGCCCTATTTTACATGGCATCATTTTACCTATTCGTTCGCCTAAGGTTGCC
AAGCTTTATCAAACCGTTTGGATGAAAGAAGGCTCACCGTTAATGGTGTACAGCAAGCGACAGCAAGTCGAGTTGCAGGC
AAAACTCAATTGCCCTGTGGAAATTGGTATGACCTATGGCACACCCAGCGTACTTGATGGCGTGAACAAGCTTCAAGCTC
AAGGTGTGGATGAGATTTGCGTTTTACCTCTGTACCCCCAGTATTCAGGCACCACAACGGGAGCGGCGTACGATGCACTT
GCGCACGCGTTGCGTAAGGTTGCTGTCGTACCCAGTATTCAGTTTATTCGTGACTATCATGATCACCCTTTGTATATCAA
AGCATTGGCTGAATCAGTACGTCAATCATGGCAGGTGCAAGGCAAAGGGGATTACCTGCTTTGCTCCTATCACGGTATTC
CACAACGCTACGCCGATAATGGCGATGTCTATCCTCTGCATTGCGAAATGACAACCGAGTTACTGCGTCTCGAATTAGGG
TTGGACAAATCCCAAATTGGCACCACCTATCAATCTCGCTTTGGTCGAGAAGAGTGGCTGCAACCCTATACGGATAAAAC
GTTGGAATCGTTGCCCGCGAAGGGCATTAAGTCTCTCGATGTGATAACCCCTGCATTTTCGGTTGATTGTTTAGAGACGT
TAGAAGAAATCTCAGAGCAAGGCCAAGAAAGCTTTCTGCATGCGGGTGGTGAGCAGTATCGTTTTATTCCTTGTTTAAAC
GATGCCCCAAGTCACATTGAAATGATGGCAAGGCTTGTTACAGAGCGGTAA

Upstream 100 bases:

>100_bases
TATAGTGAAGCGACCTTAAGGTCGCTTTTTTATTATGGCCATCAGCAGTTTAGTTTTGTCATTATTCACAATGGCTCAAA
TGACGTTGCACAACTGATCG

Downstream 100 bases:

>100_bases
TGCGTTCTCATTGCAAGATTCTTATCCTCAACGCCGTTAATCTCACGGCGTTTTTTATGCCGACTATCGGTGTTTCTCCA
AGCCAAATAGCGTAAAGCTT

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase [H]

Number of amino acids: Translated: 336; Mature: 335

Protein sequence:

>336_residues
MSPPFRKTTFSHYRRESMNNTKKRGVLLVNLGTPEEATAPAVKRFLSQFLHDQRVVDMTRWLWCPILHGIILPIRSPKVA
KLYQTVWMKEGSPLMVYSKRQQVELQAKLNCPVEIGMTYGTPSVLDGVNKLQAQGVDEICVLPLYPQYSGTTTGAAYDAL
AHALRKVAVVPSIQFIRDYHDHPLYIKALAESVRQSWQVQGKGDYLLCSYHGIPQRYADNGDVYPLHCEMTTELLRLELG
LDKSQIGTTYQSRFGREEWLQPYTDKTLESLPAKGIKSLDVITPAFSVDCLETLEEISEQGQESFLHAGGEQYRFIPCLN
DAPSHIEMMARLVTER

Sequences:

>Translated_336_residues
MSPPFRKTTFSHYRRESMNNTKKRGVLLVNLGTPEEATAPAVKRFLSQFLHDQRVVDMTRWLWCPILHGIILPIRSPKVA
KLYQTVWMKEGSPLMVYSKRQQVELQAKLNCPVEIGMTYGTPSVLDGVNKLQAQGVDEICVLPLYPQYSGTTTGAAYDAL
AHALRKVAVVPSIQFIRDYHDHPLYIKALAESVRQSWQVQGKGDYLLCSYHGIPQRYADNGDVYPLHCEMTTELLRLELG
LDKSQIGTTYQSRFGREEWLQPYTDKTLESLPAKGIKSLDVITPAFSVDCLETLEEISEQGQESFLHAGGEQYRFIPCLN
DAPSHIEMMARLVTER
>Mature_335_residues
SPPFRKTTFSHYRRESMNNTKKRGVLLVNLGTPEEATAPAVKRFLSQFLHDQRVVDMTRWLWCPILHGIILPIRSPKVAK
LYQTVWMKEGSPLMVYSKRQQVELQAKLNCPVEIGMTYGTPSVLDGVNKLQAQGVDEICVLPLYPQYSGTTTGAAYDALA
HALRKVAVVPSIQFIRDYHDHPLYIKALAESVRQSWQVQGKGDYLLCSYHGIPQRYADNGDVYPLHCEMTTELLRLELGL
DKSQIGTTYQSRFGREEWLQPYTDKTLESLPAKGIKSLDVITPAFSVDCLETLEEISEQGQESFLHAGGEQYRFIPCLND
APSHIEMMARLVTER

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX [H]

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family [H]

Homologues:

Organism=Homo sapiens, GI60499025, Length=340, Percent_Identity=27.0588235294118, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI60499021, Length=331, Percent_Identity=26.8882175226586, Blast_Score=89, Evalue=5e-18,
Organism=Escherichia coli, GI1786681, Length=313, Percent_Identity=57.1884984025559, Blast_Score=354, Evalue=4e-99,
Organism=Saccharomyces cerevisiae, GI6324750, Length=337, Percent_Identity=26.4094955489614, Blast_Score=87, Evalue=3e-18,
Organism=Drosophila melanogaster, GI17864156, Length=336, Percent_Identity=24.1071428571429, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI24651774, Length=269, Percent_Identity=23.4200743494424, Blast_Score=75, Evalue=9e-14,
Organism=Drosophila melanogaster, GI45552018, Length=166, Percent_Identity=26.5060240963855, Blast_Score=65, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001015
- InterPro:   IPR019772 [H]

Pfam domain/function: PF00762 Ferrochelatase [H]

EC number: =4.99.1.1 [H]

Molecular weight: Translated: 38122; Mature: 37991

Theoretical pI: Translated: 7.27; Mature: 7.27

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSPPFRKTTFSHYRRESMNNTKKRGVLLVNLGTPEEATAPAVKRFLSQFLHDQRVVDMTR
CCCCCCCHHHHHHHHHHHCCHHHCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
WLWCPILHGIILPIRSPKVAKLYQTVWMKEGSPLMVYSKRQQVELQAKLNCPVEIGMTYG
HHHHHHHHHHEECCCCCHHHHHHHHHHHCCCCCEEEECCCCCEEEEEECCCCEEEEEECC
TPSVLDGVNKLQAQGVDEICVLPLYPQYSGTTTGAAYDALAHALRKVAVVPSIQFIRDYH
CHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHCC
DHPLYIKALAESVRQSWQVQGKGDYLLCSYHGIPQRYADNGDVYPLHCEMTTELLRLELG
CCCCHHHHHHHHHHHHCEECCCCCEEEEEECCCCHHHCCCCCEEEEEHHHHHHHHHHHHC
LDKSQIGTTYQSRFGREEWLQPYTDKTLESLPAKGIKSLDVITPAFSVDCLETLEEISEQ
CCHHHHCCHHHHHCCHHHHCCCHHHHHHHHCCCCCCCHHHHCCCCHHHHHHHHHHHHHHH
GQESFLHAGGEQYRFIPCLNDAPSHIEMMARLVTER
HHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
SPPFRKTTFSHYRRESMNNTKKRGVLLVNLGTPEEATAPAVKRFLSQFLHDQRVVDMTR
CCCCCCHHHHHHHHHHHCCHHHCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
WLWCPILHGIILPIRSPKVAKLYQTVWMKEGSPLMVYSKRQQVELQAKLNCPVEIGMTYG
HHHHHHHHHHEECCCCCHHHHHHHHHHHCCCCCEEEECCCCCEEEEEECCCCEEEEEECC
TPSVLDGVNKLQAQGVDEICVLPLYPQYSGTTTGAAYDALAHALRKVAVVPSIQFIRDYH
CHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHCC
DHPLYIKALAESVRQSWQVQGKGDYLLCSYHGIPQRYADNGDVYPLHCEMTTELLRLELG
CCCCHHHHHHHHHHHHCEECCCCCEEEEEECCCCHHHCCCCCEEEEEHHHHHHHHHHHHC
LDKSQIGTTYQSRFGREEWLQPYTDKTLESLPAKGIKSLDVITPAFSVDCLETLEEISEQ
CCHHHHCCHHHHHCCHHHHCCCHHHHHHHHCCCCCCCHHHHCCCCHHHHHHHHHHHHHHH
GQESFLHAGGEQYRFIPCLNDAPSHIEMMARLVTER
HHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA