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The map label for this gene is cobW [H]

Identifier: 27363492

GI number: 27363492

Start: 1131

End: 2117

Strand: Reverse

Name: cobW [H]

Synonym: VV1_0002

Alternate gene names: 27363492

Gene position: 2117-1131 (Counterclockwise)

Preceding gene: 27363493

Following gene: 27363491

Centisome position: 0.06

GC content: 42.65

Gene sequence:

>987_bases
ATGTCGATGAGTAAAAAGCCAATTCCAGTCACTATCTTAGCCGGATTTTTAGGGGCAGGTAAAACCACCTTGCTCAATCA
CATTCTGACCAATGCCAATGGAATGCGCATGGCCGTTATCGTCAATGACTTTGGTTCGATAAATGTTGATGCTGAACTGG
TAAAATCTGAAAGCGACAATATGATCAGCCTAGAAAATGGTTGTGTTTGTTGTAATCTCGCTGAAGGTTTAGTGGTTTCT
GTGATGCGTTTATTAGCACTCGAACAACGTCCAGACCACATTGTGGTAGAAACGTCTGGTATTTCAGAACCAAAAGAAGT
GGCGCTGAATTTTGAAGATCCTGAGCTGCAACAGCATGCGCCTCTCAATGCGATTATCACCACCATTGATGCTAAAAATG
TACTCACTCTTGAAAAACAGATGGCAGAATTAGCTGAACAGCAAATTCAAGTAGCTGATATTGTTTTGATCAATAAAGTC
GATCTGGTAGAGCCAGATGAGCTAGCAAAAGTTAAACAATGGTGTCAGGTACAAGCGCCATTTGCAAAGCTGGTTGAAAT
AGAGTTTGGTAAAGTCGATTTGCCTATTTTATTTGAAGTACCAGAGAGGCTTCAGGTTTCATCCCATAACAGAGAACATG
GTGGCGAGCACCATCACTGCCATGATGACCATTGTGATCACGTTAACCATCAGTTTGAAACATTCAGTTTTGAAACAGAT
CGTCCCCTTTCACTGCAAGCCTTGTACCCTCTATTACAGCAGTTTTCTATCGATGCTTATCGCATGAAAGGCATCTTAAA
CCTAGATGATCGACCCGATCACCGTTGTATTTTCCAATGCACAGGACAACGTGCACAAGTGACCATTGGCGAACCATGGC
AAGAAGGCGAAACAAGAGCCACGCGTCTTGTTTTTATCGGCCCAAAAGGGGGATTAGATAGGGATGGAATGCGCAAAAAA
TTGGACGCTCTTGTGATCCAACAATAA

Upstream 100 bases:

>100_bases
ATCCGGGTGAGCCCATTCGCAACCCTGTTATTGCATAATTAACTCTAAATATAATTAAGCTCGGCGCAAGTCGAGCTTTT
TCATGAAATGATATAGAGAA

Downstream 100 bases:

>100_bases
GTTTATTGGCTCGATAAATGTAACCAAGTGTAACTAATGAAAAATAGTGTGATAAAGTGCTGTTGGGGCCAAATCGAAGT
GGAACCACGAAATCGTAGTA

Product: putative GTPases (G3E family)

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 328; Mature: 327

Protein sequence:

>328_residues
MSMSKKPIPVTILAGFLGAGKTTLLNHILTNANGMRMAVIVNDFGSINVDAELVKSESDNMISLENGCVCCNLAEGLVVS
VMRLLALEQRPDHIVVETSGISEPKEVALNFEDPELQQHAPLNAIITTIDAKNVLTLEKQMAELAEQQIQVADIVLINKV
DLVEPDELAKVKQWCQVQAPFAKLVEIEFGKVDLPILFEVPERLQVSSHNREHGGEHHHCHDDHCDHVNHQFETFSFETD
RPLSLQALYPLLQQFSIDAYRMKGILNLDDRPDHRCIFQCTGQRAQVTIGEPWQEGETRATRLVFIGPKGGLDRDGMRKK
LDALVIQQ

Sequences:

>Translated_328_residues
MSMSKKPIPVTILAGFLGAGKTTLLNHILTNANGMRMAVIVNDFGSINVDAELVKSESDNMISLENGCVCCNLAEGLVVS
VMRLLALEQRPDHIVVETSGISEPKEVALNFEDPELQQHAPLNAIITTIDAKNVLTLEKQMAELAEQQIQVADIVLINKV
DLVEPDELAKVKQWCQVQAPFAKLVEIEFGKVDLPILFEVPERLQVSSHNREHGGEHHHCHDDHCDHVNHQFETFSFETD
RPLSLQALYPLLQQFSIDAYRMKGILNLDDRPDHRCIFQCTGQRAQVTIGEPWQEGETRATRLVFIGPKGGLDRDGMRKK
LDALVIQQ
>Mature_327_residues
SMSKKPIPVTILAGFLGAGKTTLLNHILTNANGMRMAVIVNDFGSINVDAELVKSESDNMISLENGCVCCNLAEGLVVSV
MRLLALEQRPDHIVVETSGISEPKEVALNFEDPELQQHAPLNAIITTIDAKNVLTLEKQMAELAEQQIQVADIVLINKVD
LVEPDELAKVKQWCQVQAPFAKLVEIEFGKVDLPILFEVPERLQVSSHNREHGGEHHHCHDDHCDHVNHQFETFSFETDR
PLSLQALYPLLQQFSIDAYRMKGILNLDDRPDHRCIFQCTGQRAQVTIGEPWQEGETRATRLVFIGPKGGLDRDGMRKKL
DALVIQQ

Specific function: Might be involved in cobalt reduction leading to cobalt(I) corrinoids [H]

COG id: COG0523

COG function: function code R; Putative GTPases (G3E family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 cobW C-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI126722884, Length=346, Percent_Identity=29.1907514450867, Blast_Score=126, Evalue=2e-29,
Organism=Homo sapiens, GI33469141, Length=349, Percent_Identity=28.9398280802292, Blast_Score=126, Evalue=3e-29,
Organism=Homo sapiens, GI146231952, Length=348, Percent_Identity=29.0229885057471, Blast_Score=124, Evalue=9e-29,
Organism=Homo sapiens, GI148727351, Length=346, Percent_Identity=29.4797687861272, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI223941779, Length=346, Percent_Identity=28.3236994219653, Blast_Score=114, Evalue=9e-26,
Organism=Homo sapiens, GI223941776, Length=336, Percent_Identity=27.9761904761905, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI119120938, Length=131, Percent_Identity=38.9312977099237, Blast_Score=92, Evalue=1e-18,
Organism=Escherichia coli, GI87082430, Length=317, Percent_Identity=29.9684542586751, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1788499, Length=196, Percent_Identity=29.0816326530612, Blast_Score=97, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6324356, Length=281, Percent_Identity=27.4021352313167, Blast_Score=89, Evalue=7e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012824
- InterPro:   IPR003495
- InterPro:   IPR011629 [H]

Pfam domain/function: PF02492 cobW; PF07683 CobW_C [H]

EC number: NA

Molecular weight: Translated: 36665; Mature: 36533

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSMSKKPIPVTILAGFLGAGKTTLLNHILTNANGMRMAVIVNDFGSINVDAELVKSESDN
CCCCCCCCCCEEEEHHHCCCHHHHHHHHHHCCCCCEEEEEEECCCCCCCCHHHHHCCCCC
MISLENGCVCCNLAEGLVVSVMRLLALEQRPDHIVVETSGISEPKEVALNFEDPELQQHA
EEEECCCEEEEEHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHEEECCCCCCHHHCC
PLNAIITTIDAKNVLTLEKQMAELAEQQIQVADIVLINKVDLVEPDELAKVKQWCQVQAP
CCCCEEEEECCCCHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCHHHHHHHHHHHCCCC
FAKLVEIEFGKVDLPILFEVPERLQVSSHNREHGGEHHHCHDDHCDHVNHQFETFSFETD
HHHHEEEECCCCCCEEEECCCCHHHCCCCCCCCCCCCCCCCCCCHHHCCCCEEEEEECCC
RPLSLQALYPLLQQFSIDAYRMKGILNLDDRPDHRCIFQCTGQRAQVTIGEPWQEGETRA
CCCHHHHHHHHHHHHCCCHHHHCCEECCCCCCCCEEEEEECCCEEEEEECCCCCCCCCCE
TRLVFIGPKGGLDRDGMRKKLDALVIQQ
EEEEEECCCCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SMSKKPIPVTILAGFLGAGKTTLLNHILTNANGMRMAVIVNDFGSINVDAELVKSESDN
CCCCCCCCCEEEEHHHCCCHHHHHHHHHHCCCCCEEEEEEECCCCCCCCHHHHHCCCCC
MISLENGCVCCNLAEGLVVSVMRLLALEQRPDHIVVETSGISEPKEVALNFEDPELQQHA
EEEECCCEEEEEHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHEEECCCCCCHHHCC
PLNAIITTIDAKNVLTLEKQMAELAEQQIQVADIVLINKVDLVEPDELAKVKQWCQVQAP
CCCCEEEEECCCCHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCHHHHHHHHHHHCCCC
FAKLVEIEFGKVDLPILFEVPERLQVSSHNREHGGEHHHCHDDHCDHVNHQFETFSFETD
HHHHEEEECCCCCCEEEECCCCHHHCCCCCCCCCCCCCCCCCCCHHHCCCCEEEEEECCC
RPLSLQALYPLLQQFSIDAYRMKGILNLDDRPDHRCIFQCTGQRAQVTIGEPWQEGETRA
CCCHHHHHHHHHHHHCCCHHHHCCEECCCCCCCCEEEEEECCCEEEEEECCCCCCCCCCE
TRLVFIGPKGGLDRDGMRKKLDALVIQQ
EEEEEECCCCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1655697 [H]