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The map label for this gene is fabB [H]

Identifier: 23503019

GI number: 23503019

Start: 2095735

End: 2096958

Strand: Reverse

Name: fabB [H]

Synonym: BR2172

Alternate gene names: 23503019

Gene position: 2096958-2095735 (Counterclockwise)

Preceding gene: 23503020

Following gene: 23503018

Centisome position: 99.49

GC content: 58.91

Gene sequence:

>1224_bases
ATGCGGCGTGTGGTCGTAACGGGTATGGGGATCGTATCCTCAATTGGTAGCAACACCGAAGAGGTCACGGCCTCGCTGCG
CGAAGCCAAATCCGGCATCTCCCGCGCGGAAGAATATGCGGAACTGGGCTTCCGCTGCCAGGTTCATGGCGCGCCGGACA
TTGATATCGAATCACTTGTAGACCGCCGCGCCATGCGCTTCCACGGGCGGGGCACGGCATGGAATCATATCGCCATGGAT
CAGGCGATTGCAGATGCGGGGCTGACCGAGGAGGAAGTCTCCAACGAGCGTACCGGCATCATCATGGGTTCCGGCGGCCC
GTCCACCCGCACCATTGTCGATTCCGCCGATATCACCCGCGAAAAAGGCCCAAAGCGCGTCGGCCCATTCGCCGTGCCAA
AAGCCATGAGCTCGACGGCTTCGGCAACACTTGCGACCTTCTTCAAGATCAAGGGCATCAACTATTCGATTTCTTCGGCC
TGCGCGACATCGAATCATTGCATCGGCAATGCCTATGAGATGATCCAGTATGGCAAGCAGGACCGTATGTTTGCCGGCGG
CTGCGAAGACCTCGACTGGACACTTTCGGTTCTGTTCGACGCCATGGGCGCCATGTCGTCCAAATATAACGACACGCCTT
CCACCGCTTCACGCGCCTATGACAAGAACCGCGACGGCTTCGTCATCGCTGGCGGCGCAGGCGTTCTGGTTCTTGAAGAC
CTCGAAACGGCACTTGCACGCGGTGCGAAGATCTACGGCGAAATCGTGGGCTATGGCGCAACCTCCGACGGCTACGACAT
GGTTGCACCGTCTGGCGAAGGCGCAATCCGCTGCATGAAAATGGCGCTTTCGACCGTCACGTCGAAGATCGATTACATCA
ATCCGCACGCAACATCGACGCCTGCGGGCGACGCCCCGGAAATCGAAGCGATCCGCCAGATTTTCGGCGCGGGCGACGCC
TGCCCGCCAATCGCCGCCACCAAATCGCTCACCGGCCATTCGCTGGGCGCAACGGGCGTGCAGGAAGCGATCTATTCGCT
TTTGATGATGCAGAACAATTTCATTTGCGAAAGCGCGCATATCGAAGAACTGGACCCCGCCTTCGCGGATATGCCCATCG
TTCGCAAGCGCATCGATAATGTTCAGCTCAACACCGTGCTCTCCAATTCCTTCGGGTTTGGCGGCACCAACGCCACGCTG
GTGTTTCAGCGGTATCAGGGCTGA

Upstream 100 bases:

>100_bases
GCTCAAAACATGCGAAGATCGCACCTATGTAACCGCGAAGACGAGGCTGCCCCCCTCAAGGGAGAGCCGCTTTCACGGCA
TAGGTGTAAAGGAGAACGCG

Downstream 100 bases:

>100_bases
CGGAGAGGGATAATATGGAAGGTTTGATGCAAGGAAAACGCGGCCTCATCATGGGGGTCGCGAACAATCACTCACTGGCC
TGGGGCATTGCAAAACAGCT

Product: 3-oxoacyl-(acyl carrier protein) synthase I

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase I; Beta-ketoacyl-ACP synthase I; KAS I [H]

Number of amino acids: Translated: 407; Mature: 407

Protein sequence:

>407_residues
MRRVVVTGMGIVSSIGSNTEEVTASLREAKSGISRAEEYAELGFRCQVHGAPDIDIESLVDRRAMRFHGRGTAWNHIAMD
QAIADAGLTEEEVSNERTGIIMGSGGPSTRTIVDSADITREKGPKRVGPFAVPKAMSSTASATLATFFKIKGINYSISSA
CATSNHCIGNAYEMIQYGKQDRMFAGGCEDLDWTLSVLFDAMGAMSSKYNDTPSTASRAYDKNRDGFVIAGGAGVLVLED
LETALARGAKIYGEIVGYGATSDGYDMVAPSGEGAIRCMKMALSTVTSKIDYINPHATSTPAGDAPEIEAIRQIFGAGDA
CPPIAATKSLTGHSLGATGVQEAIYSLLMMQNNFICESAHIEELDPAFADMPIVRKRIDNVQLNTVLSNSFGFGGTNATL
VFQRYQG

Sequences:

>Translated_407_residues
MRRVVVTGMGIVSSIGSNTEEVTASLREAKSGISRAEEYAELGFRCQVHGAPDIDIESLVDRRAMRFHGRGTAWNHIAMD
QAIADAGLTEEEVSNERTGIIMGSGGPSTRTIVDSADITREKGPKRVGPFAVPKAMSSTASATLATFFKIKGINYSISSA
CATSNHCIGNAYEMIQYGKQDRMFAGGCEDLDWTLSVLFDAMGAMSSKYNDTPSTASRAYDKNRDGFVIAGGAGVLVLED
LETALARGAKIYGEIVGYGATSDGYDMVAPSGEGAIRCMKMALSTVTSKIDYINPHATSTPAGDAPEIEAIRQIFGAGDA
CPPIAATKSLTGHSLGATGVQEAIYSLLMMQNNFICESAHIEELDPAFADMPIVRKRIDNVQLNTVLSNSFGFGGTNATL
VFQRYQG
>Mature_407_residues
MRRVVVTGMGIVSSIGSNTEEVTASLREAKSGISRAEEYAELGFRCQVHGAPDIDIESLVDRRAMRFHGRGTAWNHIAMD
QAIADAGLTEEEVSNERTGIIMGSGGPSTRTIVDSADITREKGPKRVGPFAVPKAMSSTASATLATFFKIKGINYSISSA
CATSNHCIGNAYEMIQYGKQDRMFAGGCEDLDWTLSVLFDAMGAMSSKYNDTPSTASRAYDKNRDGFVIAGGAGVLVLED
LETALARGAKIYGEIVGYGATSDGYDMVAPSGEGAIRCMKMALSTVTSKIDYINPHATSTPAGDAPEIEAIRQIFGAGDA
CPPIAATKSLTGHSLGATGVQEAIYSLLMMQNNFICESAHIEELDPAFADMPIVRKRIDNVQLNTVLSNSFGFGGTNATL
VFQRYQG

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Specific for elongation from C-10 to unsaturated C-16 and C-18 fatty acids [H]

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=417, Percent_Identity=35.2517985611511, Blast_Score=215, Evalue=6e-56,
Organism=Homo sapiens, GI41872631, Length=335, Percent_Identity=25.6716417910448, Blast_Score=96, Evalue=6e-20,
Organism=Homo sapiens, GI223972627, Length=167, Percent_Identity=37.7245508982036, Blast_Score=94, Evalue=3e-19,
Organism=Escherichia coli, GI1788663, Length=408, Percent_Identity=60.2941176470588, Blast_Score=478, Evalue=1e-136,
Organism=Escherichia coli, GI1787337, Length=411, Percent_Identity=37.4695863746959, Blast_Score=239, Evalue=2e-64,
Organism=Caenorhabditis elegans, GI71983541, Length=416, Percent_Identity=33.6538461538462, Blast_Score=203, Evalue=1e-52,
Organism=Caenorhabditis elegans, GI71983535, Length=261, Percent_Identity=39.0804597701149, Blast_Score=160, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI17550940, Length=278, Percent_Identity=26.978417266187, Blast_Score=94, Evalue=9e-20,
Organism=Caenorhabditis elegans, GI212642053, Length=340, Percent_Identity=24.1176470588235, Blast_Score=83, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6320904, Length=449, Percent_Identity=30.2895322939866, Blast_Score=177, Evalue=2e-45,
Organism=Drosophila melanogaster, GI24644341, Length=425, Percent_Identity=36.7058823529412, Blast_Score=238, Evalue=4e-63,
Organism=Drosophila melanogaster, GI19920632, Length=338, Percent_Identity=26.9230769230769, Blast_Score=102, Evalue=3e-22,
Organism=Drosophila melanogaster, GI221330659, Length=338, Percent_Identity=26.9230769230769, Blast_Score=102, Evalue=4e-22,
Organism=Drosophila melanogaster, GI24581345, Length=431, Percent_Identity=20.8816705336427, Blast_Score=75, Evalue=6e-14,

Paralogues:

None

Copy number: 24024 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 30,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.41 [H]

Molecular weight: Translated: 43283; Mature: 43283

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRVVVTGMGIVSSIGSNTEEVTASLREAKSGISRAEEYAELGFRCQVHGAPDIDIESLV
CCEEEEECCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCHHHHH
DRRAMRFHGRGTAWNHIAMDQAIADAGLTEEEVSNERTGIIMGSGGPSTRTIVDSADITR
HHHHHHHCCCCCCCCHHHHHHHHHHCCCCHHHHCCCCCEEEEECCCCCCCEEECCCHHHH
EKGPKRVGPFAVPKAMSSTASATLATFFKIKGINYSISSACATSNHCIGNAYEMIQYGKQ
HCCCCCCCCCCCHHHHHHHHHHHHHHHHEECCCCEEHHHHHCCCCCCCHHHHHHHHHCCC
DRMFAGGCEDLDWTLSVLFDAMGAMSSKYNDTPSTASRAYDKNRDGFVIAGGAGVLVLED
CCEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCCEEEECCCCEEEEHH
LETALARGAKIYGEIVGYGATSDGYDMVAPSGEGAIRCMKMALSTVTSKIDYINPHATST
HHHHHHCCHHHHHHHEECCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCC
PAGDAPEIEAIRQIFGAGDACPPIAATKSLTGHSLGATGVQEAIYSLLMMQNNFICESAH
CCCCCHHHHHHHHHHCCCCCCCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCEECCCC
IEELDPAFADMPIVRKRIDNVQLNTVLSNSFGFGGTNATLVFQRYQG
HHHCCHHHHCCHHHHHHHCCEEEEEEECCCCCCCCCCEEEEEEECCC
>Mature Secondary Structure
MRRVVVTGMGIVSSIGSNTEEVTASLREAKSGISRAEEYAELGFRCQVHGAPDIDIESLV
CCEEEEECCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCHHHHH
DRRAMRFHGRGTAWNHIAMDQAIADAGLTEEEVSNERTGIIMGSGGPSTRTIVDSADITR
HHHHHHHCCCCCCCCHHHHHHHHHHCCCCHHHHCCCCCEEEEECCCCCCCEEECCCHHHH
EKGPKRVGPFAVPKAMSSTASATLATFFKIKGINYSISSACATSNHCIGNAYEMIQYGKQ
HCCCCCCCCCCCHHHHHHHHHHHHHHHHEECCCCEEHHHHHCCCCCCCHHHHHHHHHCCC
DRMFAGGCEDLDWTLSVLFDAMGAMSSKYNDTPSTASRAYDKNRDGFVIAGGAGVLVLED
CCEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCCEEEECCCCEEEEHH
LETALARGAKIYGEIVGYGATSDGYDMVAPSGEGAIRCMKMALSTVTSKIDYINPHATST
HHHHHHCCHHHHHHHEECCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCC
PAGDAPEIEAIRQIFGAGDACPPIAATKSLTGHSLGATGVQEAIYSLLMMQNNFICESAH
CCCCCHHHHHHHHHHCCCCCCCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCEECCCC
IEELDPAFADMPIVRKRIDNVQLNTVLSNSFGFGGTNATLVFQRYQG
HHHCCHHHHCCHHHHHHHCCEEEEEEECCCCCCCCCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]