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The map label for this gene is cobS [H]

Identifier: 23502870

GI number: 23502870

Start: 1949923

End: 1950909

Strand: Reverse

Name: cobS [H]

Synonym: BR2022

Alternate gene names: 23502870

Gene position: 1950909-1949923 (Counterclockwise)

Preceding gene: 23502872

Following gene: 23502869

Centisome position: 92.56

GC content: 57.95

Gene sequence:

>987_bases
ATGAACAAGGTTGAGCGGGATATAGCCAATTTGCCGGATACCACGGTTTCGGTACGCGAAGTATTCGGGATCGATTCCGA
CATGATGGTGCCGGCCTATGCGGCGGGCGATTCCTATGTGCCGGAACTTGATCCGGATTATCTTTTCGATCGCCAGACGA
CGCTCGCGATCCTCGCAGGCTTTGCCTATAACCGCCGCGTGATGGTTTCGGGCTATCACGGCACGGGTAAATCGACCCAT
ATCGAGCAGGTTGCAGCCCGCCTCAACTGGCCTTGCGTCCGCGTCAATCTCGACAGCCATGTCAGCCGTATCGACCTTGT
CGGCAAGGATGCGATCGTGGTGAAGGAAGGCGTGCAGGTTACGGAATTCAAGGACGGCATCCTGCCATGGGCCTACCAGC
ACAATGTCGCGCTGGTGTTCGACGAATATGATGCGGGTCGCCCGGATGTGATGTTCGTCATCCAGCGCGTTCTGGAATCG
TCGGGCCGCCTGACGCTCCTCGACCAGAGCCGCGTTATCCGTCCGCATCCCGCTTTCCGCCTGTTTGCAACCGCCAATAC
GGTCGGCCTTGGCGACACGACGGGCCTTTATCACGGCACTCAACAGATCAACCAGGCGCAGATGGACCGCTGGTCCATCG
TGACGACGCTGAACTATCTGCCGCACGACAATGAAGTGAATATCGTTCTCGCCAAGGCCAAGCATTACCAGAATGCCGAA
GGCCGCGAGATCGTGAACAAGATGGTGCGCGTGGCCGACATGACGCGCCAGGCTTTCATCAACGGCGATCTTTCAACCGT
GACGAGCCCGCGCACGGTCATTACCTGGGCCGAGAATGCCGCAATCTTCAACGATGTCGGCTTTGCCTTCCGGCTGACCT
TCCTCAACAAGTGCGATGAACTGGAACGTGCGACGGTTGCTGAATTCTATCAGCGTGCCTTCGGCGTGGAACTGCCGGAA
TCGGCAGCCAATATCGTTCTCGCCTGA

Upstream 100 bases:

>100_bases
ACTGAACACGGACGGGGCGCATATCCGGCTTGCCGGGAAAACGTGCCCCGGATGATACTTGGATATCGCGGCCGGACAGT
CCTGCCGCTCTGGAGGCATG

Downstream 100 bases:

>100_bases
TGAGAAAAGGCCCGTCGCCGGATGATCCGGCGGCGGCGCTCCATGATTTGATGCAGGCGGGGCCGTCTGCTGCAAAGTGA
AGTCGGGATAGGCAGATGTC

Product: cobalamin biosynthesis protein

Products: NA

Alternate protein names: Hydrogenobyrinic acid a,c-diamide cobaltochelatase subunit CobS [H]

Number of amino acids: Translated: 328; Mature: 328

Protein sequence:

>328_residues
MNKVERDIANLPDTTVSVREVFGIDSDMMVPAYAAGDSYVPELDPDYLFDRQTTLAILAGFAYNRRVMVSGYHGTGKSTH
IEQVAARLNWPCVRVNLDSHVSRIDLVGKDAIVVKEGVQVTEFKDGILPWAYQHNVALVFDEYDAGRPDVMFVIQRVLES
SGRLTLLDQSRVIRPHPAFRLFATANTVGLGDTTGLYHGTQQINQAQMDRWSIVTTLNYLPHDNEVNIVLAKAKHYQNAE
GREIVNKMVRVADMTRQAFINGDLSTVTSPRTVITWAENAAIFNDVGFAFRLTFLNKCDELERATVAEFYQRAFGVELPE
SAANIVLA

Sequences:

>Translated_328_residues
MNKVERDIANLPDTTVSVREVFGIDSDMMVPAYAAGDSYVPELDPDYLFDRQTTLAILAGFAYNRRVMVSGYHGTGKSTH
IEQVAARLNWPCVRVNLDSHVSRIDLVGKDAIVVKEGVQVTEFKDGILPWAYQHNVALVFDEYDAGRPDVMFVIQRVLES
SGRLTLLDQSRVIRPHPAFRLFATANTVGLGDTTGLYHGTQQINQAQMDRWSIVTTLNYLPHDNEVNIVLAKAKHYQNAE
GREIVNKMVRVADMTRQAFINGDLSTVTSPRTVITWAENAAIFNDVGFAFRLTFLNKCDELERATVAEFYQRAFGVELPE
SAANIVLA
>Mature_328_residues
MNKVERDIANLPDTTVSVREVFGIDSDMMVPAYAAGDSYVPELDPDYLFDRQTTLAILAGFAYNRRVMVSGYHGTGKSTH
IEQVAARLNWPCVRVNLDSHVSRIDLVGKDAIVVKEGVQVTEFKDGILPWAYQHNVALVFDEYDAGRPDVMFVIQRVLES
SGRLTLLDQSRVIRPHPAFRLFATANTVGLGDTTGLYHGTQQINQAQMDRWSIVTTLNYLPHDNEVNIVLAKAKHYQNAE
GREIVNKMVRVADMTRQAFINGDLSTVTSPRTVITWAENAAIFNDVGFAFRLTFLNKCDELERATVAEFYQRAFGVELPE
SAANIVLA

Specific function: Catalyzes cobalt insertion in the corrin ring [H]

COG id: COG0714

COG function: function code R; MoxR-like ATPases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI24415404, Length=212, Percent_Identity=24.5283018867925, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6323135, Length=255, Percent_Identity=23.5294117647059, Blast_Score=64, Evalue=3e-11,
Organism=Drosophila melanogaster, GI161076562, Length=202, Percent_Identity=25.2475247524752, Blast_Score=69, Evalue=6e-12,
Organism=Drosophila melanogaster, GI161076560, Length=202, Percent_Identity=25.2475247524752, Blast_Score=68, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011704
- InterPro:   IPR006537 [H]

Pfam domain/function: PF07728 AAA_5 [H]

EC number: =6.6.1.2 [H]

Molecular weight: Translated: 36672; Mature: 36672

Theoretical pI: Translated: 5.39; Mature: 5.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKVERDIANLPDTTVSVREVFGIDSDMMVPAYAAGDSYVPELDPDYLFDRQTTLAILAG
CCHHHHHHHCCCCCCCHHHHHHCCCCCCEEEEEECCCCCCCCCCCCHHHCCCHHHHHHHH
FAYNRRVMVSGYHGTGKSTHIEQVAARLNWPCVRVNLDSHVSRIDLVGKDAIVVKEGVQV
HCCCCEEEEEECCCCCCCHHHHHHHHHCCCCEEEEEHHHCCCEEEECCCCEEEEECCCEE
TEFKDGILPWAYQHNVALVFDEYDAGRPDVMFVIQRVLESSGRLTLLDQSRVIRPHPAFR
EECCCCCCCEEEECCEEEEEECCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCCCCEE
LFATANTVGLGDTTGLYHGTQQINQAQMDRWSIVTTLNYLPHDNEVNIVLAKAKHYQNAE
EEEECCCCCCCCCCCCCCCHHHHHHHHHHHHEEEEEEECCCCCCCEEEEEEECCCCCCCC
GREIVNKMVRVADMTRQAFINGDLSTVTSPRTVITWAENAAIFNDVGFAFRLTFLNKCDE
HHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCEEEEEECCCEEECCCCHHHHHHHHHHHHH
LERATVAEFYQRAFGVELPESAANIVLA
HHHHHHHHHHHHHHCCCCCCCCCCEEEC
>Mature Secondary Structure
MNKVERDIANLPDTTVSVREVFGIDSDMMVPAYAAGDSYVPELDPDYLFDRQTTLAILAG
CCHHHHHHHCCCCCCCHHHHHHCCCCCCEEEEEECCCCCCCCCCCCHHHCCCHHHHHHHH
FAYNRRVMVSGYHGTGKSTHIEQVAARLNWPCVRVNLDSHVSRIDLVGKDAIVVKEGVQV
HCCCCEEEEEECCCCCCCHHHHHHHHHCCCCEEEEEHHHCCCEEEECCCCEEEEECCCEE
TEFKDGILPWAYQHNVALVFDEYDAGRPDVMFVIQRVLESSGRLTLLDQSRVIRPHPAFR
EECCCCCCCEEEECCEEEEEECCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCCCCEE
LFATANTVGLGDTTGLYHGTQQINQAQMDRWSIVTTLNYLPHDNEVNIVLAKAKHYQNAE
EEEECCCCCCCCCCCCCCCHHHHHHHHHHHHEEEEEEECCCCCCCEEEEEEECCCCCCCC
GREIVNKMVRVADMTRQAFINGDLSTVTSPRTVITWAENAAIFNDVGFAFRLTFLNKCDE
HHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCEEEEEECCCEEECCCCHHHHHHHHHHHHH
LERATVAEFYQRAFGVELPESAANIVLA
HHHHHHHHHHHHHHCCCCCCCCCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1917840 [H]