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The map label for this gene is cobT [H]

Identifier: 23502869

GI number: 23502869

Start: 1947914

End: 1949815

Strand: Reverse

Name: cobT [H]

Synonym: BR2021

Alternate gene names: 23502869

Gene position: 1949815-1947914 (Counterclockwise)

Preceding gene: 23502870

Following gene: 23502865

Centisome position: 92.51

GC content: 61.62

Gene sequence:

>1902_bases
ATGTCAGGAATAGGCGATAATTCGCGTGATCGTAAAACGGGTCCGGTCGATTCCGAGCCGTTCAAGCGTGCGATAACGGC
TTGCGTCCGCGCCATTTCCGGCGACCATGAAATGGAAGTGGCCTTCAGCCATGACCGCCCGGCGCTGAGCGCCAATCGCG
CCCGCCTTCCCGATCTGCCGAAGCGCCCGACCGCGCATGACATTGCCGTCACGCGGGGGCTTGGCGATTCCATGGCGTTG
CGTCAGGCGCGCCACAATCCGCGCATTCATGCCGCGCTGGCGCCGGAAGGCAAGCAGGCGCGGGCGATTTTCGATGCGGT
CGAGCAGGCGCGTGTGGAAGCCATCGGCGCGCGCGCCATGGCTGGCGTGGCGGATAACCTCTCCACCATGCTGGCCGATA
AATATAGCCGTGCCAATTTTTCCGCTGTCACGACGAAGGAAGATGCGCCGCTGGAAGAGGCGGTGTCGCTTCTCCTGCGT
GAGAAGCTGACAGGCCGTCCGGCCCCGGCGGAAGCAGGCCAGGTGCTGGAGCTGTGGCGCGACTGGATCGAGCAGAAGGC
ATCTGCCGATATTGCGCGGCTTGGCGAGAACCTCGAAGACCAGCAGGCTTTTGCGCGCACGGTGCGCGATATGCTCGCCT
CCATGGATATGGCGGAAGAGCTTTCGCAGGAAGAGCCGAGCGACGACGAAGAGCAGAATGACGAGCAGACGCCGGATTCC
GATGAAAACGAGGAAGGCGGCGACGAAAATCAGGAAGGTTCCGATTCGGCTGAAAGCGAAGAGTCGGACAGTTCCAGCGA
TGAAGGCGAACAGGGCGAGATGGACGCGGCGGATGCTTCCGCCGACGAAATGGACGACAGCGAGGATATCGATGCGGAAA
CACCGGGCGATACGCGCCGTCCGAACCAGCCTTTCGCCTATTTTGCCGAGCATGTCGATTATAAGGTCTTTACGCGTGAA
TTCGACGAGGAAGTCGAGGCGACCGACCTTTGCGACGAAGCGGAACTGGACCGCCTGCGCGGTTTTCTCGACAAGCAGCT
TGCCAATTTGCAGGGCGTGGTAGGGCGTCTGGCCAACCGTTTGCAGCGCCGCCTGATGGCGCAGCAAAACCGCTCGTGGG
ATTTCGATCTGGAAGAGGGCTATCTCGATTCGGCCCGTCTGGTGCGCATCGTCATCGATCCCACGCAGCCGCTTTCCTAC
AAGCAGGAGCGCGATACGGATTTCCGCGATACGGTGGTGACGCTCGTGCTGGATAATTCCGGCTCCATGCGCGGCCGTCC
GATCACGGTGGCTGCAACCTGTGCCGATATTCTTGCCCGTACGCTGGAACGTTGCGGTGTGAAGGTGGAAATTCTGGGCT
TTACCACCAAGGCGTGGAAGGGCGGGCAATCGCGCGAAGCATGGCTTGGGTGCGGCAAGCCTGCCAATCCGGGGCGGCTC
AATGATCTTCGCCACATCGTTTACAAGAGCGCCGACGCGCCATGGCGGCGGGCACGGCGCAATCTCGGCCTGATGATGCG
CGAAGGGCTTCTGAAGGAGAATATCGACGGCGAGGCGCTGATCTGGGCGCATCAGCGGCTGCTGGGCCGTCCTGAACAGC
GCAAGATCCTGATGATGATTTCAGACGGTGCGCCGGTGGACGATTCGACGCTTTCCGTCAATCCGGGCAATTATCTGGAG
CGGCATCTGCGGGCCGTGATCGAGGAGATTGAAACGCGCTCTCCGGTGGAGCTGATCGCCATCGGCATCGGCCATGACGT
GACCCGTTATTACCAGCGCGCTGTCACAATCGTCGATGCGGAAGAACTGGCGGGCGCAATGACAGAACAACTTGCCTCGC
TCTTTGAGGAGCAGGGGGCTGCCGCTTCCGTGCGCGGACGCCGGCGTGCCGGTCGAAGATAG

Upstream 100 bases:

>100_bases
AGGCCCGTCGCCGGATGATCCGGCGGCGGCGCTCCATGATTTGATGCAGGCGGGGCCGTCTGCTGCAAAGTGAAGTCGGG
ATAGGCAGATGTCGGGCCAA

Downstream 100 bases:

>100_bases
AGCATGTCTCCCGAAAGCGGGATCCGCTCTATCTCTTTGTTTTTACACGTTATCCGACGCATCGAAGCGGATCAGAAATC
AGCCTGGTGGAGTGATTTCC

Product: cobalamin biosynthesis protein

Products: NA

Alternate protein names: Hydrogenobyrinic acid a,c-diamide cobaltochelatase subunit CobT [H]

Number of amino acids: Translated: 633; Mature: 632

Protein sequence:

>633_residues
MSGIGDNSRDRKTGPVDSEPFKRAITACVRAISGDHEMEVAFSHDRPALSANRARLPDLPKRPTAHDIAVTRGLGDSMAL
RQARHNPRIHAALAPEGKQARAIFDAVEQARVEAIGARAMAGVADNLSTMLADKYSRANFSAVTTKEDAPLEEAVSLLLR
EKLTGRPAPAEAGQVLELWRDWIEQKASADIARLGENLEDQQAFARTVRDMLASMDMAEELSQEEPSDDEEQNDEQTPDS
DENEEGGDENQEGSDSAESEESDSSSDEGEQGEMDAADASADEMDDSEDIDAETPGDTRRPNQPFAYFAEHVDYKVFTRE
FDEEVEATDLCDEAELDRLRGFLDKQLANLQGVVGRLANRLQRRLMAQQNRSWDFDLEEGYLDSARLVRIVIDPTQPLSY
KQERDTDFRDTVVTLVLDNSGSMRGRPITVAATCADILARTLERCGVKVEILGFTTKAWKGGQSREAWLGCGKPANPGRL
NDLRHIVYKSADAPWRRARRNLGLMMREGLLKENIDGEALIWAHQRLLGRPEQRKILMMISDGAPVDDSTLSVNPGNYLE
RHLRAVIEEIETRSPVELIAIGIGHDVTRYYQRAVTIVDAEELAGAMTEQLASLFEEQGAAASVRGRRRAGRR

Sequences:

>Translated_633_residues
MSGIGDNSRDRKTGPVDSEPFKRAITACVRAISGDHEMEVAFSHDRPALSANRARLPDLPKRPTAHDIAVTRGLGDSMAL
RQARHNPRIHAALAPEGKQARAIFDAVEQARVEAIGARAMAGVADNLSTMLADKYSRANFSAVTTKEDAPLEEAVSLLLR
EKLTGRPAPAEAGQVLELWRDWIEQKASADIARLGENLEDQQAFARTVRDMLASMDMAEELSQEEPSDDEEQNDEQTPDS
DENEEGGDENQEGSDSAESEESDSSSDEGEQGEMDAADASADEMDDSEDIDAETPGDTRRPNQPFAYFAEHVDYKVFTRE
FDEEVEATDLCDEAELDRLRGFLDKQLANLQGVVGRLANRLQRRLMAQQNRSWDFDLEEGYLDSARLVRIVIDPTQPLSY
KQERDTDFRDTVVTLVLDNSGSMRGRPITVAATCADILARTLERCGVKVEILGFTTKAWKGGQSREAWLGCGKPANPGRL
NDLRHIVYKSADAPWRRARRNLGLMMREGLLKENIDGEALIWAHQRLLGRPEQRKILMMISDGAPVDDSTLSVNPGNYLE
RHLRAVIEEIETRSPVELIAIGIGHDVTRYYQRAVTIVDAEELAGAMTEQLASLFEEQGAAASVRGRRRAGRR
>Mature_632_residues
SGIGDNSRDRKTGPVDSEPFKRAITACVRAISGDHEMEVAFSHDRPALSANRARLPDLPKRPTAHDIAVTRGLGDSMALR
QARHNPRIHAALAPEGKQARAIFDAVEQARVEAIGARAMAGVADNLSTMLADKYSRANFSAVTTKEDAPLEEAVSLLLRE
KLTGRPAPAEAGQVLELWRDWIEQKASADIARLGENLEDQQAFARTVRDMLASMDMAEELSQEEPSDDEEQNDEQTPDSD
ENEEGGDENQEGSDSAESEESDSSSDEGEQGEMDAADASADEMDDSEDIDAETPGDTRRPNQPFAYFAEHVDYKVFTREF
DEEVEATDLCDEAELDRLRGFLDKQLANLQGVVGRLANRLQRRLMAQQNRSWDFDLEEGYLDSARLVRIVIDPTQPLSYK
QERDTDFRDTVVTLVLDNSGSMRGRPITVAATCADILARTLERCGVKVEILGFTTKAWKGGQSREAWLGCGKPANPGRLN
DLRHIVYKSADAPWRRARRNLGLMMREGLLKENIDGEALIWAHQRLLGRPEQRKILMMISDGAPVDDSTLSVNPGNYLER
HLRAVIEEIETRSPVELIAIGIGHDVTRYYQRAVTIVDAEELAGAMTEQLASLFEEQGAAASVRGRRRAGRR

Specific function: Catalyzes cobalt insertion in the corrin ring [H]

COG id: COG4547

COG function: function code H; Cobalamin biosynthesis protein CobT (nicotinate-mononucleotide:5, 6-dimethylbenzimidazole phosphoribosyltransferase)

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 VWFA domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006538
- InterPro:   IPR002035 [H]

Pfam domain/function: PF06213 CobT [H]

EC number: =6.6.1.2 [H]

Molecular weight: Translated: 70225; Mature: 70093

Theoretical pI: Translated: 4.49; Mature: 4.49

Prosite motif: PS50234 VWFA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGIGDNSRDRKTGPVDSEPFKRAITACVRAISGDHEMEVAFSHDRPALSANRARLPDLP
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCCC
KRPTAHDIAVTRGLGDSMALRQARHNPRIHAALAPEGKQARAIFDAVEQARVEAIGARAM
CCCCCCHHHHHCCCCHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHH
AGVADNLSTMLADKYSRANFSAVTTKEDAPLEEAVSLLLREKLTGRPAPAEAGQVLELWR
HHHHHHHHHHHHHHHHCCCCCEECCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
DWIEQKASADIARLGENLEDQQAFARTVRDMLASMDMAEELSQEEPSDDEEQNDEQTPDS
HHHHHHHCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
DENEEGGDENQEGSDSAESEESDSSSDEGEQGEMDAADASADEMDDSEDIDAETPGDTRR
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHCCCCCCCCCCCCCCCCCC
PNQPFAYFAEHVDYKVFTREFDEEVEATDLCDEAELDRLRGFLDKQLANLQGVVGRLANR
CCCCHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LQRRLMAQQNRSWDFDLEEGYLDSARLVRIVIDPTQPLSYKQERDTDFRDTVVTLVLDNS
HHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCHHCCCCHHHEEEEEEECCC
GSMRGRPITVAATCADILARTLERCGVKVEILGFTTKAWKGGQSREAWLGCGKPANPGRL
CCCCCCCEEHHHHHHHHHHHHHHHCCCEEEEEEEEHHHCCCCCCCHHHCCCCCCCCCCHH
NDLRHIVYKSADAPWRRARRNLGLMMREGLLKENIDGEALIWAHQRLLGRPEQRKILMMI
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHCCCCCCEEEEEE
SDGAPVDDSTLSVNPGNYLERHLRAVIEEIETRSPVELIAIGIGHDVTRYYQRAVTIVDA
ECCCCCCCCEEECCCHHHHHHHHHHHHHHHHCCCCEEEEEEECCHHHHHHHHHHHHEECH
EELAGAMTEQLASLFEEQGAAASVRGRRRAGRR
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCC
>Mature Secondary Structure 
SGIGDNSRDRKTGPVDSEPFKRAITACVRAISGDHEMEVAFSHDRPALSANRARLPDLP
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCCC
KRPTAHDIAVTRGLGDSMALRQARHNPRIHAALAPEGKQARAIFDAVEQARVEAIGARAM
CCCCCCHHHHHCCCCHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHH
AGVADNLSTMLADKYSRANFSAVTTKEDAPLEEAVSLLLREKLTGRPAPAEAGQVLELWR
HHHHHHHHHHHHHHHHCCCCCEECCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
DWIEQKASADIARLGENLEDQQAFARTVRDMLASMDMAEELSQEEPSDDEEQNDEQTPDS
HHHHHHHCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
DENEEGGDENQEGSDSAESEESDSSSDEGEQGEMDAADASADEMDDSEDIDAETPGDTRR
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHCCCCCCCCCCCCCCCCCC
PNQPFAYFAEHVDYKVFTREFDEEVEATDLCDEAELDRLRGFLDKQLANLQGVVGRLANR
CCCCHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LQRRLMAQQNRSWDFDLEEGYLDSARLVRIVIDPTQPLSYKQERDTDFRDTVVTLVLDNS
HHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCHHCCCCHHHEEEEEEECCC
GSMRGRPITVAATCADILARTLERCGVKVEILGFTTKAWKGGQSREAWLGCGKPANPGRL
CCCCCCCEEHHHHHHHHHHHHHHHCCCEEEEEEEEHHHCCCCCCCHHHCCCCCCCCCCHH
NDLRHIVYKSADAPWRRARRNLGLMMREGLLKENIDGEALIWAHQRLLGRPEQRKILMMI
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHCCCCCCEEEEEE
SDGAPVDDSTLSVNPGNYLERHLRAVIEEIETRSPVELIAIGIGHDVTRYYQRAVTIVDA
ECCCCCCCCEEECCCHHHHHHHHHHHHHHHHCCCCEEEEEEECCHHHHHHHHHHHHEECH
EELAGAMTEQLASLFEEQGAAASVRGRRRAGRR
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1917840 [H]