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The map label for this gene is apt [H]

Identifier: 23502408

GI number: 23502408

Start: 1489210

End: 1489770

Strand: Reverse

Name: apt [H]

Synonym: BR1540

Alternate gene names: 23502408

Gene position: 1489770-1489210 (Counterclockwise)

Preceding gene: 23502409

Following gene: 23502402

Centisome position: 70.68

GC content: 56.33

Gene sequence:

>561_bases
TTGAAAGGACTGAAAATGGAATCCGGGTTTAAGGTCACCTTGAAGGATGCGATCAGAACCATTCCGGATTATCCGAAACC
CGGCGTTCAATTCCGCGACGTCACCACGCTCATGGGCAATGCGCAGGCCTTTCGCCGCGCCGTCGATGAACTGGTCTATC
CCTATGCGGGTAACAGGATTGACAAGGTGGCGGGGATCGAGGCGCGCGGTTTTATTCTTGGCGGTGCAATTGCTCACCAG
CTTTCGGCGGGCTTCGTGCCAATCCGCAAGAAGGGCAAGCTGCCGCGCGATACGGTGCGCATCGCATACAGTCTTGAATA
TGGCGTCGATGAAATGGAAATGCATCGTGACGCCATTGAAAAGGGTGAGCGTGTCGTTCTCGTGGATGATCTGATTGCAA
CGGGTGGAACGGCGGAAGCTGCTGCCAAGCTTCTGCTCCAGATGGGAGCGGAAATTGTTGCCGCCTGCTTTATCATTGAC
CTGCCGGACTTAGGCGGGCGAAAGAAGCTGGAGGCGCTTGGCCTGCCGGTGCGCACCCTTGTCGCGTTTGAAGGCGATTG
A

Upstream 100 bases:

>100_bases
AAGGTGCTTGGCGTGGCTGCCAGATCGTGATTGAAGAATTTCACAAACAGGACCATGCCAGATTAGCCTGGGGTAAGGCT
GTCTGCTCCCCACCATCCCC

Downstream 100 bases:

>100_bases
GGATACGAAAAAGCTCGGACAATGCTCCGGGCTTTGTTGTTTCAGGCCGTTGCTTTCGGCGGCAGTTTCACCATGGCCGC
ATTGTCGAAGGACAAGACTT

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT [H]

Number of amino acids: Translated: 186; Mature: 186

Protein sequence:

>186_residues
MKGLKMESGFKVTLKDAIRTIPDYPKPGVQFRDVTTLMGNAQAFRRAVDELVYPYAGNRIDKVAGIEARGFILGGAIAHQ
LSAGFVPIRKKGKLPRDTVRIAYSLEYGVDEMEMHRDAIEKGERVVLVDDLIATGGTAEAAAKLLLQMGAEIVAACFIID
LPDLGGRKKLEALGLPVRTLVAFEGD

Sequences:

>Translated_186_residues
MKGLKMESGFKVTLKDAIRTIPDYPKPGVQFRDVTTLMGNAQAFRRAVDELVYPYAGNRIDKVAGIEARGFILGGAIAHQ
LSAGFVPIRKKGKLPRDTVRIAYSLEYGVDEMEMHRDAIEKGERVVLVDDLIATGGTAEAAAKLLLQMGAEIVAACFIID
LPDLGGRKKLEALGLPVRTLVAFEGD
>Mature_186_residues
MKGLKMESGFKVTLKDAIRTIPDYPKPGVQFRDVTTLMGNAQAFRRAVDELVYPYAGNRIDKVAGIEARGFILGGAIAHQ
LSAGFVPIRKKGKLPRDTVRIAYSLEYGVDEMEMHRDAIEKGERVVLVDDLIATGGTAEAAAKLLLQMGAEIVAACFIID
LPDLGGRKKLEALGLPVRTLVAFEGD

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis [H]

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4502171, Length=170, Percent_Identity=44.7058823529412, Blast_Score=149, Evalue=2e-36,
Organism=Homo sapiens, GI71773201, Length=121, Percent_Identity=48.7603305785124, Blast_Score=121, Evalue=3e-28,
Organism=Escherichia coli, GI1786675, Length=172, Percent_Identity=51.7441860465116, Blast_Score=183, Evalue=5e-48,
Organism=Caenorhabditis elegans, GI17509087, Length=178, Percent_Identity=42.1348314606742, Blast_Score=131, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6323619, Length=178, Percent_Identity=38.2022471910112, Blast_Score=113, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6320649, Length=173, Percent_Identity=38.150289017341, Blast_Score=102, Evalue=5e-23,
Organism=Drosophila melanogaster, GI17136334, Length=172, Percent_Identity=36.6279069767442, Blast_Score=113, Evalue=9e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005764
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.7 [H]

Molecular weight: Translated: 20172; Mature: 20172

Theoretical pI: Translated: 8.43; Mature: 8.43

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGLKMESGFKVTLKDAIRTIPDYPKPGVQFRDVTTLMGNAQAFRRAVDELVYPYAGNRI
CCCCCCCCCCEEEHHHHHHHCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHCCCCCCCH
DKVAGIEARGFILGGAIAHQLSAGFVPIRKKGKLPRDTVRIAYSLEYGVDEMEMHRDAIE
HHHCCCCCCCEEEHHHHHHHHHCCCCEECCCCCCCHHHEEEEEEECCCCCHHHHHHHHHH
KGERVVLVDDLIATGGTAEAAAKLLLQMGAEIVAACFIIDLPDLGGRKKLEALGLPVRTL
CCCEEEEEEHHHHCCCCHHHHHHHHHHHHHHHHHHHHHEECCCCCCCHHHHHHCCCHHHE
VAFEGD
EEECCC
>Mature Secondary Structure
MKGLKMESGFKVTLKDAIRTIPDYPKPGVQFRDVTTLMGNAQAFRRAVDELVYPYAGNRI
CCCCCCCCCCEEEHHHHHHHCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHCCCCCCCH
DKVAGIEARGFILGGAIAHQLSAGFVPIRKKGKLPRDTVRIAYSLEYGVDEMEMHRDAIE
HHHCCCCCCCEEEHHHHHHHHHCCCCEECCCCCCCHHHEEEEEEECCCCCHHHHHHHHHH
KGERVVLVDDLIATGGTAEAAAKLLLQMGAEIVAACFIIDLPDLGGRKKLEALGLPVRTL
CCCEEEEEEHHHHCCCCHHHHHHHHHHHHHHHHHHHHHEECCCCCCCHHHHHHCCCHHHE
VAFEGD
EEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA