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The map label for this gene is fbcH [H]

Identifier: 23502409

GI number: 23502409

Start: 1490078

End: 1490965

Strand: Reverse

Name: fbcH [H]

Synonym: BR1541

Alternate gene names: 23502409

Gene position: 1490965-1490078 (Counterclockwise)

Preceding gene: 23502410

Following gene: 23502408

Centisome position: 70.74

GC content: 57.43

Gene sequence:

>888_bases
ATGAAGGACGTAACGATGAAAAACATCCTCAAGAACTTCGCTGCCTTCGGTATCGCTCCGCTGGTCGCGCTTGGGTTGTC
GATGGGCGGTGCTCTTGCAGCAGAAGGCGCTAACCCCGCCGAGCCGGATCATTTCCCGATCCACCATCCGAAGCAGGAAA
GCTGGAGCTTTGCCGGTCCATTCGGCACCTATGACAAGGGGCAGCTTCAGCGCGGTCTCAAGGTTTATAAGGAAGTCTGC
TCGGCCTGCCATTCGATGAACCTCGTGGCATTCCGCACGCTGGAAGGCCTTGGTTATTCGCCGGAACAGGTCAAGGCTCT
GGCGGCGGAATATGAAGTCGAAGACGGCCCGAATGCGGATGGCGAAATGTTCACCCGCGCCGCGCTTCCGACGGATCATT
TCCCGGCGCCATATCCCAACGCCAACGCTGCTGCAGCGGCTAATAATGGAGCGGCTCCGCCGGATCTCTCCCTTATCGCC
AAGGCGCGTTCGGTGGAGCGTGGCTTCCCGCAGTTCATTTTCGACATATTCACGCAATATGCCGAAGGCGGACCGGATTA
TATCCATTCGCTTTTGACCGGCTTCGATGAGCAGCCGCCCGCAGGCATGCAGATTGCCGAAGGTACGCACTACAATCCGT
ACTTCATCTCGGCAAAGGCGCTTGCCATGGCCAAGCCGCTTAGCGATGAACAGGTCACCTATGAAGATGGCACACCGGAA
ACAGTGGATCAGTATGCGCGTGACGTCTCGGCTTTCCTGATGTGGGCCGCTGAGCCGCATCTGGAAGACCGCAAGAAGAC
CGGCTTCCGGGTCATTGTCTTCCTGGTTCTCTTCGCGGGGCTTGTTTACATTGCCAAGCGTTCGATCTGGTCGGATGTGA
AGCACTAA

Upstream 100 bases:

>100_bases
AACTCGATCACCGAGGCGGTTCTGGCAAAGGGTGAAGGCAAGGCTGAGATTGCCCCCGTGGAAATCTCTGCGGAAACCAA
GGGCTGATGCAGCGAGAGAT

Downstream 100 bases:

>100_bases
ACTGCCGGAGCGGTTCCTGTAAAAATTGCAGGCGAGACAGCTTGAGGATTGGGCGCCGAAAGGCGCCCATTTCTTTTGCG
CTTTGGACCGGATTTTCTGG

Product: ubiquinol-cytochrome c reductase, cytochrome c1

Products: Q; ferrocytochrome c

Alternate protein names: NA

Number of amino acids: Translated: 295; Mature: 295

Protein sequence:

>295_residues
MKDVTMKNILKNFAAFGIAPLVALGLSMGGALAAEGANPAEPDHFPIHHPKQESWSFAGPFGTYDKGQLQRGLKVYKEVC
SACHSMNLVAFRTLEGLGYSPEQVKALAAEYEVEDGPNADGEMFTRAALPTDHFPAPYPNANAAAAANNGAAPPDLSLIA
KARSVERGFPQFIFDIFTQYAEGGPDYIHSLLTGFDEQPPAGMQIAEGTHYNPYFISAKALAMAKPLSDEQVTYEDGTPE
TVDQYARDVSAFLMWAAEPHLEDRKKTGFRVIVFLVLFAGLVYIAKRSIWSDVKH

Sequences:

>Translated_295_residues
MKDVTMKNILKNFAAFGIAPLVALGLSMGGALAAEGANPAEPDHFPIHHPKQESWSFAGPFGTYDKGQLQRGLKVYKEVC
SACHSMNLVAFRTLEGLGYSPEQVKALAAEYEVEDGPNADGEMFTRAALPTDHFPAPYPNANAAAAANNGAAPPDLSLIA
KARSVERGFPQFIFDIFTQYAEGGPDYIHSLLTGFDEQPPAGMQIAEGTHYNPYFISAKALAMAKPLSDEQVTYEDGTPE
TVDQYARDVSAFLMWAAEPHLEDRKKTGFRVIVFLVLFAGLVYIAKRSIWSDVKH
>Mature_295_residues
MKDVTMKNILKNFAAFGIAPLVALGLSMGGALAAEGANPAEPDHFPIHHPKQESWSFAGPFGTYDKGQLQRGLKVYKEVC
SACHSMNLVAFRTLEGLGYSPEQVKALAAEYEVEDGPNADGEMFTRAALPTDHFPAPYPNANAAAAANNGAAPPDLSLIA
KARSVERGFPQFIFDIFTQYAEGGPDYIHSLLTGFDEQPPAGMQIAEGTHYNPYFISAKALAMAKPLSDEQVTYEDGTPE
TVDQYARDVSAFLMWAAEPHLEDRKKTGFRVIVFLVLFAGLVYIAKRSIWSDVKH

Specific function: Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis. c1 functions as an electron donor to cytochrome c [H]

COG id: COG2857

COG function: function code C; Cytochrome c1

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 cytochrome c domain [H]

Homologues:

Organism=Homo sapiens, GI21359867, Length=246, Percent_Identity=46.3414634146341, Blast_Score=216, Evalue=3e-56,
Organism=Caenorhabditis elegans, GI17506225, Length=280, Percent_Identity=41.0714285714286, Blast_Score=151, Evalue=3e-37,
Organism=Saccharomyces cerevisiae, GI6324639, Length=291, Percent_Identity=41.9243986254296, Blast_Score=220, Evalue=2e-58,
Organism=Drosophila melanogaster, GI24658292, Length=248, Percent_Identity=43.9516129032258, Blast_Score=200, Evalue=1e-51,
Organism=Drosophila melanogaster, GI21358225, Length=247, Percent_Identity=40.4858299595142, Blast_Score=189, Evalue=3e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016175
- InterPro:   IPR005798
- InterPro:   IPR005797
- InterPro:   IPR002326
- InterPro:   IPR021157
- InterPro:   IPR009056
- InterPro:   IPR016174 [H]

Pfam domain/function: PF00032 Cytochrom_B_C; PF00033 Cytochrom_B_N; PF02167 Cytochrom_C1 [H]

EC number: 1.10.2.2

Molecular weight: Translated: 32133; Mature: 32133

Theoretical pI: Translated: 5.16; Mature: 5.16

Prosite motif: PS51007 CYTC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKDVTMKNILKNFAAFGIAPLVALGLSMGGALAAEGANPAEPDHFPIHHPKQESWSFAGP
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHEECCCCCCCCCCCCCCCCCCCCCCCCCC
FGTYDKGQLQRGLKVYKEVCSACHSMNLVAFRTLEGLGYSPEQVKALAAEYEVEDGPNAD
CCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCC
GEMFTRAALPTDHFPAPYPNANAAAAANNGAAPPDLSLIAKARSVERGFPQFIFDIFTQY
HHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHH
AEGGPDYIHSLLTGFDEQPPAGMQIAEGTHYNPYFISAKALAMAKPLSDEQVTYEDGTPE
HCCCHHHHHHHHHCCCCCCCCCCEECCCCCCCCEEEHHHHHHHHCCCCCCCEEECCCCCH
TVDQYARDVSAFLMWAAEPHLEDRKKTGFRVIVFLVLFAGLVYIAKRSIWSDVKH
HHHHHHHHHHHHHHHHCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKDVTMKNILKNFAAFGIAPLVALGLSMGGALAAEGANPAEPDHFPIHHPKQESWSFAGP
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHEECCCCCCCCCCCCCCCCCCCCCCCCCC
FGTYDKGQLQRGLKVYKEVCSACHSMNLVAFRTLEGLGYSPEQVKALAAEYEVEDGPNAD
CCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCC
GEMFTRAALPTDHFPAPYPNANAAAAANNGAAPPDLSLIAKARSVERGFPQFIFDIFTQY
HHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHH
AEGGPDYIHSLLTGFDEQPPAGMQIAEGTHYNPYFISAKALAMAKPLSDEQVTYEDGTPE
HCCCHHHHHHHHHCCCCCCCCCCEECCCCCCCCEEEHHHHHHHHCCCCCCCEEECCCCCH
TVDQYARDVSAFLMWAAEPHLEDRKKTGFRVIVFLVLFAGLVYIAKRSIWSDVKH
HHHHHHHHHHHHHHHHCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: QH2; ferricytochrome c

Specific reaction: QH2 + 2 ferricytochrome c = Q + 2 ferrocytochrome c

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 2541921; 12597275 [H]