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The map label for this gene is penA [H]

Identifier: 23502308

GI number: 23502308

Start: 1396044

End: 1397867

Strand: Reverse

Name: penA [H]

Synonym: BR1437

Alternate gene names: 23502308

Gene position: 1397867-1396044 (Counterclockwise)

Preceding gene: 23502309

Following gene: 23502307

Centisome position: 66.32

GC content: 59.38

Gene sequence:

>1824_bases
ATGCGGCTGAGATTGTTTTCGGCAAAGAAAAAGGCGCCTGATGGCTCCATTCACGGTGAAGTGCCGGCCGGTGATGAAAA
GCTGGCCGGTAATATGGCGTTTGTCGGCTCGCGCAAGCGCCATGGCAACCGCGCGCGCAACCGGCTCTGGATGGCCATTG
CCTGTTTCGCCGGCATTTATGGCGTGATGGCTGGCAAGCTTGTCTATTTCGGCATGATCGGTGGCGTGGATCAAGATGCC
GCCGGTCCGTTTGTGCACCAGCTTGCATCACGCCCCGACATTCTTGACCGCAATGGCGAAATTCTCGCAACCGATATCAA
GACCGCATCGCTCTATGCGGAGCCGCGCAAGATCGTGGACCCGGACGAAACCATCGAAATGCTGTCGACTGTTTTGCCGG
ATCTCGACTGGGAGGCGACCTATAAGCGCCTGAAGAGTGGGGCCGGTTTCGTCTGGATCAAGCGCGGGCTGACGCCGAAG
CAGCAAAGCCAGATCATGGCGCTCGGTGTGCCGGGCATTGGCTTCCGCACGGAAAAACGCCGCTTTTATCCCGGTGGCCC
GACCGCTTCGCATATTCTCGGTCTCGTCAATGTCGATAATCAGGGCATTGCGGGCATGGAGAAATATATCGATAGCCAGG
GGCTGAGCGATCTGCGCTCCGTCGGCCTTGCAACGGGGCAGTCGCTGGAGCCGGTGCATCTTTCCATCGATATTCGCGTG
CAGCACATCATGCGCGATGTTCTGGTCAAGGCCATGGAGCGCTACCGGGCAATCGCGGCTGGCGCTGTGGTGCTGAACGT
CAAGACGGGCGAAGTGATCGCCATGTCGTCCGTACCGGATTTCGACCCGAATAATCCGGTGCACGCGCTGGACAAGGATC
GCCTCAACCGCATGTCGGCAGGCACTTATGAAATGGGCTCGACCATCAAGAGCTTCACGACGGCCATGGCGCTCGATTCC
GGCAAGTTCACCTTGCAGTCGAAGCTCGACGCCTCGCGTCCGCTGGTGTTCGGCCGCCAGACCATCCGCGACTTCCACGG
CAAGGGCCGCTGGCTCACCTTGCCGGAGGTTTTCATCTTCTCGTCCAATATCGGTTCAGGCCGTGAAGCGGACGCCGTCG
GCATCGAAGGGCATCGCGCCTTCCTCAAGAAGATCGGCCTTCTCGACCGTATGCAGACGGAATTGCCGGAAGTGGCGCGC
CCCGTTGAGCCGCGCGTGTGGAAAAAGGTTCATTCCATGACCATTTCCTTCGGTCACGGCATGATGACCACGCCGCTTCA
GACGGCTGTGGGGGCTGCCGCTTTGATGAATGGCGGCAAGCTGATCGAGCCGACTTTCCTGCCGCGTACGGAAGCGCAGG
CGGCTCGGGCCAGCAAGCAGGTGATCCATCCACAGGTTTCTGCCGATATGCGCTATCTCTACCGGCTGAACTCAACTGCC
CCTGGCGGTTCGGGCCGGCGCGCGACGGTTCCGGGCTACCGTGTCGGTGGCAAGACCGGCACGGCGGAAAAGGTGATCAA
TGGCCGCTATTCCAAGGATGTGCGCTTCAACGCTTTCCTGGCGTCATTCCCGATGGATAATCCCACCTATGTCGTGCTTA
CCATCATTGATGAGCCGAAGCCGGAAGAGGGCAAGTTCAGCGCCACCGCCGGTCTTAATGCGGCGCCCATGGTGGCTGAA
ATCATTCGCCGTTCCGCATCATTTCTTGGGGTCAGTCCCGATTTCCGCAAGGAAGCTTTGCCTGCTTCGGTGGAAAACGT
CAGCGGCAGGCCCGATTTTCAACAGGAAGTGCCGCCAGCAATGGTTTCAAACGAATACGATTGA

Upstream 100 bases:

>100_bases
AGATCATCTCCGGCAGTGACGAATTGGTTGCAAGCGGTGTGCTCGAACGGGATGCGATTACCACGGGCAGCGTCAGGAAG
AGCGGGGCGAGGCACTGACC

Downstream 100 bases:

>100_bases
TTCGCATAAGGCTGTCTCTGTATCGACGTGCACGCAACTGAACCTGGATTTGGTATGACCATGAAACTGAAGGAAATCGC
TCTCTTTAATGAGCTGGCCT

Product: penicillin-binding protein

Products: NA

Alternate protein names: PBP-2 [H]

Number of amino acids: Translated: 607; Mature: 607

Protein sequence:

>607_residues
MRLRLFSAKKKAPDGSIHGEVPAGDEKLAGNMAFVGSRKRHGNRARNRLWMAIACFAGIYGVMAGKLVYFGMIGGVDQDA
AGPFVHQLASRPDILDRNGEILATDIKTASLYAEPRKIVDPDETIEMLSTVLPDLDWEATYKRLKSGAGFVWIKRGLTPK
QQSQIMALGVPGIGFRTEKRRFYPGGPTASHILGLVNVDNQGIAGMEKYIDSQGLSDLRSVGLATGQSLEPVHLSIDIRV
QHIMRDVLVKAMERYRAIAAGAVVLNVKTGEVIAMSSVPDFDPNNPVHALDKDRLNRMSAGTYEMGSTIKSFTTAMALDS
GKFTLQSKLDASRPLVFGRQTIRDFHGKGRWLTLPEVFIFSSNIGSGREADAVGIEGHRAFLKKIGLLDRMQTELPEVAR
PVEPRVWKKVHSMTISFGHGMMTTPLQTAVGAAALMNGGKLIEPTFLPRTEAQAARASKQVIHPQVSADMRYLYRLNSTA
PGGSGRRATVPGYRVGGKTGTAEKVINGRYSKDVRFNAFLASFPMDNPTYVVLTIIDEPKPEEGKFSATAGLNAAPMVAE
IIRRSASFLGVSPDFRKEALPASVENVSGRPDFQQEVPPAMVSNEYD

Sequences:

>Translated_607_residues
MRLRLFSAKKKAPDGSIHGEVPAGDEKLAGNMAFVGSRKRHGNRARNRLWMAIACFAGIYGVMAGKLVYFGMIGGVDQDA
AGPFVHQLASRPDILDRNGEILATDIKTASLYAEPRKIVDPDETIEMLSTVLPDLDWEATYKRLKSGAGFVWIKRGLTPK
QQSQIMALGVPGIGFRTEKRRFYPGGPTASHILGLVNVDNQGIAGMEKYIDSQGLSDLRSVGLATGQSLEPVHLSIDIRV
QHIMRDVLVKAMERYRAIAAGAVVLNVKTGEVIAMSSVPDFDPNNPVHALDKDRLNRMSAGTYEMGSTIKSFTTAMALDS
GKFTLQSKLDASRPLVFGRQTIRDFHGKGRWLTLPEVFIFSSNIGSGREADAVGIEGHRAFLKKIGLLDRMQTELPEVAR
PVEPRVWKKVHSMTISFGHGMMTTPLQTAVGAAALMNGGKLIEPTFLPRTEAQAARASKQVIHPQVSADMRYLYRLNSTA
PGGSGRRATVPGYRVGGKTGTAEKVINGRYSKDVRFNAFLASFPMDNPTYVVLTIIDEPKPEEGKFSATAGLNAAPMVAE
IIRRSASFLGVSPDFRKEALPASVENVSGRPDFQQEVPPAMVSNEYD
>Mature_607_residues
MRLRLFSAKKKAPDGSIHGEVPAGDEKLAGNMAFVGSRKRHGNRARNRLWMAIACFAGIYGVMAGKLVYFGMIGGVDQDA
AGPFVHQLASRPDILDRNGEILATDIKTASLYAEPRKIVDPDETIEMLSTVLPDLDWEATYKRLKSGAGFVWIKRGLTPK
QQSQIMALGVPGIGFRTEKRRFYPGGPTASHILGLVNVDNQGIAGMEKYIDSQGLSDLRSVGLATGQSLEPVHLSIDIRV
QHIMRDVLVKAMERYRAIAAGAVVLNVKTGEVIAMSSVPDFDPNNPVHALDKDRLNRMSAGTYEMGSTIKSFTTAMALDS
GKFTLQSKLDASRPLVFGRQTIRDFHGKGRWLTLPEVFIFSSNIGSGREADAVGIEGHRAFLKKIGLLDRMQTELPEVAR
PVEPRVWKKVHSMTISFGHGMMTTPLQTAVGAAALMNGGKLIEPTFLPRTEAQAARASKQVIHPQVSADMRYLYRLNSTA
PGGSGRRATVPGYRVGGKTGTAEKVINGRYSKDVRFNAFLASFPMDNPTYVVLTIIDEPKPEEGKFSATAGLNAAPMVAE
IIRRSASFLGVSPDFRKEALPASVENVSGRPDFQQEVPPAMVSNEYD

Specific function: Synthesis of cross-linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786272, Length=573, Percent_Identity=27.0506108202443, Blast_Score=173, Evalue=3e-44,
Organism=Escherichia coli, GI1786854, Length=536, Percent_Identity=23.5074626865672, Blast_Score=79, Evalue=9e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 66127; Mature: 66127

Theoretical pI: Translated: 10.12; Mature: 10.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLRLFSAKKKAPDGSIHGEVPAGDEKLAGNMAFVGSRKRHGNRARNRLWMAIACFAGIY
CEEEEECCCCCCCCCCCCCCCCCCCHHHCCCEEEECCCHHCCCHHHHHHHHHHHHHHHHH
GVMAGKLVYFGMIGGVDQDAAGPFVHQLASRPDILDRNGEILATDIKTASLYAEPRKIVD
HHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCCCCCCCCEEEEECCHHHHHCCCCCCCC
PDETIEMLSTVLPDLDWEATYKRLKSGAGFVWIKRGLTPKQQSQIMALGVPGIGFRTEKR
CHHHHHHHHHHCCCCCHHHHHHHHHCCCCEEEEECCCCCHHHCCEEEEECCCCCCCCCCC
RFYPGGPTASHILGLVNVDNQGIAGMEKYIDSQGLSDLRSVGLATGQSLEPVHLSIDIRV
EECCCCCCHHHEEEEEEECCCCCHHHHHHHHHCCHHHHHHHHHCCCCCCCCEEEEEEHHH
QHIMRDVLVKAMERYRAIAAGAVVLNVKTGEVIAMSSVPDFDPNNPVHALDKDRLNRMSA
HHHHHHHHHHHHHHHHHHHCCEEEEEEECCCEEEECCCCCCCCCCCCCCCCHHHHHHHCC
GTYEMGSTIKSFTTAMALDSGKFTLQSKLDASRPLVFGRQTIRDFHGKGRWLTLPEVFIF
CCHHHHHHHHHHHHHHHCCCCCEEEHHHCCCCCCEEECHHHHHHHCCCCCEEECCEEEEE
SSNIGSGREADAVGIEGHRAFLKKIGLLDRMQTELPEVARPVEPRVWKKVHSMTISFGHG
ECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHEEECCCC
MMTTPLQTAVGAAALMNGGKLIEPTFLPRTEAQAARASKQVIHPQVSADMRYLYRLNSTA
CCCCHHHHHHHHHHHHCCCCEECCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHEECCCC
PGGSGRRATVPGYRVGGKTGTAEKVINGRYSKDVRFNAFLASFPMDNPTYVVLTIIDEPK
CCCCCCEECCCCEEECCCCCCHHHHHCCCCCCCCEEEEEEEECCCCCCCEEEEEEECCCC
PEEGKFSATAGLNAAPMVAEIIRRSASFLGVSPDFRKEALPASVENVSGRPDFQQEVPPA
CCCCCEEECCCCCCHHHHHHHHHHHHHHCCCCCCHHHHCCCCCHHCCCCCCCHHHHCCCH
MVSNEYD
HHCCCCC
>Mature Secondary Structure
MRLRLFSAKKKAPDGSIHGEVPAGDEKLAGNMAFVGSRKRHGNRARNRLWMAIACFAGIY
CEEEEECCCCCCCCCCCCCCCCCCCHHHCCCEEEECCCHHCCCHHHHHHHHHHHHHHHHH
GVMAGKLVYFGMIGGVDQDAAGPFVHQLASRPDILDRNGEILATDIKTASLYAEPRKIVD
HHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCCCCCCCCEEEEECCHHHHHCCCCCCCC
PDETIEMLSTVLPDLDWEATYKRLKSGAGFVWIKRGLTPKQQSQIMALGVPGIGFRTEKR
CHHHHHHHHHHCCCCCHHHHHHHHHCCCCEEEEECCCCCHHHCCEEEEECCCCCCCCCCC
RFYPGGPTASHILGLVNVDNQGIAGMEKYIDSQGLSDLRSVGLATGQSLEPVHLSIDIRV
EECCCCCCHHHEEEEEEECCCCCHHHHHHHHHCCHHHHHHHHHCCCCCCCCEEEEEEHHH
QHIMRDVLVKAMERYRAIAAGAVVLNVKTGEVIAMSSVPDFDPNNPVHALDKDRLNRMSA
HHHHHHHHHHHHHHHHHHHCCEEEEEEECCCEEEECCCCCCCCCCCCCCCCHHHHHHHCC
GTYEMGSTIKSFTTAMALDSGKFTLQSKLDASRPLVFGRQTIRDFHGKGRWLTLPEVFIF
CCHHHHHHHHHHHHHHHCCCCCEEEHHHCCCCCCEEECHHHHHHHCCCCCEEECCEEEEE
SSNIGSGREADAVGIEGHRAFLKKIGLLDRMQTELPEVARPVEPRVWKKVHSMTISFGHG
ECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHEEECCCC
MMTTPLQTAVGAAALMNGGKLIEPTFLPRTEAQAARASKQVIHPQVSADMRYLYRLNSTA
CCCCHHHHHHHHHHHHCCCCEECCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHEECCCC
PGGSGRRATVPGYRVGGKTGTAEKVINGRYSKDVRFNAFLASFPMDNPTYVVLTIIDEPK
CCCCCCEECCCCEEECCCCCCHHHHHCCCCCCCCEEEEEEEECCCCCCCEEEEEEECCCC
PEEGKFSATAGLNAAPMVAEIIRRSASFLGVSPDFRKEALPASVENVSGRPDFQQEVPPA
CCCCCEEECCCCCCHHHHHHHHHHHHHHCCCCCCHHHHCCCCCHHCCCCCCCHHHHCCCH
MVSNEYD
HHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3126399 [H]