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The map label for this gene is lpxD

Identifier: 23502031

GI number: 23502031

Start: 1132214

End: 1133269

Strand: Reverse

Name: lpxD

Synonym: BR1153

Alternate gene names: 23502031

Gene position: 1133269-1132214 (Counterclockwise)

Preceding gene: 23502032

Following gene: 23502030

Centisome position: 53.77

GC content: 58.43

Gene sequence:

>1056_bases
ATGGCAGATCCCATTTTTTTCAAACCGTCGCGTGAGCTCACGATTGGCGATGTAGCAGATTTCACCGGTGCAAGCCTTCG
AGACCCGAAGCTTGCGCCGCGTTCTGTTGAACGGCTGGCTTCCCTGAAGGATGCCGGGGAGGGTGCGCTTGTCTTCGTGG
AAGGCAAGAAAAACGTCAGCAGTCTCGTCGGTCTCAAGGCGGCGGGTGTGCTTTGCACCGAATCTCTCGCCGACAGCGTA
CCGTCTGGTATTGCGGTTCTCGTCTCGCGCCATCCGCATCGCGATTTCTCCGCCGTAGGACGCATGTTGTTTCCGGCTTC
CGTGCGCCCGGAAAGCTGGCTTGGGGAAACAGGCATATCGCCAGCAGCCTTTATTCACCCAACCGCACAGATAGAAGACG
GTGCGACGGTTGAAGCCGGTGCCGTTATCGGCAGCGGCGTGACAATCGGGGCAGGCACTCTGATTGCCGCTACCGCGGTG
ATCGGACAAAACTGTCAGATCGGCCGCAACAGCTATATCGCCCCCGGCGTTTCGGTGCAGTGCGCCTTTATTGGCAATAA
TGTTTCCCTGCATCCGGGTGTGCGCATCGGGCAGGACGGATTTGGCTATGTTCCGGGCGCGGCAGGGCTTGATAAGGTGC
CGCAGCTCGGCCGGGTTATCATTCAGGACAATGTAGAGATTGGGGCAAATACCACGGTCGATCGTGGCTCACTTGATGAC
ACGGTCATTGGCGAGGGCACCAAGATCGATAATCTGGTGCAGATTGCGCATAATGTGCGCATCGGTCGATTTTGCCTCGT
AGCTGCGCATTGCGGCATTTCCGGTAGCTGCGTTATCGGCGACCAGACCATGCTCGGTGGCCGCGTCGGGCTTGCTGATC
ATCTGATCATCGGTTCGCGTGTGCAGGTTGCCGCGGCAAGCGGCGTTATGAACGACATACCCGATGGCGAGCGTTGGGGG
GGCATCCCTGCGCGGCCTATCAAGCAGTGGTTCCGCGATATTGCGAACATCCGCAGCATCGGGCAATCAAGAAAGGACGC
ATCCTCTGATGAGTGA

Upstream 100 bases:

>100_bases
CTGACAAGGTTCAGAACTTCAACTTCGGTGTATCGACAAAGTTCTGATCGATTTGCCTTTTCTCGGGGCGCCTTTACGCC
CCGAGGAAGAAAGTGTTTTG

Downstream 100 bases:

>100_bases
TGACAATCAGACCAAGTTGGAAGCCGCGGATATTCAGGCACTCCTGGCTGTGCTTCCGCATCGTTATCCCTTTTTGCTGA
TTGACCGCATTGTGGATATC

Product: UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 351; Mature: 350

Protein sequence:

>351_residues
MADPIFFKPSRELTIGDVADFTGASLRDPKLAPRSVERLASLKDAGEGALVFVEGKKNVSSLVGLKAAGVLCTESLADSV
PSGIAVLVSRHPHRDFSAVGRMLFPASVRPESWLGETGISPAAFIHPTAQIEDGATVEAGAVIGSGVTIGAGTLIAATAV
IGQNCQIGRNSYIAPGVSVQCAFIGNNVSLHPGVRIGQDGFGYVPGAAGLDKVPQLGRVIIQDNVEIGANTTVDRGSLDD
TVIGEGTKIDNLVQIAHNVRIGRFCLVAAHCGISGSCVIGDQTMLGGRVGLADHLIIGSRVQVAAASGVMNDIPDGERWG
GIPARPIKQWFRDIANIRSIGQSRKDASSDE

Sequences:

>Translated_351_residues
MADPIFFKPSRELTIGDVADFTGASLRDPKLAPRSVERLASLKDAGEGALVFVEGKKNVSSLVGLKAAGVLCTESLADSV
PSGIAVLVSRHPHRDFSAVGRMLFPASVRPESWLGETGISPAAFIHPTAQIEDGATVEAGAVIGSGVTIGAGTLIAATAV
IGQNCQIGRNSYIAPGVSVQCAFIGNNVSLHPGVRIGQDGFGYVPGAAGLDKVPQLGRVIIQDNVEIGANTTVDRGSLDD
TVIGEGTKIDNLVQIAHNVRIGRFCLVAAHCGISGSCVIGDQTMLGGRVGLADHLIIGSRVQVAAASGVMNDIPDGERWG
GIPARPIKQWFRDIANIRSIGQSRKDASSDE
>Mature_350_residues
ADPIFFKPSRELTIGDVADFTGASLRDPKLAPRSVERLASLKDAGEGALVFVEGKKNVSSLVGLKAAGVLCTESLADSVP
SGIAVLVSRHPHRDFSAVGRMLFPASVRPESWLGETGISPAAFIHPTAQIEDGATVEAGAVIGSGVTIGAGTLIAATAVI
GQNCQIGRNSYIAPGVSVQCAFIGNNVSLHPGVRIGQDGFGYVPGAAGLDKVPQLGRVIIQDNVEIGANTTVDRGSLDDT
VIGEGTKIDNLVQIAHNVRIGRFCLVAAHCGISGSCVIGDQTMLGGRVGLADHLIIGSRVQVAAASGVMNDIPDGERWGG
IPARPIKQWFRDIANIRSIGQSRKDASSDE

Specific function: Lipid A biosynthesis; third step. [C]

COG id: COG1044

COG function: function code M; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxD subfamily

Homologues:

Organism=Escherichia coli, GI1786376, Length=316, Percent_Identity=36.3924050632911, Blast_Score=161, Evalue=5e-41,
Organism=Escherichia coli, GI1786378, Length=209, Percent_Identity=32.0574162679426, Blast_Score=76, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXD_BRUA1 (B2S603)

Other databases:

- EMBL:   CP000887
- RefSeq:   YP_001935074.1
- ProteinModelPortal:   B2S603
- SMR:   B2S603
- GeneID:   6328642
- GenomeReviews:   CP000887_GR
- KEGG:   bmc:BAbS19_I10930
- HOGENOM:   HBG469615
- OMA:   VQIGRVI
- ProtClustDB:   PRK00892
- HAMAP:   MF_00523
- InterPro:   IPR001451
- InterPro:   IPR018357
- InterPro:   IPR011004
- InterPro:   IPR007691
- InterPro:   IPR020573
- TIGRFAMs:   TIGR01853

Pfam domain/function: PF00132 Hexapep; PF04613 LpxD; SSF51161 Trimer_LpxA_like

EC number: 2.3.1.-

Molecular weight: Translated: 36358; Mature: 36227

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADPIFFKPSRELTIGDVADFTGASLRDPKLAPRSVERLASLKDAGEGALVFVEGKKNVS
CCCCCEECCCCCEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEECCCCHH
SLVGLKAAGVLCTESLADSVPSGIAVLVSRHPHRDFSAVGRMLFPASVRPESWLGETGIS
HHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHCCCCCCCHHHCCCCCCC
PAAFIHPTAQIEDGATVEAGAVIGSGVTIGAGTLIAATAVIGQNCQIGRNSYIAPGVSVQ
CCEEECCCCCCCCCCEEECCEEEECCEEECCHHHHHHHHHHCCCCCCCCCCEECCCCEEE
CAFIGNNVSLHPGVRIGQDGFGYVPGAAGLDKVPQLGRVIIQDNVEIGANTTVDRGSLDD
EEEECCCEEECCCCEECCCCCCCCCCCCCHHHHHHHCEEEEECCCEECCCCCCCCCCCCC
TVIGEGTKIDNLVQIAHNVRIGRFCLVAAHCGISGSCVIGDQTMLGGRVGLADHLIIGSR
CCCCCCCCHHHHHHHHHCCCHHHEEEEEECCCCCCEEEECCCCCCCCCCCCHHHEEECCC
VQVAAASGVMNDIPDGERWGGIPARPIKQWFRDIANIRSIGQSRKDASSDE
EEEEEHHCCHHCCCCCHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
ADPIFFKPSRELTIGDVADFTGASLRDPKLAPRSVERLASLKDAGEGALVFVEGKKNVS
CCCCEECCCCCEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEECCCCHH
SLVGLKAAGVLCTESLADSVPSGIAVLVSRHPHRDFSAVGRMLFPASVRPESWLGETGIS
HHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHCCCCCCCHHHCCCCCCC
PAAFIHPTAQIEDGATVEAGAVIGSGVTIGAGTLIAATAVIGQNCQIGRNSYIAPGVSVQ
CCEEECCCCCCCCCCEEECCEEEECCEEECCHHHHHHHHHHCCCCCCCCCCEECCCCEEE
CAFIGNNVSLHPGVRIGQDGFGYVPGAAGLDKVPQLGRVIIQDNVEIGANTTVDRGSLDD
EEEECCCEEECCCCEECCCCCCCCCCCCCHHHHHHHCEEEEECCCEECCCCCCCCCCCCC
TVIGEGTKIDNLVQIAHNVRIGRFCLVAAHCGISGSCVIGDQTMLGGRVGLADHLIIGSR
CCCCCCCCHHHHHHHHHCCCHHHEEEEEECCCCCCEEEECCCCCCCCCCCCHHHEEECCC
VQVAAASGVMNDIPDGERWGGIPARPIKQWFRDIANIRSIGQSRKDASSDE
EEEEEHHCCHHCCCCCHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA